Yung-Chih Chen

Analyzing the shear-induced sensitization of mechanosensitive ion channel Piezo-1 in human aortic endothelial cells

Austin Lai, Yung C Chen, Charles D Cox, Anthony Jaworowski, Karlheinz Peter, Sara Baratchi

Journal article  |  2020  |  Journal of Cellular Physiology

Mechanosensitive ion channels mediate endothelial responses to blood flow and orchestrate their physiological function in response..

A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia

HongBin Liu, Melissa Byrne, Patrick Perlmutter, Ashley Walker, Gopal R Sama, Jegadesan Subbiah, Berkay Ozcelik, Robert E Widdop, Tracey A Gaspari, Keith Byron, Yung-Chih Chen, David M Kaye, Anthony E Dear

Journal article  |  2019  |  Cardiovascular Drugs and Therapy

Purpose Drug-eluting balloon catheters (DEBc) coated with paclitaxel (PTX) have been associated with potential safety concerns. An..

Lysophosphatidylcholine is a Major Component of Platelet Microvesicles Promoting Platelet Activation and Reporting Atherosclerotic Plaque Instability

Philipp Diehl, Frederik Nienaber, Maria TK Zaldivia, Johannes Stamm, Patrick M Siegel, Natalie A Mellett, Marius Wessinger, Xiaowei Wang, James D McFadyen, Nicole Bassler, Gerhard Puetz, Nay M Htun, David Braig, Jonathon Habersberger, Thomas Helbing, Steffen U Eisenhardt, Maria Fuller, Christoph Bode, Peter J Meikle, Yung Chih Chen, et al.

Journal article  |  2019  |  Thrombosis and Haemostasis

The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response

Maria Wallert, Julia Bauer, Stefan Kluge, Lisa Schmoelz, Yung-Chih Chen, Melanie Ziegler, Amy K Searle, Alexander Maxones, Martin Schubert, Maria Thuermer, Helmut Pein, Andreas Koeberle, Oliver Werz, Marc Birringer, Karlheinz Peter, Stefan Lorkowski

Journal article  |  2019  |  Redox Biology

The plant Garcinia kola is used in African ethno-medicine to treat various oxidation- and inflammation-related diseases but its bi..

Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases

May Lin Yap, James D McFadyen, Xiaowei Wang, Melanie Ziegler, Yung-Chih Chen, Abbey Willcox, Cameron J Nowell, Andrew M Scott, Erica K Sloan, P Mark Hogarth, Geoffrey A Pietersz, Karlheinz Peter

Journal article  |  2019  |  Theranostics

Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque

Imran Rashid, Ghassan J Maghzal, Yung-Chih Chen, David Cheng, Jihan Talib, Darren Newington, Minqin Ren, Saumitra K Vajandar, Amy Searle, Ana Maluenda, Eva-Lotte Lindstedt, Andrew Jabbour, Antony J Kettle, Andre Bongers, Carl Power, Erik Michaelsson, Karlheinz Peter, Roland Stocker

Journal article  |  2018  |  European Heart Journal

Aims: As the inflammatory enzyme myeloperoxidase (MPO) is abundant in ruptured human atherosclerotic plaques, we aimed to investig..

Dual-Targeted Theranostic Delivery of miRs Arrests Abdominal Aortic Aneurysm Development

Xiaowei Wang, Amy Kate Searle, Jan David Hohmann, Ao Leo Liu, Meike-Kristin Abraham, Jathushan Palasubramaniam, Bock Lim, Yu Yao, Maria Wallert, Eefang Yu, Yung-Chih Chen, Karlheinz Peter

Journal article  |  2018  |  Molecular Therapy

GLP-1 receptor agonists: An example of the challenge for animal models to predict plaque instability/rupture and cardiovascular outcomes

Ya-Lan Ying, Yung-Chih Chen, Karin Jandeleit-Dahm, Karlheinz Peter

Journal article  |  2017  |  Atherosclerosis

Effect of insulin resistance on compound 21 mediated coronary microvascular dilation in female rats in vivo

JT Pearson, P Meagher, H Tsuchimochi, AJ Edgley, M Yoshimoto, MT Waddingham, YC Chen, KM Mirabito Colafella, LM Hilliard, K Umetani, RE Widdop, M Shirai, KM Denton

Conference Proceedings  |  2017  |  EUROPEAN HEART JOURNAL

Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques

Nay Min Htun, Yung Chih Chen, Bock Lim, Tara Schiller, Ghassan J Maghzal, Alex L Huang, Kirstin D Elgass, Jennifer Rivera, Hans G Schneider, Bayden R Wood, Roland Stocker, Karlheinz Peter

Journal article  |  2017  |  Nature Communications

Atherosclerosis is a major cause of mortality and morbidity, which is mainly driven by complications such as myocardial infarction..