Merlin Thomas

Common Comorbidities that Alter Heart Failure Prognosis - shaping new thinking for practice.

Pupalan Iyngkaran, Merlin Thomas, John D Horowitz, Paul Komesaroff, Michael Jelinek, David L Hare

Journal article  |  2020  |  Current Cardiology Reviews

At least half of all heart failure (CHF) patients will have a comorbidity that could be undertreated, requires additional speciali..

Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis

Michelle C Flynn, Michael J Kraakman, Christos Tikellis, Man KS Lee, Nordin MJ Hanssen, Helene L Kammoun, Raelene J Pickering, Dragana Dragoljevic, Annas Al-Sharea, Tessa J Barrett, Fiona Hortle, Frances L Byrne, Ellen Olzomer, Domenica A McCarthy, Casper G Schalkwijk, Josephine M Forbes, Kyle Hoehn, Liza Makowski, Graeme I Lancaster, Assam El-Osta, et al.

Journal article  |  2020  |  Circulation Research

RATIONALE: Treatment efficacy for diabetes mellitus is largely determined by assessment of HbA1c (glycated hemoglobin A1c) levels,..

Evaluating the efficacy and safety of GKT137831 in adults with type 1 diabetes and persistently elevated urinary albumin excretion: a statistical analysis plan

Alysha M De Livera, Anne Reutens, Mark Cooper, Merlin Thomas, Karin Jandeleit-Dahm, Jonathan E Shaw, Agus Salim

Journal article  |  2020  |  Trials

BACKGROUND: The investigational medicinal product GKT137831 is a selective inhibitor of NOX 1 and 4 isoforms of the nicotinamide a..

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, et al.

Journal article  |  2020  |  Gut

OBJECTIVE: We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. DESIGN: Cultu..

The Heart Failure with Preserved Ejection Fraction Conundrum-Redefining the Problem and Finding Common Ground?

P Iyngkaran, MC Thomas, C Neil, M Jelinek, M Cooper, JD Horowitz, DL Hare, DM Kaye

Journal article  |  2020  |  Current Heart Failure Reports

PURPOSE OF REVIEW: Heart failure with preserved ejection fraction (HFpEF) or diastolic heart failure (DHF) makes up more than half..

A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: Protocol and statistical considerations

Anne T Reutens, Karin Jandeleit-Dahm, Merlin Thomas, Agus Salim, Alysha M De Livera, Leon A Bach, Peter G Colman, Timothy ME Davis, Elif Ekinci, Greg Fulcher, Peter Shane Hamblin, Mark A Kotowicz, Richard J MacIsaac, Claire Morbey, David Simmons, Georgia Soldatos, Gary Wittert, Ted Wu, Mark E Cooper, Jonathan E Shaw

Journal article  |  2020  |  Contemporary Clinical Trials

PURPOSE: Kidney disease caused by type 1 diabetes can progress to end stage renal disease and can increase mortality risk. Nicotin..

Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis

Raelene J Pickering, Christos Tikellis, Carlos J Rosado, Despina Tsorotes, Alexandra Dimitropoulos, Monique Smith, Olivier Huet, Ruth M Seeber, Rekhati Abhayawardana, Elizabeth KM Johnstone, Jonathan Golledge, Yutang Wang, Karin A Jandeleit-Dahm, Mark E Cooper, Kevin DG Pfleger, Merlin C Thomas

Journal article  |  2019  |  Journal of Clinical Investigation

The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with inflammation but no relationship with circulating vitamin D status.

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Pavel Sluka, Hady Wardan, Patrick Hosking, Shaun Monagle, Merlin Thomas, John S Lubel, Peter R Gibson

Journal article  |  2019  |  Therapeutic Advances in Gastroenterology

Background: The intestinal vitamin D receptor (VDR) remains poorly characterized in patients with inflammatory bowel disease (IBD)..

RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-beta and Increasing Resistance to Apoptosis

Shinji Hagiwara, Karly Sourris, Mark Ziemann, Tieqiao Wu, Muthukumar Mohan, Aaron D McClelland, Eoin Brennan, Josephine Forbes, Melinda Coughlan, Brooke Harcourt, Sally Penfold, Bo Wang, Gavin Higgins, Raelene Pickering, Assam El-Osta, Merlin C Thomas, Mark E Cooper, Phillip Kantharidis

Journal article  |  2018  |  Diabetes

Metabolic Karma-The Atherogenic Legacy of Diabetes: The 2017 Edwin Bierman Award Lecture

Mark Emmanuel Cooper, Assam El-Osta, Terri Jean Allen, Anna Margareta Dorothea Watson, Merlin Christopher Thomas, Karin Agnes Maria Jandeleit-Dahm

Journal article  |  2018  |  Diabetes