Megan Maher

Structural and functional characterization of the mitochondrial complex IV assembly factor Coa6

Shadi Maghool, N Dinesha G Cooray, David A Stroud, David Aragao, Michael T Ryan, Megan J Maher

Journal article  |  2019  |  Life Science Alliance

Assembly factors play key roles in the biogenesis of many multi-subunit protein complexes regulating their stability, activity, an..

The purification of the sigma(FPvI)/FpvR(20) and sigma(Pvds)/FpvR(20) protein complexes is facilitated at room temperature

G Patricia Casas Garcia, Matthew A Perugini, Lain L Lamont, Megan J Maher

Journal article  |  2019  |  Protein Expression and Purification

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Ian R Monk, Nausad Shaikh, Stephanie L Begg, Mike Gajdiss, Liam KR Sharkey, Jean YH Lee, Sacha J Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M Collins, Gabriele Bierbaum, Saumya R Udagedara, Jacqueline R Morey, Neha Pulyani, Benjamin P Howden, Megan J Maher, Christopher A McDevitt, Glenn F King, et al.

Journal article  |  2019  |  Nature Communications

The crystal structure of the CopC protein from Pseudomonas fluorescens reveals amended classifications for the CopC protein family

Saumya R Udagedara, Chathuri JK Wijekoon, Zhiguang Xiao, Anthony G Wedd, Megan J Maher

Journal article  |  2019  |  Journal of Inorganic Biochemistry

High-resolution crystal structure of the reduced Grx1 from Saccharomyces cerevisiae.

Shadi Maghool, Sharon La Fontaine, Megan J Maher

Journal article  |  2019  |  Acta Crystallographica Section F Structural Biology Communications

Grx1, a cytosolic thiol-disulfide oxidoreductase, actively maintains cellular redox homeostasis using glutathione substrates (redu..

The structure and activity of the glutathione reductase from Streptococcus pneumoniae

Mwilye Sikanyika, David Aragao, Christopher A McDevitt, Megan J Maher

Journal article  |  2019  |  Acta Crystallographica Section F Structural Biology Communications

Crystal structure of bacterial succinate: quinone oxidoreductase flavoprotein SdhA in complex with its assembly factor SdhE

Megan J Maher, Anuradha S Herath, Saumya R Udagedara, David A Dougan, Kaye N Truscott

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

The central active site arginine in sulfite oxidizing enzymes alters kinetic properties by controlling electron transfer and redox interactions

Ju-Chun Hsiao, Aaron P McGrath, Linda Kielmann, Palraj Kalimuthu, Farzana Darain, Paul V Bernhardt, Jeffrey Harmer, Mihwa Lee, Kimberley Meyers, Megan J Maher, Ulrike Kappler

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Bioenergetics

Integrated activities of two alternative sigma factors coordinate iron acquisition and uptake by Pseudomonas aeruginosa

Rebecca J Edgar, Georgina E Hampton, G Patricia Casas Garcia, Megan J Maher, Matthew A Perugini, David F Ackerley, Iain L Lamont

Journal article  |  2017  |  Molecular Microbiology

The crystal structures of a copper-bound metallochaperone from Saccharomyces cerevisiae

Mihwa Lee, N Dinesha G Cooray, Megan J Maher

Journal article  |  2017  |  Journal of Inorganic Biochemistry

Structural basis of interprotein electron transfer in bacterial sulfite oxidation

Aaron P McGrath, Elise L Laming, G Patricia Casas Garcia, Marc Kvansakul, J Mitchell Guss, Jill Trewhella, Benoit Calmes, Paul V Bernhardt, Graeme R Hanson, Ulrike Kappler, Megan J Maher

Journal article  |  2015  |  eLife

COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2

David A Stroud, Megan J Maher, Caroline Lindau, F-Nora Voegtle, Ann E Frazier, Elliot Surgenor, Hayley Mountford, Abeer P Singh, Matteo Bonas, Silke Oeljeklaus, Bettina Warscheid, Chris Meisinger, David R Thorburn, Michael T Ryan

Journal article  |  2015  |  Human Molecular Genetics

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

Stephanie L Begg, Bart A Eijkelkamp, Zhenyao Luo, Rafael M Counago, Jacqueline R Morey, Megan J Maher, Cheryl-lynn Y Ong, Alastair G McEwan, Bostjan Kobe, Megan L O'Mara, James C Paton, Christopher A McDevitt

