Anna Calkin

Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines

Simon T Bond, Aowen Zhuang, Christine Yang, Eleanor AM Gould, Tim Sikora, Yingying Liu, Ying Fu, Kevin Watt, Yanie Tan, Helen Kiriazis, Graeme Lancaster, Paul Gregorevic, Darren C Henstridge, Julie R McMullen, Peter J Meikle, Anna C Calkin, Brian G Drew

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVE: CRISPR/Cas9 technology has revolutionized gene editing and fast tracked our capacity to manipulate genes of interest fo..

SOD2 in skeletal muscle: New insights from an inducible deletion model.

Aowen Zhuang, Christine Yang, Yingying Liu, Yanie Tan, Simon T Bond, Shannen Walker, Tim Sikora, Adrienne Laskowski, Arpeeta Sharma, Judy B de Haan, Peter J Meikle, Takahiko Shimizu, Melinda T Coughlan, Anna C Calkin, Brian G Drew

Journal article  |  2021  |  Redox Biol

Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently associated with impairments in ske..

Lipin 1 modulates mRNA splicing during fasting adaptation in liver

Huan Wang, Tracey W Chan, Ajay A Vashisht, Brian G Drew, Anna C Calkin, Thurl E Harris, James A Wohlschlegel, Xinshu Xiao, Karen Reue

Journal article  |  2021  |  JCI INSIGHT

Lipin 1 regulates cellular lipid homeostasis through roles in glycerolipid synthesis (through phosphatidic acid phosphatase activi..

Genome-Wide Association Study Identifies a Functional SIDT2 Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease

Paola Leon-Mimila, Hugo Villamil-Ramirez, Luis R Macias-Kauffer, Leonor Jacobo-Albavera, Blanca E Lopez-Contreras, Rosalinda Posadas-Sanchez, Carlos Posadas-Romero, Sandra Romero-Hidalgo, Sofia Moran-Ramos, Mayra Dominguez-Perez, Marisol Olivares-Arevalo, Priscilla Lopez-Montoya, Roberto Nieto-Guerra, Victor Acuna-Alonzo, Gaston Macin-Perez, Rodrigo Barquera-Lozano, Blanca E Del-Rio-Navarro, Israel Gonzalez-Gonzalez, Francisco Campos-Perez, Francisco Gomez-Perez, et al.

Journal article  |  2021  |  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Objective: Low HDL-C (high-density lipoprotein cholesterol) is the most frequent dyslipidemia in Mexicans, but few studies have ex..

FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption

Bethan L Clifford, Leslie R Sedgeman, Kevin J Williams, Pauline Morand, Angela Cheng, Kelsey E Jarrett, Alvin P Chan, Madelaine C Brearley-Sholto, Annika Wahlstrom, Julianne W Ashby, William Barshop, James Wohlschlegel, Anna C Calkin, Yingying Liu, Anders Thorell, Peter J Meikle, Brian G Drew, Julia J Mack, Hanns-Ulrich Marschall, Elizabeth J Tarling, et al.

Journal article  |  2021  |  CELL METABOLISM

FXR agonists are used to treat non-alcoholic fatty liver disease (NAFLD), in part because they reduce hepatic lipids. Here, we sho..

Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner

Aowen Zhuang, Anna C Calkin, Shannen Lau, Helen Kiriazis, Daniel G Donner, Yingying Liu, Simon T Bond, Sarah C Moody, Eleanor AM Gould, Timothy D Colgan, Sergio Ruiz Carmona, Michael Inouye, Thomas Q de Aguiar Vallim, Elizabeth J Tarling, Gregory A Quaife-Ryan, James E Hudson, Enzo R Porrello, Paul Gregorevic, Xiao-Ming Gao, Xiao-Jun Du, et al.

Journal article  |  2021  |  ISCIENCE

Long non-coding RNAs (lncRNAs) have been demonstrated to influence numerous biological processes, being strongly implicated in the..

The Impact of Simvastatin on Lipidomic Markers of Cardiovascular Risk in Human Liver Cells Is Secondary to the Modulation of Intracellular Cholesterol

Yvette L Schooneveldt, Corey Giles, Michael F Keating, Natalie A Mellett, Aaron W Jurrjens, Sudip Paul, Anna C Calkin, Peter J Meikle

Journal article  |  2021  |  METABOLITES

Statins are the first-line lipid-lowering therapy for reducing cardiovascular disease (CVD) risk. A plasma lipid ratio of two phos..

Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance

Simon T Bond, Emily J King, Darren C Henstridge, Adrian Tran, Sarah C Moody, Christine Yang, Yingying Liu, Natalie A Mellett, Artika P Nath, Michael Inouye, Elizabeth J Tarling, Thomas Q de Aguiar Vallim, Peter J Meikle, Anna C Calkin, Brian G Drew

Journal article  |  2021  |  NATURE COMMUNICATIONS

The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have be..

Lack of Strategic Funding and Long-Term Job Security Threaten to Have Profound Effects on Cardiovascular Researcher Retention in Australia.

Rachel E Climie, Jason HY Wu, Anna C Calkin, Niamh Chapman, Sally C Inglis, Katrina M Mirabito Colafella, Dean S Picone, Joanne TM Tan, Emma Thomas, Helena M Viola, Steven G Wise, Andrew J Murphy, Mark R Nelson, Stephen J Nicholls, Livia C Hool, Kerry Doyle, Gemma A Figtree, Francine Z Marques, undefined Australian Cardiovascular Alliance

Journal article  |  2020  |  Heart Lung Circ

BACKGROUND: Cardiovascular disease is the leading cause of death in Australia. Investment in research solutions has been demonstra..

Addressing Gender Equity in Senior Leadership Roles in Translational Science

Dianna J Magliano, Vaughan G Macefield, Tracey M Ellis, Anna C Calkin

Journal article  |  2020  |  ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

Inequities for women exist across many leverage points of an academic career in science, technology, engineering, mathematics, and..