Ross Hannan

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J Deans, Kum Kum Khanna, et al.

Journal article  |  2020  |  Nature Communications

Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cance..

PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth

Bashar M Thejer, Partho P Adhikary, Amandeep Kaur, Sarah L Teakel, Ashleigh Van Oosterum, Ishith Seth, Marina Pajic, Katherine M Hannan, Megan Pavy, Perlita Poh, Jalal A Jazayeri, Thiri Zaw, Dana Pascovici, Marina Ludescher, Michael Pawlak, Juan C Cassano, Lynne Turnbull, Mitra Jazayeri, Alexander C James, Craig P Coorey, et al.

Journal article  |  2020  |  BMC Molecular and Cell Biology

BACKGROUND: Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with det..

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

Rita Ferreira, John S Schneekloth, Konstantin I Panov, Katherine M Hannan, Ross D Hannan

Journal article  |  2020  |  Cells

Transcription of the ribosomal RNA genes (rDNA) that encode the three largest ribosomal RNAs (rRNA), is mediated by RNA Polymerase..

A functional genetic screen defines the AKT-induced senescence signaling network

Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson

Journal article  |  2020  |  Cell Death & Differentiation

Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival..

Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer

Shunfei Yan, Piyush Madhamshettiwar, Kaylene Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen Sheppard, Katherine Hannan, Ross Hannan, Elaine Sanij, Richard Pearson, Keefe Chan

Journal article  |  2019

Abstract Limited effective therapeutic options are available for patients with recurrent high-grade serous carcinoma (HGSC), the m..

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

EP Kusnadi, AS Trigos, C Cullinane, DL Goode, O Larsson, JR Devlin, KT Chan, DP De Souza, MJ McConville, GA McArthur, G Thomas, E Sanij, G Poortinga, RD Hannan, KM Hannan, J Kang, RB Pearson

Journal article  |  2019  |  bioRxiv

Abstract Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our first-i..

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

Pei Y Liu, Andrew E Tee, Giorgio Milazzo, Katherine M Hannan, Jesper Maag, Sujanna Mondal, Bernard Atmadibrata, Nenad Bartonicek, Hui Peng, Nicholas Ho, Chelsea Mayoh, Roberto Ciaccio, Yuting Sun, Michelle J Henderson, Jixuan Gao, Celine Everaert, Amy J Hulme, Matthew Wong, Qing Lan, Belamy B Cheung, et al.

Journal article  |  2019  |  Nature Communications

The majority of patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression di..

Migration of Small Ribosomal Subunits on the 5 ' Untranslated Regions of Capped Messenger RNA

Nikolay E Shirokikh, Yulia S Dutikova, Maria A Staroverova, Ross D Hannan, Thomas Preiss

Journal article  |  2019  |  International Journal of Molecular Sciences

PGRMC1 phosphorylation and cell plasticity 1: glycolysis, mitochondria, tumor growth

Bashar Thejer, Partho Adhikary, Amandeep Kaur, Sarah Teakel, Ashleigh Van Oosterum, Ishith Seth, Marina Pajic, Kate Hannan, Megan Pavy, Perlita Poh, Jalal Jazayeri, Thiri Zaw, Dana Pascovici, Marina Ludescher, Michael Pawlak, Juan Cassano, Lynne Turnbull, Mitra Jazayeri, Alexander James, Craig Coorey, et al.

Journal article  |  2019

SUMMARY Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrime..

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Amit Khot, Natalie Brajanovski, Donald P Cameron, Nadine Hein, Kylee H Maclachlan, Elaine Sanij, John Lim, John Soong, Emma Link, Piers Blombery, Ella R Thompson, Andrew Fellowes, Karen E Sheppard, Grant A McArthur, Richard B Pearson, Ross D Hannan, Gretchen Poortinga, Simon J Harrison

Journal article  |  2019  |  Cancer Discovery

RNA polymerase I (Pol I) transcription of ribosomal RNA genes (rDNA) is tightly regulated downstream of oncogenic pathways, and it..

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Klaartje Somers, Victoria W Wen, Shiloh MC Middlemiss, Brenna Osborne, Helen Forgham, MoonSun Jung, Mawar Karsa, Molly Clifton, Angelika Bongers, Jixuan Gao, Chelsea Mayoh, Newsha Raoufi-Rad, Eric P Kusnadi, Kate M Hannan, David A Scott, Alan Kwek, Bing Liu, Claudia Flemming, Daria A Chudakova, Ruby Pandher, et al.

