Aowen Zhuang

Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion

Aowen Zhuang, Felicia YT Yap, Domenica McCarthy, Chris Leung, Karly C Sourris, Sally A Penfold, Vicki Thallas-Bonke, Melinda T Coughlan, Benjamin L Schulz, Josephine M Forbes

Journal article  |  2019  |  Scientific Reports

The accumulation of advanced glycation end products (AGEs) have been implicated in the development and progression of diabetic kid..

Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction

Danielle J Borg, Felicia YT Yap, Sahar Keshvari, David G Simmons, Linda A Gallo, Amelia K Fotheringham, Aowen Zhuang, Robyn M Slattery, Sumaira Z Hasnain, Melinda T Coughlan, Phillip Kantharidis, Josephine M Forbes

Journal article  |  2018  |  Islets

Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes

Micheal S Ward, Nicole B Flemming, Linda A Gallo, Amelia K Fotheringham, Domenica A McCarthy, Aowen Zhuang, Peter H Tang, Danielle J Borg, Hannah Shaw, Benjamin Harvie, David R Briskey, Llion A Roberts, Manuel R Plan, Michael P Murphy, Mark P Hodson, Josephine M Forbes

Journal article  |  2017  |  Scientific Reports

Mitochondrial dysfunction is a pathological mediator of diabetic kidney disease (DKD). Our objective was to test the mitochondrial..

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Aowen Zhuang, Felicia Yt Yap, Clinton Bruce, Chris Leung, Manuel R Plan, Mitchell A Sullivan, Chandana Herath, Domenica McCarthy, Karly C Sourris, Phillip Kantharidis, Melinda T Coughlan, Mark A Febbraio, Mark P Hodson, Matthew J Watt, Peter Angus, Benjamin L Schulz, Josephine M Forbes

Journal article  |  2017  |  Scientific Reports

Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?

Aowen Zhuang, Josephine M Forbes

Journal article  |  2016  |  Glycoconjugate Journal

Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice (vol 6, 26428, 2016)

Linda A Gallo, Micheal S Ward, Amelia K Fotheringham, Aowen Zhuang, Danielle J Borg, Nicole B Flemming, Ben M Harvie, Toni L Kinneally, Shang-Ming Yeh, Domenica A McCarthy, Hermann Koepsell, Volker Vallon, Carol Pollock, Usha Panchapakesan, Josephine M Forbes

Journal article  |  2016  |  Scientific Reports

Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

Linda A Gallo, Micheal S Ward, Amelia K Fotheringham, Aowen Zhuang, Danielle J Borg, Nicole B Flemming, Ben M Harvie, Toni L Kinneally, Shang-Ming Yeh, Domenica A McCarthy, Hermann Koepsell, Volker Vallon, Carol Pollock, Usha Panchapakesan, Josephine M Forbes

Journal article  |  2016  |  Scientific Reports

Regulatory T Cells Prevent Inducible BALT Formation by Dampening Neutrophilic Inflammation

Shen Yun Foo, Vivian Zhang, Amit Lalwani, Jason P Lynch, Aowen Zhuang, Chuan En Lam, Paul S Foster, Cecile King, Raymond J Steptoe, Stuart B Mazzone, Peter D Sly, Simon Phipps

Journal article  |  2015  |  The Journal of Immunology

Stress in the kidney is the road to pERdition: is endoplasmic reticulum stress a pathogenic mediator of diabetic nephropathy?

Aowen Zhuang, Josephine M Forbes

Journal article  |  2014  |  Journal of Endocrinology