Kevin Nicholas

Comparative analysis of milk microRNA in the therian lineage highlights the evolution of lactation

Christophe Lefevre, Pooja Venkat, Amit Kumar, Vengamanaidu Modepalli, Kevin R Nicholas

Journal article  |  2019  |  REPRODUCTION FERTILITY AND DEVELOPMENT

Milk is a complex secretion that has an important role in mammalian reproduction. It is only recently that sequencing technologies..

Guiding Development of the Neonate: Lessons from Mammalia

Kevin R Nicholas, Vengama Modepalli, Ashalyn P Watt, Lyn A Hinds, Amit Kumar, Christophe Lefevre, Julie A Sharp

Book Chapter  |  2019  |  Nestle Nutrition Institute workshop series

Significantly preterm and low-birthweight (LBW) babies have diminished lung and gut development, generally fail to thrive, have in..

Gene expression profiling of postnatal lung development in the marsupial gray short-tailed opossum (Monodelphis domestica) highlights conserved developmental pathways and specific characteristics during lung organogenesis

Vengamanaidu Modepalli, Amit Kumar, Julie A Sharp, Norman R Saunders, Kevin R Nicholas, Christophe Lefevre

Journal article  |  2018  |  BMC GENOMICS

BACKGROUND: After a short gestation, marsupials give birth to immature neonates with lungs that are not fully developed and in ear..

Transcriptome analysis of mammary epithelial cell gene expression reveals novel roles of the extracellular matrix.

Stephen S Wanyonyi, Amit Kumar, Ryan Du Preez, Christophe Lefevre, Kevin R Nicholas

Journal article  |  2017  |  Biochem Biophys Rep

BACKGROUND: The unique lactation strategy of the tammar wallaby (Macropus eugeni) has been invaluable in evaluating the role of la..

Dimeric but not monomeric alpha-lactalbumin potentiates apoptosis by up regulation of ATF3 and reduction of histone deacetylase activity in primary and immortalised cells

Julie A Sharp, Amelia J Brennan, Galina Polekhina, David B Ascher, Christophe Lefevre, Kevin R Nicholas

Journal article  |  2017  |  CELLULAR SIGNALLING

α-lactalbumin is a protein of dual function found in milk of most mammals. α-lactalbumin binds β-1,4-galactosyltransferase to form..

The tammar wallaby: A marsupial model to examine the timed delivery and role of bioactives in milk

Julie A Sharp, Stephen Wanyonyi, Vengama Modepalli, Ashalyn Watt, Sanjana Kuruppath, Lyn A Hinds, Amit Kumar, Helen E Abud, Christophe Lefevre, Kevin R Nicholas

Journal article  |  2017  |  GENERAL AND COMPARATIVE ENDOCRINOLOGY

It is now clear that milk has multiple functions; it provides the most appropriate nutrition for growth of the newborn, it deliver..

Molecular evolution of a novel marsupial S100 protein (S100A19) which is expressed at specific stages of mammary gland and gut development

Joly HL Kwek, Alicia Wynne, Christophe Lefevre, Mary Familari, Kevin R Nicholas, Julie A Sharp

Journal article  |  2013  |  MOLECULAR PHYLOGENETICS AND EVOLUTION

S100 proteins are calcium-binding proteins involved in controlling diverse intracellular and extracellular processes such as cell ..

The mammary gland-specific marsupial ELP and eutherian CTI share a common ancestral gene

Elizabeth A Pharo, Alison A De Leo, Marilyn B Renfree, Peter C Thomson, Christophe M Lefevre, Kevin R Nicholas

Journal article  |  2012  |  BMC EVOLUTIONARY BIOLOGY

BACKGROUND: The marsupial early lactation protein (ELP) gene is expressed in the mammary gland and the protein is secreted into mi..

Acute involution in the tammar wallaby: Identification of genes and putative novel milk proteins implicated in mammary gland function

Elie Khalil, Matthew Robert Digby, Peter Campbell Thomson, Christophe Lefevre, Sonia Louise Mailer, Cate Pooley, Kevin Roy Nicholas

Journal article  |  2011  |  GENOMICS

Marsupials provide a suitable alternative model to studying mammary gland involution. They have evolved a different reproductive s..

Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development

Marilyn B Renfree, Anthony T Papenfuss, Janine E Deakin, James Lindsay, Thomas Heider, Katherine Belov, Willem Rens, Paul D Waters, Elizabeth A Pharo, Geoff Shaw, Emily Swwong, Christophe M Lefevre, Kevin R Nicholas, Yoko Kuroki, Matthew J Wakefield, Kyall R Zenger, Chenwei Wang, Malcolm Ferguson-Smith, Frank W Nicholas, Danielle Hickford, et al.

Journal article  |  2011  |  GENOME BIOLOGY

BACKGROUND: We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and t..