Shirley Chang

Genome-wide analysis identifies novel susceptibility loci for myocardial infarction.

Jaana A Hartiala, Yi Han, Qiong Jia, James R Hilser, Pin Huang, Janet Gukasyan, William S Schwartzman, Zhiheng Cai, Subarna Biswas, David-Alexandre Trégouët, Nicholas L Smith, undefined INVENT Consortium, undefined CHARGE Consortium Hemostasis Working Group, undefined GENIUS-CHD Consortium, Marcus Seldin, Calvin Pan, Margarete Mehrabian, Aldons J Lusis, Peter Bazeley, Yan V Sun, et al.

Journal article  |  2021  |  European Heart Journal

AIMS: While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis, not all patients with coronary..

Midlife Leukocyte Telomere Length as an Indicator for Handgrip Strength in Late Life.

Xuling Chang, Kevin Yiqiang Chua, Ling Wang, Jianjun Liu, Jian-Min Yuan, Chiea-Chuen Khor, Chew-Kiat Heng, Woon-Puay Koh, Rajkumar Dorajoo

Journal article  |  2021  |  The Journals of Gerontology Series A

BACKGROUND: Telomere attrition has been proposed as a hallmark of aging. We previously reported on the association between blood l..

Effect of plasma polyunsaturated fatty acid levels on leukocyte telomere lengths in the Singaporean Chinese population.

Xuling Chang, Rajkumar Dorajoo, Ye Sun, Ling Wang, Choon Nam Ong, Jianjun Liu, Chiea Chuen Khor, Jian-Min Yuan, Woon Puay Koh, Yechiel Friedlander, Chew-Kiat Heng

Journal article  |  2020  |  Nutrition Journal

BACKGROUND: Shorter telomere length (TL) has been associated with poor health behaviors, increased risks of chronic diseases and e..

Interaction between a haptoglobin genetic variant and coronary artery disease (CAD) risk factors on CAD severity in Singaporean Chinese population.

Xuling Chang, Rajkumar Dorajoo, Yi Han, Ling Wang, Jianjun Liu, Chiea-Chuen Khor, Adrian F Low, Mark Yan-Yee Chan, Jian-Min Yuan, Woon-Puay Koh, Yechiel Friedlander, Chew-Kiat Heng

Journal article  |  2020  |  Molecular Genetics & Genomic Medicine

BACKGROUND: Haptoglobin (Hp) is a plasma protein with strong anti-inflammation and antioxidant activities. Its plasma level is kno..

A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population.

Rajkumar Dorajoo, Ye Sun, Yi Han, Tingjing Ke, Ayala Burger, Xuling Chang, Hui Qi Low, Weihua Guan, Rozenn N Lemaitre, Chiea-Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Choon Nam Ong, E Shyong Tai, Jianjun Liu, Rob M van Dam, Chew-Kiat Heng, Yechiel Friedlander

Journal article  |  2015  |  Genes & Nutrition

Polyunsaturated fatty acids (PUFAs) have a major impact on human health. Recent genome-wide association studies (GWAS) have identi..