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Harshal Nandurkar's selected work
A Multi-Centre Double-Blind Randomised Placebo-Controlled Trial Of Oral Anticoagulation In..
Cell surface glucose-regulated protein 78 (GRP78) is upregulated in plasma cells of patien..
Targeting Grp-78 As A Means To Overcome Drug Resistance And As A Therapeutic Modaliaty Aga..
Targeting Grp-78 As A Means To Overcome Drug Resistance And As A Therapeutic Modaliaty Aga..
Displaying the 18 most recent projects by Harshal Nandurkar.
A Multi-Centre Double-Blind Randomised Placebo-Controlled Trial Of Oral Anticoagulation In Systemic Sclerosis-Related Pulmonary Arterial Hypertension
Scleroderma is an autoimmune disease that shortens life span by over 30 years. The main cause of death is pulmonary arterial hypertension (P..
Internal Research Grant
Displaying the 63 most recent scholarly works by Harshal Nandurkar.
Cell surface glucose-regulated protein 78 (GRP78) is upregulated in plasma cells of patients with multiple myeloma compared to monoclonal gammopathy of uncertain significance
Slavisa Ninkovic, Lenny Straszkowski, Anupa Dey, Constantine Tam, Harshal Nandurkar, Simon J Harrison, Louise Purton, Hang Quach
Conference Proceedings | 2019 | Clinical Lymphoma Myeloma and Leukemia
Active Micropump-Mixer for Rapid Antiplatelet Drug Screening in Whole Blood
Crispin Szydzik, Rose J Brazilek, Farzan Akbaridoust, Charitha de Silva, Mitchell Moon, Ivan Marusic, Andrew SH Ooi, Harshal H Nandurkar, Justin R Hamilton, Arnan Mitchell, Warwick S Nesbitt
Journal article | 2019 | Analytical Chemistry
There is a need for scalable automated lab-on-chip systems incorporating precise hemodynamic control that can be applied to high-c..
Hepatitis B management during immunosuppression for haematological and solid organ malignancies: an Australian consensus statement
Joseph Doyle, Michelle Raggatt, Monica Slavin, Sue-Anne McLachlan, Simone I Strasser, Joseph J Sasadeusz, Jessica Howell, Krispin Hajkowicz, Harshal Nandurkar, Anna Johnston, Narin Bak, Alexander J Thompson
Journal article | 2019 | Medical Journal of Australia
CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages
Anushka N Samudra, Karen M Dwyer, Carly Selan, Susanna Freddi, Lisa Murray-Segal, Mandana Nikpour, Michael J Hickey, Karlheinz Peter, Simon C Robson, Maithili Sashindranath, Peter J Cowan, Harshal H Nandurkar
Journal article | 2018 | Journal of Autoimmunity
A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury.
Melanie Ziegler, Jan David Hohmann, Amy Kate Searle, Meike-Kristin Abraham, Harshal H Nandurkar, Xiaowei Wang, Karlheinz Peter
Journal article | 2018 | European Heart Journal
Aims: CD39 is a cell membrane NTPase with anti-inflammatory and anti-platelet effects. However, its clinical use is limited by its..
Examining flow dynamics of platelet function in micro-contractions using micro-PIV
F Akbaridoust, CM de Silva, RJ Brazilek, X Chen, FJ Tovar-Lopez, E Poon, A Ooi, A Mitchell, H Nandurkar, WS Nesbitt, I Marusic
Conference Proceedings | 2018 | Proceedings of the 21st Australasian Fluid Mechanics Conference, AFMC 2018
This study examines the flow field in the near-vicinity of microcontraction-expansion geometries in microfluidic devices designed ..
Application of a strain rate gradient microfluidic device to von Willebrand's disease screening.
Rose J Brazilek, Francisco J Tovar-Lopez, Angus KT Wong, Huyen Tran, Amanda S Davis, James D McFadyen, Zane Kaplan, Sanjeev Chunilal, Shaun P Jackson, Harshal Nandurkar, Arnan Mitchell, Warwick S Nesbitt
Journal article | 2017 | Lab on a Chip
Von Willebrand's disease (VWD) is the most common inherited bleeding disorder caused by either quantitative or qualitative defects..
Thrombotic microangiopathy associated with intravenous injection of extended-release oxycodone.
Kate J Robson, Danielle Clucas, Robin Filshie, Harshal Nandurkar
Journal article | 2017 | BMJ Case Reports
We describe the case of a 35-year-old man presenting with thrombotic microangiopathy (TMA) and renal impairment following, as he l..
Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia-reperfusion injury
Maithili Sashindranath, Karen M Dwyer, Shala Dezfouli, Carly Selan, Sandra Crikis, Bo Lu, Yuping Yuan, Michael J Hickey, Karlheinz Peter, Simon C Robson, Peter J Cowan, Harshal H Nandurkar
Journal article | 2017 | Purinergic Signalling
The association of antiphospholipid antibodies with cardiopulmonary manifestations of systemic sclerosis
KB Morrisroe, W Stevens, H Nandurkar, D Prior, V Thakkar, J Roddy, J Zochling, J Sahhar, K Tymms, A Sturgess, G Major, F Kermeen, C Hill, J Walker, P Nash, E Gabbay, P Youssef, SM Proudman, M Nikpour
Journal article | 2014 | Clinical and experimental rheumatology
The Spot sign and Tranexamic acid On Preventing ICH growth - AUStralasia Trial (STOP-AUST): Protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial
Atte Meretoja, Leonid Churilov, Bruce CV Campbell, Richard I Aviv, Nawaf Yassi, Christen Barras, Peter Mitchell, Bernard Yan, Harshal Nandurkar, Christopher Bladin, Tissa Wijeratne, Neil J Spratt, Jim Jannes, Jonathan Sturm, Jayantha Rupasinghe, Jorge Zavala, Andrew Lee, Timothy Kleinig, Romesh Markus, Candice Delcourt, et al.
Journal article | 2014 | International Journal of Stroke
Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?
Jan David Hohmann, Xiaowei Wang, Stefanie Krajewski, Carly Selan, Carolyn A Haller, Andreas Straub, Elliot L Chaikof, Harshal H Nandurkar, Christoph E Hagemeyer, Karlheinz Peter
Journal article | 2013 | Blood
Glycosylation changes in hFUT1 transgenic mice increase TCR signaling and apoptosis resulting in thymocyte maturation arrest
Gregory TC Moore, Steven J Brown, Adam C Winterhalter, Mark Lust, Evelyn J Salvaris, Carly Selan, Harshal H Nandurkar, Paul V Desmond, Peter J Cowan, Anthony JF d'Apice
Journal article | 2008 | Molecular Immunology
PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid - Mechanistic analysis of a familial Cowden disease-associated PTEN mutation
Yi Xiao, Joel Yeong Chit Chia, Joanna E Gajewski, Daisy Sio Seng Lio, Terrence D Mulhern, Hong-Jian Zhu, Harshal Nandurkar, Heung-Chin Cheng
Journal article | 2007 | Cellular Signaling
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
Warren S Alexander, Elizabeth M Viney, Jian-Guo Zhang, Donald Metcalf, Maria Kauppi, Craig D Hyland, Marina R Carpinelli, William Stevenson, Ben A Croker, Adrienne A Hilton, Sarah Ellis, Carly Selan, Harshal H Nandurkar, Christopher C Goodnow, Benjamin T Kile, Nicos A Nicola, Andrew W Roberts, Douglas J Hilton
Journal article | 2006 | Proceedings of the National Academy of Sciences of the United States of America
Phosphatidylinositol 3-phosphate [PtdIns(3)P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: Endogenous PtdIns(3)P can promote GLUT4 translocation to the plasma membrane
Anne M Kong, Kristy A Horan, Absorn Sriratana, Charles G Bailey, Luke J Collyer, Harshal H Nandurkar, Assia Shisheva, Meredith J Layton, John EJ Rasko, Tony Rowe, Christina A Mitchell
Journal article | 2006 | Molecular and Cellular Biology
Intra-coronary high-dose CD34 stem cells in patients with chronic ischemic heart disease: A 12-month follow-up
AJ Boyle, R Whitbourn, S Schlicht, H Krum, A Kocher, H Nandurkar, S Bergmann, M Daniell, J O'Day, D Skerrett, D Haylock, RE Gilbert, S Itescu
Journal article | 2006 | International Journal of Cardiology
118th ENMC International Workshop on Advances in Myotubular Myopathy. 26-28 September 2003, Naarden, The Netherlands. (5th Workshop of the International Consortium on Myotubular Myopathy).
E Bertini, V Biancalana, A Bolino, A Buj Bello, M Clague, P Guicheney, H Jungbluth, W Kress, A Musaro', H Nandurkar, L Pirola, N Romero, J Senderek, U Suter, C Sewry, H Tronchere, C Wallgren-Pettersson, MJ Wishart, J Laporte
Conference Proceedings | 2004 | Neuromuscular Disorders
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation
KM Dwyer, SC Robson, HH Nandurkar, DJ Campbell, H Gock, LJ Murray-Segal, N Fisicaro, TB Mysore, E Kaczmarek, PJ Cowan, AJF d'Apice
Journal article | 2004 | Journal of Clinical Investigation
Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP
HH Nandurkar, M Layton, J Laporte, C Selan, L Corcoran, KK Caldwell, Y Mochizuki, OW Majerus, CA Mitchell
Journal article | 2003 | Proceedings of the National Academy of Sciences of the United States of America
Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: Identification of a myotubularin-related protein lacking catalytic activity
HH Nandurkar, KK Caldwell, JC Whisstock, MJ Layton, EA Gaudet, FA Norris, PW Majerus, CA Mitchell
Journal article | 2001 | Proceedings of the National Academy of Sciences of the United States of America
Honours, Awards and Fellowships
Kanematsu Memorial Award
FRACP - Fellow of the Royal Australasian College of Physicians
FRCPA - Fellow of the Royal College of Pathologists, Australia
Medicine - St Vincent'S Hospital
Haematology Society of Australia
Australian Society of Medical Research
Australian Society of Biochemistry and Molecular Biology
Royal Australasian College of Physicians
Royal College of Pathologists of Australasia
Doctor of Philosophy
University of Melbourne
Bachelor of Medicine & Bachelor of Surgery
University of Bombay