Lucy Sullivan

Ribosylation of the CD8αβ heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10.

Katharine Jennifer Goodall, Angela Nguyen, Daniel Mark Andrews, Lucy Catherine Sullivan

Journal article  |  2021  |  J Biol Chem

The CD8αβ heterodimer plays a crucial role in the stabilization between major histocompatibility complex class I molecules (MHC-I)..

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

Shoeib Moradi, Sanda Stankovic, Geraldine M O'Connor, Phillip Pymm, Bruce J MacLachlan, Camilla Faoro, Christelle Retiere, Lucy C Sullivan, Philippa M Saunders, Jacqueline Widjaja, Shea Cox-Livingstone, Jamie Rossjohn, Andrew G Brooks, Julian P Vivian

Journal article  |  2021  |  NATURE COMMUNICATIONS

The closely related inhibitory killer-cell immunoglobulin-like receptors (KIR), KIR2DL2 and KIR2DL3, regulate the activation of na..

Natural killer cell receptors regulate responses of HLA-E-restricted T cells

Lucy C Sullivan, Thi HO Nguyen, Christopher M Harpur, Sanda Stankovic, Abbie R Kanagarajah, Marios Koutsakos, Philippa M Saunders, Zhangying Cai, James A Gray, Jacqueline ML Widjaja, Jie Lin, Gabriella Pietra, Maria Cristina Mingari, Lorenzo Moretta, Jerome Samir, Fabio Luciani, Glen P Westall, Karl J Malmberg, Katherine Kedzierska, Andrew G Brooks

Journal article  |  2021  |  SCIENCE IMMUNOLOGY

Human cytomegalovirus (CMV) infection can stimulate robust human leukocyte antigen (HLA)-E-restricted CD8+ T cell responses. These..

Evaluation of Quantiferon (R)-Monitor as a biomarker of immunosuppression and predictor of infection in lung transplant recipients

Bradley J Gardiner, Sue J Lee, Yvonne Cristiano, Bronwyn J Levvey, Lucy C Sullivan, Gregory Snell, Anton Y Peleg, Glen P Westall

Journal article  |  2021  |  TRANSPLANT INFECTIOUS DISEASE

BACKGROUND: Optimizing immunosuppression in lung transplant recipients (LTR) is crucially important in minimizing the risk of infe..

Novel high-affinity EGFRvIII-specific chimeric antigen receptor T cells effectively eliminate human glioblastoma

Rebecca C Abbott, Daniel J Verdon, Fiona M Gracey, Hannah E Hughes-Parry, Melinda Iliopoulos, Katherine A Watson, Matthias Mulazzani, Kylie Luong, Colleen D'Arcy, Lucy C Sullivan, Ben R Kiefel, Ryan S Cross, Misty R Jenkins

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: The increasing success of Chimeric Antigen Receptor (CAR) T cell therapy in haematological malignancies is reinvigorat..

Erratum: Novel high-affinity EGFRvIII-specific chimeric antigen receptor T cells effectively eliminate human glioblastoma.

Rebecca C Abbott, Daniel J Verdon, Fiona M Gracey, Hannah E Hughes-Parry, Melinda Iliopoulos, Katherine A Watson, Matthias Mulazzani, Kylie Luong, Colleen D'Arcy, Lucy C Sullivan, Ben R Kiefel, Ryan S Cross, Misty R Jenkins

Journal article  |  2021  |  Clin Transl Immunology

[This corrects the article DOI: 10.1002/cti2.1283.].

Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8( ) T cells

Thi HO Nguyen, Julie L McAuley, Youry Kim, Ming ZM Zheng, Nicholas A Gherardin, Dale Godfrey, Damian FJ Purcell, Lucy C Sullivan, Glen P Westall, Patrick C Reading, Katherine Kedzierska, Linda M Wakim

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Older individuals exhibit a diminished ability to respond to and clear respiratory pathogens and, as such, experience a higher rat..

Cytomegalovirus replication is associated with enrichment of distinct g 8 T cell subsets following lung transplantation: A novel therapeutic approach?

Sanda Stankovic, Martin S Davey, Evangeline M Shaw, Anouk von Borstel, Yvonne Cristiano, Bronwyn J Levvey, Jamie Rossjohn, Glen P Westall, Gregory I Snell, Andrew G Brooks, Lucy C Sullivan

Journal article  |  2020  |  JOURNAL OF HEART AND LUNG TRANSPLANTATION

BACKGROUND: Anti-viral treatments to control cytomegalovirus (CMV) after lung transplantation (LTx) are associated with toxicity a..

Harnessing HLA-E-restricted CD8 T lymphocytes for adoptive cell therapy of patients with severe COVID-19

Nadia Caccamo, Lucy C Sullivan, Andrew G Brooks, Francesco Dieli

Journal article  |  2020  |  BRITISH JOURNAL OF HAEMATOLOGY

SARS-CoV-2 is spreading worldwide, and is a pandemic virus that has infected almost 5 million individuals and causing 300.000 deat..

Natural Killer (NK) Cells: The Missing Link between Antibody-Mediated Rejection (ABMR) and Chronic Lung Allograft Dysfunction (CLAD)?

CM Fernandes Monteiro, DC Walton, Y Cristiano, BJ Levvey, GI Snell, GP Westall, AG Brooks, LC Sullivan

Conference Proceedings  |  2020  |  JOURNAL OF HEART AND LUNG TRANSPLANTATION

PURPOSE: The long-term success of lung transplantation (LTx) is limited by CLAD. The complement-independent pathway of ABMR, drive..