Damjan Vukcevic

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Paul A Lyons, James E Peters, Federico Alberici, James Liley, Richard MR Coulson, William Astle, Chiara Baldini, Francesco Bonatti, Maria C Cid, Heather Elding, Giacomo Emmi, Joerg Epplen, Loic Guillevin, David RW Jayne, Tao Jiang, Iva Gunnarsson, Peter Lamprecht, Stephen Leslie, Mark A Little, Davide Martorana, et al.

Journal article  |  2019  |  Nature Communications

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-ne..

A polygenic resilience score moderates the genetic risk for schizophrenia.

Jonathan L Hess, Daniel S Tylee, Manuel Mattheisen, undefined Schizophrenia Working Group of the Psychiatric Genomics Consortium, undefined Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Anders D Børglum, Thomas D Als, Jakob Grove, Thomas Werge, Preben Bo Mortensen, Ole Mors, Merete Nordentoft, David M Hougaard, Jonas Byberg-Grauholm, Marie Bækvad-Hansen, Tiffany A Greenwood, Ming T Tsuang, David Curtis, Stacy Steinberg, Engilbert Sigurdsson, et al.

Journal article  |  2019  |  Molecular Psychiatry

Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531-538, 2016) of rare variants that confer res..

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

Denise Harold, Siobhan Connolly, Brien P Riley, Kenneth S Kendler, Shane E McCarthy, William R McCombie, Alex Richards, Michael J Owen, Michael C O'Donovan, James Walters, Peter Donnelly, Lesley Bates, Ines Barroso, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Panos Deloukas, Audrey Duncanson, et al.

Journal article  |  2019  |  American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Genome-wide association studies (GWASs) are highly effective at identifying common risk variants for schizophrenia. Rare risk vari..

Temporal clustering of rotational glitches in the Crab pulsar

JB Carlin, A Melatos, D Vukcevic

Journal article  |  2019  |  Monthly Notices of the Royal Astronomical Society

INSIGHTS INTO THE HEALTH OF DEFENCE SIMULATED WORKFORCE SYSTEMS USING DATA FARMING AND ANALYTICS

Brendan Hill, Damjan Vukcevic, Terrence Caelli, Ana Novak

Conference Proceedings  |  2019  |  Proceedings of the 2019 Winter Simulation Conference

This work is motivated by the need for the Australian Defence Force to produce the right number of trained aircrew in the right pl..

Imputation of KIR Genes in over 80,000 Samples Reveals Previously Unknown Associations with Psoriasis

R Ahn, D Vukcevic, A Motyers, D Ellinghaus, LC Tsoi, RP Nair, J Oksenberg, J Foerster, JT Elder, A Franke, E Jorgenson, S Leslie, W Liao

Conference Proceedings  |  2018  |  EXPERIMENTAL DERMATOLOGY

The UK Biobank resource with deep phenotyping and genomic data

Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd T Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O'Connell, Adrian Cortes, Samantha Welsh, Alan Young, Mark Effingham, Gil McVean, Stephen Leslie, Naomi Allen, Peter Donnelly, Jonathan Marchini

Journal article  |  2018  |  Nature

Bayesian modelling of lung function data from multiple-breath washout tests

Robert K Mahar, John B Carlin, Sarath Ranganathan, Anne-Louise Ponsonby, Peter Vuillermin, Damjan Vukcevic

Journal article  |  2018  |  Statistics in Medicine

Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest

DJ Pappas, A Lizee, V Paunic, KR Beutner, A Motyer, D Vukcevic, S Leslie, J Biesiada, J Meller, KD Taylor, X Zheng, LP Zhao, P-A Gourraud, JA Hollenbach, SJ Mack, M Maiers

Journal article  |  2018  |  PHARMACOGENOMICS JOURNAL

Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest.

DJ Pappas, A Lizee, V Paunic, KR Beutner, A Motyer, D Vukcevic, S Leslie, J Biesiada, J Meller, KD Taylor, X Zheng, LP Zhao, P-A Gourraud, JA Hollenbach, SJ Mack, M Maiers

Journal article  |  2018  |  The Pharmacogenomics Journal

Four single nucleotide polymorphism (SNP)-based human leukocyte antigen (HLA) imputation methods (e-HLA, HIBAG, HLA*IMP:02 and MAG..

Advances in genetics and their impact on life insurance

Damjan Vukcevic, Jessica Chen

Conference Proceedings  |  2018  |  N/A

The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance

Fleur C Garton, Peter J Houweling, Damjan Vukcevic, Lyra R Meehan, Fiona XZ Lee, Monkol Lek, Kelly N Roeszler, Marshall W Hogarth, Chrystal F Tiong, Diana Zannino, Nan Yang, Stephen Leslie, Paul Gregorevic, Stewart I Head, Jane T Seto, Kathryn N North

Journal article  |  2018  |  The American Journal of Human Genetics

Large-scale imputation of killer cell immunoglobulin-like receptor copy number in psoriatic arthritis

R Ahn, D Vukcevic, A Motyer, D Ellinghaus, LC Tsoi, RP Nair, C Palmer, J Oksenberg, J Foerster, JT Elder, A Franke, S Leslie, W Liao

Conference Proceedings  |  2017  |  BRITISH JOURNAL OF DERMATOLOGY

Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank

Adrian Cortes, Calliope A Dendrou, Allan Motyer, Luke Jostins, Damjan Vukcevic, Alexander Dilthey, Peter Donnelly, Stephen Leslie, Lars Fugger, Gil McVean

Journal article  |  2017  |  Nature Genetics

Genome-wide genetic data on ~500,000 UK Biobank participants

Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O’Connell, Adrian Cortes, Samantha Welsh, Gil McVean, Stephen Leslie, Peter Donnelly, Jonathan Marchini

Journal article  |  2017  |  bioRxiv

Abstract The UK Biobank project is a large prospective cohort study of ~500,000 individuals from across the United Kingdom, aged b..

Thinking about life insurance through a genetic lens

Damjan Vukcevic, Jessica Chen

Conference Proceedings  |  2017  |  N/A

Genetic research is booming. The last decade has seen the discovery of thousands of genetic variants that confer greater risk for ..

Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1

DJ Martino, S Ashley, J Koplin, J Ellis, R Saffery, SC Dharmage, L Gurrin, MC Matheson, B Kalb, I Marenholz, K Beyer, Y-A Lee, X Hong, X Wang, D Vukcevic, A Motyer, S Leslie, KJ Allen, MAR Ferreira

Journal article  |  2017  |  CLINICAL AND EXPERIMENTAL ALLERGY

MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls

D Cosgrove, D Harold, O Mothersill, R Anney, MJ Hill, NJ Bray, G Blokland, T Petryshen, A Richards, K Mantripragada, M Owen, MC O'Donovan, M Gill, A Corvin, DW Morris, G Donohoe

Journal article  |  2017  |  Translational Psychiatry

Practical Use of Methods for Imputation of HLA Alleles from SNP Genotype Data

Allan Motyer, Damjan Vukcevic, Alexander Dilthey, Peter Donnelly, Gil McVean, Stephen Leslie

Journal article  |  2016  |  BioRxiv

Abstract The human leukocyte antigen (HLA) genes play an essential role in immune function. Typing of HLA alleles is critical for ..

Lack of transparency in software used to analyze multiple breath washout data

Robert K Mahar, Damjan Vukcevic, Louise King, John B Carlin, Sarath Ranganathan

Journal article  |  2016  |  Pediatric Pulmonology

Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children.

undefined Kenyan Bacteraemia Study Group, undefined Wellcome Trust Case Control Consortium 2 (WTCCC2), Anna Rautanen, Matti Pirinen, Tara C Mills, Kirk A Rockett, Amy Strange, Anne W Ndungu, Vivek Naranbhai, James J Gilchrist, Céline Bellenguez, Colin Freeman, Gavin Band, Suzannah J Bumpstead, Sarah Edkins, Eleni Giannoulatou, Emma Gray, Serge Dronov, Sarah E Hunt, Cordelia Langford, et al.

