Laura Cook

The parasite cytokine mimic Hp-TGM potently replicates the regulatory effects of TGF-beta on murine CD4( ) T cells

Madeleine PJ White, Danielle J Smyth, Laura Cook, Steven F Ziegler, Megan K Levings, Rick M Maizels

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

Transforming growth factor-beta (TGF-β) family proteins mediate many vital biological functions in growth, development and regulat..

Prebiotic enriched exclusive enteral nutrition suppresses colitis via gut microbiome modulation and expansion of anti-inflammatory T cells in a mouse model of colitis.

Genelle R Healey, Kevin Tsai, Alana Schick, Daniel J Lisko, Laura Cook, Bruce A Vallance, Kevan Jacobson

Journal article  |  2021  |  Cell Mol Gastroenterol Hepatol

BACKGROUND & AIMS: Exclusive enteral nutrition (EEN) is used to treat pediatric Crohn's disease (CD), but therapeutic benefits are..

Induction of stable human FOXP3( ) Tregs by a parasite-derived TGF-beta mimic

Laura Cook, Kyle T Reid, Elmeri Hakkinen, Brett Bie, Shigeru Tanaka, Danielle J Smyth, Madeleine PJ White, May Q Wong, Qing Huang, Jana K Gillies, Steven F Ziegler, Rick M Maizels, Megan K Levings

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

Immune homeostasis in the intestine is tightly controlled by FOXP3+ regulatory T cells (Tregs), defects of which are linked to the..

Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection Enhances Adaptive Immunity to C difficile Toxin B

Laura Cook, William D Rees, May Q Wong, Hannah Peters, Megan K Levings, Theodore S Steiner

Journal article  |  2021  |  GASTROENTEROLOGY

Recurrent Clostridioides difficile Infection Is Associated With Impaired T Helper Type 17 Immunity to C difficile Toxin B

Laura Cook, William D Rees, May Q Wong, William W Kwok, Megan K Levings, Theodore S Steiner

Journal article  |  2021  |  GASTROENTEROLOGY

CD73( ) CD127(high) Long-Term Memory CD4 T Cells Are Highly Proliferative in Response to Recall Antigens and Are Early Targets in HIV-1 Infection

Nabila Seddiki, John Zaunders, Chan Phetsouphanh, Vedran Brezar, Yin Xu, Helen M McGuire, Michelle Bailey, Kristin McBride, Will Hey-Cunningham, Cynthia Mee Ling Munier, Laura Cook, Stephen Kent, Andrew Lloyd, Barbara Cameron, Barbara Fazekas de St Groth, Kersten Koelsch, Mark Danta, Hakim Hocini, Yves Levy, Anthony D Kelleher

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HIV-1 infection rapidly leads to a loss of the proliferative response of memory CD4+ T lymphocytes, when cultured with recall anti..

Cross talk between human regulatory T cells and antigen-presenting cells: Lessons for clinical applications

Christine M Wardell, Katherine N MacDonald, Megan K Levings, Laura Cook

Journal article  |  2020  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cells (Tregs) have a critical role in maintaining self-tolerance and immune homeostasis. There is much interest in us..

Long-term maternal exposure to atrazine in the drinking water reduces penis length in the tammar wallaby Macropus eugenii

Laura E Cook, Yu Chen, Marilyn B Renfree, Andrew J Pask

Journal article  |  2020  |  Reproduction Fertility and Development

Marsupials are experiencing devastating population declines across Australia. Exposure to environmental endocrine disruptors, thro..

Circulating gluten-specific, but not CMV-specific, CD39( ) regulatory T cells have an oligoclonal TCR repertoire

Laura Cook, C Mee Ling Munier, Nabila Seddiki, Melinda Y Hardy, Robert P Anderson, John Zaunders, Jason A Tye-Din, Anthony D Kelleher, David van Bockel

Journal article  |  2020  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: Understanding the T cell receptor (TCR) repertoire of regulatory CD4+ T-cell (Treg) populations is important for strat..

T-Cell Specificity Matters in IBD: Impaired IL10 Production Revealed by OmpC-Tetramers

Laura Cook, Megan K Levings

Journal article  |  2020  |  CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY