Linda Earnest

Air-Liquid-Interface Differentiated Human Nose Epithelium: A Robust Primary Tissue Culture Model of SARS-CoV-2 Infection

Bang M Tran, Samantha L Grimley, Julie L McAuley, Abderrahman Hachani, Linda Earnest, Sharon L Wong, Leon Caly, Julian Druce, Damian FJ Purcell, David C Jackson, Mike Catton, Cameron J Nowell, Laura Leonie, Georgia Deliyannis, Shafagh A Waters, Joseph Torresi, Elizabeth Vincan

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The global urgency to uncover medical countermeasures to combat the COVID-19 pandemic caused by the severe acute respiratory syndr..

Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models

Michelle P Clark, Thao Huynh, Shringar Rao, Liana Mackiewicz, Hugh Mason, Shahla Romal, Michael D Stutz, Sang H Ahn, Linda Earnest, Vitina Sozzi, Margaret Littlejohn, Bang M Tran, Norbert Wiedemann, Elizabeth Vincan, Joseph Torresi, Hans J Netter, Tokameh Mahmoudi, Peter Revill, Marc Pellegrini, Gregor Ebert

Journal article  |  2021  |  CELL DEATH & DISEASE

A major unmet clinical need is a therapeutic capable of removing hepatitis B virus (HBV) genome from the liver of infected individ..

Investigating virus-host cell interactions: Comparative binding forces between hepatitis C virus-like particles and host cell receptors in 2D and 3D cell culture models

Simon Collett, Joseph Torresi, Linda Earnest Silveira, Vi Khanh Truong, Dale Christiansen, Bang M Tran, Elizabeth Vincan, Paul A Ramsland, Aaron Elbourne

Journal article  |  2021  |  JOURNAL OF COLLOID AND INTERFACE SCIENCE

Cell cultures have been successfully used to study hepatitis C virus (HCV) for many years. However, most work has been done using ..

HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models

Joseph Torresi, Manh Tran Bang, Dale Christiansen, Linda Earnest-Silveira, Renate Hilda Marianne Schwab, Elizabeth Vincan

Journal article  |  2019  |  BMC CANCER

BACKGROUND: Hepatitis B virus (HBV) is the leading cause of liver cancer, but the mechanisms by which HBV causes liver cancer are ..

Pre-clinical evaluation of a quadrivalent HCV VLP vaccine in pigs following microneedle delivery

D Christiansen, L Earnest-Silveira, B Grubor-Bauk, DK Wijesundara, I Boo, PA Ramsland, E Vincan, HE Drummer, EJ Gowans, J Torresi

Journal article  |  2019  |  SCIENTIFIC REPORTS

The introduction of directly acting antiviral agents (DAAs) has produced significant improvements in the ability to cure chronic h..

Probing and pressing surfaces of hepatitis C virus-like particles

Simon Collett, Joseph Torresi, Linda Earnest-Silveira, Dale Christiansen, Aaron Elbourne, Paul A Ramsland

Journal article  |  2019  |  JOURNAL OF COLLOID AND INTERFACE SCIENCE

Hepatitis C virus-like particles (VLPs) are being developed as a quadrivalent vaccine candidate, eliciting both humoral and cellul..

A Hepatitis C Virus DNA Vaccine Encoding a Secreted, Oligomerized Form of Envelope Proteins Is Highly Immunogenic and Elicits Neutralizing Antibodies in Vaccinated Mice

Makutiro Ghislain Masavuli, Danushka K Wijesundara, Alexander Underwood, Dale Christiansen, Linda Earnest-Silveira, Rowena Bull, Joseph Torresi, Eric J Gowans, Branka Grubor-Bauk

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Hepatitis C virus (HCV) persistently infects approximately 71 million people globally. To prevent infection a vaccine which elicit..

Immunological responses following administration of a genotype 1a/1b/2/3a quadrivalent HCV VLP vaccine

D Christiansen, L Earnest-Silveira, B Chua, P Meuleman, I Boo, B Grubor-Bauk, DC Jackson, ZY Keck, SKH Foung, HE Drummer, EJ Gowans, J Torresi

Journal article  |  2018  |  SCIENTIFIC REPORTS

The significant public health problem of Hepatitis C virus (HCV) has been partially addressed with the advent of directly acting a..

Antibody Responses to a Quadrivalent Hepatitis C Viral-Like Particle Vaccine Adjuvanted with Toll-Like Receptor 2 Agonists

Dale Christiansen, Linda Earnest-Silveira, Brendon Chua, Irene Boo, Heidi E Drummer, Branka Grubor-Bauk, Eric J Gowans, David C Jackson, Joseph Torresi

Journal article  |  2018  |  VIRAL IMMUNOLOGY

The development of an effective preventative hepatitis C virus (HCV) vaccine will reside, in part, in its ability to elicit neutra..

Large scale production of a mammalian cell derived quadrivalent hepatitis C virus like particle vaccine

L Earnest-Silveira, D Christiansen, S Herrmann, SA Ralph, S Das, EJ Gowans, J Torresi

Journal article  |  2016  |  JOURNAL OF VIROLOGICAL METHODS

A method for the large-scale production of a quadrivalent mammalian cell derived hepatitis C virus-like particles (HCV VLPs) is de..