Prof Stephen Tong

Professor Stephen Tong is a clinician scientist with a strong interest in translational research. He heads The Translational Obstetrics Group which focuses on developing concepts in the laboratory, and taking these to clinical trials.

His team is involved in three streams of laboratory studies. All three themes have lead to laboratory discoveries which they have taken to international clinical trials/prospective studies: therapeutics for ectopic pregnancy and pre-eclampsia, and non-invasive biomarkers for pregnancy complications. They have developed a medical treatment for ectopic pregnancy that has progressed from preclinical studies to phase I and II clinical trials (performed collaboration with Edinburgh, United Kingdom). They have developed a preclinical screening approach to identify candidate drugs to treat pre-eclampsia. Using this laboratory screening, they have identified a new treatment that they will soon test in a phase II randomised clinical trial in South Africa. Also, The Translational Obstetrics Group has developed a potential non-invasive biomarker test to identify fetuses’ critically hypoxic in utero and in danger of stillbirth. His team is currently running a large multi-centre study that is recruiting participants across eight major referral hospitals in Australia and New Zealand. Prof Tong has published 85-100 peer-reviewed publications. Most are published in leading specialists of his field and in prestigious interdisciplinary journals. He has previously published in The Lancet and Nature. Professor Tong currently holds four NHMRC project grants. He also holds a Clinical Career Development Fellowship Level II. He has also obtained significantly philanthropic funding. He has received two NHMRC Achievement Awards, one in 2007 (Top Ranked Clinical CDA I) and another in 2012 (Top ranked Clinical CDF II).

Find out more about Stephen Tong's experience

Stephen Tong's highlights

FEATURED Journal article

Association between maternal serum cytokine profiles at 7-10 weeks' gestation and birthweight in small for gestational age infants

Stephen Tong's selected work

Exploring The Association Between Circulating Markers Placental Insufficiency At 26-28 Wee..

Research Contracts

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and dimin..

Journal article

Developing New Diagnostics To Prevent Stillbirth

Research Grant

Aspirin use during pregnancy and the risk of bleeding complications: a Swedish population-..

Journal article

Developing New Diagnostics To Prevent Stillbirth

Research Grant

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic f..

Journal article

Projects

Displaying the 48 most recent projects by Stephen Tong.

Exploring The Association Between Circulating Markers Placental Insufficiency At 26-28 Weeks Gestation And Neonatal And Childhood Health: Gusto Cohort

2020 - 2025

Active

Validation Of Lead Marker, Splntl, In New Cohorts And Investigatlon Of 11 Additional Identified Proteins

2019 - 2020

Active

Metabolomics To Identify Pregnancies At Risk Of Fetal Growth Restriction Or Preeclampsia

2019 - 2019

Completed

Is Elevated Endothelin-1 A Reliable Marker Of Preeclampsia And Fetal Growth Restriction

2019 - 2020

Active

Identifying New Biomarkers To Predict Preeclampsia And Fetal Growth Restriction

2018 - 2020

Completed

Developing A Diagnostic Blood Test At 36 Weeks To Identify Unsuspected Fetal Growth Restriction

2018 - 2020

Completed

Apple Pie Trial

2018 - 2023

Active

Validating Mrna Biomarkers To Predict Fetal Growth Restriction

2018 - 2019

Completed

Developing A Biomarker To Prevent Stillbirth

2018 - 2019

Completed

Translating New Therapeutics And Diagnostics For Major Pregnancy Complications

My research is focussed on tackling major complications of pregnancy that are a threat to the lives of both mother’s and babies. We are deve..

2018 - 2022

Active

New Ways To Identify Fetal Macrosomia In Late Pregnancy

2017 - 2017

Completed

Identifying Biomakers For Prediction Of Preeclampsia At 28 Weeks Gestation

2017 - 2017

Completed

Treating Preterm Preeclampsia With Sulfasalazine: An Early Phase Clinical Trial

2017 - 2018

Completed

New Generation Antiplatelet Therapy To Prevent Preeclampsia

Preeclampsia, a major complication of pregnancy, affects around 3-8% of pregnancies. Sadly, there is no way to prevent or delay disease. We ..

2017 - 2019

Completed

Nanomedicine Targeted Delivery Of Therapeutics To The Placenta To Treat Preeclampsia

Preeclampsia, one of the most serious complications of pregnancy, affects around 3-8% of all pregnancies. Sadly, there is no treatment. We h..

2017 - 2020

Active

From Pathogenesis To Therapeutics: Targeting Two Signalling Pathways As A Therapeutic Strategy To Treat Preeclampsia

Preeclampsia is a serious complication of pregnancy that claims the lives of thousands of mothers and babies each year. There is no efficaci..

2017 - 2020

Active

Development Of Vinorelbine As A Tablet Based Therapy To Cure Ectopic Pregnancies

Ectopic pregnancies occur if the pregnancy implants in the Fallopian tube. They can be deadly and most are treated surgically. We will exami..

