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Prof

Ross Hannan

Honorary
The Sir Peter Maccallum Department of Oncology
science & technology
life sciences & biomedicine
animals
humans
oncology
transcription, genetic
mice
biochemistry & molecular biology
rna polymerase i
Ross Hannan's Profile Picture
Prof

Ross Hannan

 
Division
Medicine, Dentistry and Health Sciences
Ross Hannan's Profile Picture
Prof

Ross Hannan

 
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Projects

Displaying the 10 most recent projects from 26 for Ross Hannan.

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REGULATION OF RIBOSOMAL RNA GENE CHROMATIN DURING MALIGNANT TRANSFORMATION

The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats..

2016 - 2019
Completed
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ONCOGENIC SIGNALING AND CANCER THERAPY

Central to improving the management of patients with cancer is an understanding of the molecular drivers of cancer. Based on our fundamental..

2014 - 2018
Completed
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NOVEL APPROACHES TO TREAT REFRACTORY HAEMATOLOGICAL MALIGNANCIES

2015 - 2017
Completed
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Genomic analysis of DNA binding and gene regulation by the chromatin remodelling factor UBF

Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulat..

2013 - 2015
Completed
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MECHANISM OF EPIDERMAL GROWTH FACTOR RECEPTOR TRANSACTIVATION

This application examines the cellular events that control heart growth in response to angiotensin, a hormone linked to heart failure. We be..

2012 - 2014
Completed
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A NEW APPROACH TO TARGETING CELL GROWTH FOR THE TREATMENT OF CANCER

We have made the fundamental discovery that ribosomal gene transcription is not simply a 'house keeping' process in cancer cells but is requ..

2012 - 2014
Completed
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Drosophila models for regulation of myc transcription

We aim to use the animal model system, the vinegar fly, to investigate mechanism for cancer initiation. The fly has been studied for over 90..

2011 - 2014
Completed
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A FUNCTION GENOME-WIDE RNA INTEREFRENCE SCREEN TO IDENTIFY DRUGGABLE TARGETS IN DIAMOND BLACKFAN ANAEMIA - HANNAN

2013 - 2014
Completed
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INHIBITION OF POL I TRANSCRIPTION AS A NOVEL APPROACH TO TREAT PROSTATE CANCER

2012 - 2013
Completed
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Pol I and Myc driven malignacy

Synthesis of ribosomes, the cellular protein synthetic machinery, is dysregulated during cancer leading to the hypothesis that it may be cau..

2011 - 2013
Completed

26

Projects

Project Types

26

Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works from 109 for Ross Hannan.

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CX-5461 sensitises DNA damage repair proficient castrate-resistant prostate cancer to PARP inhibition.

Mitchell G Lawrence, Laura H Porter, Nicholas Choo, David Pook, Jeremy P Grummet, Carmel J Pezaro, Shahneen Sandhu, Susanne Ramm, Jennii Luu, Andrew Bakshi, David L Goode, Elaine Sanij, Richard B Pearson, Ross D Hannan, Kaylene J Simpson, Renea A Taylor, Gail P Risbridger, Luc Furic

Journal article  |  2021  |  Mol Cancer Ther

Monotherapy with poly (ADP-ribose) polymerase (PARP) inhibitors is effective for the subset of castrate-resistant prostate cancer ..

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The Ribosomal Gene Loci-The Power behind the Throne

Konstantin I Panov, Katherine Hannan, Ross D Hannan, Nadine Hein

Journal article  |  2021  |  GENES

Nucleoli form around actively transcribed ribosomal RNA (rRNA) genes (rDNA), and the morphology and location of nucleolus-associat..

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The Synthesis and Biological Evaluation of Some C-9 and C-10 Substituted Derivatives of the RNA Polymerase I Transcription Inhibitor CX-5461

Madushani Amarasiri, Yen Vo, Michael G Gardiner, Perlita Poh, Priscilla Soo, Megan Pavy, Nadine Hein, Rita Ferreira, Katherine M Hannan, Ross D Hannan, Martin G Banwell

Journal article  |  2021  |  AUSTRALIAN JOURNAL OF CHEMISTRY

The regio-isomeric alkynyl-substituted derivatives, 2 and 3, of the RNA Polymerase I (Pol I) transcription inhibitor CX-5461 (1) w..

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Cohesin mutations are synthetic lethal with stimulation of WNT signaling

Chue Vin Chin, Jisha Antony, Sarada Ketharnathan, Anastasia Labudina, Gregory Gimenez, Kate M Parsons, Jinshu He, Amee J George, Maria Michela Pallotta, Antonio Musio, Antony Braithwaite, Parry Guilford, Ross D Hannan, Julia A Horsfield

Journal article  |  2020  |  ELIFE

Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabi..

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The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

Shunfei Yan, Jiachen Xuan, Natalie Brajanovski, Madeleine RC Tancock, Piyush B Madhamshettiwar, Kaylene J Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Elaine Sanij, Richard B Pearson, Keefe T Chan

Journal article  |  2020  |  BRITISH JOURNAL OF CANCER

BACKGROUND: Intrinsic and acquired drug resistance represent fundamental barriers to the cure of high-grade serous ovarian carcino..

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Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Jennifer R Devlin, Keefe T Chan, David P De Souza, Malcolm J McConville, Grant A McArthur, George Thomas, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Katherine M Hannan, Jian Kang, Richard B Pearson

Journal article  |  2020  |  EMBO JOURNAL

Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our previous first-i..

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Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC-Driven Cancer Progression

Jixuan Gao, MoonSun Jung, Chelsea Mayoh, Pooja Venkat, Katherine M Hannan, Jamie Fletcher, Alvin Kamili, Andrew J Gifford, Eric P Kusnadi, Richard B Pearson, Ross D Hannan, Michelle Haber, Murray D Norris, Klaartje Somers, Michelle J Henderson

Journal article  |  2020  |  CANCER RESEARCH

The ability of the N-MYC transcription factor to drive cancer progression is well demonstrated in neuroblastoma, the most common e..

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Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes.

Susan Wagner, Anna Herrmannová, Vladislava Hronová, Stanislava Gunišová, Neelam D Sen, Ross D Hannan, Alan G Hinnebusch, Nikolay E Shirokikh, Thomas Preiss, Leoš Shivaya Valášek

Journal article  |  2020  |  Mol Cell

Translational control targeting the initiation phase is central to the regulation of gene expression. Understanding all of its asp..

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Harnessing the self-assembly of peptides for the targeted delivery of anti-cancer agents

Stephanie J Franks, Kate Firipis, Rita Ferreira, Katherine M Hannan, Richard J Williams, Ross D Hannan, David R Nisbet

Journal article  |  2020  |  MATERIALS HORIZONS

A significant challenge to current cancer drug treatment is mode of delivery, both in terms of efficacy and off-target toxicity to..

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rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

Jinbae Son, Katherine M Hannan, Gretchen Poortinga, Nadine Hein, Donald P Cameron, Austen RD Ganley, Karen E Sheppard, Richard B Pearson, Ross D Hannan, Elaine Sanij

Journal article  |  2020  |  FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and ..

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Scholarly Works

Keyword Analysis

Oncology and Carcinogenesis
Clinical Health
Biochemistry and Cell Biology
Expanding Knowledge
Genetics
Cardiovascular Medicine and Haematology
Zoology
Medicinal and Biomolecular Chemistry
Other Health
Pharmacology and Pharmaceutical Sciences

Credentials

Positions

Honorary

The Sir Peter Maccallum Department of Oncology

Links