Tony Huang

Evaluation of the association of heterozygous germline variants in NTHL1 with breast cancer predisposition: an international multi-center study of 47,180 subjects

Na Li, Magnus Zethoven, Simone McInerny, Lisa Devereux, Yu-Kuan Huang, Niko Thio, Dane Cheasley, Sara Gutierrez-Enriquez, Alejandro Moles-Fernandez, Orland Diez, Tu Nguyen-Dumont, Melissa C Southey, John L Hopper, Jacques Simard, Martine Dumont, Penny Soucy, Alfons Meindl, Rita Schmutzler, Marjanka K Schmidt, Muriel A Adank, et al.

Journal article  |  2021  |  NPJ BREAST CANCER

Bi-allelic loss-of-function (LoF) variants in the base excision repair (BER) gene NTHL1 cause a high-risk hereditary multi-tumor s..

SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence

Rita A Busuttil, Joshy George, Colin M House, Stephen Lade, Catherine Mitchell, Natasha S Di Costanzo, Sharon Pattison, Yu-Kuan Huang, Patrick Tan, Jae-Ho Cheong, Sun Young Rha, Alex Boussioutas

Journal article  |  2020  |  GASTRIC CANCER

OBJECTIVE: Gastric cancer patients generally have a poor outcome, particularly those with advanced-stage disease which is defined ..

High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer

Minyu Wang, Yu-Kuan Huang, Joseph CH Kong, Yu Sun, Daniela G Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha Di Costanzo, Ian R Gordon, Catherine Mitchell, Laura K Mackay, Rita A Busuttil, Paul J Neeson, Alex Boussioutas

Journal article  |  2020  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: To facilitate disease prognosis and improve precise immunotherapy of gastric cancer (GC) patients, a comprehensive stu..

Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Yu-Kuan Huang, Minyu Wang, Yu Sun, Natasha Di Costanzo, Catherine Mitchell, Adrian Achuthan, John A Hamilton, Rita A Busuttil, Alex Boussioutas

Journal article  |  2019  |  NATURE COMMUNICATIONS

Tumor-associated macrophages (TAMs), one of the most abundant immune components in gastric cancer (GC), are difficult to character..

Tumor-Infiltrating Lymphocyte Function Predicts Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

Joseph Cherng Huei Kong, Glen Robert Guerra, Rosemary Magdalena Millen, Sara Roth, Huiling Xu, Paul Joseph Neeson, Phillip Kevin Darcy, Michael Henry Kershaw, Shienny Sampurno, Jordane Malaterre, David Shi Hao Liu, Duc Pham Toan, Vignesh Narasimhan, Minyu Wang, Yu-Kuan Huang, Kumar Visvanathan, Jacob McCormick, Andrew Craig Lynch, Satish Warrier, Michael Michael, et al.

Journal article  |  2018  |  JCO PRECISION ONCOLOGY

Purpose The presence of tumor-infiltrating lymphocytes (TILs) in tumors is superior to conventional pathologic staging in predicti..

DENSITY AND DISTRIBUTION OF TUMOUR-INFILTRATING CD4 FOXP3 T CELLS SHOW STRONG PROGNOSTIC SIGNIFICANCE IN GASTRIC CANCER

Minyu Wang, Yu-Kuan Huang, Yu Sun, Heloise Halse, Natasha Di Costanzo, Rita Busuttil, Paul Neeson, Alex Boussioutas

Conference Proceedings  |  2018  |  GASTROENTEROLOGY

Irradiation Enhances the Ability of Monocytes as Nanoparticle Carrier for Cancer Therapy

Pei-Shin Jiang, Ching-Fang Yu, Chia-Yi Yen, Christopher William Woo, Shao-Hua Lo, Yu-Kuan Huang, Ji-Hong Hong, Chi-Shiun Chiang

Journal article  |  2015  |  PLOS ONE

The tumor-homing ability of monocytes renders them a potential cellular delivery system for alternative cancer therapies, although..

First Demonstration of Gold Nanorods-Mediated Photodynamic Therapeutic Destruction of Tumors via Near Infra-Red Light Activation

Raviraj Vankayala, Yu-Kuan Huang, Poliraju Kalluru, Chi-Shiun Chiang, Kuo Chu Hwang

Journal article  |  2014  |  SMALL

Previously, a large volume of papers reports that gold nanorods (Au NRs) are able to effectively kill cancer cells upon high laser..

The Role of Innate Immune Cells in Tumor Invasion and Metastasis

Yu-Kuan Huang, Rita A Busuttil, Alex Boussioutas

Journal article  |  Cancers

Metastasis is considered one of the hallmarks of cancer and enhanced tumor invasion and metastasis is significantly associated wit..