Rhys Allan

Survey of activation-induced genome architecture reveals a novel enhancer of Myc

Wing Fuk Chan, Hannah D Coughlan, Michelle Ruhle, Nadia Iannarella, Carolina Alvarado, Joanna R Groom, Christine R Keenan, Andrew J Kueh, Adam K Wheatley, Gordon K Smyth, Rhys S Allan, Timothy M Johanson

Journal article  |  2023  |  IMMUNOLOGY AND CELL BIOLOGY

The transcription factor Myc is critically important in driving cell proliferation, a function that is frequently dysregulated in ..

CIS controls the functional polarization of GM-CSF-derived macrophages

Shengbo Zhang, Jai Rautela, Naiara G Bediaga, Tatiana B Kolesnik, Yue You, Junli Nie, Laura F Dagley, Justin Bedo, Hanqing Wang, Li Sun, Robyn Sutherland, Elliot Surgenor, Nadia Iannarella, Rhys Allan, Fernando Souza-Fonseca-Guimaraes, Yi Xie, Qike Wang, Yuxia Zhang, Yuekang Xu, Stephen L Nutt, et al.

Journal article  |  2022  |  CELLULAR & MOLECULAR IMMUNOLOGY

The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the capacity to differentiate monocytes into macr..

Activation of stably silenced genes by recruitment of a synthetic de-methylating module

Wing Fuk Chan, Hannah D Coughlan, Yunshun Chen, Christine R Keenan, Gordon K Smyth, Andrew C Perkins, Timothy M Johanson, Rhys S Allan

Journal article  |  2022  |  NATURE COMMUNICATIONS

Stably silenced genes that display a high level of CpG dinucleotide methylation are refractory to the current generation of dCas9-..

In Situ HiC.

Timothy M Johanson, Rhys S Allan

Book Chapter  |  2022  |  Methods in Molecular Biology

In situ HiC uses the relative frequency of DNA-DNA ligation events to reconstruct the three-dimensional architecture of a genome. ..

Parsing the transcription factors governing T cell immunity

Timothy M Johanson, Rhys S Allan

Journal article  |  2021  |  NATURE IMMUNOLOGY

Shedding Structured Light on Molecular Immunity: The Past, Present and Future of Immune Cell Super Resolution Microscopy

Timothy M Johanson, Christine R Keenan, Rhys S Allan

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

In the two decades since the invention of laser-based super resolution microscopy this family of technologies has revolutionised t..

BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia

Emma M Carrington, Cynthia Louis, Tobias Kratina, Manuela Hancock, Christine R Keenan, Nadia Iannarella, Rhys S Allan, Ahmad Z Wardak, Peter E Czabotar, Marco J Herold, Robyn L Schenk, Christine A White, Damian D'Silva, Yuyan Yang, Wesley Wong, Huon Wong, Vanessa L Bryant, Nicholas D Huntington, Jai Rautela, Robyn M Sutherland, et al.

Journal article  |  2021  |  BLOOD ADVANCES

Neutrophils help to clear pathogens and cellular debris, but can also cause collateral damage within inflamed tissues. Prolonged n..

A microRNA expression and regulatory element activity atlas of the mouse immune system

Samuel A Rose, Aleksandra Wroblewska, Maxime Dhainaut, Hideyuki Yoshida, Jonathan M Shaffer, Anela Bektesevic, Benjamin Ben-Zvi, Andrew Rhoads, Edy Y Kim, Bingfei Yu, Yonit Lavin, Miriam Merad, Jason D Buenrostro, Brian D Brown

Journal article  |  2021  |  NATURE IMMUNOLOGY

To better define the control of immune system regulation, we generated an atlas of microRNA (miRNA) expression from 63 mouse immun..

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Simon J Hogg, Olga Motorna, Leonie A Cluse, Timothy M Johanson, Hannah D Coughlan, Ramya Raviram, Robert M Myers, Matteo Costacurta, Izabela Todorovski, Lizzy Pijpers, Stefan Bjelosevic, Tobias Williams, Shannon N Huskins, Conor J Kearney, Jennifer R Devlin, Zheng Fan, Jafar S Jabbari, Ben P Martin, Mohamed Fareh, Madison J Kelly, et al.

Journal article  |  2021  |  MOLECULAR CELL

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigen..

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Ricardo Grieshaber-Bouyer, Felix A Radtke, Pierre Cunin, Giuseppina Stifano, Anais Levescot, Brinda Vijaykumar, Nathan Nelson-Maney, Rachel B Blaustein, Paul A Monach, Peter A Nigrovic

Journal article  |  2021  |  NATURE COMMUNICATIONS

Neutrophils are implicated in multiple homeostatic and pathological processes, but whether functional diversity requires discrete ..