Journal article  |  2019  |  Oncogene

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

Elaine Sanij, Katherine Hannan, Shunfei Yan, Jiachen Xuan, Jessica Ahern, Keefe Chan, Jinbae Son, Olga Kondrashova, Elizabeth Lieschke, Matthew Wakefield, Anna Trigos, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Kum Kum Khanna, Linda Mileshkin, Grant McArthur, et al.

Journal article  |  2019

Abstract High-grade serous ovarian cancer (HGSOC) accounts for the majority of ovarian cancer and has a dismal prognosis. PARP inh..

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.

Jeannine Diesch, Megan J Bywater, Elaine Sanij, Donald P Cameron, William Schierding, Natalie Brajanovski, Jinbae Son, Jirawas Sornkom, Nadine Hein, Maurits Evers, Richard B Pearson, Grant A McArthur, Austen RD Ganley, Justin M O'Sullivan, Ross D Hannan, Gretchen Poortinga

Journal article  |  2019  |  Communications biology

The three-dimensional organization of the genome contributes to its maintenance and regulation. While chromosomal regions associat..

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

Jeannine Diesch, Megan J Bywater, Elaine Sanij, Donald P Cameron, William Schierding, Natalie Brajanovski, Jinbae Son, Jirawas Sornkom, Nadine Hein, Maurits Evers, Richard B Pearson, Grant A McArthur, Austen RD Ganley, Justin M O'Sullivan, Ross D Hannan, Gretchen Poortinga

Journal article  |  2019  |  Communications Biology

A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia

Lorena Nunez Villacis, Sheren J Al-Obaidi, Piyush Madhamshettiwar, Nadine Hein, Jun Chen, Priscilla Soo, Perlita Poh, Megan Pavy, Kaylene J Simpson, Thomas John Gonda, Richard B Pearson, Johan Flygare, Katherine M Hannan, Amee J George, Ross Hannan

Conference Proceedings  |  2018  |  Blood

Novel Combination Therapy Targeting rDNA Transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM

Kylee H Maclachlan, Andrew Cuddihy, Nadine Hein, Carleen Cullinane, Simon J Harrison, Ross Hannan, Gretchen Poortinga

Conference Proceedings  |  2018  |  Blood

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Mitchell G Lawrence, Daisuke Obinata, Shahneen Sandhu, Luke A Selth, Stephen Q Wong, Laura H Porter, Natalie Lister, David Pook, Carmel J Pezaro, David L Goode, Richard J Rebello, Ashlee K Clark, Melissa Papargiris, Jenna Van Gramberg, Adrienne R Hanson, Patricia Banks, Hong Wang, Birunthi Niranjan, Shivakumar Keerthikumar, Shelley Hedwards, et al.

Journal article  |  2018  |  European Urology

The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer.

Richard Rebello, Eric Kusnadi, Donald P Cameron, Pearson Helen, Denis Drygin, Shahneen Sandhu, Gail Risbridger, Richard B Pearson, Ross D Hannan, Luc Furic

Conference Proceedings  |  2018  |  CANCER RESEARCH

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naive melanoma but not after the development of BRAF inhibitor resistance

Claire A Martin, Carleen Cullinane, Laura Kirby, Shatha Abuhammad, Emily J Lelliott, Kelly Waldeck, Richard J Young, Natalie Brajanovski, Donald P Cameron, Rachael Walker, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Richard B Pearson, Rodney J Hicks, Grant A McArthur, Karen E Sheppard

Journal article  |  2018  |  International Journal of Cancer

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

Maheshi Udugama, Elaine Sanij, Hsiao PJ Voon, Jinbae Son, Linda Hii, Jeremy D Henson, F Lyn Chan, Fiona TM Chang, Yumei Liu, Richard B Pearson, Paul Kalitsis, Jeffrey R Mann, Philippe Collas, Ross D Hannan, Lee H Wong

