Anna Calkin

Tissue Specific Expression of Cas9 has no Impact on Whole Body Metabolism in Four Transgenic Mouse Lines.

Simon T Bond, Aowen Zhuang, Christine Yang, Eleanor AM Gould, Tim Sikora, Yingying Liu, Ying Fu, Kevin I Watt, Yanie Tan, Helen Kiriazis, Graeme I Lancaster, Paul Gregorevic, Darren C Henstridge, Julie R McMullen, Peter J Meikle, Anna C Calkin, Brian G Drew

Journal article  |  2021  |  Mol Metab

CRISPR/Cas9 technology has revolutionized gene editing and fast tracked our capacity to manipulate genes of interest for the benef..

Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner.

Aowen Zhuang, Anna C Calkin, Shannen Lau, Helen Kiriazis, Daniel G Donner, Yingying Liu, Simon T Bond, Sarah C Moody, Eleanor AM Gould, Timothy D Colgan, Sergio Ruiz Carmona, Michael Inouye, Thomas Q de Aguiar Vallim, Elizabeth J Tarling, Gregory A Quaife-Ryan, James E Hudson, Enzo R Porrello, Paul Gregorevic, Xiao-Ming Gao, Xiao-Jun Du, et al.

Journal article  |  2021  |  iScience

Long non-coding RNAs (lncRNAs) have been demonstrated to influence numerous biological processes, being strongly implicated in the..

The Impact of Simvastatin on Lipidomic Markers of Cardiovascular Risk in Human Liver Cells Is Secondary to the Modulation of Intracellular Cholesterol

Yvette L Schooneveldt, Corey Giles, Michael F Keating, Natalie A Mellett, Aaron W Jurrjens, Sudip Paul, Anna C Calkin, Peter J Meikle

Journal article  |  2021  |  METABOLITES

Statins are the first-line lipid-lowering therapy for reducing cardiovascular disease (CVD) risk. A plasma lipid ratio of two phos..

Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance

Simon T Bond, Emily J King, Darren C Henstridge, Adrian Tran, Sarah C Moody, Christine Yang, Yingying Liu, Natalie A Mellett, Artika P Nath, Michael Inouye, Elizabeth J Tarling, Thomas Q de Aguiar Vallim, Peter J Meikle, Anna C Calkin, Brian G Drew

Journal article  |  2021  |  NATURE COMMUNICATIONS

The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have be..

Lack of Strategic Funding and Long-Term Job Security Threaten to Have Profound Effects on Cardiovascular Researcher Retention in Australia.

Rachel E Climie, Jason HY Wu, Anna C Calkin, Niamh Chapman, Sally C Inglis, Katrina M Mirabito Colafella, Dean S Picone, Joanne TM Tan, Emma Thomas, Helena M Viola, Steven G Wise, Andrew J Murphy, Mark R Nelson, Stephen J Nicholls, Livia C Hool, Kerry Doyle, Gemma A Figtree, Francine Z Marques, undefined Australian Cardiovascular Alliance

Journal article  |  2020  |  Heart Lung Circ

BACKGROUND: Cardiovascular disease is the leading cause of death in Australia. Investment in research solutions has been demonstra..

Addressing Gender Equity in Senior Leadership Roles in Translational Science

Dianna J Magliano, Vaughan G Macefield, Tracey M Ellis, Anna C Calkin

Journal article  |  2020  |  ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

Inequities for women exist across many leverage points of an academic career in science, technology, engineering, mathematics, and..

Disparate Effects of Diabetes and Hyperlipidemia on Experimental Kidney Disease.

Anna MD Watson, Eleanor AM Gould, Sarah C Moody, Priyadharshini Sivakumaran, Karly C Sourris, Bryna SM Chow, Audrey Koïtka-Weber, Terri J Allen, Karin AM Jandeleit-Dahm, Mark E Cooper, Anna C Calkin

Journal article  |  2020  |  Front Physiol

It is well established that diabetes is the major cause of chronic kidney disease worldwide. Both hyperglycemia, and more recently..

IDOL regulates systemic energy balance through control of neuronal VLDLR expression.

Stephen D Lee, Christina Priest, Mikael Bjursell, Jie Gao, Douglas V Arneson, In Sook Ahn, Graciel Diamante, J Edward van Veen, Megan G Massa, Anna C Calkin, Jason Kim, Harriet Andersén, Prashant Rajbhandari, Michelle Porritt, Alba Carreras, Andrea Ahnmark, Frank Seeliger, Ingela Maxvall, Pernilla Eliasson, Magnus Althage, et al.

Journal article  |  2019  |  Nat Metab

Liver X receptors limit cellular lipid uptake by stimulating the transcription of Inducible Degrader of the LDL Receptor (IDOL), a..

The Antioxidant Moiety of MitoQ Imparts Minimal Metabolic Effects in Adipose Tissue of High Fat Fed Mice

Simon T Bond, Jisu Kim, Anna C Calkin, Brian G Drew

Journal article  |  2019  |  FRONTIERS IN PHYSIOLOGY

Mitochondrial dysfunction is associated with a diverse array of diseases ranging from dystrophy and heart failure to obesity and h..

An integrative systems genetic analysis of mammalian lipid metabolism

Benjamin L Parker, Anna C Calkin, Marcus M Seldin, Michael F Keating, Elizabeth J Tarling, Pengyi Yang, Sarah C Moody, Yingying Liu, Eser J Zerenturk, Elise J Needham, Matthew L Miller, Bethan L Clifford, Pauline Morand, Matthew J Watt, Ruth CR Meex, Kang-Yu Peng, Richard Lee, Kaushala Jayawardana, Calvin Pan, Natalie A Mellett, et al.

Journal article  |  2019  |  NATURE

Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and progression of hepatosteatosis and metabolic s..