Dr Mirella Dottori is an ARC Future Fellow and Group Leader of the Stem Cell Laboratory at the Centre for Neural Engineering, University of Melbourne, Australia. Dr Dottori undertook her PhD at Walter and Eliza Hall Institute in the field of developmental neuroscience.
Her studies in this area continued into her postdoctoral training years at the Salk Institute, La Jolla, USA. She then returned to Australia as a NHMRC Howard Florey Fellow and joined Professor Martin Pera’s group at Monash University to study human stem cell biology. In 2007, Dr Dottori established her own research group at the University of Melbourne.Since 2003, Dr Dottori’s research has been within the field of human pluripotent stem cell biology, which is one of the most rapidly advancing areas of medical research. Pluripotent cells can now be generated from human biopsy tissue and this technology allows the possibility of generating patient-specific stem cells for the development of cell replacement strategies as well as genetically appropriate in vitro human cellular models of disease and drug screening platforms. However, in order to achieve these objectives, it is firstly essential to understand how to regulate stem cell differentiation to a defined lineage. The major focus of Dr Dottori’s research is studying human pluripotent stem cells and their differentiation to specific lineages of the central and peripheral nervous system. Her research objectives are to create human cellular models of neural development and neurodegenerative diseases and also to develop stem cell therapies to promote regeneration within the nervous system.
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If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?
Differential susceptibility of human neural progenitors and neurons to ischaemic injury
Displaying the 24 most recent projects by Mirella Dottori.
Internal Research Grant
Displaying the 81 most recent scholarly works by Mirella Dottori.
Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia.
Ewa Czuba-Wojnilowicz, Serena Viventi, Sara E Howden, Simon Maksour, Amy E Hulme, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso
Journal article | 2020 | Biomaterials Science
Increasing frataxin protein levels through gene therapy is envisaged to improve therapeutic outcomes for patients with Friedreich'..
If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?
Lezanne Ooi, Mirella Dottori, Anthony L Cook, Martin Engel, Vini Gautam, Alexandra Grubman, Damian Hernandez, Anna E King, Simon Maksour, Helena Targa Dias Anastacio, Rachelle Balez, Alice Pebay, Colin Pouton, Michael Valenzuela, Anthony White, Robert Williamson
Journal article | 2020 | The Neuroscientist
Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a publ..
Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices
Tomoko Hyakumura, Stuart McDougall, Sue Finch, Karina Needham, Mirella Dottori, Bryony A Nayagam
Journal article | 2019 | Stem Cells International
Stem cells have been touted as a source of potential replacement neurons for inner ear degeneration for almost two decades now; ye..
Generation of Vestibular Tissue-Like organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System
Cristiana Mattei, Rebecca Lim, Hannah Drury, Babak Nasr, Zihui Li, Melissa A Tadros, Giovanna M D'Abaco, Kathryn S Stok, Bryony A Nayagam, Mirella Dottori
Journal article | 2019 | Frontiers in Cell and Developmental Biology
Generation of Neural Crest Progenitors from Human Pluripotent Stem Cells.
Kwaku Dad Abu-Bonsrah, Serena Viventi, Donald F Newgreen, Mirella Dottori
Journal article | 2019 | Methods in molecular biology (Clifton, N.J.)
There are a vast range of diseases and disorders that are neurocristopathic in origin, including Hirschsprung's disease, pheochrom..
Self-Organized Nanostructure Modified Microelectrode for Sensitive Electrochemical Glutamate Detection in Stem Cells-Derived Brain Organoids
Babak Nasr, Rachael Chatterton, Jason Hsien Ming Yong, Pegah Jamshidi, Giovanna Marisa D'Abaco, Andrew Robin Bjorksten, Omid Kavehei, Gursharan Chana, Mirella Dottori, Efstratios Skafidas
Journal article | 2018 | Biosensors
Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
Abdullah Jawad Alshawaf, Serena Viventi, Wanzhi Qiu, Giovanna D'Abaco, Bryony Nayagam, Michael Erlichster, Gursharan Chana, Ian Everall, Jason Ivanusic, Efstratios Skafidas, Mirella Dottori
Journal article | 2018 | SCIENTIFIC REPORTS
Long-Distance Axonal Growth and Protracted Functional Maturation of Neurons Derived from Human Induced Pluripotent Stem Cells After Intracerebral Transplantation
Jonathan C Niclis, Christopher Turner, Jennifer Durnall, Stuart McDougal, Jessica A Kauhausen, Bryan Leaw, Mirella Dottori, Clare L Parish, Lachlan H Thompson
Journal article | 2017 | STEM CELLS Translational Medicine
Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency
Duncan E Crombie, Claire L Curl, Antonia JA Raaijmakers, Priyadharshini Sivakumaran, Tejal Kulkarni, Raymond CB Wong, Itsunari Minami, Marguerite V Evans-Galea, Shiang Y Lim, Lea Delbridge, Louise A Corben, Mirella Dottori, Norio Nakatsuji, Ian A Trounce, Alex W Hewitt, Martin B Delatycki, Martin F Pera, Alice Pebay
Journal article | 2017 | AGING-US
Enteric Neural Cells From Hirschsprung Disase Patients Form Ganglia in Autologous Aneuronal Colon
Benjamin N Rollo, Dongcheng Zhang, Lincon A Stamp, Trevelyan R Menheniott, Lefteris Stathopoulos, Mark Denham, Mirella Dottori, Sebastian K King, John M Hutson, Donald F Newgreen
Journal article | 2016 | Cellular and Molecular Gastroenterology and Hepatology
The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation
Paulina Carmona-Mora, Jocelyn Widagdo, Florence Tomasetig, Cesar P Canales, Yeojoon Cha, Wei Lee, Abdullah Alshawaf, Mirella Dottori, Renee M Whan, Edna C Hardeman, Stephen J Palmer
Journal article | 2015 | Human Genetics
Multipotent Caudal Neural Progenitors Derived from Human Pluripotent Stem Cells That Give Rise to Lineages of the Central and Peripheral Nervous System
Mark Denham, Kouichi Hasegawa, Trevelyan Menheniott, Ben Rollo, Dongcheng Zhang, Shelley Hough, Abdullah Alshawaf, Fabia Febbraro, Samiramis Ighaniyan, Jessie Leung, David A Elliott, Donald F Newgreen, Martin F Pera, Mirella Dottori
Journal article | 2015 | STEM CELLS
Directing human induced pluripotent stem cells into a neurosensory lineage for auditory neuron replacement.
