Megan Maher was awarded a PhD in Inorganic Chemistry from the University of Melbourne in 1998. She carried out postdoctoral research at the University of Sydney from 1998-2005, funded by a series of independent Fellowships from the Australian Synchrotron Research Program, the Australian Research Council and the University of Sydney.
Between 2006-2007, she held the position of Team Leader in the Membrane Protein Crystallography Laboratory, headed by Professor So Iwata at Imperial College, London. In 2008 Megan returned to the Centenary Institute in Sydney, on a Career Development Fellowship funded by the Cancer Institute of NSW. Megan relocated to La Trobe University at the beginning of 2012 to take up a position as LIMS Senior Research Fellow. In 2015 she was appointed to the position of Senior Lecturer and Associate Professor in 2018. In 2017 Megan was awarded the Georgina Sweet Award for Women in Quantitative Biomedical Science and in 2018 an ARC Future Fellowship. Megan joined the School of Chemistry and Bio21 at the University of Melbourne in 2019 as part of the University’s Driving Research Momentum (DRM) strategy. Megan’s current research focuses on investigating the role of trace metals in biological systems, with a particular focus on the structural biology of metalloproteins and integral membrane protein transporters.
Please also see https://maher.science.unimelb.edu.au/ and https://www.bio21.unimelb.edu.au/maher-group
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Megan Maher's selected work
Human glutaredoxin-1 can transfer copper to isolated metal binding domains of the P1B-type..
Structural and functional characterization of the mitochondrial complex IV assembly factor..
Displaying the 9 most recent projects by Megan Maher.
Internal Research Grant
Displaying the 64 most recent scholarly works by Megan Maher.
Structural and functional characterizations of the C-terminal domains of CzcD proteins
Saumya R Udagedara, Daniel M La Porta, Christian Spehar, Ghruta Purohit, Matthew JA Hein, Monique E Fatmous, G Patricia Casas Garcia, Katherine Ganio, Christopher A McDevitt, Megan J Maher
Journal article | 2020 | Journal of Inorganic Biochemistry
Zinc is a potent antimicrobial component of the innate immune response at the host-pathogen interface. Bacteria subvert or resist ..
Human glutaredoxin-1 can transfer copper to isolated metal binding domains of the P1B-type ATPase, ATP7B.
Shadi Maghool, Sharon La Fontaine, Blaine R Roberts, Ann H Kwan, Megan J Maher
Journal article | 2020 | Scientific Reports
Intracellular copper (Cu) in eukaryotic organisms is regulated by homeostatic systems, which rely on the activities of soluble met..
Structural and functional characterization of the mitochondrial complex IV assembly factor Coa6
Shadi Maghool, N Dinesha G Cooray, David A Stroud, David Aragao, Michael T Ryan, Megan J Maher
Journal article | 2019 | Life Science Alliance
Assembly factors play key roles in the biogenesis of many multi-subunit protein complexes regulating their stability, activity, an..
Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
Ian R Monk, Nausad Shaikh, Stephanie L Begg, Mike Gajdiss, Liam KR Sharkey, Jean YH Lee, Sacha J Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M Collins, Gabriele Bierbaum, Saumya R Udagedara, Jacqueline R Morey, Neha Pulyani, Benjamin P Howden, Megan J Maher, Christopher A McDevitt, Glenn F King, et al.
Journal article | 2019 | NATURE COMMUNICATIONS
High-resolution crystal structure of the reduced Grx1 from Saccharomyces cerevisiae.
Shadi Maghool, Sharon La Fontaine, Megan J Maher
Journal article | 2019 | Acta Crystallographica Section F Structural Biology Communications
Grx1, a cytosolic thiol-disulfide oxidoreductase, actively maintains cellular redox homeostasis using glutathione substrates (redu..
