Ross Hannan

The Synthesis and Biological Evaluation of Some C-9 and C-10 Substituted Derivatives of the RNA Polymerase I Transcription Inhibitor CX-5461

Madushani Amarasiri, Yen Vo, Michael G Gardiner, Perlita Poh, Priscilla Soo, Megan Pavy, Nadine Hein, Rita Ferreira, Katherine M Hannan, Ross D Hannan, Martin G Banwell

Journal article  |  2021  |  Australian Journal of Chemistry

The regio-isomeric alkynyl-substituted derivatives, 2 and 3, of the RNA Polymerase I (Pol I) transcription inhibitor CX-5461 (1) w..

Cohesin mutations are synthetic lethal with stimulation of WNT signaling

Chue Vin Chin, Jisha Antony, Sarada Ketharnathan, Anastasia Labudina, Gregory Gimenez, Kate M Parsons, Jinshu He, Amee J George, Maria Michela Pallotta, Antonio Musio, Antony Braithwaite, Parry Guilford, Ross D Hannan, Julia A Horsfield

Journal article  |  2020  |  eLife

Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabi..

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

Shunfei Yan, Jiachen Xuan, Natalie Brajanovski, Madeleine RC Tancock, Piyush B Madhamshettiwar, Kaylene J Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Elaine Sanij, Richard B Pearson, Keefe T Chan

Journal article  |  2020  |  British Journal of Cancer

BACKGROUND: Intrinsic and acquired drug resistance represent fundamental barriers to the cure of high-grade serous ovarian carcino..

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Jennifer R Devlin, Keefe T Chan, David P De Souza, Malcolm J McConville, Grant A McArthur, George Thomas, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Katherine M Hannan, Jian Kang, Richard B Pearson

Journal article  |  2020  |  The EMBO Journal

Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our previous first-i..

Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC-Driven Cancer Progression

Jixuan Gao, MoonSun Jung, Chelsea Mayoh, Pooja Venkat, Katherine M Hannan, Jamie Fletcher, Alvin Kamili, Andrew J Gifford, Eric P Kusnadi, Richard B Pearson, Ross D Hannan, Michelle Haber, Murray D Norris, Klaartje Somers, Michelle J Henderson

Journal article  |  2020  |  Cancer Research

The ability of the N-MYC transcription factor to drive cancer progression is well demonstrated in neuroblastoma, the most common e..

Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes.

Susan Wagner, Anna Herrmannová, Vladislava Hronová, Stanislava Gunišová, Neelam D Sen, Ross D Hannan, Alan G Hinnebusch, Nikolay E Shirokikh, Thomas Preiss, Leoš Shivaya Valášek

Journal article  |  2020  |  Molecular Cell

Translational control targeting the initiation phase is central to the regulation of gene expression. Understanding all of its asp..

Harnessing the self-assembly of peptides for the targeted delivery of anti-cancer agents

Stephanie J Franks, Kate Firipis, Rita Ferreira, Katherine M Hannan, Richard J Williams, Ross D Hannan, David R Nisbet

Journal article  |  2020  |  Materials Horizons

A significant challenge to current cancer drug treatment is mode of delivery, both in terms of efficacy and off-target toxicity to..

rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

Jinbae Son, Katherine M Hannan, Gretchen Poortinga, Nadine Hein, Donald P Cameron, Austen RD Ganley, Karen E Sheppard, Richard B Pearson, Ross D Hannan, Elaine Sanij

Journal article  |  2020  |  Frontiers in Cell and Developmental Biology

Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and ..

Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade serous ovarian cancer.

Elaine Sanij, Katherine Hannan, Jiachen Xuan, Shunfei Yan, Jessica A Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Sarah Ellis, Carleen Cullinane, Gretchen Poortinga, Kum Kum Khanna, Linda Mileshkin, Grant A McArthur, John Soong, Els M Berns, et al.

Conference Proceedings  |  2020  |  Clinical Cancer Research

Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 in Drosophila

Olga Zaytseva, Naomi C Mitchell, Linna Guo, Owen J Marshall, Linda M Parsons, Ross D Hannan, David L Levens, Leonie M Quinn

Journal article  |  2020  |  Development (Cambridge)

Here, we report novel tumour suppressor activity for the Drosophila Argonaute family RNA-binding protein AGO1, a component of the ..