Alisa Glukhova

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.

Xin Zhang, Matthew J Belousoff, Peishen Zhao, Albert J Kooistra, Tin T Truong, Sheng Yu Ang, Christina Rye Underwood, Thomas Egebjerg, Petr Šenel, Gregory D Stewart, Yi-Lynn Liang, Alisa Glukhova, Hari Venugopal, Arthur Christopoulos, Sebastian GB Furness, Laurence J Miller, Steffen Reedtz-Runge, Christopher J Langmead, David E Gloriam, Radostin Danev, et al.

Journal article  |  2020  |  Molecular Cell

Peptide drugs targeting class B1 G-protein-coupled receptors (GPCRs) can treat multiple diseases; however, there remains substanti..

Structure and dynamics of the active Gs-coupled human secretin receptor.

Maoqing Dong, Giuseppe Deganutti, Sarah J Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J Belousoff, Kaleeckal G Harikumar, Christopher A Reynolds, Alisa Glukhova, Sebastian GB Furness, Arthur Christopoulos, Radostin Danev, Denise Wootten, Patrick M Sexton, Laurence J Miller

Journal article  |  2020  |  Nature Communications

The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascu..

Automatic local resolution-based sharpening of cryo-EM maps

Erney Ramirez-Aportela, Jose Luis Vilas, Alisa Glukhova, Roberto Melero, Pablo Conesa, Marta Martinez, David Maluenda, Javier Mota, Amaya Jimenez, Javier Vargas, Roberto Marabini, Patrick M Sexton, Jose Maria Carazo, Carlos Oscar S Sorzano

Journal article  |  2020  |  Bioinformatics

MOTIVATION: Recent technological advances and computational developments have allowed the reconstruction of Cryo-Electron Microsco..

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

Tyler S Beyett, Amy E Fraley, Emily Labudde, Dhabaleswar Patra, Ryan C Coleman, Akito Eguchi, Alisa Glukhova, Qiuyan Chen, Robert M Williams, Walter J Koch, David H Sherman, John JG Tesmer

Journal article  |  2019  |  Proceedings of the National Academy of Sciences of the United States of America

G protein-coupled receptor (GPCR) kinases (GRKs) are responsible for initiating desensitization of activated GPCRs. GRK5 is potent..

Molecular basis activation of lecithin: cholesterol acyltransferase by a compound that increases HDL cholesterol

Kelly A Manthei, Shyh-Ming Yang, Bolormaa Baljinnyam, Louise Chang, Alisa Glukhova, Wenmin Yuan, Lita A Freeman, David J Maloney, Anna Schwendeman, Alan T Remaley, Ajit Jadhav, John JG Tesmer

Journal article  |  2018  |  eLife

Rules of Engagement: GPCRs and G Proteins.

Alisa Glukhova, Christopher J Draper-Joyce, Roger K Sunahara, Arthur Christopoulos, Denise Wootten, Patrick M Sexton

Journal article  |  2018  |  ACS Pharmacology & Translational Science

G protein-coupled receptors (GPCRs) are a key drug target class. They account for over one-third of current pharmaceuticals, and b..

Cryo-EM structure of the active, G(s)- protein complexed, human CGRP receptor

Yi-Lynn Liang, Maryam Khoshouei, Giuseppe Deganutti, Alisa Glukhova, Cassandra Koole, Thomas S Peat, Mazdak Radjainia, Jurgen M Plitzko, Wolfgang Baumeister, Laurence J Miller, Deborah L Hay, Arthur Christopoulos, Christopher A Reynolds, Denise Wootten, Patrick M Sexton

Journal article  |  2018  |  Nature

Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination.

Yi-Lynn Liang, Peishen Zhao, Christopher Draper-Joyce, Jo-Anne Baltos, Alisa Glukhova, Tin T Truong, Lauren T May, Arthur Christopoulos, Denise Wootten, Patrick M Sexton, Sebastian GB Furness

Journal article  |  2018  |  ACS Pharmacology & Translational Science

Advances in structural biology have yielded exponential growth in G protein-coupled receptor (GPCR) structure solution. Nonetheles..

Recent advances in the determination of G protein-coupled receptor structures

David M Thal, Ziva Vuckovic, Christopher J Draper-Joyce, Yi-Lynn Liang, Alisa Glukhova, Arthur Christopoulos, Patrick M Sexton

Journal article  |  2018  |  Current Opinion in Structural Biology

G protein-coupled receptors (GPCRs) are the largest superfamily of cell surface receptor proteins and are important drug targets f..

Structural insights into G-protein-coupled receptor allostery

David M Thal, Alisa Glukhova, Patrick M Sexton, Arthur Christopoulos

Journal article  |  2018  |  Nature