Find out more about Merlin Thomas' experience
Merlin Thomas' highlights
Merlin Thomas' selected work
Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in I..
The Heart Failure with Preserved Ejection Fraction Conundrum-Redefining the Problem and Fi..
A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluati..
The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with ..
Displaying the 17 most recent scholarly works by Merlin Thomas.
Evaluating the efficacy and safety of GKT137831 in adults with type 1 diabetes and persistently elevated urinary albumin excretion: a statistical analysis plan
Alysha M De Livera, Anne Reutens, Mark Cooper, Merlin Thomas, Karin Jandeleit-Dahm, Jonathan E Shaw, Agus Salim
Journal article | 2020 | Trials
BACKGROUND: The investigational medicinal product GKT137831 is a selective inhibitor of NOX 1 and 4 isoforms of the nicotinamide a..
Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?
Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, et al.
Journal article | 2020 | Gut
OBJECTIVE: We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. DESIGN: Cultu..
The Heart Failure with Preserved Ejection Fraction Conundrum-Redefining the Problem and Finding Common Ground?
P Iyngkaran, MC Thomas, C Neil, M Jelinek, M Cooper, JD Horowitz, DL Hare, DM Kaye
Journal article | 2020 | Current Heart Failure Reports
PURPOSE OF REVIEW: Heart failure with preserved ejection fraction (HFpEF) or diastolic heart failure (DHF) makes up more than half..
A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: Protocol and statistical considerations
Anne T Reutens, Karin Jandeleit-Dahm, Merlin Thomas, Agus Salim, Alysha M De Livera, Leon A Bach, Peter G Colman, Timothy ME Davis, Elif Ekinci, Greg Fulcher, Peter Shane Hamblin, Mark A Kotowicz, Richard J MacIsaac, Claire Morbey, David Simmons, Georgia Soldatos, Gary Wittert, Ted Wu, Mark E Cooper, Jonathan E Shaw
Journal article | 2020 | Contemporary Clinical Trials
PURPOSE: Kidney disease caused by type 1 diabetes can progress to end stage renal disease and can increase mortality risk. Nicotin..
Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis
Raelene J Pickering, Christos Tikellis, Carlos J Rosado, Despina Tsorotes, Alexandra Dimitropoulos, Monique Smith, Olivier Huet, Ruth M Seeber, Rekhati Abhayawardana, Elizabeth KM Johnstone, Jonathan Golledge, Yutang Wang, Karin A Jandeleit-Dahm, Mark E Cooper, Kevin DG Pfleger, Merlin C Thomas
Journal article | 2019 | Journal of Clinical Investigation
The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with inflammation but no relationship with circulating vitamin D status
M Garg, SG Royce, C Tikellis, C Shallue, P Sluka, H Wardan, P Hosking, S Monagle, M Thomas, JS Lubel, PR Gibson
Journal article | 2019 | Therapeutic Advances in Gastroenterology
RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-beta and Increasing Resistance to Apoptosis
Shinji Hagiwara, Karly Sourris, Mark Ziemann, Tieqiao Wu, Muthukumar Mohan, Aaron D McClelland, Eoin Brennan, Josephine Forbes, Melinda Coughlan, Brooke Harcourt, Sally Penfold, Bo Wang, Gavin Higgins, Raelene Pickering, Assam El-Osta, Merlin C Thomas, Mark E Cooper, Phillip Kantharidis
Journal article | 2018 | Diabetes
Deficiency in Apoptosis Inducing Factor Recapitulates Diabetic Nephropathy via Aberrant Mitochondrial Homeostasis
Melinda T Coughlan, Gavin C Higgins, Tuong-Vi Nguyen, Sally A Penfold, Vicki Thallas-Bonke, Sih Min Tan, Georg Ramm, Nicole J Van Bergen, Darren C Henstridge, Ian A Trounce, Karly C Sourris, Brooke E Harcourt, Portia M Robb, Adrienne Laskowski, Sean L Mcgee, Ken Walder, Paul Gregorevic, Hongwei Qian, Merlin C Thomas, Brian G Drew, et al.
Conference Proceedings | 2015 | DIABETES
Suppression of microRNA-29 Expression by TGF-beta 1 Promotes Collagen Expression and Renal Fibrosis
Bo Wang, Radko Komers, Rosemarie Carew, Catherine E Winbanks, Bei Xu, Michal Herman-Edelstein, Philip Koh, Merlin Thomas, Karin Jandeleit-Dahm, Paul Gregorevic, Mark E Cooper, Phillip Kantharidis
Journal article | 2012 | Journal of the American Society of Nephrology
Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes
Mathis Grossmann, Merlin C Thomas, Sianna Panagiotopoulos, Ken Sharpe, Richard J MacIsaac, Sophie Clarke, Jeffrey D Zajac, George Jerums
Journal article | 2008 | Journal of Clinical Endocrinology & Metabolism
Abstract Context: Low testosterone levels are common in men with type 2 diabetes and may be associated with insulin..
Diastolic dysfunction is associated with anaemia in patients with Type II diabetes
Piyush M Srivastava, Merlin C Thomas, Paul Calafiore, Richard J MacIsaac, George Jerums, Louise M Burrell
Journal article | 2006 | Clinical Science
Anaemia is common in patients with diabetes and associated with an increased risk of diabetic complications. Although the role of ..
Medicine - Austin Health