Adam Kowalczyk

Improved HLA-based prediction of coeliac disease identifies two novel genetic interactions

Michael Erlichster, Justin Bedo, Efstratios Skafidas, Patrick Kwan, Adam Kowalczyk, Benjamin Goudey

Journal article  |  2020  |  European Journal of Human Genetics

Human Leucocyte Antigen (HLA) testing is useful in the clinical work-up of coeliac disease (CD) with high negative but low positiv..

Exploring effective approaches for haplotype block phasing

Ziad Al Bkhetan, Justin Zobel, Adam Kowalczyk, Karin Verspoor, Benjamin Goudey

Journal article  |  2019  |  BMC BIOINFORMATICS

BACKGROUND: Knowledge of phase, the specific allele sequence on each copy of homologous chromosomes, is increasingly recognized as..

Effect of outpatient antibiotics for urinary tract infections on antimicrobial resistance among commensal Enterobacteriaceae: a multinational prospective cohort study

AJ Stewardson, J Vervoort, N Adriaenssens, S Coenen, M Godycki-Cwirko, A Kowalczyk, BD Huttner, C Lammens, S Malhotra-Kumar, H Goossens, S Harbarth

Journal article  |  2018  |  CLINICAL MICROBIOLOGY AND INFECTION

OBJECTIVES: We quantified the impact of antibiotics prescribed in primary care for urinary tract infections (UTIs) on intestinal c..

Interactions within the MHC contribute to the genetic architecture of celiac disease

Benjamin Goudey, Gad Abraham, Eder Kikianty, Qiao Wang, Dave Rawlinson, Fan Shi, Izhak Haviv, Linda Stern, Adam Kowalczyk, Michael Inouye

Journal article  |  2017  |  PLOS ONE

Interaction analysis of GWAS can detect signal that would be ignored by single variant analysis, yet few robust interactions in hu..

Standardized ETDRS charts for mobile devices

E Kędzierska, K Petelczyc, K Kakarenko, M Bieda, A Kowalczyk, A Byszewska, A Kolodziejczyk

Journal article  |  2017  |  Photonics Letters of Poland

Charts displayed on mobile devices were verified in comparison to standardized ETDRS charts. Such a method of visual acuity assess..

Use of a Novel Nonparametric Version of DEPTH to Identify Genomic Regions Associated with Prostate Cancer Risk

Robert J MacInnis, Daniel F Schmidt, Enes Makalic, Gianluca Severi, Liesel M FitzGerald, Matthias Reumann, Miroslaw K Kapuscinski, Adam Kowalczyk, Zeyu Zhou, Benjamin Goudey, Guoqi Qian, Quang M Bui, Daniel J Park, Adam Freeman, Melissa C Southey, Ali Amin Al Olama, Zsofia Kote-Jarai, Rosalind A Eeles, John L Hopper, Graham G Giles

Journal article  |  2016  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

BACKGROUND: We have developed a genome-wide association study analysis method called DEPTH (DEPendency of association on the numbe..

A urinary microRNA signature can predict the presence of bladder urothelial carcinoma in patients undergoing surveillance

Nikhil Sapre, Geoff Macintyre, Michael Clarkson, Haroon Naeem, Marek Cmero, Adam Kowalczyk, Paul D Anderson, Anthony J Costello, Niall M Corcoran, Christopher M Hovens

Journal article  |  2016  |  BRITISH JOURNAL OF CANCER

BACKGROUND: The objective of this study was to determine whether microRNA (miRNA) profiling of urine could identify the presence o..

Development and validation of a gene expression tumour classifier for cancer of unknown primary

Richard W Tothill, Fan Shi, Lisa Paiman, Justin Bedo, Adam Kowalczyk, Linda Mileshkin, Evangeline Buela, Robert Klupacs, David Bowtell, Keith Byron

Journal article  |  2015  |  PATHOLOGY

Accurate identification of the primary tumour in cancer of unknown primary (CUP) is required for effective treatment selection and..

Curated MicroRNAs in Urine and Blood Fail to Validate as Predictive Biomarkers for High-Risk Prostate Cancer

Nikhil Sapre, Matthew KH Hong, Geoff Macintyre, Heather Lewis, Adam Kowalczyk, Anthony J Costello, Niall M Corcoran, Christopher M Hovens

Journal article  |  2014  |  PLOS ONE

PURPOSE: The purpose of this study was to determine if microRNA profiling of urine and plasma at radical prostatectomy can disting..

Accurate and Robust Genomic Prediction of Celiac Disease Using Statistical Learning

Gad Abraham, Jason A Tye-Din, Oneil G Bhalala, Adam Kowalczyk, Justin Zobel, Michael Inouye

Journal article  |  2014  |  PLOS GENETICS

Practical application of genomic-based risk stratification to clinical diagnosis is appealing yet performance varies widely depend..