Matthew Johnson

Synergy of the Polymyxin-Chloramphenicol Combination against New Delhi Metallo-beta-Lactamase-Producing Klebsiella pneumoniae Is Predominately Driven by Chloramphenicol

Nusaibah Abdul Rahim, Yan Zhu, Soon-Ee Cheah, Matthew D Johnson, Heidi H Yu, Hanna E Sidjabat, Mark S Butler, Matthew A Cooper, Jing Fu, David L Paterson, Roger L Nation, John D Boyce, Darren J Creek, Phillip J Bergen, Tony Velkov, Jian Li

Journal article  |  2021  |  ACS INFECTIOUS DISEASES

Carbapenem-resistant Klebsiella pneumoniae has been classified as an Urgent Threat by the Centers for Disease Control and Preventi..

Transcriptomic responses of a New Delhi metallo-beta-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol

Nusaibah Abdul Rahim, Soon-Ee Cheah, Matthew D Johnson, Yan Zhu, Heidi H Yu, Hanna E Sidjabat, Mark S Butler, Matthew A Cooper, Jing Fu, David L Paterson, Roger L Nation, John D Boyce, Phillip J Bergen, Tony Velkov, Jian Li

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The combination of polymyxins and chloramphenicol possesses synergistic killing activity against New Delhi metallo-β-lactamase (ND..

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome.

Daniel Fox, Anukriti Mathur, Yansong Xue, Yunqi Liu, Wei Hong Tan, Shouya Feng, Abhimanu Pandey, Chinh Ngo, Jenni A Hayward, Ines I Atmosukarto, Jason D Price, Matthew D Johnson, Nadja Jessberger, Avril AB Robertson, Gaetan Burgio, David C Tscharke, Edward M Fox, Denisse L Leyton, Nadeem O Kaakoush, Erwin Märtlbauer, et al.

Journal article  |  2020  |  Nat Commun

Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolyt..

Molecular basis for the folding of β-helical autotransporter passenger domains.

Xiaojun Yuan, Matthew D Johnson, Jing Zhang, Alvin W Lo, Mark A Schembri, Lakshmi C Wijeyewickrema, Robert N Pike, Gerard HM Huysmans, Ian R Henderson, Denisse L Leyton

Journal article  |  2018  |  Nat Commun

Bacterial autotransporters comprise a C-terminal β-barrel domain, which must be correctly folded and inserted into the outer membr..

Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins

Dene R Littler, Sheng Y Ang, Danilo G Moriel, Martina Kocan, Oded Kleifeld, Matthew D Johnson, Mai T Tran, Adrienne W Paton, James C Paton, Roger J Summers, Mark A Schembri, Jamie Rossjohn, Travis Beddoe

Journal article  |  2017  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Pertussis-like toxins are secreted by several bacterial pathogens during infection. They belong to the AB5 virulence factors, whic..

Mechanism of the Antibacterial Activity and Resistance of Polymyxins

Matthew D Johnson, Roger L Nation, Jian Li

Book Chapter  |  2017

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus

Jinxin Zhao, Soon-Ee Cheah, Kade D Roberts, Roger L Nation, Philip E Thompson, Tony Velkov, Zongjun Du, Matthew D Johnson, Jian Li

Journal article  |  2016  |  MSPHERE

Polymyxin B and colistin are exclusively active against Gram-negative pathogens and have been used in the clinic as a last-line th..

Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens

Soon-Ee Cheah, Matthew D Johnson, Yan Zhu, Brian T Tsuji, Alan Forrest, Jurgen B Bulitta, John D Boyce, Roger L Nation, Jian Li

Journal article  |  2016  |  SCIENTIFIC REPORTS

Polymyxins are often last-line therapeutic agents used to treat infections caused by multidrug-resistant A. baumannii. Recent repo..

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

Mohd Hafidz Mahamad Maifiah, Soon-Ee Cheah, Matthew D Johnson, Mei-Ling Han, John D Boyce, Visanu Thamlikitkul, Alan Forrest, Keith S Kaye, Paul Hertzog, Anthony W Purcell, Jiangning Song, Tony Velkov, Darren J Creek, Jian Li

Journal article  |  2016  |  SCIENTIFIC REPORTS

Multidrug-resistant Acinetobacter baumannii presents a global medical crisis and polymyxins are used as the last-line therapy. Thi..

Structure and functional analysis of galectin-11 of domestic sheep (Ovis aries)

Sakthivel Dhanasekaran, Adam Shahine, MD Shakif Ul Azam, Dene Littler, Sally Troy, Matthew Johnson, Jamie Rossjohn, David Piedrafita, Travis Beddoe

Conference Proceedings  |  2015  |  GLYCOBIOLOGY