Jonathan Noonan

Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization

Yung-Chih Chen, Meaghan Smith, Ya-Lan Ying, Manousos Makridakis, Jonathan Noonan, Peter Kanellakis, Alin Rai, Agus Salim, Andrew Murphy, Alex Bobik, Antonia Vlahou, David W Greening, Karlheinz Peter

Journal article  |  2023  |  COMMUNICATIONS BIOLOGY

Atherosclerotic plaque rupture leading to myocardial infarction is a major global health burden. Applying the tandem stenosis (TS)..

Pharmacological Inhibition of Factor XIIa Attenuates Abdominal Aortic Aneurysm, Reduces Atherosclerosis, and Stabilizes Atherosclerotic Plaques

Amy K Searle, Yung-Chih Chen, Maria Wallert, James D McFadyen, Ana C Maluenda, Jonathan Noonan, Peter Kanellakis, Maria TK Zaldivia, Angela Huang, Hadi Lioe, Mark Biondo, Marc W Nolte, Paolo Rossato, Alex Bobik, Con Panousis, Xiaowei Wang, Hamid Hosseini, Karlheinz Peter

Journal article  |  2022  |  THROMBOSIS AND HAEMOSTASIS

BACKGROUND: 3F7 is a monoclonal antibody targeting the enzymatic pocket of activated factor XII (FXIIa), thereby inhibiting its ca..

Molecular imaging of cardiovascular inflammation

Neil MacRitchie, Jonathan Noonan, Tomasz J Guzik, Pasquale Maffia

Journal article  |  2021  |  BRITISH JOURNAL OF PHARMACOLOGY

Cardiovascular diseases (CVDs), including atherosclerosis, are chronic inflammatory diseases characterised by a complex and evolvi..

Effects of lignocaine vs. opioids on antiplatelet activity of ticagrelor: the LOCAL trial

Himawan Fernando, Thy Duong, Kevin Huynh, Jonathan Noonan, James Shaw, Stephen J Duffy, Ziad Nehme, Karen Smith, Paul S Myles, Peter J Meikle, Karlheinz Peter, Dion Stub

Journal article  |  2021  |  EUROPEAN HEART JOURNAL

AIMS: We assessed the impact of intravenous fentanyl and lignocaine on the pharmacokinetics and pharmacodynamics of ticagrelor in ..

Lignocaine versus opioids in coronary intervention: assessing antiplatelet activity and ticagrelor levels (LOCAL) study

H Fernando, T Duong, K Huynh, J Noonan, J Shaw, S Duffy, Z Nehme, K Smith, P Myles, P Meikle, K Peter, D Stub

Journal article  |  2021  |  EUROPEAN HEART JOURNAL

Abstract Background Opioid analgesia impairs the bioavailability and antiplate..

Activation of circulating platelets in vaccine-induced thrombotic thrombocytopenia and its reversal by intravenous immunoglobulin

James D McFadyen, Prerna Sharma, Mitchell J Moon, Jonathon Noonan, Elizabeth Goodall, Huyen A Tran, Karlheinz Peter

Journal article  |  2021  |  BRITISH JOURNAL OF HAEMATOLOGY

Early Endothelial Activation in a Mouse Model of Graft vs Host Disease Following Chemotherapy

Melrine Pereira, Natasha Ting Lee, Jonathan Noonan, Abbey EH Willcox, Ilaria Calvello, Smitha Rose Georgy, Carly Selan, Joanne S Chia, Wayne Hauw, Xiaowei Wang, Karlheinz Peter, Simon C Robson, Harshal H Nandurkar, Maithili Sashindranath

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Allogenic hematopoietic stem cell transplant (allo-HSCT) can lead to sinusoidal obstruction syndrome (SOS) and graft-versus-host d..

The tandem stenosis mouse model: Towards understanding, imaging, and preventing atherosclerotic plaque instability and rupture

Jonathan Noonan, Alex Bobik, Karlheinz Peter

Journal article  |  2021  |  BRITISH JOURNAL OF PHARMACOLOGY

The rupture of unstable atherosclerotic plaques is the major cause of cardiovascular mortality and morbidity. Despite significant ..

Lignocaine Versus Opioids in Coronary Intervention: Assessing Antiplatelet Activity and Ticagrelor Levels (LOCAL) Study

H Fernando, T Duong, K Huynh, J Noonan, J Shaw, S Duffy, Z Nehme, K Smith, P Myles, P Meikle, K Peter, D Stub

Journal article  |  2021  |  Heart, Lung and Circulation

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

Laura A Bienvenu, Jonathan Noonan, Xiaowei Wang, Karlheinz Peter

Journal article  |  2020  |  CARDIOVASCULAR RESEARCH

The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a critical concern of the cor..