Sean Vittadello

Synchronized oscillations in growing cell populations are explained by demographic noise

Enrico Gavagnin, Sean T Vittadello, Gency Gunasingh, Nikolas K Haass, Matthew J Simpson, Tim Rogers, Christian A Yates

Journal article  |  2021  |  BIOPHYSICAL JOURNAL

Understanding synchrony in growing populations is important for applications as diverse as epidemiology and cancer treatment. Rece..

A novel mathematical model of heterogeneous cell proliferation

Sean T Vittadello, Scott W McCue, Gency Gunasingh, Nikolas K Haass, Matthew J Simpson

Journal article  |  2021  |  JOURNAL OF MATHEMATICAL BIOLOGY

We present a novel mathematical model of heterogeneous cell proliferation where the total population consists of a subpopulation o..

Practical parameter identifiability for spatio-temporal models of cell invasion

Matthew J Simpson, Ruth E Baker, Sean T Vittadello, Oliver J Maclaren

Journal article  |  2020  |  Journal of the Royal Society Interface

We examine the practical identifiability of parameters in a spatio-temporal reaction–diffusion model of a scratch assay. Experimen..

Examining Go-or-Grow Using Fluorescent Cell-Cycle Indicators and Cell-Cycle-Inhibiting Drugs

Sean T Vittadello, Scott W McCue, Gency Gunasingh, Nikolas K Haass, Matthew J Simpson

Journal article  |  2020  |  Biophysical Journal

The go-or-grow hypothesis states that adherent cells undergo reversible phenotype switching between migratory and proliferative st..

Mathematical models incorporating a multi-stage cell cycle replicate normally-hidden inherent synchronization in cell proliferation

Sean T Vittadello, Scott W McCue, Gency Gunasingh, Nikolas K Haass, Matthew J Simpson

Journal article  |  2019  |  JOURNAL OF THE ROYAL SOCIETY INTERFACE

We present a suite of experimental data showing that cell proliferation assays, prepared using standard methods thought to produce..

Stochastic models of cell invasion with fluorescent cell cycle indicators

Matthew J Simpson, Wang Jin, Sean T Vittadello, Tamara A Tambyah, Jacob M Ryan, Gency Gunasingh, Nikolas K Haass, Scott W McCue

Journal article  |  2018  |  PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS

Fluorescent cell cycle labelling in cell biology experiments provides real time information about the location of individual cells..

Mathematical Models for Cell Migration with Real-Time Cell Cycle Dynamics

Sean T Vittadello, Scott W McCue, Gency Gunasingh, Nikolas K Haass, Matthew J Simpson

Journal article  |  2018  |  BIOPHYSICAL JOURNAL

The fluorescent ubiquitination-based cell cycle indicator, also known as FUCCI, allows the visualization of the G1 and S/G2/M cell..

Co-universal C*-algebras associated to generalised graphs

Nathan Brownlowe, Aidan Sims, Sean T Vittadello

Journal article  |  2013  |  ISRAEL JOURNAL OF MATHEMATICS

We introduce P-graphs, which are generalisations of directed graphs in which paths have a degree in a semigroup P rather than a le..

Co-universal algebras associated to product systems, and gauge-invariant uniqueness theorems

Toke M Carlsen, Nadia S Larsen, Aidan Sims, Sean T Vittadello

Journal article  |  2011  |  PROCEEDINGS OF THE LONDON MATHEMATICAL SOCIETY

Let (G, P) be a quasi-lattice ordered group, and let X be a product system over P of Hilbert bimodules. Under mild hypotheses, we ..

Exel's crossed product for non-unital C*-algebras

Nathan Brownlowe, Iain Raeburn, Sean T Vittadello

Journal article  |  2010  |  MATHEMATICAL PROCEEDINGS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY

We consider a family of dynamical systems (A, α, L) in which is an endomorphism of a C*-algebra A and L is a transfer operator for..