Susan Ramus

Older age should not be a barrier to testing for somatic variants in homologous recombination DNA repair-related genes in patients with high-grade serous ovarian carcinoma.

Omali Pitiyarachchi, Yeh Chen Lee, Hao-Wen Sim, Sivatharsny Srirangan, Cristina Mapagu, Judy Kirk, Paul R Harnett, Rosemary L Balleine, David DL Bowtell, Goli Samimi, Alison H Brand, Deborah J Marsh, Philip Beale, Lyndal Anderson, Natalie Bouantoun, Pamela Provan, undefined INOVATe Investigators, Susan J Ramus, Anna DeFazio, Michael Friedlander

Journal article  |  2023  |  Transl Oncol

BACKGROUND: Somatic pathogenic variants (PVs) in homologous recombination DNA repair (HR)-related genes found in high-grade serous..

Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility.

Lauren M Hurwitz, Penelope M Webb, Susan J Jordan, Jennifer A Doherty, Holly R Harris, Marc T Goodman, Yurii B Shvetsov, Francesmary Modugno, Kirsten B Moysich, Joellen M Schildkraut, Andrew Berchuck, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Susan J Ramus, Anna H Wu, Celeste Leigh Pearce, Nicolas Wentzensen, Shelley S Tworoger, Paul DP Pharoah, et al.

Journal article  |  2023  |  JAMA Netw Open

IMPORTANCE: Frequent aspirin use is associated with reduced ovarian cancer risk, but it is unknown whether genetic factors modify ..

Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.

Ashley Weir, Eun-Young Kang, Nicola S Meagher, Gregg S Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J Riggan, Aleksandra Gentry-Maharaj, Andy Ryan, Naveena Singh, Martin Widschwendter, Jennifer Alsop, Michael S Anglesio, Matthias W Beckmann, Jessica Berger, Christiani Bisinotto, Jessica Boros, Alison H Brand, James D Brenton, Angela Brooks-Wilson, et al.

Journal article  |  2023  |  Br J Cancer

BACKGROUND: Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (H..

Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis.

Zhuxuan Fu, Maria Mori Brooks, Sarah Irvin, Susan Jordan, Katja KH Aben, Hoda Anton-Culver, Elisa V Bandera, Matthias W Beckmann, Andrew Berchuck, Angela Brooks-Wilson, Jenny Chang-Claude, Linda S Cook, Daniel W Cramer, Kara L Cushing-Haugen, Jennifer A Doherty, Arif B Ekici, Peter A Fasching, Renée T Fortner, Simon A Gayther, Aleksandra Gentry-Maharaj, et al.

Journal article  |  2023  |  J Natl Cancer Inst

BACKGROUND: The role of ovulation in epithelial ovarian cancer (EOC) is supported by the consistent protective effects of parity a..

Profiling the immune landscape in mucinous ovarian carcinoma.

Nicola S Meagher, Phineas Hamilton, Katy Milne, Shelby Thornton, Bronwyn Harris, Ashley Weir, Jennifer Alsop, Christiani Bisinoto, James D Brenton, Angela Brooks-Wilson, Derek S Chiu, Kara L Cushing-Haugen, Sian Fereday, Dale W Garsed, Simon A Gayther, Aleksandra Gentry-Maharaj, Blake Gilks, Mercedes Jimenez-Linan, Catherine J Kennedy, Nhu D Le, et al.

Journal article  |  2023  |  Gynecol Oncol

OBJECTIVE: Mucinous ovarian carcinoma (MOC) is a rare histotype of ovarian cancer, with low response rates to standard chemotherap..

Lifestyle and personal factors associated with having macroscopic residual disease after ovarian cancer primary cytoreductive surgery.

Minh Tung Phung, Penelope M Webb, Anna DeFazio, Sian Fereday, Alice W Lee, David DL Bowtell, Peter A Fasching, Ellen L Goode, Marc T Goodman, Beth Y Karlan, Jenny Lester, Keitaro Matsuo, Francesmary Modugno, James D Brenton, Toon Van Gorp, Paul DP Pharoah, Joellen M Schildkraut, Karen McLean, Rafael Meza, Bhramar Mukherjee, et al.

Journal article  |  2023  |  Gynecol Oncol

OBJECTIVE: The presence of macroscopic residual disease after primary cytoreductive surgery (PCS) is an important factor influenci..

CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study.

Eun-Young Kang, Ashley Weir, Nicola S Meagher, Kyo Farrington, Gregg S Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J Riggan, Adelyn Bolithon, Gordana Popovic, Betty Leung, Katrina Tang, Neil Lambie, Joshua Millstein, Jennifer Alsop, Michael S Anglesio, Beyhan Ataseven, Ellen Barlow, Matthias W Beckmann, Jessica Berger, et al.

Journal article  |  2022  |  Cancer

BACKGROUND: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma ..

Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia

Lauren M Hurwitz, Mary K Townsend, Susan J Jordan, Alpa V Patel, Lauren R Teras, James V Lacey, Jennifer A Doherty, Holly R Harris, Marc T Goodman, Yurii B Shvetsov, Francesmary Modugno, Kirsten B Moysich, Kim Robien, Anna Prizment, Joellen M Schildkraut, Andrew Berchuck, Renee T Fortner, Andrew T Chan, Nicolas Wentzensen, Patricia Hartge, et al.

Journal article  |  2022  |  JOURNAL OF CLINICAL ONCOLOGY

PURPOSE: Frequent aspirin use has been associated with reduced ovarian cancer risk, but no study has comprehensively assessed for ..

Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S Meagher, Kylie L Gorringe, Matthew Wakefield, Adelyn Bolithon, Chi Nam Ignatius Pang, Derek S Chiu, Michael S Anglesio, Kylie-Ann Mallitt, Jennifer A Doherty, Holly R Harris, Joellen M Schildkraut, Andrew Berchuck, Kara L Cushing-Haugen, Ksenia Chezar, Angela Chou, Adeline Tan, Jennifer Alsop, Ellen Barlow, Matthias W Beckmann, Jessica Boros, et al.

Journal article  |  2022  |  CLINICAL CANCER RESEARCH

PURPOSE: Advanced-stage mucinous ovarian carcinoma (MOC) has poor chemotherapy response and prognosis and lacks biomarkers to aid ..

The genomic and immune landscape of long-term survivors of high-grade serous ovarian cancer

Dale W Garsed, Ahwan Pandey, Sian Fereday, Catherine J Kennedy, Kazuaki Takahashi, Kathryn Alsop, Phineas T Hamilton, Joy Hendley, Yoke-Eng Chiew, Nadia Traficante, Pamela Provan, Dinuka Ariyaratne, George Au-Yeung, Nicholas W Bateman, Leanne Bowes, Alison Brand, Elizabeth L Christie, Julie M Cunningham, Michael Friedlander, Bronwyn Grout, et al.

Journal article  |  2022  |  NATURE GENETICS

Fewer than half of all patients with advanced-stage high-grade serous ovarian cancers (HGSCs) survive more than five years after d..