Jonathan Noonan

Effects of lignocaine vs. opioids on antiplatelet activity of ticagrelor: the LOCAL trial.

Himawan Fernando, Thy Duong, Kevin Huynh, Jonathan Noonan, James Shaw, Stephen J Duffy, Ziad Nehme, Karen Smith, Paul S Myles, Peter J Meikle, Karlheinz Peter, Dion Stub

Journal article  |  2021  |  Eur Heart J

AIMS: We assessed the impact of intravenous fentanyl and lignocaine on the pharmacokinetics and pharmacodynamics of ticagrelor in ..

Activation of circulating platelets in vaccine-induced thrombotic thrombocytopenia and its reversal by intravenous immunoglobulin

James D McFadyen, Prerna Sharma, Mitchell J Moon, Jonathon Noonan, Elizabeth Goodall, Huyen A Tran, Karlheinz Peter

Journal article  |  2021  |  BRITISH JOURNAL OF HAEMATOLOGY

Molecular Imaging of Cardiovascular Inflammation.

Neil MacRitchie, Jonathan Noonan, Tomasz J Guzik, Pasquale Maffia

Journal article  |  2021  |  Br J Pharmacol

Cardiovascular diseases (CVD), including atherosclerosis, are chronic inflammatory diseases characterised by a complex and evolvin..

Early Endothelial Activation in a Mouse Model of Graft vs Host Disease Following Chemotherapy

Melrine Pereira, Natasha Ting Lee, Jonathan Noonan, Abbey EH Willcox, Ilaria Calvello, Smitha Rose Georgy, Carly Selan, Joanne S Chia, Wayne Hauw, Xiaowei Wang, Karlheinz Peter, Simon C Robson, Harshal H Nandurkar, Maithili Sashindranath

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Allogenic hematopoietic stem cell transplant (allo-HSCT) can lead to sinusoidal obstruction syndrome (SOS) and graft-versus-host d..

The tandem stenosis mouse model: Towards understanding, imaging, and preventing atherosclerotic plaque instability and rupture

Jonathan Noonan, Alex Bobik, Karlheinz Peter

Journal article  |  2021  |  BRITISH JOURNAL OF PHARMACOLOGY

The rupture of unstable atherosclerotic plaques is the major cause of cardiovascular mortality and morbidity. Despite significant ..

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

Laura A Bienvenu, Jonathan Noonan, Xiaowei Wang, Karlheinz Peter

Journal article  |  2020  |  CARDIOVASCULAR RESEARCH

The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a critical concern of the cor..

The aorta can act as a site of naive CD4 T-cell priming

Neil MacRitchie, Gianluca Grassia, Jonathan Noonan, Jennifer E Cole, Catherine E Hughes, Juliane Schroeder, Robert A Benson, Clement Cochain, Alma Zernecke, Tomasz J Guzik, Paul Garside, Claudia Monaco, Pasquale Maffia

Journal article  |  2020  |  CARDIOVASCULAR RESEARCH

AIMS: Aortic adaptive immunity plays a role in atherosclerosis; however, the precise mechanisms leading to T-cell activation in th..

A Novel Triple-Cell Two-Dimensional Model to Study Immune-Vascular Interplay in Atherosclerosis

Jonathan Noonan, Gianluca Grassia, Neil MacRitchie, Paul Garside, Tomasz J Guzik, Angela C Bradshaw, Pasquale Maffia

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Atherosclerosis is a complex inflammatory pathology underpinning cardiovascular diseases (CVD), which are the leading cause of dea..

Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide

Roxana Loperena, Justin P Van Beusecum, Hana A Itani, Noah Engel, Fanny Laroumanie, Liang Xiao, Fernando Elijovich, Cheryl L Laffer, Juan S Gnecco, Jonathan Noonan, Pasquale Maffia, Barbara Jasiewicz-Honkisz, Marta Czesnikiewicz-Guzik, Tomasz Mikolajczyk, Tomasz Sliwa, Sergey Dikalov, Cornelia M Weyand, Tomasz J Guzik, David G Harrison

Journal article  |  2018  |  CARDIOVASCULAR RESEARCH

Aims: Monocytes play an important role in hypertension. Circulating monocytes in humans exist as classical, intermediate, and non-..

Molecular imaging of atherosclerosis: spotlight on Raman spectroscopy and surface-enhanced Raman scattering

Neil MacRitchie, Gianluca Grassia, Jonathan Noonan, Paul Garside, Duncan Graham, Pasquale Maffia

Journal article  |  2018  |  HEART

To accurately predict atherosclerotic plaque progression, a detailed phenotype of the lesion at the molecular level is required. H..