Julie Healer

Trends Talk MAM 2020: Growing Strong on the 20th Anniversary

Alexis Kaushansky, Carol Sibley, Geoff McFadden, Susan Charman, Denise Doolan, Michael Good, Erika Flannery, Julie Healer, Michael Duffy, Terrie Taylor, Alister Craig, Leann Tilley, Paul Gilson

Journal article  |  2020  |  Trends in Parasitology

Development and validation of serological markers for detecting recent Plasmodium vivax infection

Rhea J Longley, Michael T White, Eizo Takashima, Jessica Brewster, Masayuki Morita, Matthias Harbers, Thomas Obadia, Leanne J Robinson, Fumie Matsuura, Zoe SJ Liu, Connie SN Li-Wai-Suen, Wai-Hong Tham, Julie Healer, Christele Huon, Chetan E Chitnis, Wang Nguitragool, Wuelton Monteiro, Carla Proietti, Denise L Doolan, Andre M Siqueira, et al.

Journal article  |  2020  |  Nature Medicine

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undete..

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle

Paola Favuzza, Manuel de Lera Ruiz, Jennifer K Thompson, Tony Triglia, Anna Ngo, Ryan WJ Steel, Marissa Vavrek, Janni Christensen, Julie Healer, Christopher Boyce, Zhuyan Guo, Mengwei Hu, Tanweer Khan, Nicholas Murgolo, Lianyun Zhao, Jocelyn Sietsma Penington, Kitsanapong Reaksudsan, Kate Jarman, Melanie H Dietrich, Lachlan Richardson, et al.

Journal article  |  2020  |  Cell Host & Microbe

Artemisin combination therapy (ACT) is the main treatment option for malaria, which is caused by the intracellular parasite Plasmo..

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes

Julie Healer, Wilson Wong, Jennifer K Thompson, Wengqiang He, Richard W Birkinshaw, Kazutoyo Miura, Carol A Long, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Willem A de Jongh, Christopher Weir, Ella Svahn, Peter E Czabotar, Wai-Hong Tham, Ivo Mueller, Paul N Barlow, Alan F Cowman

Journal article  |  2019  |  Cellular Microbiology

Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria

Wen-Qiang He, Ahmad Rushdi Shakri, Rukmini Bhardwaj, Camila T Franca, Danielle I Stanisic, Julie Healer, Benson Kiniboro, Leanne J Robinson, Micheline Guillotte-Blisnick, Christele Huon, Peter Siba, Alan Cowman, Christopher L King, Wai-Hong Tham, Chetan E Chitnis, Ivo Mueller

Journal article  |  2019  |  PLOS Neglected Tropical Diseases

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex

Wilson Wong, Rick Huang, Sebastien Menant, Chuan Hong, Jarrod J Sandow, Richard W Birkinshaw, Julie Healer, Anthony N Hodder, Usheer Kanjee, Christopher J Tonkin, Denise Heckmann, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Manoj T Duraisingh, Peter E Czabotar, Willem A de Jongh, Wai-Hong Tham, Andrew I Webb, Zhiheng Yu, et al.

Journal article  |  2019  |  Nature

A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial

Rebecca Pawliw, Rebecca Farrow, Silvana Sekuloski, Helen Jennings, Julie Healer, Phuong Thuan, Pri Sathe, Cielo Pasay, Krystal Evans, Alan F Cowman, Louis Schofield, Nanhua Chen, James McCarthy, Katharine Trenholme

Journal article  |  2018  |  Malaria Journal

Mechanisms of naturally acquired immunity to P-falciparum and approaches to identify merozoite antigen targets

Julie Healer, Chris Y Chiu, Diana S Hansen

Journal article  |  2018  |  Parasitology

Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

Camila Tenorio Franca, Michael T White, Wen-Qiang He, Jessica B Hostetler, Jessica Brewster, Gabriel Frato, Indu Malhotra, Jakub Gruszczyk, Christele Huon, Enmoore Lin, Benson Kiniboro, Anjali Yadava, Peter Siba, Mary R Galinski, Julie Healer, Chetan Chitnis, Alan F Cowman, Eizo Takashima, Takafumi Tsuboi, Wai-Hong Tham, et al.

