Alex Smith

Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease

Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S Jayawardana, Agus Salim, Natalie A Mellett, Adam Alexander T Smith, Gavriel Olshansky, Brian G Drew, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Matthias Arnold, Kwangsik Nho, Andrew J Saykin, et al.

Journal article  |  2020  |  Nature Communications

Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex mo..

Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study

Hyunsin H Sung, Andrew J Sinclair, Kevin Huynh, Adam AT Smith, Natalie A Mellett, Peter J Meikle, Xiao Q Su

Journal article  |  2020  |  Nutrients

This is a follow-up of our previous postprandial study and it focused on the plasma lipidomic responses to 30 days of krill oil (K..

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

Habtamu B Beyene, Gavriel Olshansky, Adam Alexander T Smith, Corey Giles, Kevin Huynh, Michelle Cinel, Natalie A Mellett, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F Watts, Jonathan S Shaw, Eric K Moses, Dianna J Magliano, Peter J Meikle

Journal article  |  2020  |  PLoS Biology

Obesity and related metabolic diseases show clear sex-related differences. The growing burden of these diseases calls for better u..

The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System

Dionysios V Chartoumpekis, Panos G Ziros, Ilias Georgakopoulos-Soares, Adam AT Smith, Ana Claudia Marques, Mark Ibberson, Peter A. Kopp, Ioannis Habeos, Ioannis P Trougakos, Nicholas KH Khoo, Gerasimos P Sykiotis

Journal article  |  2020  |  Antioxidants

BACKGROUND: Thyroid follicular cells have physiologically high levels of reactive oxygen species because oxidation of iodide is es..

Mapping the Associations of the Plasma Lipidome With Insulin Resistance and Response to an Oral Glucose Tolerance Test

Habtamu B Beyene, Steven Hamley, Corey Giles, Kevin Huynh, Alexander Smith, Michelle Cinel, Natalie A Mellet, Maria G Morales-Scholz, Danielle Kloosterman, Kirsten F Howlett, Greg M Kowalski, Christopher S Shaw, Dianna J Magliano, Clinton R Bruce, Peter J Meikle

Journal article  |  2020  |  The Journal of Clinical Endocrinology & Metabolism

CONTEXT: Insulin resistance (IR) remains a global health challenge. Lipidomics offers an opportunity to identify biomarkers and be..

Maternal sleep disturbances in late pregnancy and the association with emergency caesarean section: A prospective cohort study

Sarah-Jane Paine, T Leigh Signal, Bronwyn Sweeney, Monique Priston, Diane Muller, Alexander Smith, Mark Huthwaite, Philippa Gander, Kathryn Lee

Journal article  |  2020  |  Sleep Health

OBJECTIVES:To investigate the association between measures of sleep quality, sleep duration and sleep disorder symptoms in late pr..

Differential plasma postprandial lipidomic responses to krill oil and fish oil supplementations in women: A randomized crossover study

Hyunsin H Sung, Andrew J Sinclair, Kevin Huynh, Alexander T Smith, Natalie A Mellett, Peter J Meikle, Xiao Q Su

Journal article  |  2019  |  Nutrition

OBJECTIVES: There is no convincing evidence that krill oil (KO) consumption results in a higher incorporation of long chain ω-3 po..

A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development

Tiffany Bouchery, Kara Filbey, Amy Shepherd, Jodie Chandler, Deepa Patel, Alfonso Schmidt, Mali Camberis, Adeline Peignier, Adam AT Smith, Karen Johnston, Gavin Painter, Mark Pearson, Paul Giacomin, Alex Loukas, Maria-Elena Bottazzi, Peter Hotez, Graham LeGros

Journal article  |  2018  |  PLOS Pathogens

As part of on-going efforts to control hookworm infection, the "human hookworm vaccine initiative" has recognised blood feeding as..

cis-Acting Complex-Trait-Associated lincRNA Expression Correlates with Modulation of Chromosomal Architecture

Jennifer Yihong Tan, Adam Alexander Thil Smith, Maria Ferreira da Silva, Cyril Matthey-Doret, Rico Rueedi, Reyhan Sonmez, David Ding, Zoltan Kutalik, Sven Bergmann, Ana Claudia Marques

Journal article  |  2017  |  Cell Reports

Intergenic long noncoding RNAs (lincRNAs) are the largest class of transcripts in the human genome. Although many have recently be..

Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles

Lisa M Connor, Shiau-Choot Tang, Emmanuelle Cognard, Sotaro Ochiai, Kerry L Hilligan, Samuel I Old, Christophe Pellefigues, Ruby F White, Deepa Patel, Adam Alexander T Smith, David A Eccles, Olivier Lamiable, Melanie J McConnell, Franca Ronchese

Journal article  |  2017  |  Journal of Experimental Medicine

The dendritic cell signals required for the in vivo priming of IL-4-producing T cells are unknown. We used RNA sequencing to chara..