2017 - 2020

Active

Identify Unsuspected Fetal Growth Restriction (Fgr)

2016 - 2018

Completed

Preeclampsia Therapeutics Screening Of Gsk Small Molecules

2016 - 2017

Completed

Gem3

2016 - 2019

Completed

Fetal Longtitudinal Assessment Of Growth (Flag) Study

2016 - 2017

Completed

Noninvasive Prenatal Testing (Nipt) To Detect Early Stage Ovarian Cancer (The Neo Study)

2016 - 2018

Completed

Systematic Screening Approach To Identify New Therapeutics For Preeclampsia

Preeclampsia is a pregnancy complication where factors are released from the placenta into the mum's bloodstream, causing widespread blood v..

2016 - 2019

Completed

Sulfasalazine - A Novel Treatment Option For Preclampsia

2015 - 2015

Completed

The Pre-Eclampsia Intervention With Esomeprazole (Pie) Trial: A Double Blind Randomised Placebo-Controlled Trial To Treat Early Onset Pre-Eclampsia

2015 - 2016

Completed

Purchase Of The Floid Cell Imaging Station

2014 - 2014

Completed

Developing A Clinical Blood Test For Women With Preterm Ruptured Membranes (<32 Weeks Gestation) To Identify Those Developing Chorioamnionitis

2014 - 2015

Completed

Improving Pregnancy Outcomes For Women With Preeclampsia

This project will substantially improve our understanding of the potential causes of vascular complications of pregnancy including preeclamp..

2014 - 2016

Completed

Developing Diagnostics And Therapeutics For Preeclampsia: Targeting A Novel Placental Specific Sflt-1 Variant

Preeclampsia is a dreaded disease of pregnancy, globally responsible for thousands of deaths of mothers and babies. It is caused by a protei..

2014 - 2016

Completed

Improving The Prediction And Detection Of Contributors To Term Stillbirth

Stillbirths are a global human tragedy, with 1 in 130 of all pregnancies in Australia ending in stillbirth. We propose to use ultrasound and..

2014 - 2017

Completed

Treating Severe Early Onset Preeclampsia With Pravastatin: An Early Phase Clinical Trial

2013 - 2014

Completed

Understanding How Sflt-1, A Toxin Of Preeclampsia Is Released

2013 - 2014

Completed

Developing A Biomarker Blood Test At 28 Weeks To Identify Pregnancies At High Risk Of Fetal Growth Restriction And Stillbirth

2013 - 2014

Completed

Developing Molecular Therapeutics And Diagnostics For Pregnancy Complications

Pregnancy complications still causes the death of mothers, and their babies. During this fellowship, we will be developing new treatments an..

2013 - 2016

Completed

Blocking Soluble Endoglin Release As A Therapeutic Strategy For Severe Preeclampsia.

2012 - 2012

Completed

Measuring Rna In Maternal Blood To Monitor The Wellbeing Of Growth-Restricted Fetuses

Severely growth restricted fetuses are at peril of stillbirth from low oxygenation. While ultrasound monitoring improves outcomes, babies ar..

2012 - 2015

Completed

Measuring A Hypoxia Gene Signature In Maternal Blood To Identify The Hypoxic Growth Restricted Fetus

2012 - 2012

Completed

Assessment Of Fetal Well-Bing With Fetal Doppler Examination Prior To Induction Of Labour At Term

2012 - 2013

Completed

CAREER DEVELOPMENT AWARD - CLINICAL

Recent evidence has pointed to the beginning of pregnancy as the time when biological cascades begin that cause common diseases of pregnancy..

2011 - 2011

Completed

DEVELOPMENT OF NOVEL MEDICAL THERAPIES TO CURE ECTOPIC PREGNANCIES

Ectopic pregnancies are conceptions implanting outside the womb, mainly the fallopian tube. They are pathological, and can erode straight th..

2011 - 2013

Completed

Measuring Hypoxia Regulated Rna Of Placental Origin In Maternal Blood As A Novel Approach To Monitor Wellbeing Of The Growth Restricted Fetus

2011 - 2012

Completed

First Trimester Prediction Of Low Birthweight

2009 - 2009

Completed

1st Trimester Ghrelin And Its Relationship To Low Birthweight

2008 - 2008

Completed

Identifying Early Pregnancy Biomarkers Of Impending Miscarriage

2007 - 2007

Completed

48

Projects

Project Types

Research Grant

Research Contracts

Scholarly Works

Displaying the 234 most recent scholarly works by Stephen Tong.

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia.

Natalie K Binder, Fiona C Brownfoot, Sally Beard, Ping Cannon, Tuong V Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article | 2020 | Pregnancy Hypertension

Development and repurposing of therapies that show promise in the prevention or treatment of preeclampsia would be a major advance..

Aspirin use during pregnancy and the risk of bleeding complications: a Swedish population-based cohort study.

Roxanne Hastie, Stephen Tong, Anna-Karin Wikström, Anna Sandström, Susanne Hesselman, Lina Bergman

Journal article | 2020 | American Journal of Obstetrics and Gynecology

BACKGROUND: Aspirin is offered to pregnant women to prevent preeclampsia, a severe obstetrical complication. Large studies of nonp..

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic factors from the placenta: Implications for the treatment of preeclampsia

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Tuong Nguyen, Laura Tuohey, Cathy Cluver, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2020 | Placenta

INTRODUCTION: The antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are elevated in p..

