Yung-Chih Chen

Plasma levels of trimethylamine-N-oxide can be increased with 'healthy' and 'unhealthy' diets and do not correlate with the extent of atherosclerosis but with plaque instability

Yen Chin Koay, Yung-Chih Chen, Jibran A Wali, Alison WS Luk, Mengbo Li, Hemavarni Doma, Rosa Reimark, Maria TK Zaldivia, Habteab T Habtom, Ashley E Franks, Gabrielle Fusco-Allison, Jean Yang, Andrew Holmes, Stephen J Simpson, Karlheinz Peter, John F O'Sullivan

Journal article  |  2021  |  CARDIOVASCULAR RESEARCH

AIMS: The microbiome-derived metabolite trimethylamine-N-oxide (TMAO) has attracted major interest and controversy both as a diagn..

Analyzing the shear-induced sensitization of mechanosensitive ion channel Piezo-1 in human aortic endothelial cells

Austin Lai, Yung C Chen, Charles D Cox, Anthony Jaworowski, Karlheinz Peter, Sara Baratchi

Journal article  |  2020  |  JOURNAL OF CELLULAR PHYSIOLOGY

Mechanosensitive ion channels mediate endothelial responses to blood flow and orchestrate their physiological function in response..

Helical flow: A means to identify unstable plaques and a new direction for the design of vascular grafts and stents

Sara Baratchi, Yung-Chih Chen, Karlheinz Peter

Journal article  |  2020  |  ATHEROSCLEROSIS

A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia

HongBin Liu, Melissa Byrne, Patrick Perlmutter, Ashley Walker, Gopal R Sama, Jegadesan Subbiah, Berkay Ozcelik, Robert E Widdop, Tracey A Gaspari, Keith Byron, Yung-Chih Chen, David M Kaye, Anthony E Dear

Journal article  |  2019  |  Cardiovascular Drugs and Therapy

Purpose Drug-eluting balloon catheters (DEBc) coated with paclitaxel (PTX) have been associated with potential safety concerns. An..

Lysophosphatidylcholine is a Major Component of Platelet Microvesicles Promoting Platelet Activation and Reporting Atherosclerotic Plaque Instability

Philipp Diehl, Frederik Nienaber, Maria TK Zaldivia, Johannes Stamm, Patrick M Siegel, Natalie A Mellett, Marius Wessinger, Xiaowei Wang, James D McFadyen, Nicole Bassler, Gerhard Puetz, Nay M Htun, David Braig, Jonathon Habersberger, Thomas Helbing, Steffen U Eisenhardt, Maria Fuller, Christoph Bode, Peter J Meikle, Yung Chih Chen, et al.

Journal article  |  2019  |  THROMBOSIS AND HAEMOSTASIS

BACKGROUND:  Microvesicles (MVs) are small cell-derived vesicles, which are mainly released by activated cells. They are part of a..

The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response

Maria Wallert, Julia Bauer, Stefan Kluge, Lisa Schmoelz, Yung-Chih Chen, Melanie Ziegler, Amy K Searle, Alexander Maxones, Martin Schubert, Maria Thuermer, Helmut Pein, Andreas Koeberle, Oliver Werz, Marc Birringer, Karlheinz Peter, Stefan Lorkowski

Journal article  |  2019  |  REDOX BIOLOGY

The plant Garcinia kola is used in African ethno-medicine to treat various oxidation- and inflammation-related diseases but its bi..

Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases

May Lin Yap, James D McFadyen, Xiaowei Wang, Melanie Ziegler, Yung-Chih Chen, Abbey Willcox, Cameron J Nowell, Andrew M Scott, Erica K Sloan, P Mark Hogarth, Geoffrey A Pietersz, Karlheinz Peter

Journal article  |  2019  |  THERANOSTICS

Rationale: Platelets are increasingly recognized as mediators of tumor growth and metastasis. Hypothesizing that activated platele..

Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque

Imran Rashid, Ghassan J Maghzal, Yung-Chih Chen, David Cheng, Jihan Talib, Darren Newington, Minqin Ren, Saumitra K Vajandar, Amy Searle, Ana Maluenda, Eva-Lotte Lindstedt, Andrew Jabbour, Antony J Kettle, Andre Bongers, Carl Power, Erik Michaelsson, Karlheinz Peter, Roland Stocker

Journal article  |  2018  |  EUROPEAN HEART JOURNAL

Aims: As the inflammatory enzyme myeloperoxidase (MPO) is abundant in ruptured human atherosclerotic plaques, we aimed to investig..

Dual-Targeted Theranostic Delivery of miRs Arrests Abdominal Aortic Aneurysm Development

Xiaowei Wang, Amy Kate Searle, Jan David Hohmann, Ao Leo Liu, Meike-Kristin Abraham, Jathushan Palasubramaniam, Bock Lim, Yu Yao, Maria Wallert, Eefang Yu, Yung-Chih Chen, Karlheinz Peter

Journal article  |  2018  |  MOLECULAR THERAPY

Abdominal aortic aneurysm (AAA) is an often deadly disease without medical, non-invasive treatment options. The upregulation of va..

GLP-1 receptor agonists: An example of the challenge for animal models to predict plaque instability/rupture and cardiovascular outcomes

Ya-Lan Ying, Yung-Chih Chen, Karin Jandeleit-Dahm, Karlheinz Peter

Journal article  |  2017  |  ATHEROSCLEROSIS