Kevin Huynh

Heritability of 596 lipid species and genetic correlation with cardiovascular traits in the Busselton Family Heart Study[S]

Gemma Cadby, Phillip E Melton, Nina S McCarthy, Corey Giles, Natalie A Mellett, Kevin Huynh, Joseph Hung, John Beilby, Marie-Pierre Dube, Gerald F Watts, John Blangero, Peter J Meikle, Eric K Moses

Journal article  |  2020  |  Journal of Lipid Research

CVD is the leading cause of death worldwide, and genetic investigations into the human lipidome may provide insight into CVD risk...

Mapping the Associations of the Plasma Lipidome With Insulin Resistance and Response to an Oral Glucose Tolerance Test

Habtamu B Beyene, Steven Hamley, Corey Giles, Kevin Huynh, Alexander Smith, Michelle Cinel, Natalie A Mellet, Maria G Morales-Scholz, Danielle Kloosterman, Kirsten F Howlett, Greg M Kowalski, Christopher S Shaw, Dianna J Magliano, Clinton R Bruce, Peter J Meikle

Journal article  |  2020  |  The Journal of Clinical Endocrinology & Metabolism

CONTEXT: Insulin resistance (IR) remains a global health challenge. Lipidomics offers an opportunity to identify biomarkers and be..

Sex and APOE epsilon 4 genotype modify the Alzheimer's disease serum metabolome

Matthias Arnold, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak MahmoudianDehkordi, Gregory Louie, M Arthur Moseley, J Will Thompson, Lisa St John-Williams, Jessica D Tenenbaum, Colette Blach, Rui Chang, Roberta D Brinton, Rebecca Baillie, Xianlin Han, John Q Trojanowski, Leslie M Shaw, Ralph Martins, et al.

Journal article  |  2020  |  Nature Communications

Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype ..

Development and variation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients

Mika Hilvo, Peter J Meikle, Eva Ringdal Pedersen, Grethe S Tell, Indu Dhar, Hermann Brenner, Ben Schoettker, Mitja Laaperi, Dimple Kauhanen, Kaisa M Koistinen, Antti Jylha, Kevin Huynh, Natalie A Mellett, Andrew M Tonkin, David R Sullivan, John Simes, Paul Nestel, Wolfgang Koenig, Dietrich Rothenbacher, Ottar Nygard, et al.

Journal article  |  2020  |  European Heart Journal

AIMS: Distinct ceramide lipids have been shown to predict the risk for cardiovascular disease (CVD) events, especially cardiovascu..

Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility

Sih Min Tan, Mark Ziemann, Vicki Thallas-Bonke, Matthew Snelson, Vinod Kumar, Adrienne Laskowski, Tuong-Vi Nguyen, Kevin Huynh, Michele V Clarke, Renata Libianto, Scott T Baker, Alison Skene, David A Power, Richard J MacIsaac, Darren C Henstridge, Rick A Wetsel, Assam El-Osta, Peter J Meikle, Scott G Wilson, Josephine M Forbes, et al.

Journal article  |  2020  |  Diabetes

The sequelae of diabetes mellitus include microvascular complications such as diabetic kidney disease (DKD), which involves glucos..

Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease

Wei Ling Florence Lim, Kevin Huynh, Pratishtha Chatterjee, Ian Martins, Kaushala S Jayawardana, Corey Giles, Natalie A Mellett, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Brian G Drew, Colin L Masters, Peter J Meikle, Ralph N Martins

Journal article  |  2020  |  Journal of Alzheimer's Disease

BACKGROUND: Lipid metabolism is altered in Alzheimer's disease (AD); however, the relationship between AD risk factors (age, APOEɛ..

Differential plasma postprandial lipidomic responses to krill oil and fish oil supplementations in women: A randomized crossover study

Hyunsin H Sung, Andrew J Sinclair, Kevin Huynh, Alexander T Smith, Natalie A Mellett, Peter J Meikle, Xiao Q Su

Journal article  |  2019  |  Nutrition

OBJECTIVES: There is no convincing evidence that krill oil (KO) consumption results in a higher incorporation of long chain ω-3 po..