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction

Sally Beard, Natasha Pritchard, Natalie Binder, Karen Schindler, Natasha De Alwis, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Natalie J Hannan

Journal article | 2020 | Placenta

INTRODUCTION: Oxidative damage and biochemical ageing are implicated in placental dysfunction and potentially fetal death. Cellula..

Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth

Natalie J Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Stephen Tong

Journal article | 2020 | BMC Medicine

BACKGROUND: Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricte..

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Nguyen Tuong-Vi, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong

Journal article | 2020 | Nature Communications

Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental ins..

Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction

Natasha de Alwis, Sally Beard, Yeukai T Mangwiro, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Stephen Tong, Natalie J Hannan

Journal article | 2020 | Pregnancy Hypertension

OBJECTIVES: There is avid interest in pravastatin as a therapeutic intervention for pre-eclampsia, however little is known on stat..

The New Generation Antiplatelet Agent Prasugrel Represents an Exciting Novel Candidate Therapy for Preeclampsia.

Natasha De Alwis, Natalie Binder, Sally Beard, Nguyen Vi, Kaitu'u-Lino Tu'uhevaha, Stephen Tong, Natalie Hannan

Conference Proceedings | 2020 | REPRODUCTIVE SCIENCES

GDF15 is Increased in Preeclampsia and May be Regulated via Transcription Factors EGR1 and SP1.

Tess Cruickshank, Teresa M MacDonald, Susan P Walker, Natalie J Hannan, Damanpreet Singh, Ping Cannon, Alesia Harper, Murray Elizabeth, Tuong-Vi Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings | 2020 | REPRODUCTIVE SCIENCES

Syndecan-1 is Reduced in Fetal Growth Restriction and Cleaved by Matrix Metalloproteinases.

Damanpreet Singh, Teresa M MacDonald, Susan P Walker, Tess Cruickshank, Natalie J Hannan, Ping Cannon, Alesia Harper, Elizabeth Murray, Nguyen Tuong-Vi, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings | 2020 | REPRODUCTIVE SCIENCES

Circulating Delta-like homolog 1 (DLK1) at 36 weeks is correlated with birthweight and is of placental origin

Teresa M MacDonald, Susan P Walker, Richard Hiscock, Ping Cannon, Alesia Harper, Elizabeth Murray, Lisa Hui, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Natasha de Alwis, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2020 | Placenta

Accuracy of clinical suspicion of growth restriction at term despite a normal growth ultrasound: A retrospective cohort study

Brittany Green, Lisa Hui, Roxanne Hastie, Stephen Tong, Fiona C Brownfoot

Journal article | 2020 | Australian and New Zealand Journal of Obstetrics and Gynaecology

Acupuncture in pregnancy; primum non nocere

R Hastie, BW Mol, S Tong

Journal article | 2020 | BJOG: An International Journal of Obstetrics & Gynaecology

It is thought that around 10% of pregnant women turn to acupuncture to alleviate troublesome pregnancy ailments: vomiting, pelvic,..

Appropriate-for-gestational-age infants who exhibit reduced antenatal growth velocity display postnatal catch-up growth.

Emma J McLaughlin, Richard J Hiscock, Alice J Robinson, Lisa Hui, Stephen Tong, Kirsten M Dane, Anna L Middleton, Susan P Walker, Teresa M MacDonald

Journal article | 2020 | PLOS ONE

BACKGROUND: Postnatally, small-for-gestational-age (SGA; birthweight 20 customised estimated fetal weight centiles), and AGA-NG to..

Combination methotrexate and gefitinib: A potential medical treatment for inoperable nontubal ectopic pregnancy

Stella Italiano, Stephen Tong, Emma Readman, Meredith Tassone, Roxanne Hastie, Natasha Pritchard

Conference Proceedings | 2019 | Journal of Obstetrics and Gynaecology Research

The incidence of hypertensive disorders of pregnancy following sperm donation in IVF: an Australian state-wide retrospective cohort study

Amber L Kennedy, Cathryn J Stern, Stephen Tong, Roxanne Hastie, Franca Agresta, Susan P Walker, Fiona C Brownfoot, Vivien MacLachlan, Beverley J Vollenhoven, Anthea C Lindquist

Journal article | 2019 | Human Reproduction

STUDY QUESTION: Does IVF using donor sperm increase the risk of hypertensive disorders of pregnancy and fetal growth restriction (..

Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia

Cameron Yung, Teresa M MacDonald, Susan P Walker, Ping Cannon, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2019 | Placenta

INTRODUCTION: Death associated protein kinase-1 (DAPK-1) is highly expressed in the placenta relative to all other human tissues. ..

Sulfasalazine decreases soluble fms-like tyrosine kinase-1 secretion potentially via inhibition of upstream placental epidermal growth factor receptor signalling

Roxanne Hastie, Fiona C Brownfoot, Ping Cannon, Nguyen Vi, Laura Tuohey, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | Placenta

OBJECTIVES: Preeclampsia is a hypertensive disorder of pregnancy with no available medical treatment. We recently reported sulfasa..

