Alex Smith

Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice

Sudip Paul, Aliki A Rasmiena, Kevin Huynh, Adam Alexander T Smith, Natalie A Mellett, Karin Jandeleit-Dahm, Graeme I Lancaster, Peter J Meikle

Journal article  |  2021  |  METABOLITES

Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and are thought to..

Novel Lipid Species for Detecting and Predicting Atrial Fibrillation in Patients With Type 2 Diabetes

Yow Keat Tham, Kaushala S Jayawardana, Zahir H Alshehry, Corey Giles, Kevin Huynh, Adam Alexander T Smith, Jenny YY Ooi, Sophia Zoungas, Graham S Hillis, John Chalmers, Peter J Meikle, Julie R McMullen

Journal article  |  2021  |  DIABETES

The incidence of atrial fibrillation (AF) is higher in patients with diabetes. The goal of this study was to assess if the additio..

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies (vol 18, e3000870, 2020)

Habtamu B Beyene, Gavriel Olshansky, Adam Alexander T Smith, Corey Giles, Kevin Huynh, Michelle Cinel, Natalie A Mellett, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F Watts, Jonathan E Shaw, Eric K Moses, Dianna J Magliano, Peter J Meikle

Journal article  |  2020  |  PLOS BIOLOGY

[This corrects the article DOI: 10.1371/journal.pbio.3000870.].

Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease

Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S Jayawardana, Agus Salim, Natalie A Mellett, Adam Alexander T Smith, Gavriel Olshansky, Brian G Drew, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Matthias Arnold, Kwangsik Nho, Andrew J Saykin, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex mo..

Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study

Hyunsin H Sung, Andrew J Sinclair, Kevin Huynh, Adam AT Smith, Natalie A Mellett, Peter J Meikle, Xiao Q Su

Journal article  |  2020  |  NUTRIENTS

This is a follow-up of our previous postprandial study and it focused on the plasma lipidomic responses to 30 days of krill oil (K..

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

Habtamu B Beyene, Gavriel Olshansky, Adam Alexander T Smith, Corey Giles, Kevin Huynh, Michelle Cinel, Natalie A Mellett, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F Watts, Jonathan S Shaw, Eric K Moses, Dianna J Magliano, Peter J Meikle

Journal article  |  2020  |  PLOS BIOLOGY

Obesity and related metabolic diseases show clear sex-related differences. The growing burden of these diseases calls for better u..

The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System

Dionysios V Chartoumpekis, Panos G Ziros, Ilias Georgakopoulos-Soares, Adam AT Smith, Ana Claudia Marques, Mark Ibberson, Peter A. Kopp, Ioannis Habeos, Ioannis P Trougakos, Nicholas KH Khoo, Gerasimos P Sykiotis

Journal article  |  2020  |  ANTIOXIDANTS

BACKGROUND: Thyroid follicular cells have physiologically high levels of reactive oxygen species because oxidation of iodide is es..

The Contribution of lincRNAs at the Interface between Cell Cycle Regulation and Cell State Maintenance

Adriano Biasini, Adam Alexander Thil Smith, Baroj Abdulkarim, Maria Ferreira da Silva, Jennifer Yihong Tan, Ana Claudia Marques

Journal article  |  2020  |  ISCIENCE

Cell cycle progression is controlled by the interplay of established cell cycle regulators. Changes in these regulators' activity ..

Mapping the Associations of the Plasma Lipidome With Insulin Resistance and Response to an Oral Glucose Tolerance Test

Habtamu B Beyene, Steven Hamley, Corey Giles, Kevin Huynh, Alexander Smith, Michelle Cinel, Natalie A Mellet, Maria G Morales-Scholz, Danielle Kloosterman, Kirsten F Howlett, Greg M Kowalski, Christopher S Shaw, Dianna J Magliano, Clinton R Bruce, Peter J Meikle

Journal article  |  2020  |  JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

CONTEXT: Insulin resistance (IR) remains a global health challenge. Lipidomics offers an opportunity to identify biomarkers and be..

A semi-automated technique for adenoma quantification in the Apc(Min) mouse using FeatureCounter

Amy L Shepherd, A Alexander T Smith, Kirsty A Wakelin, Sabine Kuhn, Jianping Yang, David A Eccles, Franca Ronchese

Journal article  |  2020  |  SCIENTIFIC REPORTS

Colorectal cancer is a major contributor to death and disease worldwide. The ApcMin mouse is a widely used model of intestinal neo..