Jonathan Noonan

The tandem stenosis mouse model: Towards understanding, imaging, and preventing atherosclerotic plaque instability and rupture

Jonathan Noonan, Alex Bobik, Karlheinz Peter

Journal article  |  2021  |  BRITISH JOURNAL OF PHARMACOLOGY

The rupture of unstable atherosclerotic plaques is the major cause of cardiovascular mortality and morbidity. Despite significant ..

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

Laura A Bienvenu, Jonathan Noonan, Xiaowei Wang, Karlheinz Peter

Journal article  |  2020  |  CARDIOVASCULAR RESEARCH

The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a critical concern of the cor..

The aorta can act as a site of naive CD4 T-cell priming

Neil MacRitchie, Gianluca Grassia, Jonathan Noonan, Jennifer E Cole, Catherine E Hughes, Juliane Schroeder, Robert A Benson, Clement Cochain, Alma Zernecke, Tomasz J Guzik, Paul Garside, Claudia Monaco, Pasquale Maffia

Journal article  |  2020  |  CARDIOVASCULAR RESEARCH

AIMS: Aortic adaptive immunity plays a role in atherosclerosis; however, the precise mechanisms leading to T-cell activation in th..

A Novel Triple-Cell Two-Dimensional Model to Study Immune-Vascular Interplay in Atherosclerosis

Jonathan Noonan, Gianluca Grassia, Neil MacRitchie, Paul Garside, Tomasz J Guzik, Angela C Bradshaw, Pasquale Maffia

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Atherosclerosis is a complex inflammatory pathology underpinning cardiovascular diseases (CVD), which are the leading cause of dea..

Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide

Roxana Loperena, Justin P Van Beusecum, Hana A Itani, Noah Engel, Fanny Laroumanie, Liang Xiao, Fernando Elijovich, Cheryl L Laffer, Juan S Gnecco, Jonathan Noonan, Pasquale Maffia, Barbara Jasiewicz-Honkisz, Marta Czesnikiewicz-Guzik, Tomasz Mikolajczyk, Tomasz Sliwa, Sergey Dikalov, Cornelia M Weyand, Tomasz J Guzik, David G Harrison

Journal article  |  2018  |  CARDIOVASCULAR RESEARCH

Aims: Monocytes play an important role in hypertension. Circulating monocytes in humans exist as classical, intermediate, and non-..

Molecular imaging of atherosclerosis: spotlight on Raman spectroscopy and surface-enhanced Raman scattering

Neil MacRitchie, Gianluca Grassia, Jonathan Noonan, Paul Garside, Duncan Graham, Pasquale Maffia

Journal article  |  2018  |  HEART

To accurately predict atherosclerotic plaque progression, a detailed phenotype of the lesion at the molecular level is required. H..

In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy

Jonathan Noonan, Steven M Asiala, Gianluca Grassia, Neil MacRitchie, Kirsten Gracie, Jake Carson, Matthew Moores, Mark Girolami, Angela C Bradshaw, Tomasz J Guzik, Gavin R Meehan, Hannah E Scales, James M Brewer, Iain B McInnes, Naveed Sattar, Karen Faulds, Paul Garside, Duncan Graham, Pasquale Maffia

Journal article  |  2018  |  THERANOSTICS

Vascular immune-inflammatory responses play a crucial role in the progression and outcome of atherosclerosis. The ability to asses..

Multiplex detection of endothelial cell activation biomarkers using surface enhanced raman spectroscopy (sers)

Jonathan Noonan, Gianluca Grassia, Neil Macritchie, Steven Asiala, Kirsten Gracie, Karen Faulds, Iain B Mcinnes, Paul Garside, Duncan Graham, Pasquale Maffia

Conference Proceedings  |  2017  |  ATHEROSCLEROSIS

THE AORTA CAN ACT AS SITE OF T CELL PRIMING AND PROMOTES A LOCAL CD4 ADAPTIVE IMMUNE RESPONSE IN EARLY STAGE ATHEROSCLEROSIS IN APOLIPOPROTEIN-E-/- MICE

Neil MacRitchie, Gianluca Grassia, Catherine Hughes, Jonathan Noonan, Juliane Schroeder, Paul Garside, Pasquale Maffia

Conference Proceedings  |  2017  |  HEART

Development of a sers-nanoparticle based system for the multiplex detection of vascular adhesion molecules

Jonathan Noonan, Steven Asiala, Gianluca Grassia, Neil MacRitchie, Kirsten Gracie, Karen Faulds, Iain B McInnes, Paul Garside, Duncan Graham, Pasquale Maffia

Conference Proceedings  |  2017  |  HEART