Yow Keat Tham

FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K

Kate L Weeks, Yow Keat Tham, Suzan G Yildiz, Yonali Alexander, Daniel G Donner, Helen Kiriazis, Claudia A Harmawan, Amy Hsu, Bianca C Bernardo, Aya Matsumoto, Ronald A DePinho, E Dale Abel, Elizabeth A Woodcock, Julie R McMullen

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The insulin-like growth factor 1 receptor (IGF1R) and phosphoinositide 3-kinase p110α (PI3K) are critical regulators of exercise-i..

Novel Lipid Species for Detecting and Predicting Atrial Fibrillation in Patients With Type 2 Diabetes

Yow Keat Tham, Kaushala S Jayawardana, Zahir H Alshehry, Corey Giles, Kevin Huynh, Adam Alexander T Smith, Jenny YY Ooi, Sophia Zoungas, Graham S Hillis, John Chalmers, Peter J Meikle, Julie R McMullen

Journal article  |  2021  |  DIABETES

The incidence of atrial fibrillation (AF) is higher in patients with diabetes. The goal of this study was to assess if the additio..

Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets

Yow Keat Tham, Bianca C Bernardo, Kevin Huynh, Jenny YY Ooi, Xiao Ming Gao, Helen Kiriazis, Corey Giles, Peter J Meikle, Julie R McMullen

Journal article  |  2018  |  CELL REPORTS

Exercise-induced heart growth provides protection against cardiovascular disease, whereas disease-induced heart growth leads to he..

Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies

Yow Keat Tham, Kevin Huynh, Natalie A Mellett, Darren C Henstridge, Helen Kiriazis, Jenny YY Ooi, Aya Matsumoto, Natalie L Patterson, Junichi Sadoshima, Peter J Meikle, Julie R McMullen

Journal article  |  2018  |  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cardiac myocyte membranes contain lipids which remodel dramatically in response to heart growth and remodeling. Lipid species have..

Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling

Bianca C Bernardo, Kate L Weeks, Thawin Pongsukwechkul, Xiaoming Gao, Helen Kiriazis, Nelly Cemerlang, Esther JH Boey, Yow Keat Tham, Chad J Johnson, Hongwei Qian, Xiao-Jun Du, Paul Gregorevic, Julie R McMullen

Journal article  |  2018  |  CLINICAL SCIENCE

We previously showed that medium chain acyl-coenzyme A dehydrogenase (MCAD, key regulator of fatty acid oxidation) is positively m..

Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: identification of sex-, disease- and treatment-regulated miRNAs

Bianca C Bernardo, Jenny YY Ooi, Aya Matsumoto, Yow Keat Tham, Saloni Singla, Helen Kiriazis, Natalie L Patterson, Junichi Sadoshima, Susanna Obad, Rubyc Y Lin, Julie R McMullen

Journal article  |  2016  |  JOURNAL OF PHYSIOLOGY-LONDON

KEY POINTS: MicroRNA (miRNA)-based therapies are in development for numerous diseases, including heart disease. Currently, very li..

Inhibition of miR-154 Protects Against Cardiac Dysfunction and Fibrosis in a Mouse Model of Pressure Overload

Bianca C Bernardo, Sally S Nguyen, Xiao-Ming Gao, Yow Keat Tham, Jenny YY Ooi, Natalie L Patterson, Helen Kiriazis, Yidan Su, Colleen J Thomas, Ruby CY Lin, Xiao-Jun Du, Julie R McMullen

Journal article  |  2016  |  SCIENTIFIC REPORTS

Expression of miR-154 is upregulated in the diseased heart and was previously shown to be upregulated in the lungs of patients wit..

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

Yow Keat Tham, Bianca C Bernardo, Jenny YY Ooi, Kate L Weeks, Julie R McMullen

Journal article  |  2015  |  ARCHIVES OF TOXICOLOGY

The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the heart to increased workload, a cardiac ..

Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy

Bianca C Bernardo, Sally S Nguyen, Catherine E Winbanks, Xiao-Ming Gao, Esther JH Boey, Yow Keat Tham, Helen Kiriazis, Jenny YY Ooi, Enzo R Porrello, Sindhu Igoor, Colleen J Thomas, Paul Gregorevic, Ruby CY Lin, Xiao-Jun Du, Julie R McMullen

Journal article  |  2014  |  FASEB JOURNAL

Expression of microRNA-652 (miR-652) increases in the diseased heart, decreases in a setting of cardioprotection, and is inversely..

The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

Geeta Sapra, Yow Keat Tham, Nelly Cemerlang, Aya Matsumoto, Helen Kiriazis, Bianca C Bernardo, Darren C Henstridge, Jenny YY Ooi, Lynette Pretorius, Esther JH Boey, Lydia Lim, Junichi Sadoshima, Peter J Meikle, Natalie A Mellet, Elizabeth A Woodcock, Silvana Marasco, Tomomi Ueyama, Xiao-Jun Du, Mark A Febbraio, Julie R McMullen

Journal article  |  2014  |  NATURE COMMUNICATIONS

Heart failure (HF) and atrial fibrillation (AF) share common risk factors, frequently coexist and are associated with high mortali..