Brendan Houston

A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships.

Brendan J Houston, Antoni Riera-Escamilla, Margot J Wyrwoll, Albert Salas-Huetos, Miguel J Xavier, Liina Nagirnaja, Corinna Friedrich, Don F Conrad, Kenneth I Aston, Csilla Krausz, Frank Tüttelmann, Moira K O'Bryan, Joris A Veltman, Manon S Oud

Journal article  |  2021  |  Hum Reprod Update

BACKGROUND: Human male infertility has a notable genetic component, including well-established diagnoses such as Klinefelter syndr..

Exome sequencing reveals variants in known and novel candidate genes for severe sperm motility disorders.

MS Oud, BJ Houston, L Volozonoka, FK Mastrorosa, GS Holt, BKS Alobaidi, PF deVries, G Astuti, L Ramos, RI Mclachlan, MK O'Bryan, JA Veltman, HE Chemes, H Sheth

Journal article  |  2021  |  Hum Reprod

STUDY QUESTION: What are the causative genetic variants in patients with male infertility due to severe sperm motility disorders? ..

Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure

Jimmaline J Hardy, Margot J Wyrwoll, William Mcfadden, Agnieszka Malcher, Nadja Rotte, Nijole C Pollock, Sarah Munyoki, Maria V Veroli, Brendan J Houston, Miguel J Xavier, Laura Kasak, Margus Punab, Maris Laan, Sabine Kliesch, Peter Schlegel, Thomas Jaffe, Kathleen Hwang, Josip Vukina, Miguel A Brieno-Enriquez, Kyle Orwig, et al.

Journal article  |  2021  |  HUMAN GENETICS

Male infertility impacts millions of couples yet, the etiology of primary infertility remains largely unknown. A critical element ..

Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility

Chunyu Liu, Chaofeng Tu, Lingbo Wang, Huan Wu, Brendan J Houston, Francesco K Mastrorosa, Wen Zhang, Ying Shen, Jiaxiong Wang, Shixiong Tian, Lanlan Meng, Jiangshan Cong, Shenmin Yang, Yiwen Jiang, Shuyan Tang, Yuyan Zeng, Mingrong Lv, Ge Lin, Jinsong Li, Hexige Saiyin, et al.

Journal article  |  2021  |  AMERICAN JOURNAL OF HUMAN GENETICS

Asthenoteratozoospermia characterized by multiple morphological abnormalities of the flagella (MMAF) has been identified as a sub-..

The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse

Brendan J Houston, Liina Nagirnaja, D Jo Merriner, Anne E O'Connor, Hidenobu Okuda, Kenan Omurtag, Craig Smith, Kenneth I Aston, Donald F Conrad, Moira K O'Bryan

Journal article  |  2021  |  DEVELOPMENTAL DYNAMICS

BACKGROUND: Male infertility is a prevalent clinical presentation for which there is likely a strong genetic component due to the ..

Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development

Brendan J Houston, Manon S Oud, Daniel M Aguirre, D Jo Merriner, Anne E O'Connor, Ozlem Okutman, Stephane Viville, Richard Burke, Joris A Veltman, Moira K O'Bryan

Journal article  |  2020  |  G3-GENES GENOMES GENETICS

Globozoospermia is a rare form of male infertility where men produce round-headed sperm that are incapable of fertilizing an oocyt..

A framework for high-resolution phenotyping of candidate male infertility mutants: from human to mouse

Brendan J Houston, Donald F Conrad, Moira K O'Bryan

Journal article  |  2020  |  HUMAN GENETICS

Male infertility is a heterogeneous condition of largely unknown etiology that affects at least 7% of men worldwide. Classical gen..

Reproductive health research in Australia and New Zealand: highlights from the Annual Meeting of the Society for Reproductive Biology, 2019

Amy Winship, Jacqueline Donoghue, Brendan J Houston, Jacinta H Martin, Tessa Lord, Alaknanda Adwal, Macarena Gonzalez, Elodie Desroziers, Gulfam Ahmad, Dulama Richani, Elizabeth G Bromfield

Journal article  |  2020  |  REPRODUCTION FERTILITY AND DEVELOPMENT

The 2019 meeting of the Society for Reproductive Biology (SRB) provided a platform for the dissemination of new knowledge and inno..

Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia

MS Oud, O Okutman, LAJ Hendricks, PF de Vries, BJ Houston, LELM Vissers, MK O'Bryan, L Ramos, HE Chemes, S Viville, JA Veltman

Journal article  |  2020  |  HUMAN REPRODUCTION

STUDY QUESTION: Can exome sequencing identify new genetic causes of globozoospermia? SUMMARY ANSWER: Exome sequencing in 15 cases ..

Whole-body exposures to radiofrequency-electromagnetic energy can cause DNA damage in mouse spermatozoa via an oxidative mechanism

Brendan J Houston, Brett Nixon, Kristen E McEwan, Jacinta H Martin, Bruce V King, R John Aitken, Geoffry N De Iuliis

Journal article  |  2019  |  Scientific Reports

Artificially generated radiofrequency-electromagnetic energy (RF-EME) is now ubiquitous in our environment owing to the utilizatio..