Changes in plasma lipids predict pravastatin efficacy in secondary prevention

Kaushala S Jayawardana, Piyushkumar A Mundra, Corey Giles, Christopher K Barlow, Paul J Nestel, Elizabeth H Barnes, Adrienne Kirby, Peter Thompson, David R Sullivan, Zahir H Alshehry, Natalie A Mellett, Kevin Huynh, Malcolm J McConville, Sophia Zoungas, Graham S Hillis, John Chalmers, Mark Woodward, Ian C Marschner, Gerard Wong, Bronwyn A Kingwell, et al.

Journal article  |  2019  |  JCI Insight

Exceptional human longevity is associated with a specific plasma phenotype of ether lipids

I Pradas, M Jove, K Huynh, J Puig, M Ingles, C Borras, J Vina, PJ Meikle, R Pamplona

Journal article  |  2019  |  Redox Biology

High-Throughput Plasma Lipidomics: Detailed Mapping of the Associations with Cardiometabolic Risk Factors

Kevin Huynh, Christopher K Barlow, Kaushala S Jayawardana, Jacquelyn M Weir, Natalie A Mellett, Michelle Cinel, Dianna J Magliano, Jonathan E Shaw, Brian G Drew, Peter J Meikle

Journal article  |  2019  |  Cell Chemical Biology

Disentangling the genetic overlap between cholesterol and suicide risk

Emma EM Knowles, Joanne E Curran, Peter J Meikle, Kevin Huynh, Samuel R Mathias, Harald HH Goring, John L VandeBerg, Michael C Mahaney, Maria Jalbrzikowski, Marian K Mosior, Laura F Michael, Rene L Olvera, Ravi Duggirala, Laura Almasy, David C Glahn, John Blangero

Journal article  |  2018  |  Neuropsychopharmacology

Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression

Kang-Yu Peng, Matthew J Watt, Sander Rensen, Jan Willem Greve, Kevin Huynh, Kaushala S Jayawardana, Peter J Meikle, Ruth CR Meex

Journal article  |  2018  |  Journal of Lipid Research

Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention

Piyushkumar A Mundra, Christopher K Barlow, Paul J Nestel, Elizabeth H Barnes, Adrienne Kirby, Peter Thompson, David R Sullivan, Zahir H Alshehry, Natalie A Mellett, Kevin Huynh, Kaushala S Jayawardana, Corey Giles, Malcolm J McConville, Sophia Zoungas, Graham S Hillis, John Chalmers, Mark Woodward, Gerard Wong, Bronwyn A Kingwell, John Simes, et al.

Journal article  |  2018  |  JCI Insight

Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets

Yow Keat Tham, Bianca C Bernardo, Kevin Huynh, Jenny YY Ooi, Xiao Ming Gao, Helen Kiriazis, Corey Giles, Peter J Meikle, Julie R McMullen

Journal article  |  2018  |  Cell Reports

Lipidomics Reveals a Tissue-Specific Fingerprint

Irene Pradas, Kevin Huynh, Rosanna Cabre, Victoria Ayala, Peter J Meikle, Mariona Jove, Reinald Pamplona

Journal article  |  2018  |  Frontiers in Physiology

Lipidomic Profiling of Murine Macrophages Treated with Fatty Acids of Varying Chain Length and Saturation Status

Kevin Huynh, Gerard Pernes, Natalie A Mellett, Peter J Meikle, Andrew J Murphy, Graeme I Lancaster

Journal article  |  2018  |  Metabolites

Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies

Yow Keat Tham, Kevin Huynh, Natalie A Mellett, Darren C Henstridge, Helen Kiriazis, Jenny YY Ooi, Aya Matsumoto, Natalie L Patterson, Junichi Sadoshima, Peter J Meikle, Julie R McMullen

