Paul Donnelly

Preparation of bis(thiosemicarbazone) derivatives and their metal complexes

PS Donnelly

Preparation of nitrogen-containing macrocyclic conjugates as radiopharmaceuticals

PS Donnelly, M MA, D Scanlon

Metal delivery agents and therapeutic uses of the same

K BARNHAM, P DONNELLY, A WHITE

Preparation of metal complexes for therapeutic uses

K BARNHAM, P DONNELLY, A WHITE

Preparation of transition metal thiosemicarbazone derivative complexes for medical imaging and therapy

R Dilworth, M Peach, M Heslop, P DONNELLY

Method of Treatment of Neurodegenerative Disease

PS DONNELLY, T WHITE, KJ BARNHAM

Therapeutic Efficacy of a Bivalent Inhibitor of Prostate-Specific Membrane Antigen Labeled with( 67)Cu

Lachlan E McInnes, Carleen Cullinane, Peter D Roselt, Susan Jackson, Benjamin J Blyth, Ellen M van Dam, Nicholas A Zia, Matthew J Harris, Rodney J Hicks, Paul S Donnelly

Journal article  |  2021  |  Journal of Nuclear Medicine

Radionuclide therapy targeting prostate-specific membrane antigen (PSMA) is promising for prostate cancer. We previously reported ..

Imaging Somatostatin Positive Tumors with Tyr3-Octreotate/Octreotide Conjugated to Desferrioxamine B Squaramide Radiolabeled with either Zirconium-89 or Gallium-68.

Asif Noor, Jessica K Van Zuylekom, Stacey E Rudd, Peter D Roselt, Mohammad B Haskali, Eddie Yan, Michael Wheatcroft, Rodney J Hicks, Carleen Cullinane, Paul S Donnelly

Journal article  |  2021  |  Bioconjugate Chemistry

Radiolabeled derivatives of Tyr3-octreotide and Tyr3-octreotate, synthetic analogues of the peptide hormone somatostatin, can be u..

A clinical trial of non-invasive imaging with an anti-HIV antibody labelled with copper-64 in people living with HIV and uninfected controls

James H McMahon, Jennifer M Zerbato, Jillian SY Lau, Jaclyn L Lange, Michael Roche, Carolin Tumpach, Ashanti Dantanarayana, Ajantha Rhodes, Judy Chang, Thomas A Rasmussen, Charlene A Mackenzie, Karen Alt, Michelle Hagenauer, Janine Roney, Jessica O'Bryan, Alexandra Carey, Richard McIntyre, Paul Beech, Graeme J O'Keefe, Christian W Wichmann, et al.

Journal article  |  2021  |  EBioMedicine

BACKGROUND: A research priority in finding a cure for HIV is to establish methods to accurately locate and quantify where and how ..

Peptide Receptor Radionuclide Therapy with Cu-67-CuSarTATE Is Highly Efficacious Against a Somatostatin-Positive Neuroendocrine Tumor Model

Carleen Cullinane, Charmaine M Jeffery, Peter D Roselt, Ellen M van Dam, Susan Jackson, Kevin Kuan, Price Jackson, David Binns, Jessica van Zuylekom, Matthew J Harris, Rodney J Hicks, Paul S Donnelly

Journal article  |  2020  |  Journal of Nuclear Medicine

Peptide receptor radionuclide therapy (PRRT) using radiolabeled octreotate is an effective treatment for somatostatin receptor 2-e..

Improved non-invasive positron emission tomographic imaging of chemotherapy-induced tumor cell death using Zirconium-89-labeled APOMAB®.

Vasilios Liapis, William Tieu, Stacey E Rudd, Paul S Donnelly, Nicole L Wittwer, Michael P Brown, Alexander H Staudacher

Journal article  |  2020  |  EJNMMI Radiopharmacy and Chemistry

PURPOSE: The chimeric monoclonal antibody (mAb) chDAB4 (APOMAB®) targets the Lupus associated (La)/Sjögren Syndrome-B (SSB) antige..

Harnessing Cu-64/Cu-67 for a theranostic approach to pretargeted radioimmunotherapy

Outi Keinanen, Kimberly Fung, James M Brennan, Nicholas Zia, Matt Harris, Ellen van Dam, Colin Biggin, Amos Hedt, Jon Stoner, Paul S Donnelly, Jason S Lewis, Brian M Zeglis

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of USA

Over the past decade, theranostic imaging has emerged as a powerful clinical tool in oncology for identifying patients likely to r..

Bivalent Inhibitors of Prostate-Specific Membrane Antigen Conjugated to Desferrioxamine B Squaramide Labeled with Zirconium-89 or Gallium-68 for Diagnostic Imaging of Prostate Cancer

Asif Noor, Jessica K Van Zuylekom, Stacey E Rudd, Kelly Waldeck, Peter D Roselt, Mohammad B Haskali, Michael P Wheatcroft, Eddie Yan, Rodney J Hicks, Carleen Cullinane, Paul S Donnelly

Journal article  |  2020  |  Journal of Medicinal Chemistry

Prostate-specific membrane antigen (PSMA) is a carboxypeptidase that is overexpressed in prostate cancer and is an excellent candi..

Gallium Fluoride Complexes with Acyclic Bispicolinic Ligands as Potential New Fluorine-18 Labelled Imaging Agents

HuiJing Koay, Mohammad B Haskali, Peter D Roselt, Jonathan M White, Paul S Donnelly

Journal article  |  2020  |  European Journal of Inorganic Chemistry

The positron-emitting radionuclide, fluorine-18, is used to radiolabel molecules to develop tracers for diagnostic imaging with po..

Copper Bis(thiosemicarbazonato)-stilbenyl Complexes That Bind to Amyloid-beta Plaques

Asif Noor, David J Hayne, SinChun Lim, Jessica K Van Zuylekom, Carleen Cullinane, Peter D Roselt, Catriona A McLean, Jonathan M White, Paul S Donnelly

Journal article  |  2020  |  Inorganic Chemistry

Alzheimer's disease is characterized by the presence of extracellular amyloid-β plaques. Positron emission tomography (PET) imagin..

Preclinical Evaluation of a High-Affinity Sarcophagine-Containing PSMA Ligand for Cu-64/Cu-67-Based Theranostics in Prostate Cancer

James M Kelly, Shashikanth Ponnala, Alejandro Amor-Coarasa, Nicholas A Zia, Anastasia Nikolopoulou, Clarence Williams, David J Schlyer, Stephen G DiMagno, Paul S Donnelly, John W Babich

Journal article  |  2020  |  Molecular Pharmaceutics

The application of small molecules targeting prostate-specific membrane antigen (PSMA) has emerged as a highly promising clinical ..