Charlie Bell

CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity

April C Watt, Paloma Cejas, Molly J DeCristo, Otto Metzger-Filho, Enid YN Lam, Xintao Qiu, Haley BrinJones, Nikolas Kesten, Rhiannon Coulson, Alba Font-Tello, Klothilda Lim, Raga Vadhi, Veerle W Daniels, Joan Montero, Len Taing, Clifford A Meyer, Omer Gilan, Charles C Bell, Keegan D Korthauer, Claudia Giambartolomei, et al.

Journal article  |  2021  |  NATURE CANCER

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) were designed to induce cancer cell cycle arrest. Recent stu..

An Erg-driven transcriptional program controls B cell lymphopoiesis.

Ashley P Ng, Hannah D Coughlan, Soroor Hediyeh-Zadeh, Kira Behrens, Timothy M Johanson, Michael Sze Yuan Low, Charles C Bell, Omer Gilan, Yih-Chih Chan, Andrew J Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A Dawson, et al.

Journal article  |  2020  |  Nature Communications

B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimat..

Principles and mechanisms of non-genetic resistance in cancer

Charles C Bell, Omer Gilan

Journal article  |  2020  |  BRITISH JOURNAL OF CANCER

As well as undergoing genetic evolution, cancer cells can alter their epigenetic state to adapt and resist treatment. This non-gen..