Systematic review of areca (betel nut) use and adverse pregnancy outcomes

Manarangi De Silva, Leeanne Panisi, Fiona C Brownfoot, Anthea Lindquist, Susan P Walker, Stephen Tong, Roxanne Hastie

Journal article | 2019 | International Journal of Gynecology & Obstetrics

Prediction of adverse maternal outcomes in preeclampsia at term

Tarini D Paul, Roxanne Hastie, Stephen Tong, Emerson Keenan, Richard Hiscock, Fiona C Brownfoot

Journal article | 2019 | Pregnancy Hypertension

Preeclampsia complicates 5-8% of all pregnancies and is associated with high rates of maternal and perinatal morbidity. The majori..

Predictive Value of the Signs and Symptoms Preceding Eclampsia A Systematic Review

Roxanne Hastie, Fiona C Brownfoot, Catherine A Cluver, Susan P Walker, Susanne Hesselman, Stephen Tong, Lina Bergman

Journal article | 2019 | Obstetrics & Gynecology

OBJECTIVE: To estimate the predictive value of signs and symptoms that occur before onset of eclampsia among pregnant women. DATA ..

Screening circulating proteins to identify biomarkers of fetal macrosomia.

Tess Cruickshank, Tu'uhevaha J Kaitu'u-Lino, Ping Cannon, Alesia Harper, Tuong-Vi Nguyen, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Roxanne Hastie, Stephen Tong, Susan P Walker, Teresa M MacDonald

Journal article | 2019 | BMC Research Notes

OBJECTIVE: Fetal macrosomia is a major risk factor for shoulder dystocia, which can lead to birth asphyxia, maternal and neonatal ..

Maternal mortality at the National Referral Hospital in Honiara, Solomon Islands over a five-year period

Manarangi De Silva, Leeanne Panisi, Anita Maepioh, Rebecca Mitchell, Anthea Lindquist, Stephen Tong, Roxanne Hastie

Journal article | 2019 | Australian and New Zealand Journal of Obstetrics and Gynaecology

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | Placenta

Pregnancy complications such as fetal growth restriction and preeclampsia are diseases with limited biomarkers for prediction, and..

Cerebral-placental-uterine ratio as novel predictor of late fetal growth restriction: prospective cohort study

TM Macdonald, L Hui, AJ Robinson, KM Dane, AL Middleton, S Tong, SP Walker

Journal article | 2019 | Ultrasound in Obstetrics & Gynecology

OBJECTIVES: Fetal growth restriction (FGR) is a major risk factor for stillbirth and most commonly arises from uteroplacental insu..

Blood-based biomarkers in the maternal circulation associated with fetal growth restriction

Stephen Tong, Tu'uhevaha Joy Kaitu'u-Lino, Susan Philippa Walker, Teresa Mary MacDonald

Journal article | 2019 | Prenatal Diagnosis

Fetal growth restriction (FGR) is associated with threefold to fourfold increased risk of stillbirth. Identifying FGR, through its..

A double blind, randomised, placebo-controlled trial to evaluate the efficacy of metformin to treat preterm pre-eclampsia (PI2 Trial): study protocol

Catherine Cluver, Susan P Walker, Ben W Mol, David Hall, Richard Hiscock, Fiona C Brownfoot, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2019 | BMJ Open

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women A Swedish Population Register-Based Cohort Study

Roxanne Hastie, Lina Bergman, Catherin A Cluver, Anna Wikman, Natalie J Hannan, Susan P Walker, Anna-Karin Wikstrom, Stephen Tong, Susanne Hesselman

Journal article | 2019 | Hypertension

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women.

Roxanne Hastie, Lina Bergman, Catherin A Cluver, Anna Wikman, Natalie J Hannan, Susan P Walker, Anna-Karin Wikström, Stephen Tong, Susanne Hesselman

Journal article | 2019 | Hypertension

Preeclampsia is a hypertensive disorder of pregnancy with a high rate of maternal and neonatal morbidity and mortality. The only d..

Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Roxanne Hastie, Natasha De Alwis, Ping Cannon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Journal article | 2019 | Pregnancy Hypertension

Incidence of Preeclampsia among Women Using Proton Pump Inhibitors during Pregnancy &It- A Swedish Population Register Based Cohort Study.

Roxanne Hastie, Bergman Lina, Catherine Cluver, Susan P Walker, Anna-Karin Wikstrom, Stephen Tong, Susanne Hesselman

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

Epidermal Growth Factor and Mitochondrial Respiration-Two Pathways That Regulate Placental Growth Factor Secretion from Placental Cells.

Carole-Anne Whigham, Roxanne Hastie, Natalie Hannan, Ping Canon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

Gonadotrophin Releasing Hormone Receptor Antagonists are a Potential Targeted Treatment for Ectopic Pregnancy.

Lisa Campbell, Natalie Hannan, Stephen Tong, Mohamed Bedaiwy, Nicola Gray, Andrew W Horne

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

Fiona C Brownfoot, Natalie J Hannan, Ping Cannon, Nguyen Vi, Roxanne Hastie, Laura J Parry, Sevvandi Senadheera, Laura Tuohey, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | EBioMedicine

Accuracy of Clinical Suspicion of Growth Restriction at Term Despite a Normal Growth Ultrasound.

