Layla Zhu

CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1.

Wenying Zhu, Kate E Jarman, Noor A Lokman, Heidi A Neubauer, Lorena T Davies, Briony L Gliddon, Houng Taing, Paul AB Moretti, Martin K Oehler, Melissa R Pitman, Stuart M Pitson

Journal article  |  2017  |  Cancer Research

Sphingosine kinase 1 (SK1) is a key regulator of the cellular balance between proapoptotic and prosurvival sphingolipids. Oncogeni..

CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1.

W Zhu, BL Gliddon, KE Jarman, PAB Moretti, T Tin, LV Parise, JM Woodcock, JA Powell, A Ruszkiewicz, MR Pitman, SM Pitson

Journal article  |  2017  |  Oncogene

CIB1 (calcium and integrin binding protein 1) is a small intracellular protein with numerous interacting partners, and hence has b..

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Jason A Powell, Alexander C Lewis, Wenying Zhu, John Toubia, Melissa R Pitman, Craig T Wallington-Beddoe, Paul AB Moretti, Diana Iarossi, Saumya E Samaraweera, Nik Cummings, Hayley S Ramshaw, Daniel Thomas, Andrew H Wei, Angel F Lopez, Richard J D'Andrea, Ian D Lewis, Stuart M Pitson

Journal article  |  2017  |  Blood