The central active site arginine in sulfite oxidizing enzymes alters kinetic properties by controlling electron transfer and redox interactions
Ju-Chun Hsiao, Aaron P McGrath, Linda Kielmann, Palraj Kalimuthu, Farzana Darain, Paul V Bernhardt, Jeffrey Harmer, Mihwa Lee, Kimberley Meyers, Megan J Maher, Ulrike Kappler
Journal article | 2018 | Biochimica et Biophysica Acta (BBA) - Bioenergetics
COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2
David A Stroud, Megan J Maher, Caroline Lindau, F-Nora Voegtle, Ann E Frazier, Elliot Surgenor, Hayley Mountford, Abeer P Singh, Matteo Bonas, Silke Oeljeklaus, Bettina Warscheid, Chris Meisinger, David R Thorburn, Michael T Ryan
Journal article | 2015 | Human Molecular Genetics
Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae
Stephanie L Begg, Bart A Eijkelkamp, Zhenyao Luo, Rafael M Counago, Jacqueline R Morey, Megan J Maher, Cheryl-lynn Y Ong, Alastair G McEwan, Bostjan Kobe, Megan L O'Mara, James C Paton, Christopher A McDevitt
Journal article | 2015 | NATURE COMMUNICATIONS
A GTPase Chimera Illustrates an Uncoupled Nucleotide Affinity and Release Rate, Providing Insight into the Activation Mechanism
Amy P Guilfoyle, Chandrika N Deshpande, Josep Font Sadurni, Miriam-Rose Ash, Samuel Tourle, Gerhard Schenk, Megan J Maher, Mika Jormakka
Journal article | 2014 | Biophysical Journal
A suite of Switch I and Switch II mutant structures from the G-protein domain of FeoB
Miriam-Rose Ash, Megan J Maher, J Mitchell Guss, Mika Jormakka
Journal article | 2011 | Acta Crystallographica Section D Biological Crystallography
The acquisition of ferrous iron in prokaryotes is achieved by the G-protein-coupled membrane protein FeoB. This protein possesses ..
Unprecedented Binding Cooperativity between Cu-I and Cu-II in the Copper Resistance Protein CopK from Cupriavidus metallidurans CH34: Implications from Structural Studies by NMR Spectroscopy and X-Ray Crystallography
Lee Xin Chong, Miriam-Rose Ash, Megan J Maher, Mark G Hinds, Zhiguang Xiao, Anthony G Wedd
Journal article | 2009 | Journal of the American Chemical Society
Thioredoxin A active-site mutants form mixed disulfide dimers that resemble enzyme-substrate reaction intermediates
Thijs RHM Kouwen, Jun Andrell, Rianne Schrijver, Jean-Yves F Dubois, Megan J Maher, So Iwata, Elisabeth P Carpenter, Jan Maarten van Dijl
Journal article | 2008 | Journal of Molecular Biology
Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form
Mihwa Lee, Megan J Maher, J Mitchell Guss
Journal article | 2007 | Acta Crystallographica Section F Structural Biology and Crystallization Communications
Mutation of the surface valine residues 8 and 44 in the rubredoxin from Clostridium pasteurianum: solvent access versus structural changes as determinants of reversible potential
ZG Xiao, MJ Maher, M Cross, CS Bond, JM Guss, AG Wedd
Journal article | 2000 | JBIC Journal of Biological Inorganic Chemistry
Rubredoxin from Clostridium pasteurianum. Structures of G10A, G43A and C10VG43A mutant proteins. Mutation of conserved glycine 10 to valine causes the 9-10 peptide link to invert
MJ Maher, ZG Xiao, MCJ Wilce, JM Guss, AG Wedd
Journal article | 1999 | Acta Crystallographica Section D Biological Crystallography
The rubredoxin from Clostridium pasteurianum: Mutation of the iron cysteinyl ligands to serine. Crystal and molecular structures of oxidized and dithionite-treated forms of the Cys42Ser mutant
ZG Xiao, MJ Lavery, M Ayhan, SDB Scrofani, MCJ Wilce, JM Guss, PA Tregloan, GN George, AG Wedd
Journal article | 1998 | Journal of the American Chemical Society
COMPARISON OF NATIVE AND MUTANT PROTEINS PROVIDES A SEQUENCE-SPECIFIC ASSIGNMENT OF THE CYSTEINYL LIGAND PROTON NMR RESONANCES IN THE 2[FE4S4] FERREDOXIN FROM CLOSTRIDIUM-PASTEURIANUM
SDB SCROFANI, PS BRERETON, AM HAMER, MJ LAVERY, SG MCDOWALL, GA VINCENT, RTC BROWNLEE, NJ HOOGENRAAD, M SADEK, AG WEDD
Journal article | 1994 | Biochemistry
A sequence-specific assignment is presented for the eight low-field paramagnetically shifted cysteinyl ligand proton NMR resonance..
Honours, Awards and Fellowships
Georgina Sweet Award for Women in Quantitative Biomedical Science
ARC Future Fellow
La Trobe University LIMS Senior Research Fellow
Cancer Institute of NSW Career Development Fellow
The University of Sydney SESQUI Postdoctoral Fellow
ARC Australian Postdoctoral Fellow
Australian Synchrotron Research Program Postdoctoral Fellow
Associate Professor In Chemical Biology
Society of Biological Inorganic Chemistry
Lorne Conference on Protein Structure and Function Organising and Program Commitee
Australian Society of Biophysics
Society of Crystallographers in Australia and New Zealand
Australian Society of Biochemistry and Molecular Biology
Doctor of Philosophy
University of Melbourne
Bachelor of Science (Hons)
University of Melbourne
Bachelor of Science
The University of Queensland