Simon T Bond

Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines

Simon T Bond, Aowen Zhuang, Christine Yang, Eleanor AM Gould, Tim Sikora, Yingying Liu, Ying Fu, Kevin Watt, Yanie Tan, Helen Kiriazis, Graeme Lancaster, Paul Gregorevic, Darren C Henstridge, Julie R McMullen, Peter J Meikle, Anna C Calkin, Brian G Drew

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVE: CRISPR/Cas9 technology has revolutionized gene editing and fast tracked our capacity to manipulate genes of interest fo..

SOD2 in skeletal muscle: New insights from an inducible deletion model.

Aowen Zhuang, Christine Yang, Yingying Liu, Yanie Tan, Simon T Bond, Shannen Walker, Tim Sikora, Adrienne Laskowski, Arpeeta Sharma, Judy B de Haan, Peter J Meikle, Takahiko Shimizu, Melinda T Coughlan, Anna C Calkin, Brian G Drew

Journal article  |  2021  |  Redox Biol

Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently associated with impairments in ske..

Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner

Aowen Zhuang, Anna C Calkin, Shannen Lau, Helen Kiriazis, Daniel G Donner, Yingying Liu, Simon T Bond, Sarah C Moody, Eleanor AM Gould, Timothy D Colgan, Sergio Ruiz Carmona, Michael Inouye, Thomas Q de Aguiar Vallim, Elizabeth J Tarling, Gregory A Quaife-Ryan, James E Hudson, Enzo R Porrello, Paul Gregorevic, Xiao-Ming Gao, Xiao-Jun Du, et al.

Journal article  |  2021  |  ISCIENCE

Long non-coding RNAs (lncRNAs) have been demonstrated to influence numerous biological processes, being strongly implicated in the..

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance

Simon T Bond, Emily J King, Darren C Henstridge, Adrian Tran, Sarah C Moody, Christine Yang, Yingying Liu, Natalie A Mellett, Artika P Nath, Michael Inouye, Elizabeth J Tarling, Thomas Q de Aguiar Vallim, Peter J Meikle, Anna C Calkin, Brian G Drew

Journal article  |  2021  |  NATURE COMMUNICATIONS

The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have be..

Reducing hepatic PKD activity lowers circulating VLDL cholesterol

Amanda J Genders, Timothy Connor, Shona Morrison, Simon T Bond, Brian G Drew, Peter J Meikle, Kirsten F Howlett, Sean L McGee

Journal article  |  2020  |  JOURNAL OF ENDOCRINOLOGY

Protein kinase D (PKD) is emerging as an important kinase regulating energy balance and glucose metabolism; however, whether hepat..

The Antioxidant Moiety of MitoQ Imparts Minimal Metabolic Effects in Adipose Tissue of High Fat Fed Mice

Simon T Bond, Jisu Kim, Anna C Calkin, Brian G Drew

Journal article  |  2019  |  FRONTIERS IN PHYSIOLOGY

Mitochondrial dysfunction is associated with a diverse array of diseases ranging from dystrophy and heart failure to obesity and h..

The E3 ligase MARCH5 is a PPAR gamma target gene that regulates mitochondria and metabolism in adipocytes

Simon T Bond, Sarah C Moody, Yingying Liu, Mete Civelek, Claudio J Villanueva, Paul Gregorevic, Bronwyn A Kingwell, Andrea L Hevener, Aldons J Lusis, Darren C Henstridge, Anna C Calkin, Brian G Drew

Journal article  |  2019  |  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial dynamics refers to the constant remodeling of mitochondrial populations by multiple cellular pathways that help main..

Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells

Ashfaqul Hogue, Priyadharshini Sivakumaran, Simon T Bond, Naomi XY Ling, Anne M Kong, John W Scott, Nadeeka Bandara, Damian Hernandez, Guei-Sheung Liu, Raymond CB Wong, Michael T Ryan, Derek J Hausenloy, Bruce E Kemp, Jonathan S Oakhill, Brian G Drew, Alice Pebay, Shiang Y Lim

Journal article  |  2018  |  CELL DEATH DISCOVERY

Human induced pluripotent stem cells (iPSCs) are a valuable tool for studying the cardiac developmental process in vitro, and card..

Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer

Simon T Bond, Kevin A McEwen, Prusothman Yoganantharajah, Yann Gibert

Book Chapter  |  2018  |  Methods in Molecular Biology

The Agilent Seahorse Extracellular Flux Analyzer can be used to measure the oxygen consumption rate (OCR) and extra cellular acidi..