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan anemia patient

Parvathy Venugopal, Sarah Moore, David M Lawrence, Amee J George, Ross D Hannan, Sarah CE Bray, Luen Bik To, Richard J D'Andrea, Jinghua Feng, Amanda Tirimacco, Alexandra L Yeoman, Chun Chun Young, Miriam Fine, Andreas W Schreiber, Christopher N Hahn, Christopher Barnett, Ben Saxon, Hamish S Scott

Journal article  |  2017  |  Haematologica

Inhibition of Pol I Transcription a New Chance in the Fight Against Cancer

Nadine Hein, Kathrine M Hannan, James D'Rozario, Ross Hannan

Journal article  |  2017  |  Technology in Cancer Research & Treatment

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways

Nagaraj S Moily, Angelique R Ormsby, Aleksandar Stojilovic, Yasmin M Ramdzan, Jeannine Diesch, Ross D Hannan, Michelle S Zajac, Anthony J Hannan, Alicia Oshlack, Danny M Hatters

Journal article  |  2017  |  Molecular and Cellular Neuroscience

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R Devlin, Amee J George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J Harrison, James D Rozario, et al.

Journal article  |  2017  |  Blood

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Sandy S Hung, Analia Lesmana, Abigail Peck, Rachel Lee, Elly Tchoubrieva, Katherine M Hannan, Jane Lin, Karen E Sheppard, Katarzyna Jastrzebski, Leonie M Quinn, Lawrence I Rothblum, Richard B Pearson, Ross D Hannan, Elaine Sanij

Journal article  |  2017  |  Gene

A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer

Shunfei Yan, Keefe T Chan, Kaylene J Simpson, Elaine Sanij, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Richard B Pearson

Conference Proceedings  |  2017  |  Synthetic Lethality and Viability

Genomic characterisation of E mu-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Marcus Lefebure, Richard W Tothill, Elizabeth Kruse, Edwin D Hawkins, Jake Shortt, Geoffrey M Matthews, Gareth P Gregory, Benjamin P Martin, Madison J Kelly, Izabela Todorovski, Maria A Doyle, Richard Lupat, Jason Li, Jan Schroeder, Meaghan Wall, Stuart Craig, Gretchen Poortinga, Don Cameron, Megan Bywater, Lev Kats, et al.

Journal article  |  2017  |  Nature Communications

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis

Louise E Kerry, Elaine E Pegg, Donald P Cameron, James Budzak, Gretchen Poortinga, Katherine M Hannan, Ross D Hannan, Gloria Rudenko

Journal article  |  2017  |  PLOS Neglected Tropical Diseases

Therapeutic Approaches Targeting MYC-Driven Prostate Cancer

Richard J Rebello, Richard B Pearson, Ross D Hannan, Luc Furic

Journal article  |  2017  |  Genes

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

Shunfei Yan, Daniel Frank, Jinbae Son, Katherine M Hannan, Ross D Hannan, Keefe T Chan, Richard B Pearson, Elaine Sanij

Journal article  |  2017  |  International Journal of Molecular Sciences

The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer

Richard J Rebello, Eric Kusnadi, Donald P Cameron, Helen B Pearson, Analia Lesmana, Jennifer R Devlin, Denis Drygin, Ashlee K Clark, Laura Porter, John Pedersen, Shahneen Sandhu, Gail P Risbridger, Richard B Pearson, Ross D Hannan, Luc Furic

Journal article  |  2016  |  Clinical Cancer Research

MLK4 activates the NF-kappa B network to drive mesenchymal transition in glioblastoma

Leonie M Quinn, Ross D Hannan

Journal article  |  2016  |  Translational Cancer Research

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies

Andrew J Colebatch, Leon Di Stefano, Stephen Q Wong, Ross D Hannan, Paul M Waring, Alexander Dobrovic, Grant A McArthur, Anthony T Papenfuss

Journal article  |  2016  |  Oncotarget

Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth

Linna Guo, Olga Zaysteva, Zuqin Nie, Naomi C Mitchell, Jue Er Amanda Lee, Thomas Ware, Linda Parsons, Rodney Luwor, Gretchen Poortinga, Ross D Hannan, David L Levens, Leonie M Quinn

Journal article  |  2016  |  Nucleic Acids Research

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence

Keefe T Chan, Lassi Paavolainen, Katherine M Hannan, Amee J George, Ross D Hannan, Kaylene J Simpson, Peter Horvath, Richard B Pearson