Journal article  |  2016  |  The American Journal of Human Genetics

Bacteremia (bacterial bloodstream infection) is a major cause of illness and death in sub-Saharan Africa but little is known about..

The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis.

PC Robinson, PJ Leo, JJ Pointon, J Harris, K Cremin, LA Bradbury, undefined Wellcome Trust Case Control Consortium, undefined Australasian Osteoporosis Genetics Consortium (AOGC), S Stebbings, AA Harrison, DM Evans, EL Duncan, BP Wordsworth, MA Brown, undefined Australasian Osteoporosis Genetics Consortium AOGC

Journal article  |  2016  |  Genes & Immunity

Acute anterior uveitis (AAU) involves inflammation of the iris and ciliary body of the eye. It occurs both in isolation and as a c..

Upskilling the epidemiological workforce with advanced biostatistics training: The ViCBiostat Summer School

J Simpson, A Forbes, R Wolfe, L Gurrin, K Lee, T Schuster, D VUKCEVIC, J Kasza, M Moreno-Betancur, S Zakoumis, A DeLivera, C Nguyen, D Cattram, A Karahalios, J McKenzie, E Milanzi, J Carlin

Journal article  |  2016  |  Australasian Epidemiologist

Imputation of KIR Types from SNP Variation Data

Damjan Vukcevic, James A Traherne, Sigrid Naess, Eva Ellinghaus, Yoichiro Kamatani, Alexander Dilthey, Mark Lathrop, Tom H Karlsen, Andre Franke, Miriam Moffatt, William Cookson, John Trowsdale, Gil McVean, Stephen Sawcer, Stephen Leslie

Journal article  |  2015  |  The American Journal of Human Genetics

The influence of sighing respirations on infant lung function measured using multiple breath washout gas mixing techniques

Damjan Vukcevic, John B Carlin, Louise King, Graham L Hall, Anne-Louise Ponsonby, Peter D Sly, Peter Vuillermin, Sarath Ranganathan

Journal article  |  2015  |  Physiological Reports

The correlation between reading and mathematics ability at age twelve has a substantial genetic component.

Oliver SP Davis, Gavin Band, Matti Pirinen, Claire MA Haworth, Emma L Meaburn, Yulia Kovas, Nicole Harlaar, Sophia J Docherty, Ken B Hanscombe, Maciej Trzaskowski, Charles JC Curtis, Amy Strange, Colin Freeman, Céline Bellenguez, Zhan Su, Richard Pearson, Damjan Vukcevic, Cordelia Langford, Panos Deloukas, Sarah Hunt, et al.

Journal article  |  2014  |  Nature Communications

Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we sh..

Bayesian test for colocalisation between pairs of genetic association studies using summary statistics.

Claudia Giambartolomei, Damjan Vukcevic, Eric E Schadt, Lude Franke, Aroon D Hingorani, Chris Wallace, Vincent Plagnol

Journal article  |  2014  |  PLoS Genetics

Genetic association studies, in particular the genome-wide association study (GWAS) design, have provided a wealth of novel insigh..

Genome-wide estimates of inbreeding in unrelated individuals and their association with cognitive ability

Robert A Power, Craig Nagoshi, John C DeFries, Robert Plomin

Journal article  |  2014  |  European Journal of Human Genetics

A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation.

undefined Psychosis Endophenotypes International Consortium, undefined Wellcome Trust Case-Control Consortium 2, Elvira Bramon, Matti Pirinen, Amy Strange, Kuang Lin, Colin Freeman, Céline Bellenguez, Zhan Su, Gavin Band, Richard Pearson, Damjan Vukcevic, Cordelia Langford, Panos Deloukas, Sarah Hunt, Emma Gray, Serge Dronov, Simon C Potter, Avazeh Tashakkori-Ghanbaria, Sarah Edkins, et al.

