Pramod Subedi

Construction of a Highly Sensitive Thiol-Reactive AIEgen-Peptide Conjugate for Monitoring Protein Unfolding and Aggregation in Cells

Soheila Sabouri, Mengjie Liu, Shouxiang Zhang, Bicheng Yao, Hamid Soleimaninejad, Amy A Baxter, Georgina Armendariz-Vidales, Pramod Subedi, Chong Duan, Xiaoding Lou, Conor F Hogan, Begona Heras, Ivan KH Poon, Yuning Hong

Journal article  |  2021  |  ADVANCED HEALTHCARE MATERIALS

Impairment of the protein quality control network leads to the accumulation of unfolded and aggregated proteins. Direct detection ..

Salmonella enterica BcfH Is a Trimeric Thioredoxin-Like Bifunctional Enzyme with Both Thiol Oxidase and Disulfide Isomerase Activities

Pramod Subedi, Jason J Paxman, Geqing Wang, Lilian Hor, Yaoqin Hong, Anthony D Verderosa, Andrew E Whitten, Santosh Panjikar, Carlos F Santos-Martin, Jennifer L Martin, Makrina Totsika, Begona Heras

Journal article  |  2021  |  ANTIOXIDANTS & REDOX SIGNALING

Aims: Thioredoxin (TRX)-fold proteins are ubiquitous in nature. This redox scaffold has evolved to enable a variety of functions, ..

Structural bioinformatic analysis of DsbA proteins and their pathogenicity associated substrates

Carlos Santos-Martin, Geqing Wang, Pramod Subedi, Lilian Hor, Makrina Totsika, Jason John Paxman, Begona Heras

Journal article  |  2021  |  COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL

The disulfide bond (DSB) forming system and in particular DsbA, is a key bacterial oxidative folding catalyst. Due to its role in ..

COVID-19 in Nepal: Diagnostic and Management Dilemma

Pramod Subedi, Rajiv Khadge, Sanjog Timilsina, Kritika Poudel

Journal article  |  2020  |  International Journal of Travel Medicine and Global Health

Impact of COVID-19 pandemic on socioeconomic and mental health aspects in Nepal

Kritika Poudel, Pramod Subedi

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY

BACKGROUND: Public health concern is increasing with recent rise in the number of COVID-19 cases in Nepal. To curb this pandemic, ..

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment

Tze Cin Owyong, Pramod Subedi, Jieru Deng, Elizabeth Hinde, Jason J Paxman, Jonathan M White, Weisan Chen, Begoña Heras, Wallace WH Wong, Yuning Hong

Journal article  |  2020  |  Angewandte Chemie

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment

Tze Cin Owyong, Pramod Subedi, Jieru Deng, Elizabeth Hinde, Jason J Paxman, Jonathan M White, Weisan Chen, Begona Heras, Wallace WH Wong, Yuning Hong

Journal article  |  2020  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Environmental polarity is an important factor that drives biomolecular interactions to regulate cell function. Herein, a general m..

The Scs disulfide reductase system cooperates with the metallochaperone CueP in Salmonella copper resistance

Pramod Subedi, Jason J Paxman, Geqing Wang, Ashwinie A Ukuwela, Zhiguang Xiao, Begona Heras

Journal article  |  2019  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The human pathogen Salmonella enterica serovar Typhimurium (S Typhimurium) contains a complex disulfide bond (Dsb) catalytic machi..

Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens

Roxanne P Smith, Biswaranjan Mohanty, Shakeel Mowlaboccus, Jason J Paxman, Martin L Williams, Stephen J Headey, Geqing Wang, Pramod Subedi, Bradley C Doak, Charlene M Kahler, Martin J Scanlon, Begona Heras

Journal article  |  2018  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The worldwide incidence of neisserial infections, particularly gonococcal infections, is increasingly associated with antibiotic-r..

Autotransporter Adhesins in Escherichia coli Pathogenesis

Julieanne L Vo, Gabriela Constanza Martinez Ortiz, Pramod Subedi, Shivakumar Keerthikumar, Suresh Mathivanan, Jason J Paxman, Begona Heras

Journal article  |  2017  |  PROTEOMICS

Most bacteria produce adhesion molecules to facilitate the interaction with host cells and establish successful infections. An imp..