Journal article  |  2016  |  ASSAY and Drug Development Technologies

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

Jian Kang, Eric P Kusnadi, Allison J Ogden, Rodney J Hicks, Lukas Bammert, Ulrike Kutay, Sandy Hung, Elaine Sanij, Ross D Hannan, Katherine M Hannan, Richard B Pearson

Journal article  |  2016  |  Oncotarget

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George, Katherine M Hannan, Gretchen Poortinga, Karen E Sheppard, Kum Kum Khanna, Ricky W Johnstone, Denis Drygin, Grant A McArthur, Richard B Pearson, Elaine Sanij, Ross D Hannan

Journal article  |  2016  |  Oncotarget

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Jennifer R Devlin, Katherine M Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Pui Yee Ng, Amee J George, Jake Shortt, Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Jian Kang, Denis Drygin, Sean O'Brien, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Journal article  |  2016  |  Cancer Discovery

Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia

Sara E Sjogren, Kavitha Siva, Shamit Soneji, Amee J George, Marcus Winkler, Pekka Jaako, Marcin Wlodarski, Stefan Karlsson, Ross D Hannan, Johan Flygare

Journal article  |  2015  |  British Journal of Haematology

S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila

Naomi C Mitchell, Elissaveta B Tchoubrieva, Arjun Chahal, Simone Woods, Amanda Lee, Jane I Lin, Linda Parsons, Katarzyna Jastrzebski, Gretchen Poortinga, Katherine M Hannan, Richard B Pearson, Ross D Hannan, Leonie M Quinn

Journal article  |  2015  |  Cellular Signalling

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy

Simone J Woods, Katherine M Hannan, Richard B Pearson, Ross D Hannan

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models

Jue Er Amanda Lee, Naomi C Mitchell, Olga Zaytseva, Arjun Chahal, Peter Mendis, Amandine Cartier-Michaud, Linda M Parsons, Gretchen Poortinga, David L Levens, Ross D Hannan, Leonie M Quinn

Journal article  |  2015  |  Nature Communications

Unexpected role of CDK4 in a G2/M checkpoint

Karen E Sheppard, Richard B Pearson, Ross D Hannan

Journal article  |  2015  |  Cell Cycle

PR55 alpha-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

O Gilan, J Diesch, M Amalia, K Jastrzebski, AC Chueh, NM Verrills, RB Pearson, JM Mariadason, E Tulchinsky, RD Hannan, AS Dhillon

Journal article  |  2015  |  Oncogene

Genome wide mapping of UBF binding-sites in mouse and human cell lines

Jeannine Diesch, Ross D Hannan, Elaine Sanij

Journal article  |  2015  |  Genomics Data

Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer

Lloyd Pereira, John M Mariadason, Ross D Hannan, Amardeep S Dhillon

Journal article  |  2015  |  Frontiers in Oncology

Regulation of rDNA transcription in response to growth factors, nutrients and energy

Eric P Kusnadi, Katherine M Hannan, Rodney J Hicks, Ross D Hannan, Richard B Pearson, Jian Kang

Journal article  |  2015  |  Gene

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes

Elaine Sanij, Jeannine Diesch, Analia Lesmana, Gretchen Poortinga, Nadine Hein, Grace Lidgerwood, Donald P Cameron, Jason Ellul, Gregory J Goodall, Lee H Wong, Amardeep S Dhillon, Nourdine Hamdane, Lawrence I Rothblum, Richard B Pearson, Izhak Haviv, Tom Moss, Ross D Hannan

Journal article  |  2015  |  Genome Research

Targeting RNA polymerase I to treat MYC-driven cancer

G Poortinga, LM Quinn, RD Hannan

Journal article  |  2015  |  Oncogene

Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease

Jeannine Diesch, Ross D Hannan, Elaine Sanij

Journal article  |  2014  |  Cell & Bioscience

Conditional Inactivation of Upstream Binding Factor Reveals Its Epigenetic Functions and the Existence of a Somatic Nucleolar Precursor Body

Nourdine Hamdane, Victor Y Stefanovsky, Michel G Tremblay, Attila Nemeth, Eric Paquet, Frederic Lessard, Elaine Sanij, Ross Hannan, Tom Moss

