Brendan Houston

Impact of Chronic Multi-Generational Exposure to an Environmentally Relevant Atrazine Concentration on Testicular Development and Function in Mice

Nicola D Kolaitis, Bethany J Finger, D Jo Merriner, Joseph Nguyen, Brendan J Houston, Moira K O'Bryan, Jessica M Stringer, Nadeen Zerafa, Ngoc Nguyen, Karla J Hutt, Gerard A Tarulli, Mark P Green

Journal article  |  2023  |  CELLS

A common herbicide, atrazine, is associated with poor health. Atrazine acts as an endocrine disruptor at supra-environmental level..

Zinc finger RNA binding protein 2 (ZFR2) is not required for male fertility in the mouse

Lachlan M Cauchi, Brendan J Houston, Liina Nagirnaja, Anne E O'Connor, D Jo Merriner, Kenneth Aston, Peter N Schlegel, Don F Conrad, Richard Burke, Moira K O'Bryan

Journal article  |  2022  |  DEVELOPMENTAL BIOLOGY

BACKGROUND: Thousands of genes are expressed during spermatogenesis and male infertility has a strong genetic component. Within th..

Genetics of Male Infertility

Brendan J HOUSTON, Moira K O’BRYAN

Journal article  |  2022  |  Fertility & Reproduction

Background: Male infertility is a common condition that affects at least 7% of men in Western countries and is associated with an ..

DDB1-and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for male fertility in mice

Brendan J Houston, Alexandra M Lopes, Maris Laan, Liina Nagirnaja, Anne E O'Connor, D Jo Merriner, Joseph Nguyen, Margus Punab, Antoni Riera-Escamilla, Csilla Krausz, Kenneth Ivan Aston, Donald F Conrad, Moira K O'Bryan

Journal article  |  2022  |  DEVELOPMENTAL BIOLOGY

Male infertility is a common condition affecting at least 7% of men worldwide and is often genetic in origin. Using whole exome se..

Commentary on "CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice"

Brendan Houston

Journal article  |  2022  |  ASIAN JOURNAL OF ANDROLOGY

Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) Alters Testis Germ Cell Content, but Does Not Impact Fertility in Mice

Brendan J Houston, Anne E O'Connor, Degang Wang, Georgia Goodchild, D Jo Merriner, Haitong Luan, Don F Conrad, Liina Nagirnaja, Kenneth Aston, Sabine Kliesch, Margot J Wyrwoll, Corinna Friedrich, Frank Tuettelmann, Craig Harrison, Moira K O'Bryan, Kelly Walton

Journal article  |  2022  |  ENDOCRINOLOGY

Testicular-derived inhibin B (α/β B dimers) acts in an endocrine manner to suppress pituitary production of follicle-stimulating h..

A de novo paradigm for male infertility.

MS Oud, RM Smits, HE Smith, FK Mastrorosa, GS Holt, BJ Houston, PF de Vries, BKS Alobaidi, LE Batty, H Ismail, J Greenwood, H Sheth, A Mikulasova, GDN Astuti, C Gilissen, K McEleny, H Turner, J Coxhead, S Cockell, DDM Braat, et al.

Journal article  |  2022  |  Nat Commun

De novo mutations are known to play a prominent role in sporadic disorders with reduced fitness. We hypothesize that de novo mutat..

A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships

Brendan J Houston, Antoni Riera-Escamilla, Margot J Wyrwoll, Albert Salas-Huetos, Miguel J Xavier, Liina Nagirnaja, Corinna Friedrich, Don F Conrad, Kenneth Aston, Csilla Krausz, Frank Tuttelmann, Moira K O'Bryan, Joris A Veltman, Manon S Oud

Journal article  |  2021  |  HUMAN REPRODUCTION UPDATE

BACKGROUND: Human male infertility has a notable genetic component, including well-established diagnoses such as Klinefelter syndr..

Exome sequencing reveals variants in known and novel candidate genes for severe sperm motility disorders

MS Oud, BJ Houston, L Volozonoka, FK Mastrorosa, GS Holt, BKS Alobaidi, PF deVries, G Astuti, L Ramos, R Mclachlan, MK O'Bryan, JA Veltman, HE Chemes, H Sheth

Journal article  |  2021  |  HUMAN REPRODUCTION

STUDY QUESTION: What are the causative genetic variants in patients with male infertility due to severe sperm motility disorders? ..

Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure

Jimmaline J Hardy, Margot J Wyrwoll, William Mcfadden, Agnieszka Malcher, Nadja Rotte, Nijole C Pollock, Sarah Munyoki, Maria V Veroli, Brendan J Houston, Miguel J Xavier, Laura Kasak, Margus Punab, Maris Laan, Sabine Kliesch, Peter Schlegel, Thomas Jaffe, Kathleen Hwang, Josip Vukina, Miguel A Brieno-Enriquez, Kyle Orwig, et al.

Journal article  |  2021  |  HUMAN GENETICS

Male infertility impacts millions of couples yet, the etiology of primary infertility remains largely unknown. A critical element ..