Corey Giles

Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools.

Pooranee K Morgan, Kevin Huynh, Gerard Pernes, Paula M Miotto, Natalie A Mellett, Corey Giles, Peter J Meikle, Andrew J Murphy, Graeme I Lancaster

Journal article  |  2021  |  J Biol Chem

Adipose-tissue-resident macrophages (ATMs) maintain metabolic homeostasis but also contribute to obesity-induced adipose tissue in..

Lipidomic Signatures of Changes in Adiposity: A Large Prospective Study of 5849 Adults from the Australian Diabetes, Obesity and Lifestyle Study

Habtamu B Beyene, Gavriel Olshansky, Corey Giles, Kevin Huynh, Michelle Cinel, Natalie A Mellett, Adam Alexander T Smith, Jonathan E Shaw, Dianna J Magliano, Peter J Meikle

Journal article  |  2021  |  METABOLITES

Lipid metabolism is tightly linked to adiposity. Comprehensive lipidomic profiling offers new insights into the dysregulation of l..

Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3

Nicholas B Blackburn, Peter J Meikle, Juan M Peralta, Satish Kumar, Ana C Leandro, Melissa A Bellinger, Corey Giles, Kevin Huynh, Michael C Mahaney, Harald HH Goring, John L VandeBerg, Sarah Williams-Blangero, David C Glahn, Ravindranath Duggirala, John Blangero, Laura F Michael, Joanne E Curran

Journal article  |  2021  |  CIRCULATION-GENOMIC AND PRECISION MEDICINE

BACKGROUND: The identification and understanding of therapeutic targets for atherosclerotic cardiovascular disease is of fundament..

The Impact of Simvastatin on Lipidomic Markers of Cardiovascular Risk in Human Liver Cells Is Secondary to the Modulation of Intracellular Cholesterol

Yvette L Schooneveldt, Corey Giles, Michael F Keating, Natalie A Mellett, Aaron W Jurrjens, Sudip Paul, Anna C Calkin, Peter J Meikle

Journal article  |  2021  |  METABOLITES

Statins are the first-line lipid-lowering therapy for reducing cardiovascular disease (CVD) risk. A plasma lipid ratio of two phos..

Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer

Hui-Ming Lin, Kevin Huynh, Manish Kohli, Winston Tan, Arun A Azad, Nicole Yeung, Kate L Mahon, Blossom Mak, Peter D Sutherland, Andrew Shepherd, Natalie Mellett, Maria Docanto, Corey Giles, Margaret M Centenera, Lisa M Butler, Peter J Meikle, Lisa G Horvath

Journal article  |  2021  |  PROSTATE CANCER AND PROSTATIC DISEASES

BACKGROUND: Dysregulated lipid metabolism is associated with more aggressive pathology and poorer prognosis in prostate cancer (PC..

Novel Lipid Species for Detecting and Predicting Atrial Fibrillation in Patients With Type 2 Diabetes

Yow Keat Tham, Kaushala S Jayawardana, Zahir H Alshehry, Corey Giles, Kevin Huynh, Adam Alexander T Smith, Jenny YY Ooi, Sophia Zoungas, Graham S Hillis, John Chalmers, Peter J Meikle, Julie R McMullen

Journal article  |  2021  |  DIABETES

The incidence of atrial fibrillation (AF) is higher in patients with diabetes. The goal of this study was to assess if the additio..

Clinical lipidomics: realizing the potential of lipid profiling

Thomas G Meikle, Kevin Huynh, Corey Giles, Peter J Meikle

Journal article  |  2021  |  JOURNAL OF LIPID RESEARCH

Dysregulation of lipid metabolism plays a major role in the aetiology and sequelae of inflammatory disorders, cardiometabolic and ..

Genome‐wide study of the human lipidome and links to Alzheimer’s disease risk

Peter J Meikle, Corey Giles, Gemma Cadby, Kevin Huynh, Natalie A Mellett, Gavriel Olshansky, Alexander Smith, Anh Nguyen, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor LL Villemagne, David Ames, Colin L Masters, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J Saykin, et al.

Journal article  |  2020  |  Alzheimer's & Dementia

Background Dysregulation of lipid metabolism is as an important – and modifiable – risk factor for the initiation and progression ..

Identification of concordant plasma lipid signatures in Alzheimer’s disease: Validation between two independent studies of Alzheimer’s disease

Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S Jayawardana, Agus Salim, Natalie A Mellett, Alexander Smith, Gavriel Olshansky, Brian G Drew, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor LL Villemagne, David Ames, Colin L Masters, Matthias Arnold, Kwangsik Nho, Andrew J Saykin, et al.

Journal article  |  2020  |  Alzheimer's & Dementia

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies (vol 18, e3000870, 2020)

Habtamu B Beyene, Gavriel Olshansky, Adam Alexander T Smith, Corey Giles, Kevin Huynh, Michelle Cinel, Natalie A Mellett, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F Watts, Jonathan E Shaw, Eric K Moses, Dianna J Magliano, Peter J Meikle

Journal article  |  2020  |  PLOS BIOLOGY

[This corrects the article DOI: 10.1371/journal.pbio.3000870.].