Journal article  |  2014  |  PLOS GENETICS

Targeting the nucleolus for cancer intervention

Jaclyn E Quin, Jennifer R Devlin, Donald Cameron, Kate M Hannan, Richard B Pearson, Ross D Hannan

Journal article  |  2014  |  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells

Jeannine Diesch, Elaine Sanij, Omer Gilan, Christopher Love, Hoanh Tran, Nicholas I Fleming, Jason Ellul, Marcia Amalia, Izhak Haviv, Richard B Pearson, Eugene Tulchinsky, John M Mariadason, Oliver M Sieber, Ross D Hannan, Amardeep S Dhillon

Journal article  |  2014  |  PLOS ONE

Targeting the nucleolus for cancer-specific activation of p53

Denis Drygin, Sean E O'Brien, Ross D Hannan, Grant A McArthur, Daniel D Von Hoff

Journal article  |  2014  |  Drug Discovery Today

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

Karen E Sheppard, Carleen Cullinane, Katherine M Hannan, Meaghan Wall, Joanna Chan, Frances Barber, Jung Foo, Donald Cameron, Amelia Neilsen, Pui Ng, Jason Ellul, Margarete Kleinschmidt, Kathryn M Kinross, David D Bowtell, James G Christensen, Rodney J Hicks, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Wayne A Phillips, et al.

Journal article  |  2013  |  EUROPEAN JOURNAL OF CANCER

A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation

Amee J George, Brooke W Purdue, Cathryn M Gould, Daniel W Thomas, Yanny Handoko, Hongwei Qian, Gregory A Quaife-Ryan, Kylie A Morgan, Kaylene J Simpson, Walter G Thomas, Ross D Hannan

Journal article  |  2013  |  JOURNAL OF CELL SCIENCE

The nucleolus: an emerging target for cancer therapy

Nadine Hein, Katherine M Hannan, Amee J George, Elaine Sanij, Ross D Hannan

Journal article  |  2013  |  Trends in Molecular Medicine

AKT signalling is required for ribosomal RNA synthesis and progression of E mu-Myc B-cell lymphoma in vivo

Jennifer R Devlin, Katherine M Hannan, Pui Y Ng, Megan J Bywater, Jake Shortt, Carleen Cullinane, Grant A McArthur, Ricky W Johnstone, Ross D Hannan, Richard B Pearson

Journal article  |  2013  |  FEBS JOURNAL

Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches

Amee J George, Ross D Hannan, Walter G Thomas

Journal article  |  2013  |  FEBS JOURNAL

Targeting RNA polymerase I transcription and the nucleolus for cancer therapy

Ross D Hannan, Denis Drygin, Richard B Pearson

Journal article  |  2013  |  Expert Opinion On Therapeutic Targets

A Novel Mouse Model of Atherosclerotic Plaque Instability for Drug Testing and Mechanistic/Therapeutic Discoveries Using Gene and MicroRNA Expression Profiling

Yung-Chih Chen, Anh Viet Bui, Jeannine Diesch, Richard Manasseh, Christian Hausding, Jennifer Rivera, Izhak Haviv, Alex Agrotis, Nay Min Htun, Jeremy Jowett, Christoph Eugen Hagemeyer, Ross D Hannan, Alex Bobik, Karlheinz Peter

Journal article  |  2013  |  Circulation Research

Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart

Simon R Foster, Enzo R Porrello, Brooke Purdue, Hsiu-Wen Chan, Anja Voigt, Sabine Frenzel, Ross D Hannan, Karen M Moritz, David G Simmons, Peter Molenaar, Eugeni Roura, Ulrich Boehm, Wolfgang Meyerhof, Walter G Thomas

Journal article  |  2013  |  PLoS One

Dysregulation of the basal RNA polymerase transcription apparatus in cancer

Megan J Bywater, Richard B Pearson, Grant A McArthur, Ross D Hannan

Journal article  |  2013  |  Nature Reviews Cancer

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Jake Shortt, Benjamin P Martin, Andrea Newbold, Katherine M Hannan, Jennifer R Devlin, Adele J Baker, Rachael Ralli, Carleen Cullinane, Clemens A Schmitt, Maurice Reimann, Michael N Hall, Meaghan Wall, Ross D Hannan, Richard B Pearson, Grant A McArthur, Ricky W Johnstone

