Hyun Jae Lee

An introduction to spatial transcriptomics for biomedical research

Cameron G Williams, Hyun Jae Lee, Takahiro Asatsuma, Roser Vento-Tormo, Ashraful Haque

Journal article  |  2022  |  GENOME MEDICINE

Single-cell transcriptomics (scRNA-seq) has become essential for biomedical research over the past decade, particularly in develop..

Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria.

Athina Georgiadou, Claire Dunican, Pablo Soro-Barrio, Hyun Jae Lee, Myrsini Kaforou, Aubrey J Cunnington

Journal article  |  2022  |  Elife

Recent initiatives to improve translation of findings from animal models to human disease have focussed on reproducibility but qua..

A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity

Yannick O Alexandre, Dominik Schienstock, Hyun Jae Lee, Luke C Gandolfo, Cameron G Williams, Sapna Devi, Bhupinder Pal, Joanna R Groom, Wang Cao, Susan N Christo, Claire L Gordon, Graham Starkey, Rohit D'Costa, Laura K Mackay, Ashraful Haque, Burkhard Ludewig, Gabrielle T Belz, Scott N Mueller

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

The spleen is a compartmentalized organ that serves as a blood filter and safeguard of systemic immune surveillance. Labyrinthine ..

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S Meehan, Adam G Nelson, David P Fairlie, Jeffrey YW Mak, Sidonia BG Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Mucosal-associated Invariant T (MAIT) cells are recognized for their antibacterial functions. The protective capacity of MAIT cell..

Exposure to host inflammation in vivo induces rapid transcriptomic change and impaired maturation in malaria parasites

Lianne IM Lansink, Jessica A Engel, Hyun Jae Lee, Megan SF Soon, Cameron G Williams, Rosemary A Aogo, Deborah Cromer, Miles P Davenport, David S Khoury, Ashraful Haque

Conference Proceedings  |  2021  |  JOURNAL OF IMMUNOLOGY

Abstract We previously reported slowing of the Plasmodium life-cycle in acutely-infected wild-type but not immune-d..

Transcriptome dynamics of CD4( ) T cells during malaria maps gradual transit from effector to memory

Megan SF Soon, Hyun Jae Lee, Jessica A Engel, Jasmin Straube, Bryce S Thomas, Clara PS Pernold, Lachlan S Clarke, Pawat Laohamonthonkul, Rohit N Haldar, Cameron G Williams, Lianne IM Lansink, Marcela L Moreira, Michael Bramhall, Lambros T Koufariotis, Scott Wood, Xi Chen, Kylie R James, Tapio Lonnberg, Steven W Lane, Gabrielle T Belz, et al.

Journal article  |  2020  |  NATURE IMMUNOLOGY

The dynamics of CD4+ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial che..

Single-cell transcriptomics of alloreactive CD4( ) T cells over time reveals divergent fates during gut graft-versus-host disease

Jessica A Engel, Hyun Jae Lee, Cameron G Williams, Rachel Kuns, Stuart Olver, Lianne IM Lansink, Megan SF Soon, Stacey B Andersen, Joseph E Powell, Valentine Svensson, Sarah A Teichmann, Geoffrey R Hill, Antiopi Varelias, Motoko Koyama, Ashraful Haque

Journal article  |  2020  |  JCI INSIGHT

Acute gastrointestinal (GI) graft-versus-host disease (GVHD) is a primary determinant of mortality after allogeneic hematopoietic ..

Modelling pathogen load dynamics to elucidate mechanistic determinants of host-Plasmodium falciparum interactions

Athina Georgiadou, Hyun Jae Lee, Michael Walther, Anna E van Beek, Fadlila Fitriani, Diana Wouters, Taco W Kuijpers, Davis Nwakanma, Umberto D'Alessandro, Eleanor M Riley, Thomas D Otto, Azra Ghani, Michael Levin, Lachlan J Coin, David J Conway, Michael T Bretscher, Aubrey J Cunnington

Journal article  |  2019  |  NATURE MICROBIOLOGY

During infection, increasing pathogen load stimulates both protective and harmful aspects of the host response. The dynamics of th..

Development of circulating CD4( ) T-cell memory

Megan SF Soon, Jessica A Engel, Hyun J Lee, Ashraful Haque

Journal article  |  2019  |  IMMUNOLOGY AND CELL BIOLOGY

The ability of circulating CD4+ T cells to retain memories of previous antigenic encounters is a cardinal feature of the adaptive ..

Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

Hyun Jae Lee, Athina Georgiadou, Michael Walther, Davis Nwakanma, Lindsay B Stewart, Michael Levin, Thomas D Otto, David J Conway, Lachlan J Coin, Aubrey J Cunnington

Journal article  |  2018  |  SCIENCE TRANSLATIONAL MEDICINE

The pathogenesis of infectious diseases depends on the interaction of host and pathogen. In Plasmodium falciparum malaria, host an..