Merlin Thomas

Severe acute respiratory syndrome coronavirus 2 as a potential cause of type 1 diabetes facilitated by spike protein receptor binding domain attachment to human islet cells: An illustrative case study and experimental data

Nisha Venkatesh, Natalie Astbury, Merlin C Thomas, Carlos J Rosado, Evan Pappas, Balasubramanian Krishnamurthy, Richard J MacIsaac, Thomas WH Kay, Helen E Thomas, David N O'Neal

Journal article  |  2021  |  DIABETIC MEDICINE

AIMS: Aim of this study is to report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, responsible for coron..

Dimeric phosphorylation of glyoxalase I alters its symmetry and substrate binding mechanism: simulation studies.

Lisa Michelle Barber, Zakir Hussain, Merlin Thomas, Andrew Hung

Journal article  |  2021  |  J Biomol Struct Dyn

Glyoxalase I (GLO1) is a dimeric esterase of the glyoxalase system. Phosphorylation of the residue T106 has been found to inhibit ..

Dietary intake and hospitalisation due to diabetic ketoacidosis and hypoglycaemia in individuals with type 1 diabetes.

Aila J Ahola, Valma Harjutsalo, Merlin C Thomas, Carol Forsblom, Per-Henrik Groop

Journal article  |  2021  |  Sci Rep

We investigated the association between diet and risk of hospitalisation for diabetic ketoacidosis (DKA) or hypoglycaemia in type ..

Common Comorbidities that Alter Heart Failure Prognosis - shaping new thinking for practice.

Pupalan Iyngkaran, Merlin Thomas, John D Horowitz, Paul Komesaroff, Michael Jelinek, David L Hare

Journal article  |  2020  |  Curr Cardiol Rev

At least half of all heart failure (CHF) patients will have a comorbidity that could be undertreated, requires additional speciali..

Dicarbonyl-mediated AGEing and diabetic kidney disease.

Alexandra Dimitropoulos, Carlos J Rosado, Merlin C Thomas

Journal article  |  2020  |  J Nephrol

Increased glycolytic flux into the diabetic kidney, combined with glycolytic inefficiencies introduced by oxidative stress, acts t..

Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis

Michelle C Flynn, Michael J Kraakman, Christos Tikellis, Man KS Lee, Nordin MJ Hanssen, Helene L Kammoun, Raelene J Pickering, Dragana Dragoljevic, Annas Al-Sharea, Tessa J Barrett, Fiona Hortle, Frances L Byrne, Ellen Olzomer, Domenica A McCarthy, Casper G Schalkwijk, Josephine M Forbes, Kyle Hoehn, Liza Makowski, Graeme I Lancaster, Assam El-Osta, et al.

Journal article  |  2020  |  CIRCULATION RESEARCH

RATIONALE: Treatment efficacy for diabetes mellitus is largely determined by assessment of HbA1c (glycated hemoglobin A1c) levels,..

Forensic interrogation of diabetic endothelitis in cardiovascular diseases and clinical translation in heart failure

Merlin C Thomas, Pupalan Iyngkaran

Journal article  |  2020  |  WORLD JOURNAL OF CARDIOLOGY

Diabetic heart disease (DHD) can be classified as a primary consequence from several pathophysiological manifestation of diabetes ..

Empagliflozin modulates renal sympathetic and heart rate baroreflexes in a rabbit model of diabetes.

Cindy Gueguen, Sandra L Burke, Benjamin Barzel, Nina Eikelis, Anna MD Watson, Jay C Jha, Kristy L Jackson, Yusuke Sata, Kyungjoon Lim, Gavin W Lambert, Karin AM Jandeleit-Dahm, Mark E Cooper, Merlin C Thomas, Geoffrey A Head

Journal article  |  2020  |  Diabetologia

AIMS/HYPOTHESIS: We determined whether empagliflozin altered renal sympathetic nerve activity (RSNA) and baroreflexes in a diabete..

Evaluating the efficacy and safety of GKT137831 in adults with type 1 diabetes and persistently elevated urinary albumin excretion: a statistical analysis plan

Alysha M De Livera, Anne Reutens, Mark Cooper, Merlin Thomas, Karin Jandeleit-Dahm, Jonathan E Shaw, Agus Salim

Journal article  |  2020  |  TRIALS

BACKGROUND: The investigational medicinal product GKT137831 is a selective inhibitor of NOX 1 and 4 isoforms of the nicotinamide a..

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, et al.

Journal article  |  2020  |  GUT

OBJECTIVE: We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. DESIGN: Cultu..