Megan Maher

Insane in the membrane: developments in protein folding, protein transport, and signaling by GPCRs.

Megan J Maher, Oliver P Ernst

Journal article  |  2021  |  Curr Opin Struct Biol

The structural basis of bacterial manganese import

Stephanie L Neville, Jennie Sjoehamn, Jacinta A Watts, Hugo MacDermott-Opeskin, Stephen J Fairweather, Katherine Ganio, Alex Carey Hulyer, Aaron P McGrath, Andrew J Hayes, Tess R Malcolm, Mark R Davies, Norimichi Nomura, So Iwata, Megan L O'Mara, Megan J Maher, Christopher A McDevitt

Journal article  |  2021  |  SCIENCE ADVANCES

Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC) permeases serve as the primary import p..

Structural and Functional Investigation of the Periplasmic Arsenate-Binding Protein ArrX from Chrysiogenes arsenatis

Nilakhi Poddar, Consuelo Badilla, Shadi Maghool, Thomas H Osborne, Joanne M Santini, Megan J Maher

Journal article  |  2021  |  BIOCHEMISTRY

The anaerobic bacterium Chrysiogenes arsenatis respires using the oxyanion arsenate (AsO43-) as the terminal electron acceptor, wh..

What Role Does COA6 Play in Cytochrome C Oxidase Biogenesis: A Metallochaperone or Thiol Oxidoreductase, or Both?

Shadi Maghool, Michael T Ryan, Megan J Maher

Journal article  |  2020  |  International Journal of Molecular Sciences

Complex IV (cytochrome c oxidase; COX) is the terminal complex of the mitochondrial electron transport chain. Copper is essential ..

Structural and functional characterizations of the C-terminal domains of CzcD proteins

Saumya R Udagedara, Daniel M La Porta, Christian Spehar, Ghruta Purohit, Matthew JA Hein, Monique E Fatmous, G Patricia Casas Garcia, Katherine Ganio, Christopher A McDevitt, Megan J Maher

Journal article  |  2020  |  JOURNAL OF INORGANIC BIOCHEMISTRY

Zinc is a potent antimicrobial component of the innate immune response at the host-pathogen interface. Bacteria subvert or resist ..

Human glutaredoxin-1 can transfer copper to isolated metal binding domains of the P1B-type ATPase, ATP7B.

Shadi Maghool, Sharon La Fontaine, Blaine R Roberts, Ann H Kwan, Megan J Maher

Journal article  |  2020  |  Scientific Reports

Intracellular copper (Cu) in eukaryotic organisms is regulated by homeostatic systems, which rely on the activities of soluble met..

Structural and functional characterization of the mitochondrial complex IV assembly factor Coa6

Shadi Maghool, N Dinesha G Cooray, David A Stroud, David Aragao, Michael T Ryan, Megan J Maher

Journal article  |  2019  |  LIFE SCIENCE ALLIANCE

Assembly factors play key roles in the biogenesis of many multi-subunit protein complexes regulating their stability, activity, an..

The purification of the sigma(FPvI)/FpvR(20) and sigma(Pvds)/FpvR(20) protein complexes is facilitated at room temperature

G Patricia Casas Garcia, Matthew A Perugini, Lain L Lamont, Megan J Maher

Journal article  |  2019  |  PROTEIN EXPRESSION AND PURIFICATION

Bacteria contain sigma (σ) factors that control gene expression in response to various environmental stimuli. The alternative sigm..

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Ian R Monk, Nausad Shaikh, Stephanie L Begg, Mike Gajdiss, Liam KR Sharkey, Jean YH Lee, Sacha J Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M Collins, Gabriele Bierbaum, Saumya R Udagedara, Jacqueline R Morey, Neha Pulyani, Benjamin P Howden, Megan J Maher, Christopher A McDevitt, Glenn F King, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates peptidogl..

The crystal structure of the CopC protein from Pseudomonas fluorescens reveals amended classifications for the CopC protein family

Saumya R Udagedara, Chathuri JK Wijekoon, Zhiguang Xiao, Anthony G Wedd, Megan J Maher

Journal article  |  2019  |  JOURNAL OF INORGANIC BIOCHEMISTRY

The bacterial CopC family of proteins are periplasmic copper binding proteins that act in copper detoxification. These proteins co..