Kevin Huynh

Effects of lignocaine vs. opioids on antiplatelet activity of ticagrelor: the LOCAL trial.

Himawan Fernando, Thy Duong, Kevin Huynh, Jonathan Noonan, James Shaw, Stephen J Duffy, Ziad Nehme, Karen Smith, Paul S Myles, Peter J Meikle, Karlheinz Peter, Dion Stub

Journal article  |  2021  |  Eur Heart J

AIMS: We assessed the impact of intravenous fentanyl and lignocaine on the pharmacokinetics and pharmacodynamics of ticagrelor in ..

Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase

HM Lin, B Mak, N Yeung, K Huynh, TG Meikle, NA Mellett, EM Kwan, H Fettke, B Tran, ID Davis, KL Mahon, A Zhang, MR Stockler, K Briscoe, G Marx, M Crumbaker, PD Stricker, P Du, J Yu, S Jia, et al.

Journal article  |  2021  |  EBioMedicine

Background: Intrinsic resistance to androgen receptor signalling inhibitors (ARSI) occurs in 20–30% of men with metastatic castrat..

Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer.

Hui-Ming Lin, Nicole Yeung, Jordan F Hastings, David R Croucher, Kevin Huynh, Thomas G Meikle, Natalie A Mellett, Edmond M Kwan, Ian D Davis, Ben Tran, Kate L Mahon, Alison Zhang, Martin R Stockler, Karen Briscoe, Gavin Marx, Patricia Bastick, Megan L Crumbaker, Anthony M Joshua, Arun A Azad, Peter J Meikle, et al.

Journal article  |  2021  |  Cancers (Basel)

Circulating lipids or cytokines are associated with prognosis in metastatic castration-resistant prostate cancer (mCRPC). This stu..

Lipidomic Signatures of Changes in Adiposity: A Large Prospective Study of 5849 Adults from the Australian Diabetes, Obesity and Lifestyle Study

Habtamu B Beyene, Gavriel Olshansky, Corey Giles, Kevin Huynh, Michelle Cinel, Natalie A Mellett, Adam Alexander T Smith, Jonathan E Shaw, Dianna J Magliano, Peter J Meikle

Journal article  |  2021  |  METABOLITES

Lipid metabolism is tightly linked to adiposity. Comprehensive lipidomic profiling offers new insights into the dysregulation of l..

Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis

Geraldine J Ooi, Peter J Meikle, Kevin Huynh, Wendy Brown, Paul Burton, Matthew J Watt

Journal article  |  2021  |  JOURNAL OF HEPATOLOGY

BACKGROUNDS & AIMS: Obesity often leads to non-alcoholic fatty liver disease (NAFLD), which can progress from simple steatosis (no..

Dihydrosphingosine driven enrichment of sphingolipids attenuates TGF beta induced collagen synthesis in cardiac fibroblasts

Ruth R Magaye, Feby Savira, Xin Xiong, Kevin Huynh, Peter J Meikle, Christopher Reid, Bernard L Flynn, David Kaye, Danny Liew, Bing H Wang

Journal article  |  2021  |  IJC HEART & VASCULATURE

The sphingolipid de novo synthesis pathway, encompassing the sphingolipids, the enzymes and the cell membrane receptors, are being..

Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3

Nicholas B Blackburn, Peter J Meikle, Juan M Peralta, Satish Kumar, Ana C Leandro, Melissa A Bellinger, Corey Giles, Kevin Huynh, Michael C Mahaney, Harald HH Goring, John L VandeBerg, Sarah Williams-Blangero, David C Glahn, Ravindranath Duggirala, John Blangero, Laura F Michael, Joanne E Curran

Journal article  |  2021  |  CIRCULATION-GENOMIC AND PRECISION MEDICINE

BACKGROUND: The identification and understanding of therapeutic targets for atherosclerotic cardiovascular disease is of fundament..

Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice

Sudip Paul, Aliki A Rasmiena, Kevin Huynh, Adam Alexander T Smith, Natalie A Mellett, Karin Jandeleit-Dahm, Graeme I Lancaster, Peter J Meikle

Journal article  |  2021  |  METABOLITES

Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and are thought to..

Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer

Hui-Ming Lin, Kevin Huynh, Manish Kohli, Winston Tan, Arun A Azad, Nicole Yeung, Kate L Mahon, Blossom Mak, Peter D Sutherland, Andrew Shepherd, Natalie Mellett, Maria Docanto, Corey Giles, Margaret M Centenera, Lisa M Butler, Peter J Meikle, Lisa G Horvath

Journal article  |  2021  |  PROSTATE CANCER AND PROSTATIC DISEASES

BACKGROUND: Dysregulated lipid metabolism is associated with more aggressive pathology and poorer prognosis in prostate cancer (PC..

The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring

Gerard Wong, Jacquelyn M Weir, Priti Mishra, Kevin Huynh, Brunda Nijagal, Varsha Gupta, Birit FP Broekman, Mary Foong-Fong Chong, Shiao-Yng Chan, Kok Hian Tan, Dedreia Tull, Malcolm McConville, Philip C Calder, Keith M Godfrey, Yap Seng Chong, Peter D Gluckman, Michael J Meaney, Peter J Meikle, Neerja Karnani

Journal article  |  2021  |  TRANSLATIONAL PSYCHIATRY

While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determina..