Journal article  |  2013  |  BLOOD

Dysregulation of RNA polymerase I transcription during disease

KM Hannan, E Sanij, LI Rothblum, RD Hannan, RB Pearson

Journal article  |  2013  |  Biochimica et Biophysica Acta. Gene Regulatory Mechanisms

Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis

Yeliz Boglev, Andrew P Badrock, Andrew J Trotter, Qian Du, Elsbeth J Richardson, Adam C Parslow, Sebastian J Markmiller, Nathan E Hall, Tanya A de Jong-Curtain, Annie Y Ng, Heather Verkade, Elke A Ober, Holly A Field, Donghun Shin, Chong H Shin, Katherine M Hannan, Ross D Hannan, Richard B Pearson, Seok-Hyung Kim, Kevin C Ess, et al.

Journal article  |  2013  |  PLoS Genetics

The mTORC1 Inhibitor Everolimus Prevents and Treats E mu-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Meaghan Wall, Gretchen Poortinga, Kym L Stanley, Ralph K Lindemann, Michael Bots, Christopher J Chan, Megan J Bywater, Kathryn M Kinross, Megan V Astle, Kelly Waldeck, Katherine M Hannan, Jake Shortt, Mark J Smyth, Scott W Lowe, Ross D Hannan, Richard B Pearson, Ricky W Johnstone, Grant A McArthur

Journal article  |  2013  |  CANCER DISCOVERY

AKT-independent PI3-K signaling in cancer - emerging role for SGK3.

Maressa A Bruhn, Richard B Pearson, Ross D Hannan, Karen E Sheppard

Journal article  |  2013  |  Cancer Management and Research

The phosphoinositide 3-kinase (PI3-K) signaling pathway plays an important role in a wide variety of fundamental cellular processe..

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie Cluse, Denis Drygin, Kenna Anderes, Nanni Huser, Chris Proffitt, Joshua Bliesath, Mustapha Haddach, Michael K Schwaebe, David M Ryckman, William G Rice, Clemens Schmitt, Scott W Lowe, Ricky W Johnstone, et al.

Journal article  |  2012  |  Cancer Cell

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, RD Hannan, RB Pearson

Journal article  |  2012  |  Oncogene

A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells

JL Pakay, J Diesch, O Gilan, Y-Y Yip, E Sayan, W Kolch, JM Mariadason, RD Hannan, E Tulchinsky, AS Dhillon

Journal article  |  2012  |  Oncogene

The Nucleolus and Ribosomal Genes in Aging and Senescence

Nadine Hein, Elaine Sanij, Jaclyn Quin, Katherine M Hannan, Austen Ganley, Ross D Hannan

Book Chapter  |  2012

Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone

Jane I Lin, Naomi C Mitchell, Marina Kalcina, Elly Tchoubrieva, Mary J Stewart, Steven J Marygold, Cherryl D Walker, George Thomas, Sally J Leevers, Richard B Pearson, Leonie M Quinn, Ross D Hannan

Journal article  |  2011  |  PLoS Genetics

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

Joanna C Chan, Katherine M Hannan, Kim Riddell, Yee Ng Pui, Abigail Peck, Rachel S Lee, Sandy Hung, Megan V Astle, Megan Bywater, Meaghan Wall, Gretchen Poortinga, Katarzyna Jastrzebski, Karen E Sheppard, Brian A Hemmings, Michael N Hall, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Journal article  |  2011  |  Science Signaling

A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth

Katarzyna Jastrzebski, Katherine M Hannan, Colin M House, Sandy S-C Hung, Richard B Pearson, Ross D Hannan

Journal article  |  2011  |  Cellular Signaling

Determination of the Exact Molecular Requirements for Type 1 Angiotensin Receptor Epidermal Growth Factor Receptor Transactivation and Cardiomyocyte Hypertrophy

Nicola J Smith, Hsiu-Wen Chan, Hongwei Qian, Allison M Bourne, Katherine M Hannan, Fiona J Warner, Rebecca H Ritchie, Richard B Pearson, Ross D Hannan, Walter G Thomas

Journal article  |  2011  |  Hypertension

Hfp, the Drosophila homolog of the mammalian c-myc transcriptional-repressor and tumor suppressor FIR, inhibits dmyc transcription and cell growth