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Weight Loss and Exercise Alter the High-Density Lipoprotein Lipidome and Improve High-Density Lipoprotein Functionality in Metabolic Syndrome

Anmar A Khan, Piyushkumar A Mundra, Nora E Straznicky, Paul J Nestel, Gerard Wong, Ricardo Tan, Kevin Huynh, Theodore W Ng, Natalie A Mellett, Jacquelyn M Weir, Christopher K Barlow, Zahir H Alshehry, Gavin W Lambert, Bronwyn A Kingwell, Peter J Meikle

Journal article  |  2018  |  Arteriosclerosis, Thrombosis, and Vascular Biology

The lipidome in major depressive disorder: Shared genetic influence for ether-phosphatidylcholines, a plasma-based phenotype related to inflammation, and disease risk

EEM Knowles, K Huynh, PJ Meikle, HHH Goring, RL Olvera, SR Mathias, R Duggirala, L Almasy, J Blangero, JE Curran, DC Glahn

Journal article  |  2017  |  European Psychiatry

Muscle Sympathetic Nerve Activity Is Associated With Elements of the Plasma Lipidomic Profile in Young Asian Adults

Nina Eikelis, Elisabeth A Lambert, Sarah Phillips, Carolina Ika Sari, Piyushkumar A Mundra, Jacquelyn M Weir, Kevin Huynh, Mariee T Grima, Nora E Straznicky, John B Dixon, Markus P Schlaich, Peter J Meikle, Gavin W Lambert

Journal article  |  2017  |  The Journal of Clinical Endocrinology & Metabolism

Serum phosphatidylinositol as a biomarker for bipolar disorder liability

Emma EM Knowles, Peter J Meikle, Kevin Huynh, Harald HH Goring, Rene L Olvera, Samuel R Mathias, Ravi Duggirala, Laura Almasy, John Blangero, Joanne E Curran, David C Glahn

Journal article  |  2017  |  Bipolar Disorders

Lipidomic Profiles in Diabetes and Dementia

Kevin Huynh, Ralph N Martins, Peter J Meikle

Journal article  |  2017  |  Journal of Alzheimer's Disease

Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice (vol 243, pg 598, 2015)

Aliki A Rasmiena, Christopher K Barlow, Nada Stefanovic, Kevin Huynh, Ricardo Tan, Arpeeta Sharma, Dedreia Tull, Judy B de Haan, Peter J Meikle

Journal article  |  2016  |  Atherosclerosis

Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial

Andrew L Siebel, Khiang Trinh Si, Melissa F Formosa, Piyushkumar A Mundra, Alaina K Natoli, Medini Reddy-Luthmoodo, Kevin Huynh, Anmar A Khan, Andrew L Carey, Gerrit van Hall, Claudio Cobelli, Chiara Dalla-Man, Jim D Otvos, Kerry-Anne Rye, Jan Johansson, Allan Gordon, Norman CW Wong, Dmitri Sviridov, Philip Barter, Stephen J Duffy, et al.

Journal article  |  2016  |  Metabolism

Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice

Aliki A Rasmiena, Christopher K Barlow, Nada Stefanovic, Kevin Huynh, Ricardo Tan, Arpeeta Sharma, Dedreia Tull, Judy B de Haan, Peter J Meikle

Journal article  |  2015  |  Atherosclerosis

The prediction of type 2 diabetes in women with previous gestational diabetes mellitus using lipidomics

Martha Lappas, Piyushkumar A Mundra, Gerard Wong, Kevin Huynh, Debra Jinks, Harry M Georgiou, Michael Permezel, Peter J Meikle

Journal article  |  2015  |  Diabetologia

Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment

Peter J Meikle, Piyushkumar A Mundra, Gerard Wong, Khairunnessa Rahman, Kevin Huynh, Christopher K Barlow, Alastair MP Duly, Paul S Haber, John B Whitfield, Devanshi Seth

Journal article  |  2015  |  PLOS ONE