Journal article  |  2017  |  eLife

Vaccines to Accelerate Malaria Elimination and Eventual Eradication

Julie Healer, Alan F Cowman, David C Kaslow, Ashley J Birkett

Journal article  |  2017  |  Cold Spring Harbor Perspectives in Medicine

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

Lin Chen, Yibin Xu, Wilson Wong, Jennifer K Thompson, Julie Healer, Ethan D Goddard-Borger, Michael C Lawrence, Alan F Cowman

Journal article  |  2017  |  eLife

Malaria: Biology and Disease

Alan F Cowman, Julie Healer, Danushka Marapana, Kevin Marsh

Journal article  |  2016  |  Cell

Different Regions of Plasmodium falciparum Erythrocyte-Binding Antigen 175 Induce Antibody Responses to Infection of Varied Efficacy

Chris Y Chiu, Michael T White, Julie Healer, Jenny K Thompson, Peter M Siba, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article  |  2016  |  Journal of Infectious Diseases

Vaccine development

J Healer, AF Cowman

Book Chapter  |  2016

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

Lin Chen, Yibin Xu, Julie Healer, Jenny K Thompson, Brian J Smith, Michael C Lawrence, Alan F Cowman

Journal article  |  2014  |  eLife

A Next-generation Genetically Attenuated Plasmodium falciparum Parasite Created by Triple Gene Deletion

Sebastian A Mikolajczak, Viswanathan Lakshmanan, Matthew Fishbaugher, Nelly Camargo, Anke Harupa, Alexis Kaushansky, Alyse N Douglass, Michael Baldwin, Julie Healer, Matthew O'Neill, Phuong Thuan, Alan Cowman, Stefan HI Kappe

Journal article  |  2014  |  Molecular Therapy

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria

Chris YH Chiu, Julie Healer, Jennifer K Thompson, Lin Chen, Aiki Kaul, Laxman Savergave, Arjun Raghuwanshi, Connie SN Li Wai Suen, Peter M Siba, Louis Schofield, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article  |  2014  |  Frontiers in Microbiology

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

Michele Spring, Jittawadee Murphy, Robin Nielse, Megan Dowler, Jason W Bennett, Stasya Zarling, Jack Williams, Patricia de la Vega, Lisa Ware, Jack Komisar, Mark Polhemus, Thomas L Richie, Judy Epstein, Cindy Tamminga, Ilin Chuang, Nancy Richie, Michael O'Neil, D Gray Heppner, Julie Healer, Matthew O'Neill, et al.

Journal article  |  2013  |  Vaccine

Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum

Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman

Journal article  |  2013  |  PLoS One

Identification and Prioritization of Merozoite Antigens as Targets of Protective Human Immunity to Plasmodium falciparum Malaria for Vaccine and Biomarker Development

Jack S Richards, Thangavelu U Arumugam, Linda Reiling, Julie Healer, Anthony N Hodder, Freya JI Fowkes, Nadia Cross, Christine Langer, Satoru Takeo, Alex D Uboldi, Jennifer K Thompson, Paul R Gilson, Ross L Coppel, Peter M Siba, Christopher L King, Motomi Torii, Chetan E Chitnis, David L Narum, Ivo Mueller, Brendan S Crabb, et al.

Journal article  |  2013  |  Journal of Immunology

Modulation of PF10_0355 (MSPDBL2) Alters Plasmodium falciparum Response to Antimalarial Drugs

Daria Van Tyne, Alessandro D Uboldi, Julie Healer, Alan F Cowman, Dyann F Wirth

Journal article  |  2013  |  Antimicrobial Agents and Chemotherapy

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

Anthony N Hodder, Peter E Czabotar, Alessandro D Uboldi, Oliver B Clarke, Clara S Lin, Julie Healer, Brian J Smith, Alan F Cowman

Journal article  |  2012  |  Journal of Biological Chemistry

Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum

Wai-Hong Tham, Julie Healer, Alan F Cowman

Journal article  |  2012  |  Trends in Parasitology

Discovery of GAMA, a Plasmodium falciparum Merozoite Micronemal Protein, as a Novel Blood-Stage Vaccine Candidate Antigen

Thangavelu U Arumugam, Satoru Takeo, Tsutomu Yamasaki, Amporn Thonkukiatkul, Kazutoyo Miura, Hitoshi Otsuki, Hong Zhou, Carole A Long, Jetsumon Sattabongkot, Jennifer Thompson, Danny W Wilson, James G Beeson, Julie Healer, Brendan S Crabb, Alan F Cowman, Motomi Torii, Takafumi Tsuboi

Journal article  |  2011  |  Infect. Immun.