Brittany Green, Lisa Hui, Roxanne Hastie, Stephen Tong, Fiona C Brownfoot

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

Comparing the Ability of Pravastatin, Simvastatin and Rosuvastatin to Quench Markers of Endothelial Dysfunction in Pregnancy.

Natasha de Alwis, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Fiona Brownfoot, Stephen Tong, Natalie Hannan

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

The Diagnostic Accuracy of the Signs and Symptoms Preceding Eclampsia, a Systematic Review.

Roxanne Hastie, Fiona C Brownfoot, Catherine Cluver, Susan P Walker, Susanne Hesselman, Stephen Tong, Lina Bergman

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

New Generation Antiplatelet Agents Mitigate Pathophysiological Aspects of Preeclampsia in Both Human and Mouse Models of Preeclampsia, Representing Exciting Novel Candidate Therapeutics.

Natalie Hannan, Sally Beard, Natalie Binder, Natasha De Alwis, Natasha Pritchard, Tu'uhevaha Kaitu'u-Lino, Stephen Tong

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

Esomeprazole to treat women with preeclampsia: possible implications in the nitric oxide homeostasis Reply

Catherine Cluver, Natalie Hannan, Stephen Tong

Journal article | 2019 | American Journal of Obstetrics and Gynecology

High-dose compared with low-dose oxytocin for induction of labour of nulliparous women at term

Natasha Prichard, Anthea Lindquist, Richard Hiscock, Sophie Ruff, Stephen Tong, Fiona C Brownfoot

Journal article | 2019 | The Journal of Maternal-Fetal & Neonatal Medicine

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Ping Cannon, Vi Nguyen Tuong, Roxanne Hastie, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | Scientific Reports

A Systematic Review of Proton Pump Inhibitors for the Prevention and Treatment of Preeclampsia and Gestational Hypertension

Manarangi De Silva, Fiona Brownfoot, Natalie J Hannan, Susan P Walker, Catherine A Cluver, Anthea Lindquist, Stephen Tong, Roxanne Hastie

Journal article | 2019 | Open Journal of Obstetrics and Gynecology

A multi-centre, double-blind, placebo-controlled, randomised trial of combination methotrexate and gefitinib versus methotrexate alone to treat tubal ectopic pregnancies (GEM3): trial protocol

James May, Colin Duncan, Ben Mol, Siladitya Bhattacharya, Jane Daniels, Lee Middleton, Catherine Hewitt, Arri Coomarasamy, Davor Jurkovic, Tom Bourne, Cecilia Bottomley, Alexandra Peace-Gadsby, Ann Doust, Stephen Tong, Andrew W Horne

Journal article | 2018 | Trials

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia

Clare L Whitehead, Tu'uhevaha J Kaitu'u-Lino, Natalie K Binder, Sally Beard, Natasha De Alwis, Fiona Brownfoot, Stephen Tong, Natalie J Hannan

Journal article | 2018 | Pregnancy Hypertension

Esomeprazole to treat women with preterm preeclampsia: a randomized placebo controlled trial

Catherine A Cluver, Natalie J Hannan, Erika van Papendorp, Richard Hiscock, Sally Beard, Ben W Mol, Gerhard B Theron, David R Hall, Eric H Decloedt, Marietjie Stander, Kim T Adams, Megan Rensburg, Pawel Schubert, Susan P Walker, Stephen Tong

Journal article | 2018 | American Journal of Obstetrics and Gynecology

Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome

Roxanne Hastie, Louie Ye, Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Vi Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2018 | Pregnancy Hypertension

AURORA KINASE EXPRESSION IS NOT ALTERED IN GROWTH RESTRICTED OR PREECLAMPTIC PLACENTAS, AND IS NOT CHANGED WITH PLACENTAL AGING

Natasha Pritchard, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Stephen Tong, Natalie Hannan

Conference Proceedings | 2018 | PLACENTA

WATER-SOLUBLE EXTRACT OF CINNAMOMUM CASSIA AND ZINGIBER OFFICINALE INCREASE PLACENTAL GROWTH FACTOR AND DECREASE SFLT-1 SECRETED FROM ENDOTHELIAL AND PLACENTAL CELLS

Kenji Onda, Sally Beard, Rhotaro Shiota, Masaru Sakamaki, Stephen Tong, Toshihiko Hirano, Natalie J Hannan

Conference Proceedings | 2018 | PLACENTA

Predicting the Progression of Preeclampsia to Severe Disease at Term

T Paul, S Tong, R Hastie, F Brownfoot

Conference Proceedings | 2018 | AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

NOVEL STRATEGIES TO TREAT PREECLAMPSIA: FROM NEW DRUGS TO NEW DELIVERY

Natalie Hannan, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Stephen Tong

Conference Proceedings | 2018 | PLACENTA

TWO PARALLEL PATHWAYS REGULATING SFLT-1 SECRETION FROM PLACENTA

Roxanne Hastie, Fiona C Brownfoot, Natalie J Hannan, Ping Cannon, Nguyen Tuong-Vi, Natasha Pritchard, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings | 2018 | PLACENTA

Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks' gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

Teresa M MacDonald, Tran Chuong, Tu'uhevaha J Kaitu'u-Lino, Shaun P Brennecke, Richard J Hiscock, Lisa Hui, Kirsten M Dane, Anna L Middleton, Ping Cannon, Susan P Walker, Stephen Tong

Journal article | 2018 | BMC PREGNANCY AND CHILDBIRTH

ELABELA/APELA Levels Are Not Decreased in the Maternal Circulation or Placenta among Women with Preeclampsia

Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Sungsam Gong, Justyna Dopierala, Gordon CS Smith, D Stephen Charnock-Jones, Stephen Tong

Journal article | 2018 | The American Journal of Pathology

Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Ping Cannon, Nguyen Vi, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2018 | Pregnancy Hypertension

Gefitinib and Methotrexate to Treat Ectopic Pregnancies with a Pre-Treatment Serum hCG 1000-10,000 IU/L: Phase II Open Labe Single Arm Multi-Centre Trial

Monika M Skubisz, Stephen Tong, Ann Doust, Jill Mollison, Terrance G Johns, Peter Neil, Miranda Robinson, Siladitya Bhattacharya, Euan Wallace, Nicole Krzys, W Colin Duncan, Andrew W Horne

Journal article | 2018 | EBioMedicine

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia

Natalie J Hannan, Natalie K Binder, Sally Beard, Nguyen Tuong-Vi, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2018 | PLOS ONE

Accurately Predicting the Risk of Serious Maternal Morbidity in Preterm Preeclampsia: Can It Be Done?

Kirsten R Palmer, Stephen Tong

Journal article | 2018 | Hypertension

sFlt-1 Transcription and Secretion is Regulated through the Mitochondrial Electron Transport Chain - A New Mechanism to Target for Treating Preeclampsia.

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Nguyen Tuong-Vi, Stephen Tong

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

Combination Sulfasalazine and Metformin Are Additive in Reducing Placental Anti-Angiogenic Factor Secretion and Up-Regulating Angiogenic Factors.

Fiona C Brownfoot, Stephen Tong, Ping Cannon, Nguyen Vi, Natalie Hannan, Roxanne Hastie, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

Altered Placental Expression of Candidate Blood Markers of Severe Fetal Growth Restriction is Driven by Hypoxia.

Natasha De Alwis, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Susan Walker, Stephen Tong, Natalie J Hannan

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

Circulating mRNA Coding Adrenomedullin is Decreased in Women Destined to Develop Pre-Eclampsia and May Be of Placental and/or Endothelial Origin.

Carole-Anne Whigham, Teresa MacDonald, Sue Walker, Natalie Hannan, Ping Canon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

Vinorelbine Potently Induces Placental Cell Death, Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy

Roxanne Hastie, Elgene Lim, Pavel Sluka, Lisa Campbell, Andrew W Horne, Lenore Ellett, Natalie J Hannan, Fiona Brownfoot, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2018 | EBioMedicine

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Sally Beard, Ping Cannon, Roxanne Hastie, Tuong V Nguyen, Natalie K Binder, Stephen Tong, Natalie J Hannan

Journal article | 2018 | PLOS ONE

Severe placental insufficiency, acidemia and imminent stillbirth are associated with changes in circulating levels of mRNA coding NR4A2, RCBTB2 and EMP1

Stephen Tong, Clare Whitehead, Susan Walker, Gordon Lavinia, Jo Said, Katie Groom, Scott Petersen, Sean Seeho, Amanda Henry, Stefan Kane, Natalie Hannan, Owen Stock

Conference Proceedings | 2018 | AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Roxanne Hastie, Ashwini Chand, Ping Cannon, Minh Deo, Laura Tuohey, Clare Whitehead, Natalie J Hannan, Stephen Tong

Journal article | 2017 | Hypertension

sFlt-1 and soluble endoglin concentrations in serum vs plasma in preterm preeclampsia: Are they interchangeable for biomarker studies?

Fiona Brownfoot, Tu'uhevaha Kaitu'u-Lino, Sally Beard, Stephen Tong, Natalie Hannan

Journal article | 2017 | Pregnancy Hypertension

Reply

S Tong, BW Mol, SP Walker

Journal article | 2017 | American Journal of Obstetrics and Gynecology

Epidermal Growth Factor Rescues Endothelial Dysfunction in Primary Human Tissues In Vitro

Roxanne Hastie, Stephen Tong, Natalie J Hannan, Fiona Brownfoot, Ping Cannon, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2017 | Reproductive Sciences

Comment on: Preventing preeclampsia with aspirin: does dose or timing matter? REPLY

Stephen Tong, Ben W Mol, Susan P Walker

Journal article | 2017 | American Journal of Obstetrics and Gynecology

Reduced growth velocity across the third trimester is associated with placental insufficiency in fetuses born at a normal birthweight: a prospective cohort study

Teresa M MacDonald, Lisa Hui, Stephen Tong, Alice J Robinson, Kirsten M Dane, Anna L Middleton, Susan P Walker

Journal article | 2017 | BMC Medicine

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment

Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Minh Deo, Sally Beard, Tuong V Nguyen, Kirsten R Palmer, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2017 | Scientific Reports

The circulating microRNA-200 family in whole blood are potential biomarkers for high-grade serous epithelial ovarian cancer

Adam Pendlebury, Natalie J Hannan, Natalie Binder, Sally Beard, Monica Mcgauran, Peter Grant, Stephen Tong, Clare L Whitehead

Journal article | 2017 | Biomedical Reports

Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia

Kirsten R Palmer, Tu'uhevaha J Kaitu'u-Lino, Ping Cannon, Laura Tuohey, Manarangi S De Silva, Manuel Varas-Godoy, Stephanie Acuna, Jose Galaz, Stephen Tong, Sebastian E Illanes

Journal article | 2017 | The Journal of Maternal-Fetal & Neonatal Medicine

Enoxaparin for the prevention of preeclampsia and intrauterine growth restriction in women with a history: a randomized trial

Katie M Groom, Lesley M McCowan, Laura K Mackay, Arier C Lee, Joanne M Said, Stefan C Kane, Susan P Walker, Thijs E van Mens, Natalie J Hannan, Stephen Tong, Larry W Chamley, Peter R Stone, Claire McLintock

Journal article | 2017 | American Journal of Obstetrics and Gynecology

Variable effect of maternal oral glucose load on circulating cell-free placental mRNAs

Teresa Mary MacDonald, Tu'uhevaha Joy Kaitu'u-Lino, Susan Philippa Walker, Kirsten Margaret Dane, Elizabeth Beatrice Lockie, Stephen Tong, Clare Louise Whitehead, Lisa Hui

Journal article | 2017 | The Journal of Maternal-Fetal & Neonatal Medicine

Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction

Natalie J Hannan, Sally Beard, Natalie K Binder, Kenji Onda, Tu'uhevaha J Kaitu'u-Lino, Qi Chen, Laura Tuohey, Manarangi De Silva, Stephen Tong

Journal article | 2017 | Placenta

Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction

Kenji Onda, Stephen Tong, Sally Beard, Natalie Binder, Masanaga Muto, Sevvandi N Senadheera, Laura Parry, Mark Dilworth, Lewis Renshall, Fiona Brownfoot, Roxanne Hastie, Laura Tuohey, Kirsten Palmer, Toshihiko Hirano, Masahito Ikawa, Tu'uhevaha Kaitu'u-Lino, Natalie J Hannan

Journal article | 2017 | Hypertension

Preventing preeclampsia with aspirin: does dose or timing matter?

Stephen Tong, Ben W Mol, Susan P Walker

Journal article | 2017 | American Journal of Obstetrics and Gynecology

Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis

KR Palmer, S Tong, TJ Kaitu'u-Lino

Journal article | 2017 | MOLECULAR HUMAN REPRODUCTION

Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta

Louie Ye, Amy Gratton, Natalie J Hannan, Ping Cannon, Minh Deo, Kirsten R Palmer, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot

Journal article | 2016 | PLACENTA

Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia

Amy M Gratton, Louie Ye, Fiona C Brownfoot, Natalie J Hannan, Clare Whitehead, Ping Cannon, Minh Deo, Peter J Fuller, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2016 | Placenta

Measuring circulating placental RNAs to non-invasively assess the placental transcriptome and to predict pregnancy complications

Clare L Whitehead, Susan P Walker, Stephen Tong

Journal article | 2016 | Prenatal Diagnosis

ATF3 is a negative regulator of inflammation in human fetal membranes

Ratana Lim, Gillian Barker, Stella Liong, Caitlyn Nguyen-Ngo, Stephen Tong, Tu'uhevaha Kaitu'u-Lino, Martha Lappas

Journal article | 2016 | PLACENTA

Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening

Paul A Cohen, Nicola Flowers, Stephen Tong, Natalie Hannan, Mark D Pertile, Lisa Hui

Journal article | 2016 | BMC MEDICINE

A comparison of sample collection methods for quantifying cell-free fetal neurodevelopment transcripts in amniotic fluid.

Lisa Hui, Stephen Tong, Tu'Uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article | 2016 | BMC Research Notes

BACKGROUND: Cell-free RNA (cfRNA) transcripts known to be expressed by the fetal brain are detectable by quantitative reverse tran..

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia

Aneta Dobierzewska, Macarena Palominos, Marianela Sanchez, Michael Dyhr, Katja Helgert, Pia Venegas-Araneda, Stephen Tong, Sebastian E Illanes

Journal article | 2016 | PLOS ONE

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2016 | BMC PREGNANCY AND CHILDBIRTH

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta

Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Natalie J Hannan, Fiona Brownfoot, Manarangi De Silva, Ping Cannon, Laura Tuohey, Stephen Tong

Journal article | 2016 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation

Clare L Whitehead, Helen McNamara, Susan P Walker, Maria Alexiadis, Peter J Fuller, Daniel K Vickers, Natalie J Hannan, Roxanne Hastie, Laura Tuohey, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2016 | American Journal of Obstetrics and Gynecology

Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production

Kirsten R Palmer, Stephen Tong, Laura Tuohey, Ping Cannon, Louie Ye, Natalie J Hannan, Fiona C Brownfoot, Sebastian E Illanes, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2016 | Biology of Reproduction

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Laura Tuohey, Laura J Parry, Sevvandi Senadheera, Sebastian E Illanes, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2016 | American Journal of Obstetrics and Gynecology

