Lucy Sullivan

Natural killer cell receptors regulate responses of HLA-E-restricted T cells.

Lucy C Sullivan, Thi HO Nguyen, Christopher M Harpur, Sanda Stankovic, Abbie R Kanagarajah, Marios Koutsakos, Philippa M Saunders, Zhangying Cai, James A Gray, Jacqueline ML Widjaja, Jie Lin, Gabriella Pietra, Maria Cristina Mingari, Lorenzo Moretta, Jerome Samir, Fabio Luciani, Glen P Westall, Karl J Malmberg, Katherine Kedzierska, Andrew G Brooks

Journal article  |  2021  |  Science Immunology

Human cytomegalovirus (CMV) infection can stimulate robust human leukocyte antigen (HLA)-E-restricted CD8+ T cell responses. These..

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C.

Shoeib Moradi, Sanda Stankovic, Geraldine M O'Connor, Phillip Pymm, Bruce J MacLachlan, Camilla Faoro, Christelle Retière, Lucy C Sullivan, Philippa M Saunders, Jacqueline Widjaja, Shea Cox-Livingstone, Jamie Rossjohn, Andrew G Brooks, Julian P Vivian

Journal article  |  2021  |  Nature Communications

The closely related inhibitory killer-cell immunoglobulin-like receptors (KIR), KIR2DL2 and KIR2DL3, regulate the activation of na..

Evaluation of Quantiferon (R)-Monitor as a biomarker of immunosuppression and predictor of infection in lung transplant recipients

Bradley J Gardiner, Sue J Lee, Yvonne Cristiano, Bronwyn J Levvey, Lucy C Sullivan, Gregory Snell, Anton Y Peleg, Glen P Westall

Journal article  |  2021  |  Transplant Infectious Disease

BACKGROUND: Optimizing immunosuppression in lung transplant recipients (LTR) is crucially important in minimizing the risk of infe..

Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8( ) T cells

Thi HO Nguyen, Julie L McAuley, Youry Kim, Ming ZM Zheng, Nicholas A Gherardin, Dale Godfrey, Damian FJ Purcell, Lucy C Sullivan, Glen P Westall, Patrick C Reading, Katherine Kedzierska, Linda M Wakim

Journal article  |  2021  |  Clinical and Translational Immunology

Older individuals exhibit a diminished ability to respond to and clear respiratory pathogens and, as such, experience a higher rat..

Cytomegalovirus replication is associated with enrichment of distinct g 8 T cell subsets following lung transplantation: A novel therapeutic approach?

Sanda Stankovic, Martin S Davey, Evangeline M Shaw, Anouk von Borstel, Yvonne Cristiano, Bronwyn J Levvey, Jamie Rossjohn, Glen P Westall, Gregory I Snell, Andrew G Brooks, Lucy C Sullivan

Journal article  |  2020  |  Journal of Heart and Lung Transplantation

BACKGROUND: Anti-viral treatments to control cytomegalovirus (CMV) after lung transplantation (LTx) are associated with toxicity a..

Harnessing HLA-E-restricted CD8 T lymphocytes for adoptive cell therapy of patients with severe COVID-19

Nadia Caccamo, Lucy C Sullivan, Andrew G Brooks, Francesco Dieli

Journal article  |  2020  |  British Journal of Haematology

SARS-CoV-2 is spreading worldwide, and is a pandemic virus that has infected almost 5 million individuals and causing 300.000 deat..

Natural Killer (NK) Cells: The Missing Link between Antibody-Mediated Rejection (ABMR) and Chronic Lung Allograft Dysfunction (CLAD)?

CM Fernandes Monteiro, DC Walton, Y Cristiano, BJ Levvey, GI Snell, GP Westall, AG Brooks, LC Sullivan

Conference Proceedings  |  2020  |  The Journal of Heart and Lung Transplantation

A Potential Role for NKG2C gamma delta T Cells as a Cellular Therapy in Combating Post-Lung Transplant Cytomegalovirus Infection

S Stankovic, MS Davey, EM Shaw, Y Cristiano, GI Snell, GP Westall, AG Brooks, LC Sullivan

Conference Proceedings  |  2020  |  The Journal of Heart and Lung Transplantation

HLA Epitope Mismatch Load (epMM) Allows Classification of Immunological Risk and Correlates with Patient Survival Following Lung Transplantation (LTx)

SJ Hiho, MA Paraskeva, DC Walton, MB Diviney, BJ Levvey, GI Snell, LC Sullivan, GP Westall

Conference Proceedings  |  2020  |  The Journal of Heart and Lung Transplantation

Can Avoiding So-Called HLA High Risk Epitope Mismatches (REM) Improve Lung Transplant (LTx) Outcomes?

SJ Hiho, MA Paraskeva, DC Walton, MB Diviney, BJ Levvey, GI Snell, LC Sullivan, GP Westall

Conference Proceedings  |  2020  |  The Journal of Heart and Lung Transplantation