Nicola J Cranna, Naomi C Mitchell, Ross D Hannan, Leonie M Quinn

Journal article  |  2011  |  Fly

c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

Gretchen Poortinga, Meaghan Wall, Elaine Sanij, Kasia Siwicki, Jason Ellul, Daniel Brown, Timothy P Holloway, Ross D Hannan, Grant A McArthur

Journal article  |  2011  |  Nucleic Acids Research

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

Denis Drygin, Amy Lin, Josh Bliesath, Caroline B Ho, Sean E O'Brien, Chris Proffitt, Mayuko Omori, Mustapha Haddach, Michael K Schwaebe, Adam Siddiqui-Jain, Nicole Streiner, Jaclyn E Quin, Elaine Sanij, Megan J Bywater, Ross D Hannan, David Ryckman, Kenna Anderes, William G Rice

Journal article  |  2011  |  Cancer Research

Signaling to the Ribosome in Cancer-It Is More Than Just mTORC1

Katherine M Hannan, Elaine Sanij, Nadine Hein, Ross D Hannan, Richard B Pearson

Journal article  |  2011  |  IUBMB Life

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity.

Rachel S Lee, Colin M House, Briony E Cristiano, Ross D Hannan, Richard B Pearson, Katherine M Hannan

Journal article  |  2011  |  Enzyme Research

The AKT protooncogene mediates many cellular processes involved in normal development and disease states such as cancer. The three..

Second AKT: The rise of SGK in cancer signalling

Maressa A Bruhn, Richard B Pearson, Ross D Hannan, Karen E Sheppard

Journal article  |  2010  |  Growth Factors

Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner

Naomi C Mitchell, Timothy M Johanson, Nicola J Cranna, Amanda Lee Jue Er, Helena E Richardson, Ross D Hannan, Leonie M Quinn

Journal article  |  2010  |  Development

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

Lee H Wong, James D McGhie, Marcus Sim, Melissa A Anderson, Soyeon Ahn, Ross D Hannan, Amee J George, Kylie A Morgan, Jeffrey R Mann, KH Andy Choo

Journal article  |  2010  |  Genome Research

The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin

Elaine Sanij, Ross D Hannan

Journal article  |  2009  |  EPIGENETICS

The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin.

Elaine Sanij, Ross D Hannan

Journal article  |  2009  |  Epigenetics

Somatic cells have approximately 200 hundred copies of ribosomal RNA (rRNA) genes (rDNA) per haploid genome of which only a fracti..

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

Meaghan Wall, Gretchen Poortinga, Katherine M Hannan, Richard B Pearson, Ross D Hannan, Grant A McArthur

Journal article  |  2008  |  Blood

Chromatin organization and expression.

Elaine Sanij, Ross D Hannan

Journal article  |  2008  |  Genome Biology

A report on the 29th Lorne Genome Conference on the Organization and Expression of the Genome, Lorne, Australia, 17-21 February 20..

Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis

RAD Bathgate, ED Lekgabe, JT McGuane, Y Su, T Pham, T Ferraro, S Layfield, RD Hannan, WG Thomas, CS Samuel, X-J Du

Journal article  |  2008  |  Molecular and Cellular Endocrinology

Transgenic alpha(1A)-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival

Xiao-Jun Du, Xiao-Ming Gao, Helen Kiriazis, Xiao-Lei Moore, Ziqiu Ming, Yidan Su, Angela M Finch, Ross A Hannan, Anthony M Dart, Robert M Graham

Journal article  |  2006  |  Cardiovascular Research

Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: A possible role for SGK1

Kerrie Lister, Dominic J Autelitano, Anna Jenkins, Ross D Hannan, Karen E Sheppard

Journal article  |  2006  |  Cardiovascular Research

MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

G Poortinga, KM Hannan, H Snelling, CR Walkley, A Jenkins, K Sharkey, M Wall, Y Brandenburger, M Palatsides, RB Pearson, GA McArthur, RD Hannan

Journal article  |  2004  |  EMBO Journal

mTOR-Dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF

KM Hannan, Y Brandenburger, A Jenkins, K Sharkey, A Cavanaugh, L Rothblum, T Moss, G Poortinga, GA McArthur, RB Pearson, RD Hannan

Journal article  |  2003  |  Molecular and Cellular Biology