Karlheinz Peter

Platelet CXCL14: introducing a new player and potential therapeutic target in thromboinflammation.

James D McFadyen, Karlheinz Peter

Journal article  |  2020  |  Cardiovascular Research

The Tandem Stenosis Mouse Model: Towards Understanding, Imaging and Preventing Atherosclerotic Plaque Instability and Rupture.

Jonathan Noonan, Alex Bobik, Karlheinz Peter

Journal article  |  2020  |  British Journal of Pharmacology

The rupture of unstable/vulnerable atherosclerotic plaques is the major cause of cardiovascular mortality/morbidity. Despite signi..

Alarmin-activated B cells accelerate murine atherosclerosis after myocardial infarction via plasma cell-immunoglobulin-dependent mechanisms.

Tin Kyaw, Paula Loveland, Peter Kanellakis, Anh Cao, Axel Kallies, Alex L Huang, Karlheinz Peter, Ban-Hock Toh, Alex Bobik

Journal article  |  2020  |  European Heart Journal

AIMS : Myocardial infarction (MI) accelerates atherosclerosis and greatly increases the risk of recurrent cardiovascular events fo..

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

Laura A Bienvenu, Jonathan Noonan, Xiaowei Wang, Karlheinz Peter

Journal article  |  2020  |  Cardiovascular Research

The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a critical concern of the cor..

The choice of targets and ligands for site-specific delivery of nanomedicine to atherosclerosis

Adil Zia, Yuao Wu, Nguyen Tuan, Xiaowei Wang, Karlheinz Peter, Hang T Ta

Journal article  |  2020  |  Cardiovascular Research

As nanotechnologies advance into clinical medicine, novel methods for applying nanomedicine to cardiovascular diseases are emergin..

Combined Antiplatelet/Anticoagulant Drug for Cardiac Ischemia/Reperfusion Injury

Laura A Bienvenu, Ana Maluenda, James D McFadyen, Amy K Searle, Eefang Yu, Carolyn Haller, Elliot L Chaikof, Karlheinz Peter, Xiaowei Wang

Journal article  |  2020  |  Circulation Research

Analyzing the shear-induced sensitization of mechanosensitive ion channel Piezo-1 in human aortic endothelial cells

Austin Lai, Yung C Chen, Charles D Cox, Anthony Jaworowski, Karlheinz Peter, Sara Baratchi

Journal article  |  2020  |  Journal of Cellular Physiology

Mechanosensitive ion channels mediate endothelial responses to blood flow and orchestrate their physiological function in response..

Fluorine-19 Magnetic Resonance Imaging of Activated Platelets

Xiaowei Wang, Sebastian Temme, Christoph Grapentin, Jathushan Palasubramaniam, Aidan Walsh, Wolfgang Kraemer, Patricia Kleimann, Asli Havlas, Rolf Schubert, Juergen Schrader, Ulrich Floegel, Karlheinz Peter

Journal article  |  2020  |  Journal of the American Heart Association

Transcatheter Aortic Valve Implantation Represents an Anti-Inflammatory Therapy Via Reduction of Shear Stress-Induced, Piezo-1-Mediated Monocyte Activation

Sara Baratchi, Maria TK Zaldivia, Maria Wallert, Julia Loseff-Silver, Sefaa Al-Aryahi, Jalal Zamani, Peter Thurgood, Agus Salim, Nay M Htun, Dion Stub, Parisa Vahidi, Stephen J Duffy, Antony Walton, Thanh Ha Nguyen, Anthony Jaworowski, Khashayar Khoshmanesh, Karlheinz Peter

Journal article  |  2020  |  Circulation

BACKGROUND: Aortic valve stenosis is an increasingly prevalent degenerative and inflammatory disease. Transcatheter aortic valve i..

The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications

James D McFadyen, Hannah Stevens, Karlheinz Peter

Journal article  |  2020  |  Circulation Research

The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing global pandemic has presented..