Journal article  |  2015  |  Nature Communications

A GTPase Chimera Illustrates an Uncoupled Nucleotide Affinity and Release Rate, Providing Insight into the Activation Mechanism

Amy P Guilfoyle, Chandrika N Deshpande, Josep Font Sadurni, Miriam-Rose Ash, Samuel Tourle, Gerhard Schenk, Megan J Maher, Mika Jormakka

Journal article  |  2014  |  Biophysical Journal

Structural and functional analysis of a FeoB A143S G5 loop mutant explains the accelerated GDP release rate

Amy P Guilfoyle, Chandrika N Deshpande, Kimberley Vincent, Marcelo M Pedroso, Gerhard Schenk, Megan J Maher, Mika Jormakka

Journal article  |  2014  |  FEBS Journal

The magic of molybdenum

M Maher

Conference Proceedings  |  2014  |  Australian Life Scientist

Exploring the correlation between the sequence composition of the nucleotide binding G5 loop of the FeoB GTPase domain (NFeoB) and intrinsic rate of GDP release

Amy P Guilfoyle, Chandrika N Deshpande, Gerhard Schenk, Megan J Maher, Mika Jormakka

Journal article  |  2014  |  Bioscience Reports

Structure of an atypical FeoB G-domain reveals a putative domain-swapped dimer

Chandrika N Deshpande, Aaron P McGrath, Josep Font, Amy P Guilfoyle, Megan J Maher, Mika Jormakka

Journal article  |  2013  |  Acta Crystallographica Section F Structural Biology and Crystallization Communications

The bacterial SoxAX cytochromes

Ulrike Kappler, Megan J Maher

Journal article  |  2013  |  Cellular and Molecular Life Sciences

The X-ray crystal structure of a pseudoazurin from Sinorhizobium meliloti

Elise M Laming, Aaron P McGrath, J Mitchell Guss, Ulrike Kappler, Megan J Maher

Journal article  |  2012  |  Journal of Inorganic Biochemistry

The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates

Momi Iwata, Yang Lee, Tetsuo Yamashita, Takao Yagi, So Iwata, Alexander D Cameron, Megan J Maher

Journal article  |  2012  |  Proceedings of the National Academy of Sciences

The cation-dependent G-proteins: In a class of their own

Miriam-Rose Ash, Megan J Maher, J Mitchell Guss, Mika Jormakka

Journal article  |  2012  |  FEBS Letters

The structure of an N11A mutant of the G-protein domain of FeoB

Miriam-Rose Ash, Megan J Maher, J Mitchell Guss, Mika Jormakka

Journal article  |  2011  |  Acta Crystallographica Section F Structural Biology and Crystallization Communications

Molecular Basis of the Cooperative Binding of Cu(I) and Cu(II) to the CopK Protein from Cupriavidus metallidurans CH34

Miriam-Rose Ash, Lee Xin Chong, Megan J Maher, Mark G Hinds, Zhiguang Xiao, Anthony G Wedd

Journal article  |  2011  |  Biochemistry

A suite of Switch I and Switch II mutant structures from the G-protein domain of FeoB

Miriam-Rose Ash, Megan J Maher, J Mitchell Guss, Mika Jormakka

Journal article  |  2011  |  Acta Crystallographica Section D Biological Crystallography

The acquisition of ferrous iron in prokaryotes is achieved by the G-protein-coupled membrane protein FeoB. This protein possesses ..

The Initiation of GTP Hydrolysis by the G-Domain of FeoB: Insights from a Transition-State Complex Structure

Miriam-Rose Ash, Megan J Maher, J Mitchell Guss, Mika Jormakka

Journal article  |  2011  |  PLoS ONE

Insights into Structure and Function of the Active Site of SoxAX Cytochromes

James R Kilmartin, Megan J Maher, Kuakarun Krusong, Christopher J Noble, Graeme R Hanson, Paul V Bernhardt, Mark J Riley, Ulrike Kappler

Journal article  |  2011  |  Journal of Biological Chemistry

Potassium-activated GTPase Reaction in the G Protein-coupled Ferrous Iron Transporter B

Miriam-Rose Ash, Amy Guilfoyle, Ronald J Clarke, Mitchell Guss, Megan J Maher, Mika Jormakka

Journal article  |  2010  |  Journal of Biological Chemistry

Crystal structure of A(3)B(3) complex of V-ATPase from Thermus thermophilus

Megan J Maher, Satoru Akimoto, Momi Iwata, Koji Nagata, Yoshiko Hori, Masasuke Yoshida, Shigeyuki Yokoyama, So Iwata, Ken Yokoyama

