Chloe Gerak

Biophysical characterization of the ETV6 PNT domain polymerization interfaces

Chloe AN Gerak, Sophia Y Cho, Maxim Kolesnikov, Mark Okon, Michael EP Murphy, Richard B Sessions, Michel Roberge, Lawrence P McIntosh

Journal article  |  2021  |  JOURNAL OF BIOLOGICAL CHEMISTRY

ETV6 is an E26 transformation specific family transcriptional repressor that self-associates by its PNT domain to facilitate coope..

A Multipronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization

Chloe AN Gerak, Si Miao Zhang, Aruna D Balgi, Ivan J Sadowski, Richard B Sessions, Lawrence P McIntosh, Michel Roberge

Journal article  |  2020  |  SLAS DISCOVERY

ETV6 is an ETS family transcriptional repressor for which head-to-tail polymerization of its PNT domain facilitates cooperative bi..

Biophysical characterization of the ETV6 PNT domain polymerization interfaces

Chloe Gerak, Sophia Cho, Maxim Kolesnikov, Mark Okon, Michael Murphy, Richard Sessions, Michel Roberge, Lawrence McIntosh

Journal article  |  2020

ETV6 is an ETS family transcriptional repressor that self-associates by its PNT domain to facilitate cooperative DNA binding. Chro..

A Multi-pronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization

Chloe Gerak, Si Miao Zhang, Aruna Balgi, Ivan Sadowski, Richard Sessions, Lawrence McIntosh, Michel Roberge

Journal article  |  2020

ETV6 is an ETS family transcriptional repressor for which head-to-tail polymerization of its PNT domain facilitates cooperative bi..

The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418

Michael W Ferguson, Chloe AN Gerak, Christalle CT Chow, Ettore J Rastelli, Kyle E Elmore, Florian Stahl, Sara Hosseini-Farahabadi, Alireza Baradaran-Heravi, Don M Coltart, Michel Roberge

Journal article  |  2019  |  PLOS ONE

Nonsense mutations constitute ~10% of TP53 mutations in cancer. They introduce a premature termination codon that gives rise to tr..

Both Chemical and Non-Chemical Steps Limit the Catalytic Efficiency of Family 4 Glycoside Hydrolases

Natalia Sannikova, Chloe AN Gerak, Fahimeh S Shidmoossavee, Dustin T King, Saeideh Shamsi Kazem Abadi, Andrew R Lewis, Andrew J Bennet

Journal article  |  2018  |  BIOCHEMISTRY

The glycoside hydrolase family 4 (GH4) α-galactosidase from Citrobacter freundii (MelA) catalyzes the hydrolysis of fluoro-substit..

The role of silk in courtship and chemical communication of the false widow spider, Steatoda grossa (Araneae: Theridiidae)

Catherine Scott, Chloe Gerak, Sean McCann, Gerhard Gries

Journal article  |  2018  |  JOURNAL OF ETHOLOGY

In spiders, sex pheromones are often associated with silk produced by females, and function in mate attraction, recognition, and e..