Mary-Jane Gething

Lobe IB of the ATPase domain of Kar2p/BiP interacts with Ire1p to negatively regulate the unfolded protein response in Saccharomyces cerevisiae

Alicia Todd-Corlett, Ellene Jones, Conrad Seghers, Mary-Jane Gething

Journal article  |  2007  |  JOURNAL OF MOLECULAR BIOLOGY

The endoplasmic reticulum HSP70 chaperone BiP/Kar2p is both the sensor for the unfolded protein response (UPR) in the yeast Saccha..

SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiae

Bhupinder Pal, Nickie C Chan, Leon Helfenbaum, Kaeling Tan, William P Tansey, Mary-Jane Gething

Journal article  |  2007  |  MOLECULAR BIOLOGY OF THE CELL

The Saccharomyces cerevisiae basic leucine zipper transcription factor Hac1p is synthesized in response to the accumulation of unf..

The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins

Laurence Goffin, Sadanand Vodala, Christine Fraser, Joanne Ryan, Mark Timms, Sarina Meusburger, Bruno Catimel, Edouard C Nice, Pamela A Silver, Chong-Yun Xiao, David A Jans, Mary-Jane H Gething

Journal article  |  2006  |  MOLECULAR BIOLOGY OF THE CELL

The Ire1p transmembrane receptor kinase/endonuclease transduces the unfolded protein response (UPR) from the endoplasmic reticulum..

Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity?

AW Purcell, A Todd, G Kinoshita, TA Lynch, CL Keech, MJ Gething, TP Gordon

Journal article  |  2003  |  CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Patterns of autoantibody production are diagnostic of many autoimmune disorders; the recent observation of additional autospecific..

The yeast inositol polyphosphate 5-phosphatase Inp54p localizes to the endoplasmic reticulum via a C-terminal hydrophobic anchoring tail. Regulation of secretion from the endoplasmic reticulum

F Wiradjaja, LM Ooms, JC Whisstock, B McColl, L Helfenbaum, JF Sambrook, MJ Gething, CA Mitchell

Journal article  |  2001  |  Journal of Biological Chemistry

The budding yeast Saccharomyces cerevisiae has four inositol polyphosphate 5-phosphatase (5-phosphatase) genes, INP51, INP52, INP5..