Yow Keat Tham

Lipids regulated by exercise and phosphoinositide 3-kinase: potential role as biomarkers and therapeutic targets for cardiovascular disease

TG Belkin, YK Tham, JR McMullen

Journal article  |  2023  |  Current Opinion in Physiology

Lipids are organic biomolecules that provide structural support to cells, but are also important for energy storage and signaling...

Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice

Yow Keat Tham, Bianca C Bernardo, Bethany Claridge, Gunes S Yildiz, Liesel Min-Linn Woon, Simon Bond, Haoyun Fang, Jenny YY Ooi, Aya Matsumoto, Jieting Luo, Celeste MK Tai, Claudia A Harmawan, Helen Kiriazis, Daniel G Donner, Natalie A Mellett, E Dale Abel, Sohaib A Khan, David P De Souza, Sheik Nadeem Elahee Doomun, Kevin Liu, et al.

Journal article  |  2023  |  Nature Cardiovascular Research

Estrogen receptor a deficiency in cardiac myocytes reprograms heart-derived extracellular vesicle proteome and induces obesity in female mice

Yow Keat Tham, Bianca Bernardo, Bethany Claridge, Liesel Woon, Gunes Yildiz, Jenny Ooi, Aya Matsumoto, Jieting Luo, Celeste Tai, Claudia Harmawan, Helen Kiriazis, Daniel Donner, Natalie Mellett, Dale Abel, Sohaib Khan, Peter Meikle, Kate Weeks, David Greening, Julie McMullen

Journal article  |  2022  |  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CD14 inhibition mitigates left ventricular damage and dysfunction following myocardial infarction

Aascha Brown, Helen Kiriazis, Tsin Yee Tai, Adam Parslow, Chad Johnson, Stephanie Jansen, Yow Keat Tham, Camilla Cohen, Angela Vais, Guy Krippner, Bing Wang, David Kaye, Daniel Donner

Journal article  |  2022  |  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K

Kate L Weeks, Yow Keat Tham, Suzan G Yildiz, Yonali Alexander, Daniel G Donner, Helen Kiriazis, Claudia A Harmawan, Amy Hsu, Bianca C Bernardo, Aya Matsumoto, Ronald A DePinho, E Dale Abel, Elizabeth A Woodcock, Julie R McMullen

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The insulin-like growth factor 1 receptor (IGF1R) and phosphoinositide 3-kinase p110α (PI3K) are critical regulators of exercise-i..

Oestrogen Receptor α in the Heart is Critical for Protection Against Systemic Obesity in Female Mice

Y Tham, B Bernardo, L Woon, S Yildiz, C Tai, N Mellett, P Chen, P Meikle, E Abel, S Khan, K Weeks, J McMullen

Journal article  |  2021  |  Heart, Lung and Circulation

Novel Lipid Species for Detecting and Predicting Atrial Fibrillation in Patients With Type 2 Diabetes

Yow Keat Tham, Kaushala S Jayawardana, Zahir H Alshehry, Corey Giles, Kevin Huynh, Adam Alexander T Smith, Jenny YY Ooi, Sophia Zoungas, Graham S Hillis, John Chalmers, Peter J Meikle, Julie R McMullen

Journal article  |  2021  |  DIABETES

The incidence of atrial fibrillation (AF) is higher in patients with diabetes. The goal of this study was to assess if the additio..

Forkhead box protein 01 (Fox01) is required for exercise-induced, but not PI3K-induced, physiological cardiac hypertrophy

Kate Weeks, Helen Kiriazis, Yow Keat Tham, Bianca Bernardo, Nelly Cemerlang, Julie McMullen

Conference Proceedings  |  2018  |  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets

Yow Keat Tham, Bianca C Bernardo, Kevin Huynh, Jenny YY Ooi, Xiao Ming Gao, Helen Kiriazis, Corey Giles, Peter J Meikle, Julie R McMullen

Journal article  |  2018  |  CELL REPORTS

Exercise-induced heart growth provides protection against cardiovascular disease, whereas disease-induced heart growth leads to he..

Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies

Yow Keat Tham, Kevin Huynh, Natalie A Mellett, Darren C Henstridge, Helen Kiriazis, Jenny YY Ooi, Aya Matsumoto, Natalie L Patterson, Junichi Sadoshima, Peter J Meikle, Julie R McMullen

Journal article  |  2018  |  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cardiac myocyte membranes contain lipids which remodel dramatically in response to heart growth and remodeling. Lipid species have..