Paul Donnelly

Preparation of bis(thiosemicarbazone) derivatives and their metal complexes

PS Donnelly

Preparation of nitrogen-containing macrocyclic conjugates as radiopharmaceuticals

PS Donnelly, M MA, D Scanlon

Metal delivery agents and therapeutic uses of the same

K BARNHAM, P DONNELLY, A WHITE

Preparation of metal complexes for therapeutic uses

K BARNHAM, P DONNELLY, A WHITE

Preparation of transition metal thiosemicarbazone derivative complexes for medical imaging and therapy

R Dilworth, M Peach, M Heslop, P DONNELLY

Method of Treatment of Neurodegenerative Disease

PS DONNELLY, T WHITE, KJ BARNHAM

Harnessing 64Cu/67Cu for a theranostic approach to pretargeted radioimmunotherapy.

Outi Keinänen, Kimberly Fung, James M Brennan, Nicholas Zia, Matt Harris, Ellen van Dam, Colin Biggin, Amos Hedt, Jon Stoner, Paul S Donnelly, Jason S Lewis, Brian M Zeglis

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of USA

Over the past decade, theranostic imaging has emerged as a powerful clinical tool in oncology for identifying patients likely to r..

Bivalent Inhibitors of Prostate-Specific Membrane Antigen Conjugated to Desferrioxamine B Squaramide Labeled with Zirconium-89 or Gallium-68 for Diagnostic Imaging of Prostate Cancer

Asif Noor, Jessica K Van Zuylekom, Stacey E Rudd, Kelly Waldeck, Peter D Roselt, Mohammad B Haskali, Michael P Wheatcroft, Eddie Yan, Rodney J Hicks, Carleen Cullinane, Paul S Donnelly

Journal article  |  2020  |  Journal of Medicinal Chemistry

Prostate-specific membrane antigen (PSMA) is a carboxypeptidase that is overexpressed in prostate cancer and is an excellent candi..

Copper Bis(thiosemicarbazonato)-stilbenyl Complexes That Bind to Amyloid-beta Plaques

Asif Noor, David J Hayne, SinChun Lim, Jessica K Van Zuylekom, Carleen Cullinane, Peter D Roselt, Catriona A McLean, Jonathan M White, Paul S Donnelly

Journal article  |  2020  |  Inorganic Chemistry

Alzheimer's disease is characterized by the presence of extracellular amyloid-β plaques. Positron emission tomography (PET) imagin..

Preclinical Evaluation of a High-Affinity Sarcophagine-Containing PSMA Ligand for Cu-64/Cu-67-Based Theranostics in Prostate Cancer

James M Kelly, Shashikanth Ponnala, Alejandro Amor-Coarasa, Nicholas A Zia, Anastasia Nikolopoulou, Clarence Williams, David J Schlyer, Stephen G DiMagno, Paul S Donnelly, John W Babich

Journal article  |  2020  |  Molecular Pharmaceutics

The application of small molecules targeting prostate-specific membrane antigen (PSMA) has emerged as a highly promising clinical ..

Charge neutral rhenium tricarbonyl complexes of tridentate N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

Nuchareenat Wiratpruk, Asif Noor, Catriona A McLean, Paul S Donnelly, Peter J Barnard

Journal article  |  2020  |  Dalton Transactions

Two tridentate ligand systems bearing N-heterocyclic carbene (NHC), amine and carboxylate donor groups coupled to benzothiazole- o..

Identification of the Side Products That Diminish the Yields of the Monoamidated Product in Metal-Catalyzed C-H Amidation of 2-Phenylpyridine with Arylisocyanates

Alasdair I McKay, Weam AO Altalhi, Lachlan E McInnes, Milena L Czyz, Allan J Canty, Paul S Donnelly, Richard AJ O'Hair

Journal article  |  2020  |  The Journal of Organic Chemistry

The Ru(II)-catalyzed amidation of 2-arylpyridines with aryl isocyanates via C-H bond activation is less efficient than described p..

Palladium-Mediated CO2 Extrusion Followed by Insertion of Isocyanates for the Synthesis of Benzamides: Translating Fundamental Mechanistic Studies To Develop a Catalytic Protocol

Yang Yang, Allan J Canty, Alasdair McKay, Paul S Donnelly, Richard AJ O'Hair

Journal article  |  2020  |  Organometallics

Cu-II(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

Adam Southon, Kathryn Szostak, Karla M Acevedo, Krista A Dent, Irene Volitakis, Abdel A Belaidi, Kevin J Barnham, Peter J Crouch, Scott Ayton, Paul S Donnelly, Ashley Bush

Journal article  |  2020  |  British Journal of Pharmacology

BACKGROUND AND PURPOSE: Diacetyl-bis(4-methyl-3-thiosemicarbazonato)copperII (CuII (atsm)) ameliorates neurodegeneration and delay..

A conceptual framework for the development of iridium(iii) complex-based electrogenerated chemiluminescence labels

Lifen Chen, David J Hayne, Egan H Doeven, Johnny Agugiaro, David JD Wilson, Luke C Henderson, Timothy U Connell, Yi Heng Nai, Richard Alexander, Serena Carrara, Conor F Hogan, Paul S Donnelly, Paul S Francis

Journal article  |  2019  |  Chemical Science

A Sarcophagine Containing PSMA Ligand for Targeting Prostate Cancer with Cu-64/67

JM Kelly, S Ponnala, A Nikolopoulou, N Zia, C Williams, PS Donnelly, JW Babich

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING