Megan Maher

Mitochondrial COA7 is a heme-binding protein with disulfide reductase activity, which acts in the early stages of complex IV assembly

Luke E Formosa, Shadi Maghool, Alice J Sharpe, Boris Reljic, Linden Muellner-Wong, David A Stroud, Michael T Ryan, Megan J Maher

Journal article  |  2022  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytochrome c oxidase (COX) assembly factor 7 (COA7) is a metazoan-specific assembly factor, critical for the biogenesis of mitocho..

Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Erin B Brazel, Aimee Tan, Stephanie L Neville, Amy R Iverson, Saumya R Udagedara, Bliss A Cunningham, Mwilye Sikanyika, David MP De Oliveira, Bernhard Keller, Lisa Bohlmann, Ibrahim M El-Deeb, Katherine Ganio, Bart A Eijkelkamp, Alastair G McEwan, Mark von Itzstein, Megan J Maher, Mark J Walker, Jason W Rosch, Christopher A McDevitt

Journal article  |  2022  |  CELL REPORTS

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multidrug-res..

Crystal structure of a complex between the electron-transfer partners arsenite oxidase and cytochrome c552, from the arsenite respiring bacterium Rhizobium sp. NT-26

Nilakhi Poddar, Joanne M Santini, Megan J Maher

Journal article  |  2021  |  Acta Crystallographica Section A Foundations and Advances

Structural insights into the ferroxidase and iron sequestration mechanisms of ferritin from Caenorhabditis elegans

Tess R Malcolm, Sanjeedha Mohamed Mubarak, Eric Hanssen, Hamish G Brown, Gawain McColl, Megan J Maher, Guy NL Jameson

Journal article  |  2021  |  Acta Crystallographica Section A Foundations and Advances

Insane in the membrane: developments in protein folding, protein transport, and signaling by GPCRs.

Megan J Maher, Oliver P Ernst

Journal article  |  2021  |  Curr Opin Struct Biol

Structural characterisation of mitochondrial complex IV assembly factors

Shadi Maghool, Luke E Formosa, G Cooray, N Dinesha, David A Stroud, David Aragao, Michael T Ryan, Megan J Maher

Journal article  |  2021  |  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES

The structural basis of bacterial manganese import

Stephanie L Neville, Jennie Sjoehamn, Jacinta A Watts, Hugo MacDermott-Opeskin, Stephen J Fairweather, Katherine Ganio, Alex Carey Hulyer, Aaron P McGrath, Andrew J Hayes, Tess R Malcolm, Mark R Davies, Norimichi Nomura, So Iwata, Megan L O'Mara, Megan J Maher, Christopher A McDevitt

Journal article  |  2021  |  SCIENCE ADVANCES

Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC) permeases serve as the primary import p..

The structure of the ABC transporter PsaBC shows that bacterial manganese import is achieved by unique architectural features that are conserved across the kingdoms of life

Stephanie L Neville, Jennie Sjohamn, Jacinta A Watts, Hugo MacDermott-Opeskin, Stephen J Fairweather, Katherine Ganio, Alex Carey Hulyer, Andrew J Hayes, Aaron P McGrath, Tess R Malcolm, Mark R Davies, Norimichi Nomura, Iwata So, Megan L O'Mara, Christopher A McDevitt, Megan J Maher

Journal article  |  2021  |  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES

Structural and Functional Investigation of the Periplasmic Arsenate-Binding Protein ArrX from Chrysiogenes arsenatis

Nilakhi Poddar, Consuelo Badilla, Shadi Maghool, Thomas H Osborne, Joanne M Santini, Megan J Maher

Journal article  |  2021  |  BIOCHEMISTRY

The anaerobic bacterium Chrysiogenes arsenatis respires using the oxyanion arsenate (AsO43-) as the terminal electron acceptor, wh..

What Role Does COA6 Play in Cytochrome C Oxidase Biogenesis: A Metallochaperone or Thiol Oxidoreductase, or Both?

Shadi Maghool, Michael T Ryan, Megan J Maher

Journal article  |  2020  |  International Journal of Molecular Sciences

Complex IV (cytochrome c oxidase; COX) is the terminal complex of the mitochondrial electron transport chain. Copper is essential ..