Niliksha Gunewardene, Nicole Van Bergen, Duncan Crombie, Karina Needham, Mirella Dottori, Bryony A Nayagam
Journal article | 2014 | BioResearch Open Access
Emerging therapies for sensorineural hearing loss include replacing damaged auditory neurons (ANs) using stem cells. Ultimately, i..
Functional Characterization of Friedreich Ataxia iPS-Derived Neuronal Progenitors and Their Integration in the Adult Brain
Matthew J Bird, Karina Needham, Ann E Frazier, Jorien van Rooijen, Jessie Leung, Shelley Hough, Mark Denham, Matthew E Thornton, Clare L Parish, Bryony A Nayagam, Martin Pera, David R Thorburn, Lachlan H Thompson, Mirella Dottori
Journal article | 2014 | PLoS One
Glycogen Synthase Kinase 3 beta and Activin/Nodal Inhibition in Human Embryonic Stem Cells Induces a Pre-Neuroepithelial State That Is Required for Specification to a Floor Plate Cell Lineage
Mark Denham, Chris Bye, Jessie Leung, Brock J Conley, Lachlan H Thompson, Mirella Dottori
Journal article | 2012 | STEM CELLS
In vivo tissue engineering chamber supports human induced pluripotent stem cell survival and rapid differentiation
Shiang Y Lim, Dcing Geun Lee, Priyadharshini Sivakumaran, Duncan Crombie, John Slavin, Mirella Dottori, Brock Conley, Mark Denham, Jessie Leung, Richard Tee, Gregory J Dusting, Alice Pebay, Rodney J Dilley
Journal article | 2012 | Biochemical and Biophysical Research Communications
Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation
Mark Denham, Clare L Parish, Bryan Leaw, Jordan Wright, Christopher A Reid, Steven Petrou, Mirella Dottori, Lachlan H Thompson
Journal article | 2012 | FRONTIERS IN CELLULAR NEUROSCIENCE
Non-Viral Generation of Neural Precursor-like Cells from Adult Human Fibroblasts.
C Maucksch, E Firmin, C Butler-Munro, Jm Montgomery, M Dottori, B Connor
Journal article | 2012 | Journal of Stem Cells & Regenerative Medicine
Recent studies have reported direct reprogramming of human fibroblasts to mature neurons by the introduction of defined neural gen..
Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients
Jun Liu, Paul J Verma, Marguerite V Evans-Galea, Martin B Delatycki, Anna Michalska, Jessie Leung, Duncan Crombie, Joseph P Sarsero, Robert Williamson, Mirella Dottori, Alice Pebay
Journal article | 2011 | Stem Cell Reviews and Reports
Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells
Caitlin E Filby, Robert Williamson, Peter van Kooy, Alice Pebay, Mirella Dottori, Ngaire J Elwood, Faten Zaibak
Journal article | 2011 | Stem Cell Research & Therapy
Comparison of Transplant Efficiency Between Spontaneously Derived and Noggin-Primed Human Embryonic Stem Cell Neural Precursors in the Quinolinic Acid Rat Model of Huntington's Disease
Elena M Vazey, Mirella Dottori, Pegah Jamshidi, Doris Tomas, Martin F Pera, Malcolm Horne, Bronwen Connor
Journal article | 2010 | Cell Transplantation
Generation of human embryonic stem cell reporter knock-in lines by homologous recombination.
Richard P Davis, Catarina Grandela, Koula Sourris, Tanya Hatzistavrou, Mirella Dottori, Andrew G Elefanty, Edouard G Stanley, Magdaline Costa
Book Chapter | 2009 | Current Protocols in Stem Cell Biology
This unit describes a series of technical procedures to form clonal human embryonic stem cell (hESC) lines that are genetically mo..
A method for genetic modification of human embryonic stem cells using electroporation
Magdaline Costa, Mirella Dottori, Koula Sourris, Pegah Jamshidi, Tanya Hatzistavrou, Richard Davis, Lisa Azzola, Steven Jackson, Sue Mei Lim, Martin Pera, Andrew G Elefanty, Edouard G Stanley
Journal article | 2007 | Nature Protocols
Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells.
M Dottori, M Down, A Hüttmann, DR Fitzpatrick, AW Boyd
Journal article | 1999 | Blood
The Eph family of receptor tyrosine kinases (RTK) has restricted temporal and spatial expression patterns during development, and ..
Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization.
M Lackmann, AC Oates, M Dottori, FM Smith, C Do, M Power, L Kravets, AW Boyd
Journal article | 1998 | Journal of Biological Chemistry
Eph receptor tyrosine kinases and their ligands (ephrins) are highly conserved protein families implicated in patterning events du..
Displaying the most recent news article by Mirella Dottori.
Honours, Awards and Fellowships
ARC Future Fellowship
DOCTORATE IN MEDICAL BIOLOGY
University of Melbourne
BACHELOR OF SCIENCE (Hons)
University of Melbourne