Yogesh Khandokar

Structural basis for disulphide-CoA inhibition of a butyryl-CoA hexameric thioesterase.

Yogesh Khandokar, Parul Srivastava, Shane Raidal, Subir Sarker, Jade K Forwood

Journal article  |  2020  |  Journal of Structural Biology

Acyl-coenzyme A thioesterases (ACTs) catalyse the hydrolysis of thioester bonds between fatty-acyl chains and coenzyme A (CoA), pr..

A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1

Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett, et al.

Journal article  |  2019  |  Science

T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function

Srinivasan Sundararaj, Jingjing Zhang, S Harsha Krovi, Romain Bedel, Kathryn D Tuttle, Natacha Veerapen, Gurdyal S Besra, Yogesh Khandokar, T Praveenaa, Jerome Le Nours, Jennifer L Matsuda, Jamie Rossjohn, Laurent Gapin

Journal article  |  2018  |  Proceedings of the National Academy of Sciences of the United States of America

Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase.

Yogesh B Khandokar, Parul Srivastava, Nathan Cowieson, Subir Sarker, David Aragao, Shubagata Das, Kate M Smith, Shane R Raidal, Jade K Forwood

Journal article  |  2017  |  Journal of Biological Chemistry

Thioesterases catalyze the cleavage of thioester bonds within many activated fatty acids and acyl-CoA substrates. They are express..

Structural insights into the assembly and regulation of distinct viral capsid complexes.

Subir Sarker, María C Terrón, Yogesh Khandokar, David Aragão, Joshua M Hardy, Mazdak Radjainia, Manuel Jiménez-Zaragoza, Pedro J de Pablo, Fasséli Coulibaly, Daniel Luque, Shane R Raidal, Jade K Forwood

Journal article  |  2016  |  Nat Commun

The assembly and regulation of viral capsid proteins into highly ordered macromolecular complexes is essential for viral replicati..

Structural and Functional Characterization of the PaaI Thioesterase from Streptococcus pneumoniae Reveals a Dual Specificity for Phenylacetyl-CoA and Medium-chain Fatty Acyl-CoAs and a Novel CoA-induced Fit Mechanism.

Yogesh B Khandokar, Parul Srivastava, Subir Sarker, Crystall MD Swarbrick, David Aragao, Nathan Cowieson, Jade K Forwood

Journal article  |  2016  |  Journal of Biological Chemistry

PaaI thioesterases are members of the TE13 thioesterase family that catalyze the hydrolysis of thioester bonds between coenzyme A ..

An efficient approach for recombinant expression and purification of the viral capsid protein from beak and feather disease virus (BFDV) in Escherichia coli.

Subir Sarker, Seyed A Ghorashi, Crystall MD Swarbrick, Yogesh B Khandokar, Zainab Himiari, Jade K Forwood, Shane R Raidal

Journal article  |  2015  |  Journal of Virological Methods

Structural insights into the biology of viruses such as beak and feather disease virus (BFDV) which do not replicate in cell cultu..

A Case Report of Decompensated Cirrhosis of Liver with Sideroblastic Anemia.

Mamun-Al Mahtab, Abdur Rahim, Sheikh Mohammad Noor-E-Alam, Faiz Ahmad Khandokar, Ahmed LutfulMubin, Salimur Rahman

Journal article  |  2015  |  Euroasian Journal of Hepato-Gastroenterology

A 35-year-old man was admitted to hospital with severe anemia. Two years back, he had presented with bleeding esophageal varices a..

Expression, purification, crystallization and preliminary X-ray analysis of the PaaI-like thioesterase SAV0944 from Staphylococcus aureus.

Yogesh B Khandokar, Noelia Roman, Kate M Smith, Parul Srivastava, Jade K Forwood

Journal article  |  2014  |  Acta Crystallographica Section F: Structural Biology Communications

Staphylococcus aureus is the causative agent of many diseases, including meningitis, bacteraemia, pneumonia, food poisoning and to..

Purification, crystallization and preliminary X-ray diffraction analysis of the N-acetyltransferase SAV0826 from Staphylococcus aureus.

Parul Srivastava, Yogesh B Khandokar, Jade K Forwood

Journal article  |  2014  |  Acta Crystallographica Section F: Structural Biology Communications

Staphylococcus aureus is a prevalent microorganism that is capable of causing a wide range of infections and diseases. Several str..