Julie Healer

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes

Julie Healer, Wilson Wong, Jennifer K Thompson, Wengqiang He, Richard W Birkinshaw, Kazutoyo Miura, Carol A Long, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Willem A de Jongh, Christopher Weir, Ella Svahn, Peter E Czabotar, Wai-Hong Tham, Ivo Mueller, Paul N Barlow, Alan F Cowman

Journal article  |  2019  |  Cellular Microbiology

Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria

Wen-Qiang He, Ahmad Rushdi Shakri, Rukmini Bhardwaj, Camila T Franca, Danielle I Stanisic, Julie Healer, Benson Kiniboro, Leanne J Robinson, Micheline Guillotte-Blisnick, Christele Huon, Peter Siba, Alan Cowman, Christopher L King, Wai-Hong Tham, Chetan E Chitnis, Ivo Mueller

Journal article  |  2019  |  PLOS Neglected Tropical Diseases

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex

Wilson Wong, Rick Huang, Sebastien Menant, Chuan Hong, Jarrod J Sandow, Richard W Birkinshaw, Julie Healer, Anthony N Hodder, Usheer Kanjee, Christopher J Tonkin, Denise Heckmann, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Manoj T Duraisingh, Peter E Czabotar, Willem A de Jongh, Wai-Hong Tham, Andrew I Webb, Zhiheng Yu, et al.

Journal article  |  2019  |  Nature

A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial

Rebecca Pawliw, Rebecca Farrow, Silvana Sekuloski, Helen Jennings, Julie Healer, Phuong Thuan, Pri Sathe, Cielo Pasay, Krystal Evans, Alan F Cowman, Louis Schofield, Nanhua Chen, James McCarthy, Katharine Trenholme

Journal article  |  2018  |  Malaria Journal

Mechanisms of naturally acquired immunity to P-falciparum and approaches to identify merozoite antigen targets

Julie Healer, Chris Y Chiu, Diana S Hansen

Journal article  |  2018  |  Parasitology

Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

Camila Tenorio Franca, Michael T White, Wen-Qiang He, Jessica B Hostetler, Jessica Brewster, Gabriel Frato, Indu Malhotra, Jakub Gruszczyk, Christele Huon, Enmoore Lin, Benson Kiniboro, Anjali Yadava, Peter Siba, Mary R Galinski, Julie Healer, Chetan Chitnis, Alan F Cowman, Eizo Takashima, Takafumi Tsuboi, Wai-Hong Tham, et al.

Journal article  |  2017  |  eLife

Vaccines to Accelerate Malaria Elimination and Eventual Eradication

Julie Healer, Alan F Cowman, David C Kaslow, Ashley J Birkett

Journal article  |  2017  |  Cold Spring Harbor Perspectives in Medicine

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

Lin Chen, Yibin Xu, Wilson Wong, Jennifer K Thompson, Julie Healer, Ethan D Goddard-Borger, Michael C Lawrence, Alan F Cowman

Journal article  |  2017  |  eLife

Malaria: Biology and Disease

Alan F Cowman, Julie Healer, Danushka Marapana, Kevin Marsh

Journal article  |  2016  |  Cell

Different Regions of Plasmodium falciparum Erythrocyte-Binding Antigen 175 Induce Antibody Responses to Infection of Varied Efficacy

Chris Y Chiu, Michael T White, Julie Healer, Jenny K Thompson, Peter M Siba, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article  |  2016  |  Journal of Infectious Diseases

Vaccine development

J Healer, AF Cowman

Book Chapter  |  2016

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

Lin Chen, Yibin Xu, Julie Healer, Jenny K Thompson, Brian J Smith, Michael C Lawrence, Alan F Cowman

Journal article  |  2014  |  eLife

A Next-generation Genetically Attenuated Plasmodium falciparum Parasite Created by Triple Gene Deletion

Sebastian A Mikolajczak, Viswanathan Lakshmanan, Matthew Fishbaugher, Nelly Camargo, Anke Harupa, Alexis Kaushansky, Alyse N Douglass, Michael Baldwin, Julie Healer, Matthew O'Neill, Phuong Thuan, Alan Cowman, Stefan HI Kappe

Journal article  |  2014  |  Molecular Therapy

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria

Chris YH Chiu, Julie Healer, Jennifer K Thompson, Lin Chen, Aiki Kaul, Laxman Savergave, Arjun Raghuwanshi, Connie SN Li Wai Suen, Peter M Siba, Louis Schofield, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article  |  2014  |  Frontiers in Microbiology

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

Michele Spring, Jittawadee Murphy, Robin Nielse, Megan Dowler, Jason W Bennett, Stasya Zarling, Jack Williams, Patricia de la Vega, Lisa Ware, Jack Komisar, Mark Polhemus, Thomas L Richie, Judy Epstein, Cindy Tamminga, Ilin Chuang, Nancy Richie, Michael O'Neil, D Gray Heppner, Julie Healer, Matthew O'Neill, et al.

Journal article  |  2013  |  Vaccine

Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum

Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman

Journal article  |  2013  |  PLoS One

Identification and Prioritization of Merozoite Antigens as Targets of Protective Human Immunity to Plasmodium falciparum Malaria for Vaccine and Biomarker Development

Jack S Richards, Thangavelu U Arumugam, Linda Reiling, Julie Healer, Anthony N Hodder, Freya JI Fowkes, Nadia Cross, Christine Langer, Satoru Takeo, Alex D Uboldi, Jennifer K Thompson, Paul R Gilson, Ross L Coppel, Peter M Siba, Christopher L King, Motomi Torii, Chetan E Chitnis, David L Narum, Ivo Mueller, Brendan S Crabb, et al.

