Alex Harris

Ethical and regulatory issues of stem cell-derived 3-dimensional organoid and tissue therapy for personalised regenerative medicine

Alexander R Harris, Mary Jean Walker, Frederic Gilbert

Journal article  |  2022  |  BMC MEDICINE

BACKGROUND: Regenerative medicine has the potential to treat genetic disorders and replace damaged or missing tissue. The use of d..

Not-So-Straightforward Decisions to Keep or Explant a Device: When Does Neural Device Removal Become Patient Coercion?

Frederic Gilbert, Paul Tubig, Alexander R Harris

Journal article  |  2022  |  AJOB Neurosci

CDKL5 deficiency disorder: molecular insights and mechanisms of pathogenicity to fast-track therapeutic development

Nicole J Van Bergen, Sean Massey, Anita Quigley, Ben Rollo, Alexander R Harris, Robert MI Kapsa, John Christodoulou

Journal article  |  2022  |  BIOCHEMICAL SOCIETY TRANSACTIONS

CDKL5 deficiency disorder (CDD) is an X-linked brain disorder of young children and is caused by pathogenic variants in the cyclin..

Investigating the feasibility and ethical implications of phenotypic screening using stem cell-derived tissue models to detect and manage disease

Alexander R Harris, Mary Jean Walker, Frederic Gilbert, Patrick McGivern

Journal article  |  2022  |  STEM CELL REPORTS

Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug develo..

Induced Pluripotent Stem Cell-Based Systems for Personalising Epilepsy Treatment: Research Ethics Challenges and New Insights for the Ethics of Personalised Medicine.

Mary Jean Walker, Jane Nielsen, Eliza Goddard, Alex Harris, Katrina Hutchison

Journal article  |  2022  |  AJOB Neurosci

ABSTRACTThis paper examines potential ethical and legal issues arising during the research, development and clinical use of a prop..

Visualising the risks of clinical trials for fair treatment and appropriate informed consent of participants

Alexander R Harris, Frederic Gilbert

Journal article  |  2022  |  GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Military Medicine Research: Incorporation of High Risk of Irreversible Harms into a Stratified Risk Framework for Clinical Trials

Alexander R Harris, Frederic Gilbert

Book Chapter  |  2022

Comparison of the In Vitro and In Vivo Electrochemical Performance of Bionic Electrodes

Alexander R Harris, Carrie Newbold, Dimitra Stathopoulos, Paul Carter, Robert Cowan, Gordon G Wallace

Journal article  |  2022  |  MICROMACHINES

The electrochemical performance of platinum electrodes was assessed in vitro and in vivo to determine the impact of electrode impl..

Restoring vision using optogenetics without being blind to the risks

Alexander R Harris, Frederic Gilbert

Journal article  |  2021  |  GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Retinit is pigmentosa is an incurable degenerative disease that causes loss of light-sensitive cells in the retina and leads to se..

Understanding charge transfer on the clinically used conical Utah electrode array: charge storage capacity, electrochemical impedance spectroscopy and effective electrode area

Alexander R Harris

Journal article  |  2021  |  JOURNAL OF NEURAL ENGINEERING

Objective. The Utah electrode is used for pre/clinical studies on neural recording and stimulation. Anecdotal and empirical report..