Journal article  |  2014  |  Biological Psychiatry

BACKGROUND: Genome-wide association studies (GWAS) have identified several loci associated with schizophrenia and/or bipolar disor..

A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility

V Damotte, L Guillot-Noel, NA Patsopoulos, L Madireddy, M El Behi, PL De Jager, SE Baranzini, I Cournu-Rebeix, B Fontaine

Journal article  |  2014  |  Genes & Immunity

Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus

Peter Donnelly, Amy Strange, Celine Bellenguez, Xueling Sim, Robert Luben, Pirro G Hysi, Wishal D Ramdas, Leonieke ME van Koolwijk, Colin Freeman, Matti Pirinen, Zhan Su, Gavin Band, Richard Pearson, Damjan Vukcevic, Cordelia Langford, Panos Deloukas, Sarah Hunt, Emma Gray, Serge Dronov, Simon C Potter, et al.

Journal article  |  2013  |  Human Molecular Genetics

Young Writers Competition: GUESTimation: Breaking the deadlock on wedding guest lists

D Vukcevic

Journal article  |  2013  |  Significance

Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.

undefined LeishGEN Consortium, undefined Wellcome Trust Case Control Consortium 2, Michaela Fakiola, Amy Strange, Heather J Cordell, E Nancy Miller, Matti Pirinen, Zhan Su, Anshuman Mishra, Sanjana Mehrotra, Gloria R Monteiro, Gavin Band, Céline Bellenguez, Serge Dronov, Sarah Edkins, Colin Freeman, Eleni Giannoulatou, Emma Gray, Sarah E Hunt, Henio G Lacerda, et al.

Journal article  |  2013  |  Nature Genetics

To identify susceptibility loci for visceral leishmaniasis, we undertook genome-wide association studies in two populations: 989 c..

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Lam C Tsoi, Sarah L Spain, Jo Knight, Eva Ellinghaus, Philip E Stuart, Francesca Capon, Jun Ding, Yanming Li, Trilokraj Tejasvi, Johann E Gudjonsson, Hyun M Kang, Michael H Allen, Ross McManus, Giuseppe Novelli, Lena Samuelsson, Joost Schalkwijk, Mona Stahle, A David Burden, Catherine H Smith, Michael J Cork, et al.

Journal article  |  2012  |  Nature Genetics

Bayesian refinement of association signals for 14 loci in 3 common diseases.

undefined Wellcome Trust Case Control Consortium, Julian B Maller, Gilean McVean, Jake Byrnes, Damjan Vukcevic, Kimmo Palin, Zhan Su, Joanna MM Howson, Adam Auton, Simon Myers, Andrew Morris, Matti Pirinen, Matthew A Brown, Paul R Burton, Mark J Caulfield, Alastair Compston, Martin Farrall, Alistair S Hall, Andrew T Hattersley, Adrian VS Hill, et al.

Journal article  |  2012  |  Nature Genetics

To further investigate susceptibility loci identified by genome-wide association studies, we genotyped 5,500 SNPs across 14 associ..

Disease model distortion in association studies.

Damjan Vukcevic, Eliana Hechter, Chris Spencer, Peter Donnelly

Journal article  |  2011  |  Genetic Epidemiology

Most findings from genome-wide association studies (GWAS) are consistent with a simple disease model at a single nucleotide polymo..

Quantifying the underestimation of relative risks from genome-wide association studies.

Chris Spencer, Eliana Hechter, Damjan Vukcevic, Peter Donnelly

Journal article  |  2011  |  PLoS Genetics

Genome-wide association studies (GWAS) have identified hundreds of associated loci across many common diseases. Most risk variants..

CISH and susceptibility to infectious diseases.

Chiea C Khor, Fredrik O Vannberg, Stephen J Chapman, Haiyan Guo, Sunny H Wong, Andrew J Walley, Damjan Vukcevic, Anna Rautanen, Tara C Mills, Kwok-Chiu Chang, Kai-Man Kam, Amelia C Crampin, Bagrey Ngwira, Chi-Chiu Leung, Cheuk-Ming Tam, Chiu-Yeung Chan, Joseph JY Sung, Wing-Wai Yew, Kai-Yee Toh, Stacey KH Tay, et al.