Placental Insufficiency in Fetuses That Slow in Growth but Are Born Appropriate for Gestational Age: A Prospective Longitudinal Study

Nadia Bardien, Clare L Whitehead, Stephen Tong, Antony Ugoni, Susan McDonald, Susan P Walker

Journal article | 2016 | PLOS ONE

Early ovarian cancer detection in non pregnant women using a clinical NIPT platform: Implications for cancer screening

Paul Cohen, Nicola Flowers, Stephen Tong, Natalie Hannan, Mark Pertile, Lisa Hui

Conference Proceedings | 2016

Expectant management of severe preterm preeclampsia: a comparison of maternal and fetal indications for delivery

Samantha S Mooney, Rilka M Lee, Stephen Tong, Fiona C Brownfoot

Journal article | 2016 | The Journal of Maternal-Fetal & Neonatal Medicine

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity

Kirsten R Palmer, Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Natalie J Hannan, Louie Ye, Natalie Binder, Ping Cannon, Laura Tuohey, Terrance G Johns, Alexis Shub, Stephen Tong

Journal article | 2015 | HYPERTENSION

Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion

Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Kenji Onda, Sally Beard, Roxanne Hastie, Natalie K Binder, Cathy Cluver, Laura Tuohey, Clare Whitehead, Fiona Brownfoot, Manarangi De Silva, Natalie J Hannan

Journal article | 2015 | HYPERTENSION

Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan, Manarangi De Silva, Natalie Binder, Laura Tuohey, Ping Cannon, Stephen Tong

Journal article | 2015 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Diagnosing a miscarriage

Elizabeth Anne McCarthy, Stephen Tong

Journal article | 2015 | British Medical Journal

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Laura Tuohey, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2015 | Molecular and Cellular Endocrinology

EGF DECREASES SFLT1 SECRETION AND ENDOTHELIAL DYSFUNCTION: A POTENTIAL THERAPEUTIC FOR PREECIAMPSIA

Roxanne Hastie, Stephen Tong, Ping Cannon, Fiona Brownfoot, Natalie Hannan, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2015 | Placenta

Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Natalie K Binder, Susan P Walker, Ping Cannon, Roxanne Hastie, Kenji Onda, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2015 | HYPERTENSION

ACTIVATING TRANSCRIPTION FACTOR 3-A KEY MOLECULE IN THE PATHOGENESIS OF PREECLAMPSIA

Tu'uhevaha Kaitu'u-Lino, Fiona Brownfoot, Natalie Hannan, Roxanne Hastie, Ping Cannon, Laura Tuohey, Stephen Tong

Conference Proceedings | 2015 | Placenta

PROTON PUMP INHIBITORS QUENCH THE PATHOPHYSIOLOGICAL CHARACTERISTICS OF PREECLAMPSIA IN BOTH HUMAN AND MOUSE MODELS AND REPRESENT AN EXCITING NOVEL CANDIDATE THERAPEUTIC

Kenji Onda, Stephen Tong, Natalie Binder, Sally Beard, Tu'uhevaha Kaitu'u-Lino, Masanaga Muto, Masahito Ikawa, Mark Dilworth, Lewis Renshal, Sevvandi Senadheera, Laura Parry, Roxanne Hastie, Fiona Brownfoot, Laura Tuohey, Kirsten Palmer, Natalie Hannan

Conference Proceedings | 2015 | Placenta

Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14

TJ Kaitu'u-Lino, R Hastie, P Cannon, H Nguyen, S Lee, NJ Hannan, S Tong

Journal article | 2015 | Placenta

Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial Dysfunction

Harmeet Singh, Min Zhao, Qi Chen, Yao Wang, Ying Li, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Guiying Nie

Journal article | 2015 | The Journal of Clinical Endocrinology & Metabolism

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

Owen Stock, Lavinia Gordon, Jada Kapoor, Susan P Walker, Clare Whitehead, Tu'uhevaha J Kaitu'u-Lino, Gabrielle Pell, Natalie J Hannan, Stephen Tong

Journal article | 2015 | REPRODUCTIVE SCIENCES

Paternal obesity in a rodent model affects placental gene expression in a sex-specific manner

Natalie K Binder, Sally A Beard, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Natalie J Hannan, David K Gardner

Journal article | 2015 | REPRODUCTION

Treatment of Early-Onset Preeclampsia With Continuous Positive Airway Pressure

Clare Whitehead, Stephen Tong, Danielle Wilson, Mark Howard, Susan P Walker

Journal article | 2015 | Obstetrics & Gynecology

Sofalcone Upregulates the Nuclear Factor (Erythroid-Derived 2)-Like 2/Heme Oxygenase-1 Pathway, Reduces Soluble fms-Like Tyrosine Kinase-1, and Quenches Endothelial Dysfunction Potential Therapeutic for Preeclampsia

Kenji Onda, Stephen Tong, Anzu Nakahara, Mei Kondo, Hideaki Monchusho, Toshihiko Hirano, Tu'uhevaha Kaitu'u-Lino, Sally Beard, Natalie Binder, Laura Tuohey, Fiona Brownfoot, Natalie J Hannan

Journal article | 2015 | HYPERTENSION