Kathryn Munro

The beta-Secretase Substrate Seizure 6-Like Protein (SEZ6L) Controls Motor Functions in Mice

Emma Ong-Palsson, Jasenka Rudan Njavro, Yvette Wilson, Martina Pigoni, Andree Schmidt, Stephan A Mueller, Michael Meyer, Jana Hartmann, Marc Aurel Busche, Jenny M Gunnersen, Kathryn M Munro, Stefan F Lichtenthaler

Journal article  |  2021  |  MOLECULAR NEUROBIOLOGY

The membrane protein seizure 6-like (SEZ6L) is a neuronal substrate of the Alzheimer's disease protease BACE1, and little is known..

BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory

A Nash, HJM Gijsen, BJ Hrupka, KS-L Teng, SF Lichtenthaler, H Takeshima, JM Gunnersen, KM Munro

Journal article  |  2021  |  SCIENTIFIC REPORTS

BACE inhibitors, which decrease BACE1 (β-secretase 1) cleavage of the amyloid precursor protein, are a potential treatment for Alz..

Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties

Amelia Nash, Timothy D Aumann, Martina Pigoni, Stefan F Lichtenthaler, Hiroshi Takeshima, Kathryn M Munro, Jenny M Gunnersen

Journal article  |  2020  |  CEREBRAL CORTEX

Seizure-related gene 6 (Sez6), Sez6-Like (Sez6L), and Sez6-Like 2 (Sez6L2) comprise a family of homologous proteins widely express..

Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System

Kathryn M Munro, Amelia Nash, Martina Pigoni, Stefan F Lichtenthaler, Jenny M Gunnersen

Journal article  |  2016  |  JOURNAL OF MOLECULAR NEUROSCIENCE

Inhibition of the protease β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is a promising treatment strategy for Alzhei..

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

Martina Pigoni, Johanna Wanngren, Peer-Hendrik Kuhn, Kathryn M Munro, Jenny M Gunnersen, Hiroshi Takeshima, Regina Feederle, Iryna Voytyuk, Bart De Strooper, Mikail D Levasseur, Brian J Hrupka, Stephan A Mueller, Stefan F Lichtenthaler

Journal article  |  2016  |  MOLECULAR NEURODEGENERATION

BACKGROUND: The protease BACE1 (beta-site APP cleaving enzyme) is a major drug target in Alzheimer's disease. However, BACE1 thera..

Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's disease

Mark Murphy, Yvette M Wilson, Ernesto Vargas, Kathryn M Munro, Belinda Smith, Amy Huang, Qiao-Xin Li, Junhua Xiao, Colin L Masters, Christopher A Reid, Graham L Barrett

Journal article  |  2015  |  NEUROBIOLOGY OF AGING

Alzheimer's disease (AD) is an extremely prevalent cause of dementia. It is characterized by progressive memory loss, confusion, a..

Differential Labeling of Cell-surface and Internalized Proteins after Antibody Feeding of Live Cultured Neurons

Nissa L Carrodus, Kathleen Sue-Lyn Teng, Kathryn M Munro, Matthew J Kennedy, Jenny M Gunnersen

Journal article  |  2014  |  Journal of Visualized Experiments

Differential Labeling of Cell-surface and Internalized Proteins after Antibody Feeding of Live Cultured Neurons

Nissa L Carrodus, Kathleen Sue-Lyn Teng, Kathryn M Munro, Matthew J Kennedy, Jenny M Gunnersen

Journal article  |  2014  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

In order to demonstrate the cell-surface localization of a putative transmembrane receptor in cultured neurons, we labeled the pro..

EphA4 Receptor Tyrosine Kinase Is a Modulator of Onset and Disease Severity of Experimental Autoimmune Encephalomyelitis (EAE)

Kathryn M Munro, Kirsty J Dixon, Melissa M Gresle, Anna Jonas, Dennis Kemper, William Doherty, Louis J Fabri, Catherine M Owczarek, Martin Pearse, Andrew W Boyd, Trevor J Kilpatrick, Helmut Butzkueven, Ann M Turnley

Journal article  |  2013  |  PLOS ONE

The EphA4 receptor tyrosine kinase is a major regulator of axonal growth and astrocyte reactivity and is a possible inflammatory m..

Partial change in EphA4 knockout mouse phenotype: Loss of diminished GFAP upregulation following spinal cord injury

Kirsty J Dixon, Kathryn M Munro, Andrew W Boyd, Perry F Bartlett, Ann M Turnley

Journal article  |  2012  |  NEUROSCIENCE LETTERS

In a previous study we found that the EphA4 receptor inhibits regeneration following spinal cord injury by blocking regrowth of ax..