Journal article  |  2010  |  New England Journal of Medicine

BACKGROUND: The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducib..

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

Nick Craddock, Matthew E Hurles, Niall Cardin, Richard D Pearson, Vincent Plagnol, Samuel Robson, Damjan Vukcevic, Chris Barnes, Donald F Conrad, Eleni Giannoulatou, Chris Holmes, Jonathan L Marchini, Kathy Stirrups, Martin D Tobin, Louise V Wain, Chris Yau, Jan Aerts, Tariq Ahmad, T Daniel Andrews, Hazel Arbury, et al.

Journal article  |  2010  |  Nature

Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.

N Craddock, L Jones, IR Jones, G Kirov, EK Green, D Grozeva, V Moskvina, I Nikolov, ML Hamshere, D Vukcevic, S Caesar, K Gordon-Smith, C Fraser, E Russell, N Norton, G Breen, D St Clair, DA Collier, AH Young, IN Ferrier, et al.

Journal article  |  2010  |  Molecular Psychiatry

Despite compelling evidence for a major genetic contribution to risk of bipolar mood disorder, conclusive evidence implicating spe..

Erratum: Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype (Molecular Psychiatry (2010) 15 (146-153) DOI: 10.1038/mp.2008.66)

N Craddock, L Jones, IR Jones, G Kirov, EK Green, D Grozeva, V Moskvina, I Nikolov, ML Hamshere, D Vukcevic, S Caesar, K Gordon-Smith, C Fraser, E Russell, N Norton, G Breen, D St Clair, DA Collier, AH Young, IN Ferrier, et al.

Journal article  |  2010  |  Molecular Psychiatry

Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept.

ML Hamshere, EK Green, IR Jones, L Jones, V Moskvina, G Kirov, D Grozeva, I Nikolov, D Vukcevic, S Caesar, K Gordon-Smith, C Fraser, E Russell, G Breen, D St Clair, DA Collier, AH Young, IN Ferrier, A Farmer, P McGuffin, et al.

Journal article  |  2009  |  British Journal of Psychiatry

BACKGROUND: Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenoty..

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

S Nejentsev, JMM Howson, NM Walker, J Szeszko, SF Field, HE Stevens, P Reynolds, M Hardy, E King, J Masters, J Hulme, LM Maier, D Smyth, R Bailey, JD Cooper, G Ribas, RD Campbell, DG Clayton, JA Todd, PR Burton, et al.

Journal article  |  2007  |  Nature

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Melanie Newport, Giorgio Sirugo, Emily Lyons, Fredrik Vannberg, Adrian VS Hill, Linda A Bradbury, Claire Farrar, Jennifer J Pointon, Paul Wordsworth, Matthew A Brown, Jayne A Franklyn, Joanne M Heward, Matthew J Simmonds, Stephen CL Gough, Sheila Seal, Michael R Stratton, Nazneen Rahman, Maria Ban, An Goris, Stephen J Sawcer, et al.

Journal article  |  2007  |  Nature Genetics

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Paul R Burton, David G Clayton, Lon R Cardon, Nick Craddock, Panos Deloukas, Audrey Duncanson, Dominic P Kwiatkowski, Mark I McCarthy, Willem H Ouwehand, Nilesh J Samani, John A Todd, Peter Donnelly, Jeffrey C Barrett, Dan Davison, Doug Easton, David Evans, Hin-Tak Leung, Jonathan L Marchini, Andrew P Morris, Chris CA Spencer, et al.

Journal article  |  2007  |  Nature

Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum

Paul R Gilson, Thomas Nebl, Damjan Vukcevic, Robert L Moritz, Tobias Sargeant, Terence P Speed, Louis Schofield, Brendan S Crabb

Journal article  |  2006  |  Molecular & Cellular Proteomics