Jessica Bolden

A new lymphoid-primed progenitor marked byDach1downregulation identified with single cell multi-omics

Daniela Amann-Zalcenstein, Luyi Tian, Jaring Schreuder, Sara Tomei, Dawn S Lin, Kirsten A Fairfax, Jessica E Bolden, Mark D McKenzie, Andrew Jarratt, Adrienne Hilton, Jacob T Jackson, Ladina Di Rago, Matthew P McCormack, Carolyn A de Graaf, Olivia Stonehouse, Samir Taoudi, Warren S Alexander, Stephen L Nutt, Matthew E Ritchie, Ashley P Ng, et al.

Journal article  |  2020  |  NATURE IMMUNOLOGY

A classical view of blood cell development is that multipotent hematopoietic stem and progenitor cells (HSPCs) become lineage-rest..

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

Jarny Choi, Tracey M Baldwin, Mae Wong, Jessica E Bolden, Kirsten A Fairfax, Erin C Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A Ramsay, Ashley P Ng, Maria Kauppi, Lynn M Corcoran, Wei Shi, Nick Wilson, Michael J Wilson, Warren S Alexander, Douglas J Hilton, Carolyn A de Graaf

Journal article  |  2019  |  NUCLEIC ACIDS RESEARCH

During haematopoiesis, haematopoietic stem cells differentiate into restricted potential progenitors before maturing into the many..

Identification of a Siglec-F plus granulocyte-macrophage progenitor

Jessica E Bolden, Erin C Lucas, Geyu Zhou, Jeremy A O'Sullivan, Carolyn A de Graaf, Mark D McKenzie, Ladina Di Rago, Tracey M Baldwin, Jake Shortt, Warren S Alexander, Bruce S Bochner, Matthew E Ritchie, Douglas J Hilton, Kirsten A Fairfax

Journal article  |  2018  |  JOURNAL OF LEUKOCYTE BIOLOGY

In recent years multi-parameter flow cytometry has enabled identification of cells at major stages in myeloid development; from pl..

Transcriptional profiling of eosinophil subsets in interleukin-5 transgenic mice

Kirsten A Fairfax, Jessica E Bolden, Aaron J Robinson, Erin C Lucas, Tracey M Baldwin, Kerry A Ramsay, Rebecca Cole, Douglas J Hilton, Carolyn A de Graaf

Journal article  |  2018  |  JOURNAL OF LEUKOCYTE BIOLOGY

Eosinophils are important in fighting parasitic infections and are implicated in the pathogenesis of asthma and allergy. IL-5 is a..

Haemopedia: An Expression Atlas of Murine Hematopoietic Cells

Carolyn A De Graaf, Jarny Choi, Tracey M Baldwin, Jessica E Bolden, Kirsten A Fairfax, Aaron J Robinson, Christine Biben, Clare Morgan, Kerry Ramsay, Ashley P Ng, Maria Kauppi, Elizabeth A Kruse, Tobias J Sargeant, Nick Seidenman, Angela D'Amico, Marthe C D'Ombrain, Erin C Lucas, Sandra Koernig, Adriana Baz Morelli, Michael J Wilson, et al.

Journal article  |  2016  |  STEM CELL REPORTS

Hematopoiesis is a multistage process involving the differentiation of stem and progenitor cells into distinct mature cell lineage..

Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia

Margherita Ghisi, Lev Kats, Frederick Masson, Jason Li, Tobias Kratina, Eva Vidacs, Omer Gilan, Maria A Doyle, Andrea Newbold, Jessica E Bolden, Kirsten A Fairfax, Carolyn A de Graaf, Matthew Firth, Johannes Zuber, Ross A Dickins, Lynn M Corcoran, Mark A Dawson, Gabrielle T Belz, Ricky W Johnstone

Journal article  |  2016  |  CANCER CELL

E proteins and their antagonists, the Id proteins, are transcriptional regulators important for normal hematopoiesis. We found tha..

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance.

Nilgun Tasdemir, Ana Banito, Jae-Seok Roe, Direna Alonso-Curbelo, Matthew Camiolo, Darjus F Tschaharganeh, Chun-Hao Huang, Ozlem Aksoy, Jessica E Bolden, Chi-Chao Chen, Myles Fennell, Vishal Thapar, Agustin Chicas, Christopher R Vakoc, Scott W Lowe

Journal article  |  2016  |  Cancer Discov

UNLABELLED: Oncogene-induced senescence is a potent barrier to tumorigenesis that limits cellular expansion following certain onco..

Cellular Senescence

JE Bolden, SW Lowe

Book Chapter  |  2015

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.

Jessica E Bolden, Nilgun Tasdemir, Lukas E Dow, Johan H van Es, John E Wilkinson, Zhen Zhao, Hans Clevers, Scott W Lowe

Journal article  |  2014  |  Cell Rep

BET family proteins are novel therapeutic targets for cancer and inflammation and represent the first chromatin readers against wh..

Non-cell-autonomous tumor suppression by p53.

Amaia Lujambio, Leila Akkari, Janelle Simon, Danielle Grace, Darjus F Tschaharganeh, Jessica E Bolden, Zhen Zhao, Vishal Thapar, Johanna A Joyce, Valery Krizhanovsky, Scott W Lowe

Journal article  |  2013  |  Cell

The p53 tumor suppressor can restrict malignant transformation by triggering cell-autonomous programs of cell-cycle arrest or apop..