Jeff Molendijk

Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle

James W McNamara, Benjamin L Parker, Holly K Voges, Neda R Mehdiabadi, Francesca Bolk, Feroz Ahmad, Jin D Chung, Natalie Charitakis, Jeffrey Molendijk, Antonia TL Zech, Sean Lal, Mirana Ramialison, Kathy Karavendzas, Hayley L Pointer, Petros Syrris, Luis R Lopes, Perry M Elliott, Gordon S Lynch, Richard J Mills, James E Hudson, et al.

Journal article  |  2023  |  Nature Cardiovascular Research

AbstractMuscle contraction is driven by the molecular machinery of the sarcomere. As phosphorylation is a critical regulator of mu..

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

Jeffrey Molendijk, Ronnie Blazev, Richard J Mills, Yaan-Kit Ng, Kevin Watt, Daryn Chau, Paul Gregorevic, Peter J Crouch, James BW Hilton, Leszek Lisowski, Peixiang Zhang, Karen Reue, Aldons J Lusis, James E Hudson, David E James, Marcus M Seldin, Benjamin L Parker

Journal article  |  2022  |  ELIFE

Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle meta..

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as anAMPK substrate regulating skeletal muscle function

Ronnie Blazev, Christian S Carl, Yaan-Kit Ng, Jeffrey Molendijk, Christian T Voldstedlund, Yuanyuan Zhao, Di Xiao, Andrew J Kueh, Paula M Miotto, Vanessa R Haynes, Justin P Hardee, Jin D Chung, James W McNamara, Hongwei Qian, Paul Gregorevic, Jonathan S Oakhill, Marco J Herold, Thomas E Jensen, Leszek Lisowski, Gordon S Lynch, et al.

Journal article  |  2022  |  CELL METABOLISM

Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signal..

Rapid Assessment of Lipidomics Sample Purity and Quantity Using Fourier-Transform Infrared Spectroscopy

Harley Robinson, Jeffrey Molendijk, Alok K Shah, Tony Rahman, Gregory J Anderson, Michelle M Hill

Journal article  |  2022  |  BIOMOLECULES

Despite the increasing popularity of liquid chromatography−mass spectrometry (LC-MS)-based lipidomics, there is a lack of accepted..

urPTMdb/TeaProt: Upstream and Downstream Proteomics Analysis

Jeffrey Molendijk, Rui Yip, Benjamin L Parker

Journal article  |  2022  |  JOURNAL OF PROTEOME RESEARCH

We have developed the underrepresented post-translational modification (PTM) database (urPTMdb), a PTM gene set database to accele..

Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid-induced DNA damage

Jeffrey Molendijk, Cathryn M Kolka, Henry Cairns, Sandra Brosda, Ahmed Mohamed, Alok K Shah, Ian Brown, Mark P Hodson, Thomas Hennessy, Guanghao Liu, Thomas Stoll, Renee S Richards, Michael Gartside, Kalpana Patel, Nicholas J Clemons, Wayne A Phillips, Andrew Barbour, Johan A Westerhuis, Michelle M Hill

Journal article  |  2022  |  CLINICAL AND TRANSLATIONAL MEDICINE

BACKGROUND: The risk of esophageal adenocarcinoma (EAC) is associated with gastro-esophageal reflux disease (GERD) and obesity. Li..

Western Diet Induced Remodelling of the Tongue Proteome

Mriga Dutt, Yaan-Kit Ng, Jeffrey Molendijk, Hamzeh Karimkhanloo, Luoping Liao, Ronnie Blazev, Magdalene K Montgomery, Matthew J Watt, Benjamin L Parker

Journal article  |  2021  |  PROTEOMES

The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and d..

CoffeeProt: an online tool for correlation and functional enrichment of systems genetics data

Jeffrey Molendijk, Marcus M Seldin, Benjamin L Parker

Journal article  |  2021  |  NUCLEIC ACIDS RESEARCH

The integration of genomics, transcriptomics, proteomics and phenotypic traits across genetically diverse populations is a powerfu..

Molecular and functional profiling of apical versus basolateral small extracellular vesicles derived from primary human proximal tubular epithelial cells under inflammatory conditions

Xiangju Wang, Ray Wilkinson, Katrina Kildey, Jacobus PJ Ungerer, Michelle M Hill, Alok K Shah, Ahmed Mohamed, Mriga Dutt, Jeffrey Molendijk, Helen Healy, Andrew J Kassianos

Journal article  |  2021  |  JOURNAL OF EXTRACELLULAR VESICLES

Proximal tubular epithelial cells (PTEC) are central players in inflammatory kidney diseases. However, the complex signalling mech..

Proteome-wide Systems Genetics to Identify Functional Regulators of Complex Traits

Jeffrey Molendijk, Benjamin L Parker

Journal article  |  2021  |  CELL SYSTEMS

Proteomic technologies now enable the rapid quantification of thousands of proteins across genetically diverse samples. Integratio..