The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparum

Tania F de Koning-Ward, Anna Olivieri, Lucia Bertuccini, Andrew Hood, Francesco Silvestrini, Konstantinos Charvalias, Pedro Berzosa Diaz, Grazia Camarda, Terry F McElwain, Tony Papenfuss, Julie Healer, Lucilla Baldassarri, Brendan S Crabb, Pietro Alano, Lisa C Ranford-Cartwright

Journal article  |  2008  |  Molecular Microbiology

Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum

Till S Voss, Christopher J Tonkin, Allison J Marty, Jennifer K Thompson, Julie Healer, Brendan S Crabb, Alan F Cowman

Journal article  |  2007  |  Molecular Microbiology

A conserved region in the EBL proteins is implicated in microneme targeting of the malaria parasite Plasmodium falciparum

Moritz Treeck, Nicole S Struck, Silvia Haase, Christine Langer, Susann Herrmann, Julie Healer, Alan F Cowman, Tim W Gilberger

Journal article  |  2006  |  Journal of Biological Chemistry

Transcribed var genes associated with placental malaria in Malawian women

Michael F Duffy, Aphrodite Caragounis, Rintis Noviyanti, Helen M Kyriacou, Ee Ken Choong, Katja Boysen, Julie Healer, J Alexandra Rowe, Malcolm E Molyneux, Graham V Brown, Stephen J Rogerson

Journal article  |  2006  |  Infection and Immunity

A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites

J Baum, D Richard, J Healer, M Rug, Z Krnajski, TW Gilberger, JL Green, AA Holder, AF Cowman

Journal article  |  2006  |  Journal of Biological Chemistry

Functional analysis of Plasmodium falciparum apical membrane antigen 1 utilizing interspecies domains

J Healer, T Triglia, AN Hodder, AW Gemmill, AF Cowman

Journal article  |  2005  |  Infection and Immunity

Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum

J Healer, V Murphy, AN Hodder, R Masciantonio, AW Gemmill, RF Anders, AF Cowman, A Batchelor

Journal article  |  2004  |  Mol. Microbiol.

Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species

T Triglia, J Healer, SR Caruana, AN Hodder, RF Anders, BS Crabb, AF Cowman

Journal article  |  2000  |  Molecular Microbiology

Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells

AF Cowman, DL Baldi, J Healer, KE Mills, RA O'Donnell, MB Reed, T Triglia, ME Wickham, BS Crabb

Journal article  |  2000  |  FEBS Letters

Transmission-blocking immunity to Plasmodium falciparum in malaria-immune individuals is associated with antibodies to the gamete surface protein Pfs230.

J Healer, D McGuinness, R Carter, E Riley

Journal article  |  1999  |  Parasitology

Malaria-immune human sera were tested for their ability to affect the infectivity of Plasmodium falciparum gametocytes to Anophele..

Phagocytosis does not play a major role in naturally acquired transmission-blocking immunity to Plasmodium falciparum malaria.

J Healer, A Graszynski, E Riley

Journal article  |  1999  |  Infection and Immunity

Phagocytosis of Plasmodium falciparum sexual stages in vitro and within the mosquito midgut was assayed in order to assess its rol..

Complement-mediated lysis of Plasmodium falciparum gametes by malaria-immune human sera is associated with antibodies to the gamete surface antigen Pfs230.

J Healer, D McGuinness, P Hopcroft, S Haley, R Carter, E Riley

Journal article  |  1997  |  Infection and immunity

Antibodies to the sexual-stage surface antigens of Plasmodium falciparum, Pfs230 and Pfs48/45, can abolish the infectivity of game..

Characterization of proteolytic enzymes from larval and adult Nippostrongylus brasiliensis.

J Healer, F Ashall, RM Maizels

Journal article  |  1991  |  Parasitology

Proteases from infective larval (L3) and adult stages of Nippostrongylus brasiliensis were investigated with a combination of tech..