Journal article  |  2009  |  The EMBO Journal

Dihydroorotase Inhibitors

M Lee, MJ Maher, RI Christopherson, JM Guss

Book Chapter  |  2009

Structural basis of GDP release and gating in G protein coupled Fe2 transport

Amy Guilfoyle, Megan J Maher, Mikaela Rapp, Ronald Clarke, Stephen Harrop, Mika Jormakka

Journal article  |  2009  |  The EMBO Journal

Crystal Structure of the Acid-Induced Arginine Decarboxylase from Escherichia coli: Reversible Decamer Assembly Controls Enzyme Activity

Juni Andrell, Matthew G Hicks, Tracy Palmer, Elisabeth P Carpenter, So Iwata, Megan J Maher

Journal article  |  2009  |  Biochemistry

Unprecedented Binding Cooperativity between Cu-I and Cu-II in the Copper Resistance Protein CopK from Cupriavidus metallidurans CH34: Implications from Structural Studies by NMR Spectroscopy and X-Ray Crystallography

Lee Xin Chong, Miriam-Rose Ash, Megan J Maher, Mark G Hinds, Zhiguang Xiao, Anthony G Wedd

Journal article  |  2009  |  Journal of the American Chemical Society

Thioredoxin A active-site mutants form mixed disulfide dimers that resemble enzyme-substrate reaction intermediates

Thijs RHM Kouwen, Jun Andrell, Rianne Schrijver, Jean-Yves F Dubois, Megan J Maher, So Iwata, Elisabeth P Carpenter, Jan Maarten van Dijl

Journal article  |  2008  |  Journal of Molecular Biology

Kinetic and structural analysis of mutant Escherichia coli dihydroorotases: A flexible loop stabilizes the transition state

Mihwa Lee, Megan J Maher, Richard I Christopherson, J Mitchell Guss

Journal article  |  2007  |  Biochemistry

Structures of ligand-free and inhibitor complexes of Dihydroorotase from Escherichia coli: Implications for loop movement in inhibitor design

Mihwa Lee, Camilla W Chan, Stephen C Graham, Richard I Christopherson, J Mitchell Guss, Megan J Maher

Journal article  |  2007  |  Journal of Molecular Biology

Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form

Mihwa Lee, Megan J Maher, J Mitchell Guss

Journal article  |  2007  |  Acta Crystallographica Section F Structural Biology and Crystallization Communications

Intermolecular transfer of copper ions from the CopC protein of Pseudomonas syringae. Crystal structures of fully loaded (CuCuII)-Cu-I forms

L Zhang, M Koay, MJ Mahert, Z Xiao, AG Wedd

Journal article  |  2006  |  Journal of the American Chemical Society

CopC protein from Pseudomonas syringae: Intermolecular transfer of copper from both the copper(I) and copper(II) sites

M Koay, LY Zhang, BS Yang, MJ Maher, ZG Xiao, AG Wedd

Journal article  |  2005  |  Inorganic Chemistry

Dihydroorotase from Escherichia coli: Loop movement and cooperativity between subunits

M Lee, CW Chan, JM Guss, RI Christopherson, MJ Maher

Journal article  |  2005  |  Journal of Molecular Biology

Structure of Escherichia coli aminopeptidase P in complex with the inhibitor apstatin

SC Graham, MJ Maher, WH Simmons, HC Freeman, JM Guss

Journal article  |  2004  |  Acta Crystallographica Section D Biological Crystallography

Tandem LIM domains provide synergistic binding in the LMO4 : Ldb1 complex

JE Deane, DP Ryan, M Sunde, MJ Maher, JM Guss, JE Visvader, JM Matthews

Journal article  |  2004  |  The EMBO Journal

Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum (vol D60, pg 298, 2004)

M Maher, M Cross, MCJ Wilce, JM Guss, AG Wedd

Journal article  |  2004  |  Acta Crystallographica Section D Biological Crystallography

Structure of the prolidase from Pyrococcus furiosus

MJ Maher, M Ghosh, AM Grunden, AL Menon, MWW Adams, HC Freeman, JM Guss

Journal article  |  2004  |  Biochemistry

Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum

M Maher, M Cross, MCJ Wilce, JM Guss, AG Wedd

Journal article  |  2004  |  Acta Crystallographica Section D Biological Crystallography

X-ray absorption spectroscopy of selenate reductase

MJ Maher, J Santini, IJ Pickering, RC Prince, JM Macy, GN George

Journal article  |  2004  |  Inorganic Chemistry

Auracyanin B structure in space group P6(5)

M Lee, MJ Maher, HC Freeman, JM Guss

Journal article  |  2003  |  Acta Crystallographica Section D Biological Crystallography

Crystallization of FLINC4, an intramolecular LMO4-ldb1 complex

JE Deane, MJ Maher, DB Langley, SC Graham, JE Visvader, JM Guss, JM Matthews

Journal article  |  2003  |  Acta Crystallographica Section D Biological Crystallography

Structural studies on the selenate reductase from Thauera selenatis.

