Gail Risbridger

A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells.

Jacqui A McGovern, Nathalie Bock, Abbas Shafiee, Laure C Martine, Ferdinand Wagner, Jeremy G Baldwin, Marietta Landgraf, Christoph A Lahr, Christoph Meinert, Elizabeth D Williams, Pamela M Pollock, Jim Denham, Pamela J Russell, Gail P Risbridger, Judith A Clements, Daniela Loessner, Boris M Holzapfel, Dietmar W Hutmacher

Journal article  |  2021  |  Commun Biol

Prostate cancer (PCa) is the second most commonly diagnosed cancer in men, and bone is the most frequent site of metastasis. The t..

CX-5461 sensitises DNA damage repair proficient castrate-resistant prostate cancer to PARP inhibition.

Mitchell G Lawrence, Laura H Porter, Nicholas Choo, David Pook, Jeremy P Grummet, Carmel J Pezaro, Shahneen Sandhu, Susanne Ramm, Jennii Luu, Andrew Bakshi, David L Goode, Elaine Sanij, Richard B Pearson, Ross D Hannan, Kaylene J Simpson, Renea A Taylor, Gail P Risbridger, Luc Furic

Journal article  |  2021  |  Mol Cancer Ther

Monotherapy with poly (ADP-ribose) polymerase (PARP) inhibitors is effective for the subset of castrate-resistant prostate cancer ..

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology

Gail P Risbridger, Ashlee K Clark, Laura H Porter, Roxanne Toivanen, Andrew Bakshi, Natalie L Lister, David Pook, Carmel J Pezaro, Shahneen Sandhu, Shivakumar Keerthikumar, Rosalia Quezada Urban, Melissa Papargiris, Jenna Kraska, Heather B Madsen, Hong Wang, Michelle G Richards, Birunthi Niranjan, Samantha O'Dea, Linda Teng, William Wheelahan, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-d..

High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids

Nicholas Choo, Susanne Ramm, Jennii Luu, Jean M Winter, Luke A Selth, Amy R Dwyer, Mark Frydenberg, Jeremy Grummet, Shahneen Sandhu, Theresa E Hickey, Wayne D Tilley, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence, Kaylene J Simpson

Journal article  |  2021  |  SLAS DISCOVERY

New treatments are required for advanced prostate cancer; however, there are fewer preclinical models of prostate cancer than othe..

Preclinical Evidence of the Efficacy of Lewis Y Car T Cells in Patient-Derived Models of Prostate Cancer

Gail Petuna Risbridger, Laura Helen Porter, Joe Zhu, David Byrne, Natalie Lister, Arun Azad, Michael Hofman, Ian Vela, Renea A Taylor, Paul Neeson, Phil Darcy, Joseph Trapani

Conference Proceedings  |  2021  |  Journal of the Endocrine Society

Abstract Chimeric antigen receptor T (CAR T) cell therapy is an adoptive immunotherapy that has led to new treatmen..

Androgen receptor enhancer amplification in matched patient-derived xenografts of primary and castrate-resistant prostate cancer

Laura H Porter, Andrew Bakshi, David Pook, Ashlee Clark, David Clouston, John Kourambas, David L Goode, Gail P Risbridger, Renea A Taylor, Mitchell G Lawrence

Journal article  |  2021  |  JOURNAL OF PATHOLOGY

Amplifications of the androgen receptor (AR) occur in up to 80% of men with castration-resistant prostate cancer (CRPC). Recent st..

Oxytocin receptor antagonists as a novel pharmacological agent for reducing smooth muscle tone in the human prostate

Sophie N Lee, Jenna Kraska, Melissa Papargiris, Linda Teng, Birunthi Niranjan, Johanna Hammar, Andrew Ryan, Mark Frydenberg, Nathan Lawrentschuk, Ralf Middendorff, Stuart J Ellem, Michael Whittaker, Gail P Risbridger, Betty Exintaris

Journal article  |  2021  |  SCIENTIFIC REPORTS

Pharmacotherapies for the treatment of Benign Prostatic Hyperplasia (BPH) are targeted at reducing cellular proliferation (static ..

Mast Cell-Derived SAMD14 Is a Novel Regulator of the Human Prostate Tumor Microenvironment

Linda KH Teng, Brooke A Pereira, Shivakumar Keerthikumar, Cheng Huang, Birunthi Niranjan, Sophie N Lee, Michelle Richards, Ralf B Schittenhelm, Luc Furic, David L Goode, Mitchell G Lawrence, Renea A Taylor, Stuart J Ellem, Gail P Risbridger, Natalie L Lister

Journal article  |  2021  |  CANCERS

Mast cells (MCs) are important cellular components of the tumor microenvironment and are significantly associated with poor patien..

Epigenetic regulation of OCT1 in multidrug-resistant patient-derived prostate cancer cells

Daisuke Obinata, Ken-ichi Takayama, Yutaka Suzuki, Mitchell Lawrence, Renea Taylor, Shahneen Sandhu, Gail Risbridger, Satoru Takahashi, Satoshi Inoue

Conference Proceedings  |  2021  |  CANCER SCIENCE

Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

Rayzel C Fernandes, John Toubia, Scott Townley, Adrienne R Hanson, B Kate Dredge, Katherine A Pillman, Andrew G Bert, Jean M Winter, Richard Iggo, Rajdeep Das, Daisuke Obinata, Shahneen Sandhu, Gail P Risbridger, Renea A Taylor, Mitchell G Lawrence, Lisa M Butler, Amina Zoubeidi, Philip A Gregory, Wayne D Tilley, Theresa E Hickey, et al.

Journal article  |  2021  |  CELL REPORTS

Potent therapeutic inhibition of the androgen receptor (AR) in prostate adenocarcinoma can lead to the emergence of neuroendocrine..