Kevin Huynh

Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts.

Ruth R Magaye, Feby Savira, Xin Xiong, Kevin Huynh, Peter J Meikle, Christopher Reid, Bernard L Flynn, David Kaye, Danny Liew, Bing H Wang

Journal article  |  2021  |  Int J Cardiol Heart Vasc

The sphingolipid de novo synthesis pathway, encompassing the sphingolipids, the enzymes and the cell membrane receptors, are being..

Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3

Nicholas B Blackburn, Peter J Meikle, Juan M Peralta, Satish Kumar, Ana C Leandro, Melissa A Bellinger, Corey Giles, Kevin Huynh, Michael C Mahaney, Harald HH Goring, John L VandeBerg, Sarah Williams-Blangero, David C Glahn, Ravindranath Duggirala, John Blangero, Laura F Michael, Joanne E Curran

Journal article  |  2021  |  CIRCULATION-GENOMIC AND PRECISION MEDICINE

BACKGROUND: The identification and understanding of therapeutic targets for atherosclerotic cardiovascular disease is of fundament..

Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice

Sudip Paul, Aliki A Rasmiena, Kevin Huynh, Adam Alexander T Smith, Natalie A Mellett, Karin Jandeleit-Dahm, Graeme I Lancaster, Peter J Meikle

Journal article  |  2021  |  METABOLITES

Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and are thought to..

Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis.

Geraldine J Ooi, Peter J Meikle, Kevin Huynh, Arul Earnest, Stuart K Roberts, William Kemp, Benjamin L Parker, Wendy Brown, Paul Burton, Matthew J Watt

Journal article  |  2021  |  J Hepatol

BACKGROUNDS & AIMS: Obesity often leads to non-alcoholic fatty liver disease (NAFLD), which can progress from simple steatosis (no..

Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer

Hui-Ming Lin, Kevin Huynh, Manish Kohli, Winston Tan, Arun A Azad, Nicole Yeung, Kate L Mahon, Blossom Mak, Peter D Sutherland, Andrew Shepherd, Natalie Mellett, Maria Docanto, Corey Giles, Margaret M Centenera, Lisa M Butler, Peter J Meikle, Lisa G Horvath

Journal article  |  2021  |  PROSTATE CANCER AND PROSTATIC DISEASES

BACKGROUND: Dysregulated lipid metabolism is associated with more aggressive pathology and poorer prognosis in prostate cancer (PC..

The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring

Gerard Wong, Jacquelyn M Weir, Priti Mishra, Kevin Huynh, Brunda Nijagal, Varsha Gupta, Birit FP Broekman, Mary Foong-Fong Chong, Shiao-Yng Chan, Kok Hian Tan, Dedreia Tull, Malcolm McConville, Philip C Calder, Keith M Godfrey, Yap Seng Chong, Peter D Gluckman, Michael J Meaney, Peter J Meikle, Neerja Karnani

Journal article  |  2021  |  TRANSLATIONAL PSYCHIATRY

While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determina..

Characterization of the circulating and tissue-specific alterations to the lipidome in response to moderate and major cold stress in mice

Gerard Pernes, Pooranee K Morgan, Kevin Huynh, Natalie A Mellett, Peter J Meikle, Andrew J Murphy, Darren C Henstridge, Graeme I Lancaster

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

This study analyzed the effects of 24 h of cold stress (22°C or 5°C vs. mice maintained at 30 °C) on the plasma, brown adipose tis..

Novel Lipid Species for Detecting and Predicting Atrial Fibrillation in Patients With Type 2 Diabetes

Yow Keat Tham, Kaushala S Jayawardana, Zahir H Alshehry, Corey Giles, Kevin Huynh, Adam Alexander T Smith, Jenny YY Ooi, Sophia Zoungas, Graham S Hillis, John Chalmers, Peter J Meikle, Julie R McMullen

Journal article  |  2021  |  DIABETES

The incidence of atrial fibrillation (AF) is higher in patients with diabetes. The goal of this study was to assess if the additio..

Genome‐wide study of the human lipidome and links to Alzheimer’s disease risk

Peter J Meikle, Corey Giles, Gemma Cadby, Kevin Huynh, Natalie A Mellett, Gavriel Olshansky, Alexander Smith, Anh Nguyen, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor LL Villemagne, David Ames, Colin L Masters, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J Saykin, et al.

Journal article  |  2020  |  Alzheimer's & Dementia

Background Dysregulation of lipid metabolism is as an important – and modifiable – risk factor for the initiation and progression ..

Identification of concordant plasma lipid signatures in Alzheimer’s disease: Validation between two independent studies of Alzheimer’s disease

Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S Jayawardana, Agus Salim, Natalie A Mellett, Alexander Smith, Gavriel Olshansky, Brian G Drew, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor LL Villemagne, David Ames, Colin L Masters, Matthias Arnold, Kwangsik Nho, Andrew J Saykin, et al.

Journal article  |  2020  |  Alzheimer's & Dementia