Philippa Saunders

The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function

Philippa M Saunders, Bruce J MacLachlan, Phillip Pymm, Patricia T Illing, Yuanchen Deng, Shu Cheng Wong, Clare VL Oates, Anthony W Purcell, Jamie Rossjohn, Julian P Vivian, Andrew G Brooks

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

Micropolymorphisms within human leukocyte antigen (HLA) class I molecules can change the architecture of the peptide-binding cleft..

THE ALLOTYPIC ARCHITECTURE OF HLA-B57 ALLOTYPES ALTERS PEPTIDE CONFORMATION TO REGULATE INHIBITION OF NK CELL ACTIVATION THROUGH KIR3DL1

Andrew G Brooks, Philippa M Saunders, Philip Pymm, Jacqueline ML Widjaja, Jie Lin, Jamie Rossjohn, Julian P Vivian

Conference Proceedings  |  2018  |  HLA

Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

Maureen P Martin, Vivek Naranbhai, Patrick R Shea, Ying Qi, Veron Ramsuran, Nicolas Vince, Xiaojiang Gao, Rasmi Thomas, Zabrina L Brumme, Jonathan M Carlson, Steven M Wolinsky, James J Goedert, Bruce D Walker, Florencia P Segal, Steven G Deeks, David W Haas, Stephen A Migueles, Mark Connors, Nelson Michael, Jacques Fellay, et al.

Journal article  |  2018  |  Journal of Clinical Investigation

Host Cell Restriction Factors that Limit Influenza A Infection

Fernando Villalon-Letelier, Andrew G Brooks, Philippa M Saunders, Sarah L Londrigan, Patrick C Reading

Journal article  |  2017  |  Viruses

A prominent role of PDIA6 in processing of misfolded proinsulin

Dhana G Gorasia, Nadine L Dudek, Helena Safavi-Hemami, Rochelle Ayala Perez, Ralf B Schittenhelm, Philippa M Saunders, Sheena Wee, Jon E Mangum, Michael J Hubbard, Anthony W Purcell

Journal article  |  2016  |  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition

Philippa M Saunders, Phillip Pymm, Gabriella Pietra, Victoria A Hughes, Corinne Hitchen, Geraldine M O'Connor, Fabrizio Loiacono, Jacqueline Widjaja, David A Price, Michela Falco, Maria Cristina Mingari, Lorenzo Moretta, Daniel W McVicar, Jamie Rossjohn, Andrew G Brooks, Julian P Vivian

Journal article  |  2016  |  Journal of Experimental Medicine

A bird's eye view of NK cell receptor interactions with their MHC class I ligands

Philippa M Saunders, Julian P Vivian, Geraldine M O'Connor, Lucy C Sullivan, Phillip Pymm, Jamie Rossjohn, Andrew G Brooks

Journal article  |  2015  |  Immunological Reviews

The Interaction of KIR3DL1*001 with HLA Class I Molecules Is Dependent upon Molecular Microarchitecture within the Bw4 Epitope

Philippa M Saunders, Julian P Vivian, Nikola Baschuk, Travis Beddoe, Jacqueline Widjaja, Geraldine M O'Connor, Corinne Hitchen, Phillip Pymm, Daniel M Andrews, Stephanie Gras, Daniel W McVicar, Jamie Rossjohn, Andrew G Brooks

Journal article  |  2015  |  The Journal of Immunology

The Structure of the Cytomegalovirus-Encoded m04 Glycoprotein, a Prototypical Member of the m02 Family of Immunoevasins

Richard Berry, Julian P Vivian, Felix A Deuss, Gautham R Balaji, Philippa M Saunders, Jie Lin, Dene R Littler, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2014  |  Journal of Biological Chemistry

Targeting of a natural killer cell receptor family by a viral immunoevasin

Richard Berry, Natasha Ng, Philippa M Saunders, Julian P Vivian, Jie Lin, Felix A Deuss, Alexandra J Corbett, Catherine A Forbes, Jacqueline M Widjaja, Lucy C Sullivan, Adrian D McAlister, Matthew A Perugini, Melissa J Call, Anthony A Scalzo, Mariapia A Degli-Esposti, Jerome D Coudert, Travis Beddoe, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2013  |  Nature Immunology

Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes

Soumya Badrinath, Philippa Saunders, Trevor Huyton, Susanne Aufderbeck, Oliver Hiller, Rainer Blasczyk, Christina Bade-Doeding

Journal article  |  2012  |  Haematologica

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B

Julian P Vivian, Renee C Duncan, Richard Berry, Geraldine M O'Connor, Hugh H Reid, Travis Beddoe, Stephanie Gras, Philippa M Saunders, Maya A Olshina, Jacqueline ML Widjaja, Christopher M Harpur, Jie Lin, Sebastien M Maloveste, David A Price, Bernard AP Lafont, Daniel W McVicar, Craig S Clements, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2011  |  Nature

T Cell Allorecognition via Molecular Mimicry

Whitney A Macdonald, Zhenjun Chen, Stephanie Gras, Julia K Archbold, Fleur E Tynan, Craig S Clements, Mandvi Bharadwaj, Lars Kjer-Nielsen, Philippa M Saunders, Matthew CJ Wilce, Fran Crawford, Brian Stadinsky, David Jackson, Andrew G Brooks, Anthony W Purcell, John W Kappler, Scott R Burrows, Jamie Rossjohn, James McCluskey

Journal article  |  2009  |  Immunity