Heidi Fettke

Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer

Blossom Mak, Hui-Ming Lin, Edmond M Kwan, Heidi Fettke, Tran Ben, Ian D Davis, Kate Mahon, Martin R Stockler, Karen Briscoe, Gavin Marx, Alison Zhang, Megan Crumbaker, Winston Tan, Kevin Huynh, Thomas G Meikle, Natalie A Mellett, Andrew J Hoy, Pan Du, Jianjun Yu, Shidong Jia, et al.

Journal article  |  2022  |  BMC MEDICINE

BACKGROUND: Both changes in circulating lipids represented by a validated poor prognostic 3-lipid signature (3LS) and somatic tumo..

Avelumab Combined with Stereotactic Ablative Body Radiotherapy in Metastatic Castration-resistant Prostate Cancer: The Phase 2 ICE-PAC Clinical Trial

Edmond M Kwan, Lavinia Spain, Angelyn Anton, Chun L Gan, Linda Garrett, Deborah Chang, Elizabeth Liow, Caitlin Bennett, Tiantian Zheng, Jianjun Yu, Chao Dai, Pan Du, Shidong Jia, Heidi Fettke, Claire Abou-Seif, Gargi Kothari, Mark Shaw, Phillip Parente, Carmel Pezaro, Ben Tran, et al.

Journal article  |  2022  |  EUROPEAN UROLOGY

BACKGROUND: Immune checkpoint inhibitor monotherapy in metastatic castration-resistant prostate cancer (mCRPC) has produced modest..

Prognostic and predictive utility of DNA damage response (DDR) aberrations detected in cell-free DNA (cfDNA) in metastatic castration-resistant prostate cancer (mCRPC).

Heidi Fettke, Christine Hauser, Edmond Michael Kwan, Chao Dai, Tiantian Zheng, Amy Wang, Winston Tan, Pan Du, Nicole Ng, Patricia Bukczynska, Siavash Foroughi, Lisa-Jane K Graham, Lisa Horvath, Kate Lynette Mahon, Shidong Jia, Manish Kohli, Arun Azad

Conference Proceedings  |  2022  |  JOURNAL OF CLINICAL ONCOLOGY

153 Background: The prognostic significance of DDR alterations in mCRPC remains unclear, with conflicting data from prior reports..

Age-based assessment of cell-free DNA genomic profiles in metastatic castration-resistant prostate cancer (mCRPC).

Andrea Knox, Heidi Fettke, Christine Hauser, Patricia Bukczynska, Nicole Ng, Siavash Foroughi, Lisa-Jane K Graham, Kate Lynette Mahon, Winston Tan, Tiantian Zheng, Chao Dai, Pan Du, Shidong Jia, Lisa Horvath, Manish Kohli, Arun Azad, Edmond Michael Kwan, Amy Wang

Conference Proceedings  |  2022  |  JOURNAL OF CLINICAL ONCOLOGY

150 Background: With the evolving use of targeted therapies exploiting genomic vulnerabilities in mCRPC, screening patients for s..

Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor-treated Metastatic Castration-resistant Prostate Cancer

Heidi Fettke, Edmond M Kwan, Patricia Bukczynska, Nicole Ng, Tu Nguyen-Dumont, Melissa C Southey, Ian D Davis, Andrew Mant, Phillip Parente, Carmel Pezaro, Christine Hauser, Arun A Azad

Journal article  |  2021  |  EUROPEAN UROLOGY FOCUS

Total plasma cell-free DNA (cfDNA) levels were recently shown to be prognostic in two large phase III trials of taxane chemotherap..

Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase

Hui-Ming Lin, Blossom Mak, Nicole Yeung, Kevin Huynh, Thomas G Meikle, Natalie A Mellett, Edmond M Kwan, Heidi Fettke, Ben Tran, Ian D Davis, Kate L Mahon, Alison Zhang, Martin R Stockler, Karen Briscoe, Gavin Marx, Megan Crumbaker, Phillip D Stricker, Pan Du, Jianjun Yu, Shidong Jia, et al.

Journal article  |  2021  |  EBIOMEDICINE

BACKGROUND: Intrinsic resistance to androgen receptor signalling inhibitors (ARSI) occurs in 20-30% of men with metastatic castrat..

Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer

Blossom Mak, Hui-Ming Lin, Edmond Kwan, Heidi Fettke, Ben Tran, Ian Davis, Kate Mahon, Martin Stockler, Karen Briscoe, Gavin Marx, Winston Tan, Kevin Huynh, Pan Du, Jianjun Yu, Shidong Jia, Anthony Joshua, Manish Kohli, Peter Meikle, Arun Azad, Lisa Horvath

Conference Proceedings  |  2021  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Genomic landscape of older versus younger men with metastatic castration-resistant prostate cancer

Andrea Knox, Heide Fettke, Christine Hauser, Patricia Bukczynska, Nicole Ng, Siavash Foroughi, Lisa-Jane Graham, Kate Mahon, Winston Tan, Tiantian Zheng, Jianjun Yu, Chao Dai, Pan Du, Shidong Jia, Lisa Horvarth, Manish Kohli, Arun Azad, Edmond Kwan

Conference Proceedings  |  2021  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Association of ceramide metabolism with resistance to androgen receptor signalling inhibitors in metastatic prostate cancer

H-M Lin, B Mak, K Huynh, EM Kwan, H Fettke, B Tran, ID Davis, KL Mahon, MR Stockler, K Briscoe, GM Marx, P Du, J Yu, S Jia, AM Joshua, AA Azad, LM Butler, PJ Meikle, LG Horvath

Conference Proceedings  |  2021  |  ANNALS OF ONCOLOGY

Impact of combined lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer (mCRPC)

B Mak, H-M Lin, EM Kwan, H Fettke, B Tran, ID Davis, KL Mahon, MR Stockler, K Briscoe, GM Marx, M Kohli, W Tan, K Huynh, P Du, J Yu, S Jia, AM Joshua, AA Azad, PJ Meikle, LG Horvath

Conference Proceedings  |  2021  |  ANNALS OF ONCOLOGY