MJ Maher, JM Santini, GN George

Conference Proceedings  |  2003  |  Journal of Inorganic Biochemistry

Crystallization of hamster dihydroorotase: involvement of a disulfide-linked tetrameric form

MJ Maher, DTC Huang, JM Guss, CA Collyer, RI Christopherson

Journal article  |  2003  |  Acta Crystallographica Section D Biological Crystallography

Crystallization of Pichia pastoris lysyl oxidase

M Lee, K Willingham, D Langley, MJ Maher, AE Cohen, PJ Ellis, JA Kuchar, DM Dooley, HC Freeman, JM Guss

Journal article  |  2002  |  Acta Crystallographica Section D Biological Crystallography

Crystallization and preliminary X-ray analysis of the selenate reductase from Thauera selenatis

MJ Maher, JM Macy

Journal article  |  2002  |  Acta Crystallographica Section D Biological Crystallography

Crystallization and characterization of the prolidase from Pyrococcus furiosus

K Willingham, MJ Maher, AM Grunden, M Ghosh, MWW Adams, HC Freeman, JM Guss

Journal article  |  2001  |  Acta Crystallographica Section D Biological Crystallography

Crystal structure of auracyanin, a "blue" copper protein from the green thermophilic photosynthetic bacterium Chloroflexus aurantiacus

CS Bond, RE Blankenship, HC Freeman, JM Guss, MJ Maher, FM Selvaraj, MCJ Wilce, KM Willingham

Journal article  |  2001  |  Journal of Molecular Biology

Mutation of the surface valine residues 8 and 44 in the rubredoxin from Clostridium pasteurianum: solvent access versus structural changes as determinants of reversible potential

ZG Xiao, MJ Maher, M Cross, CS Bond, JM Guss, AG Wedd

Journal article  |  2000  |  JBIC Journal of Biological Inorganic Chemistry

Rubredoxin from Clostridium pasteurianum. Structures of G10A, G43A and C10VG43A mutant proteins. Mutation of conserved glycine 10 to valine causes the 9-10 peptide link to invert

MJ Maher, ZG Xiao, MCJ Wilce, JM Guss, AG Wedd

Journal article  |  1999  |  Acta Crystallographica Section D Biological Crystallography

Investigation of the role of surface residues in the ferredoxin from Clostridium pasteurianum

PS Brereton, MJ Maher, PA Tregloan, AG Wedd

Journal article  |  1999  |  Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

The rubredoxin from Clostridium pasteurianum: Mutation of the iron cysteinyl ligands to serine. Crystal and molecular structures of oxidized and dithionite-treated forms of the Cys42Ser mutant

ZG Xiao, MJ Lavery, M Ayhan, SDB Scrofani, MCJ Wilce, JM Guss, PA Tregloan, GN George, AG Wedd

Journal article  |  1998  |  Journal of the American Chemical Society

The rubredoxin from Clostridium pasteurianum: Mutation of the conserved glycine residues 10 and 43 to alanine and valine

M Ayhan, ZG Xiao, MJ Lavery, AM Hamer, KW Nugent, SDB Scrofani, M Guss, AG Wedd

Journal article  |  1996  |  Inorganic Chemistry

COMPARISON OF NATIVE AND MUTANT PROTEINS PROVIDES A SEQUENCE-SPECIFIC ASSIGNMENT OF THE CYSTEINYL LIGAND PROTON NMR RESONANCES IN THE 2[FE4S4] FERREDOXIN FROM CLOSTRIDIUM-PASTEURIANUM

SDB SCROFANI, PS BRERETON, AM HAMER, MJ LAVERY, SG MCDOWALL, GA VINCENT, RTC BROWNLEE, NJ HOOGENRAAD, M SADEK, AG WEDD

Journal article  |  1994  |  Biochemistry

A sequence-specific assignment is presented for the eight low-field paramagnetically shifted cysteinyl ligand proton NMR resonance..