Trent Newman

Diffusion and distal linkages govern interchromosomal dynamics during meiotic prophase.

Trent AC Newman, Bruno Beltran, James M McGehee, Daniel Elnatan, Cori K Cahoon, Michael R Paddy, Daniel B Chu, Andrew J Spakowitz, Sean M Burgess

Journal article  |  2022  |  Proc Natl Acad Sci U S A

SignificanceEssential for sexual reproduction, meiosis is a specialized cell division required for the production of haploid gamet..

Riboceine Rescues Auranofin-Induced Craniofacial Defects in Zebrafish

Megan Leask, Catherine Carleton, Bryony Leeke, Trent Newman, Joseph Antoun, Mauro Farella, Julia Horsfield

Journal article  |  2021  |  ANTIOXIDANTS

Craniofacial abnormalities are a common group of congenital developmental disorders that can require intensive oral surgery as par..

Chlorogenic Acid Supplementation Benefits Zebrafish Embryos Exposed to Auranofin.

Jasper ZS Chiu, Isabella Hold, Trent AC Newman, Julia A Horsfield, Arlene McDowell

Journal article  |  2020  |  Pharmaceutics

Antioxidant supplementation may potentially be beneficial for embryonic development to reduce complications associated with increa..

Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo.

Dubravka Cukrov, Trent AC Newman, Megan Leask, Bryony Leeke, Patrizia Sarogni, Alessandra Patimo, Antonie D Kline, Ian D Krantz, Julia A Horsfield, Antonio Musio

Journal article  |  2018  |  Human Molecular Genetics

Cornelia de Lange syndrome (CdLS) is a rare disease characterized by cognitive impairment, multisystemic alterations and premature..

Long-Range Structural Changes in the Meiotic Nucleus Revealed by Changes in Stress Communication Along the Chromosome

Trent Newman, Bruno G Beltran, James McGehee, Cori Cahoon, Daniel Elnatan, Daniel Chu, Sean Burgess, Andrew Spakowitz

Journal article  |  2018  |  Biophysical Journal

The Nucleoporin Nup2 Contains a Meiotic-Autonomous Region that Promotes the Dynamic Chromosome Events of Meiosis

Daniel B Chu, Tatiana Gromova, Trent AC Newman, Sean M Burgess

Journal article  |  2017  |  GENETICS

Meiosis is a specialized cellular program required to create haploid gametes from diploid parent cells. Homologous chromosomes pai..

Dietary Intake Influences Adult Fertility and Offspring Fitness in Zebrafish

Trent Newman, Noel Jhinku, Michael Meier, Julia Horsfield

Journal article  |  2016  |  PLOS ONE

The burden of malnutrition, including both over- and undernutrition, is a major public health concern. Here we used a zebrafish mo..

A neural crest origin for cohesinopathy heart defects

Kevin Schuster, Bryony Leeke, Michael Meier, Yizhou Wang, Trent Newman, Sean Burgess, Julia A Horsfield

Journal article  |  2015  |  HUMAN MOLECULAR GENETICS

Mutations in subunits or regulators of cohesin cause a spectrum of disorders in humans known as the 'cohesinopathies'. Cohesinopat..

Embryonic oxidative stress results in reproductive impairment for adult zebrafish

Trent AC Newman, Catherine R Carleton, Bryony Leeke, Mark B Hampton, Julia A Horsfield

Journal article  |  2015  |  REDOX BIOLOGY

Exposure to environmental stressors during embryo development can have long-term effects on the adult organism. This study used th..