Journal article  |  2013  |  Journal of Immunology

Modulation of PF10_0355 (MSPDBL2) Alters Plasmodium falciparum Response to Antimalarial Drugs

Daria Van Tyne, Alessandro D Uboldi, Julie Healer, Alan F Cowman, Dyann F Wirth

Journal article  |  2013  |  Antimicrobial Agents and Chemotherapy

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

Anthony N Hodder, Peter E Czabotar, Alessandro D Uboldi, Oliver B Clarke, Clara S Lin, Julie Healer, Brian J Smith, Alan F Cowman

Journal article  |  2012  |  Journal of Biological Chemistry

Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum

Wai-Hong Tham, Julie Healer, Alan F Cowman

Journal article  |  2012  |  Trends in Parasitology

Discovery of GAMA, a Plasmodium falciparum Merozoite Micronemal Protein, as a Novel Blood-Stage Vaccine Candidate Antigen

Thangavelu U Arumugam, Satoru Takeo, Tsutomu Yamasaki, Amporn Thonkukiatkul, Kazutoyo Miura, Hitoshi Otsuki, Hong Zhou, Carole A Long, Jetsumon Sattabongkot, Jennifer Thompson, Danny W Wilson, James G Beeson, Julie Healer, Brendan S Crabb, Alan F Cowman, Motomi Torii, Takafumi Tsuboi

Journal article  |  2011  |  Infect. Immun.

The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparum

Tania F de Koning-Ward, Anna Olivieri, Lucia Bertuccini, Andrew Hood, Francesco Silvestrini, Konstantinos Charvalias, Pedro Berzosa Diaz, Grazia Camarda, Terry F McElwain, Tony Papenfuss, Julie Healer, Lucilla Baldassarri, Brendan S Crabb, Pietro Alano, Lisa C Ranford-Cartwright

Journal article  |  2008  |  Molecular Microbiology

Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum

Till S Voss, Christopher J Tonkin, Allison J Marty, Jennifer K Thompson, Julie Healer, Brendan S Crabb, Alan F Cowman

Journal article  |  2007  |  Molecular Microbiology

A conserved region in the EBL proteins is implicated in microneme targeting of the malaria parasite Plasmodium falciparum

Moritz Treeck, Nicole S Struck, Silvia Haase, Christine Langer, Susann Herrmann, Julie Healer, Alan F Cowman, Tim W Gilberger

Journal article  |  2006  |  Journal of Biological Chemistry

Transcribed var genes associated with placental malaria in Malawian women

Michael F Duffy, Aphrodite Caragounis, Rintis Noviyanti, Helen M Kyriacou, Ee Ken Choong, Katja Boysen, Julie Healer, J Alexandra Rowe, Malcolm E Molyneux, Graham V Brown, Stephen J Rogerson

Journal article  |  2006  |  Infection and Immunity

A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites

J Baum, D Richard, J Healer, M Rug, Z Krnajski, TW Gilberger, JL Green, AA Holder, AF Cowman

Journal article  |  2006  |  Journal of Biological Chemistry

Functional analysis of Plasmodium falciparum apical membrane antigen 1 utilizing interspecies domains

J Healer, T Triglia, AN Hodder, AW Gemmill, AF Cowman

Journal article  |  2005  |  Infection and Immunity

Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum

J Healer, V Murphy, AN Hodder, R Masciantonio, AW Gemmill, RF Anders, AF Cowman, A Batchelor

Journal article  |  2004  |  Mol. Microbiol.

Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species

T Triglia, J Healer, SR Caruana, AN Hodder, RF Anders, BS Crabb, AF Cowman

Journal article  |  2000  |  Molecular Microbiology

Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells

AF Cowman, DL Baldi, J Healer, KE Mills, RA O'Donnell, MB Reed, T Triglia, ME Wickham, BS Crabb

Journal article  |  2000  |  FEBS Letters

Transmission-blocking immunity to Plasmodium falciparum in malaria-immune individuals is associated with antibodies to the gamete surface protein Pfs230.

J Healer, D McGuinness, R Carter, E Riley

Journal article  |  1999  |  Parasitology

Malaria-immune human sera were tested for their ability to affect the infectivity of Plasmodium falciparum gametocytes to Anophele..

Phagocytosis does not play a major role in naturally acquired transmission-blocking immunity to Plasmodium falciparum malaria.

J Healer, A Graszynski, E Riley

Journal article  |  1999  |  Infection and Immunity

Phagocytosis of Plasmodium falciparum sexual stages in vitro and within the mosquito midgut was assayed in order to assess its rol..

Complement-mediated lysis of Plasmodium falciparum gametes by malaria-immune human sera is associated with antibodies to the gamete surface antigen Pfs230.

J Healer, D McGuinness, P Hopcroft, S Haley, R Carter, E Riley

Journal article  |  1997  |  Infection and Immunity

Antibodies to the sexual-stage surface antigens of Plasmodium falciparum, Pfs230 and Pfs48/45, can abolish the infectivity of game..

Characterization of proteolytic enzymes from larval and adult Nippostrongylus brasiliensis.

J Healer, F Ashall, RM Maizels

Journal article  |  1991  |  Parasitology

Proteases from infective larval (L3) and adult stages of Nippostrongylus brasiliensis were investigated with a combination of tech..