Paul Donnelly

Pre-targeting amyloid-beta with antibodies for potential molecular imaging of Alzheimer's disease

Katherine A Morgan, Michael de Veer, Luke A Miles, Cormac AA Kelderman, Catriona A McLean, Colin L Masters, Kevin J Barnham, Jonathan M White, Brett M Paterson, Paul S Donnelly

Journal article  |  2023  |  CHEMICAL COMMUNICATIONS

With the aim of developing the concept of pretargeted click chemistry for the diagnosis of Alzheimer's disease two antibodies spec..

Transdermal Application of Soluble CuII(atsm) Increases Brain and Spinal Cord Uptake Compared to Gavage with an Insoluble Suspension

Sara Nikseresht, James BW Hilton, Jeffrey R Liddell, Kai Kysenius, Ashley I Bush, Scott Ayton, HuiJing Koay, Paul S Donnelly, Peter J Crouch

Journal article  |  2022  |  NEUROSCIENCE

CuII(atsm) is a blood-brain barrier permeant copper(II) compound that is under investigation in human clinical trials for the trea..

ImmunoPET: IMaging of cancer imMUNOtherapy targets with positron Emission Tomography: a phase 0/1 study characterising PD-L1 with 89Zr-durvalumab (MEDI4736) PET/CT in stage III NSCLC patients receiving chemoradiation study protocol.

Fiona Hegi-Johnson, Stacey E Rudd, Christian Wichmann, Tim Akhurst, Peter Roselt, Jenny Trinh, Thomas John, Lisa Devereux, Paul S Donnelly, Rod Hicks, Andrew M Scott, Daniel Steinfort, Stephen Fox, Benjamin Blyth, Sagun Parakh, Gerard G Hanna, Jason Callahan, Kate Burbury, Michael MacManus

Journal article  |  2022  |  BMJ Open

BACKGROUND: ImmunoPET is a multicentre, single arm, phase 0-1 study that aims to establish if 89Zr-durvalumab PET/CT can be used t..

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone-Pyridylhydrazone Copper(II) Complex

Xin Yi Choo, Lachlan E McInnes, Alexandra Grubman, Joanna M Wasielewska, Irina Belaya, Emma Burrows, Hazel Quek, Jorge Canas Martin, Sanna Loppi, Annika Sorvari, Dzhessi Rait, Andrew Powell, Clare Duncan, Jeffrey R Liddell, Heikki Tanila, Jose M Polo, Tarja Malm, Katja M Kanninen, Paul S Donnelly, Anthony R White

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroinflammation has a major role in several brain disorders including Alzheimer's disease (AD), yet at present there are no effe..

P1.10-02 ImmunoPET: A Phase 0/1 Study Characterising PD-L1 with 89Zr-Durvalumab (MEDI4736) PET/CT in Stage III NSCLC Patients Receiving Chemoradiation

M MacManus, S Rudd, P Roselt, C Wichmann, J Callahan, T John, A Scott, P Donnelly, G Hanna, F Hegi-Johnson

Journal article  |  2022  |  Journal of Thoracic Oncology

MA09.05 Increased PD-L1 Tracer Uptake in Recently-irradiated Lesions in NSCLC: Preliminary Results of a Phase 0 Trial (ImmunoPET) of a Novel PET Tracer

F Hegi-Johnson, T Akhurst, S Rudd, P Donnelly, A Scott, J Callahan, P Roselt, T John, S Sithara, C Wichmann, G Hanna, M MacManus

Journal article  |  2022  |  Journal of Thoracic Oncology

P2.03-01 Initial Biodistribution Data of ImmunoPET A Phase 0/1 Study Characterising PD-L1 with 89 Zr-Durvalumab (MEDI4736) PET/CT

F Hegi-Johnson, S Rudd, J Callahan, C Wichmann, T Akhurst, P Roselt, T John, P Donnelly, A Scott, G Hanna, M MacManus

Journal article  |  2022  |  Journal of Thoracic Oncology

Hexadentate technetium-99m bis(thiosemicarbazonato) complexes: synthesis, characterisation and biodistribution

Cormac AA Kelderman, Patrick RWJ Davey, Michelle T Ma, Michael de Veer, Ekaterina Salimova, Paul S Donnelly, Brett M Paterson

Journal article  |  2022  |  DALTON TRANSACTIONS

The syntheses of non-oxido/non-nitrido bis(thiosemicarbazonato)technetium(V) complexes featuring a series of alkyl and ether subst..

Palladium-Mediated CO2 Extrusion Followed by Insertion of Allenes: Translating Mechanistic Studies to Develop a One-Pot Method for the Synthesis of Alkenes

Yang Yang, Benjamin Spyrou, Jonathan M White, Allan J Canty, Paul S Donnelly, Richard AJ O'Hair

Journal article  |  2022  |  ORGANOMETALLICS

A palladium-mediated one-pot synthesis of alkenes from aromatic carboxylic acids and allene substrates (R1R2C═C═CH2, where either:..

Synthesis of acyloin natural products by Mukaiyama hydration

Michael Ricca, Wei Zhang, Jiaqi Li, Thomas Fellowes, Jonathan M White, Paul S Donnelly, Mark A Rizzacasa

Journal article  |  2022  |  ORGANIC & BIOMOLECULAR CHEMISTRY

The acyloin natural products are a family of bioactive compounds isolated from fungi and myxobacteria. The total synthesis of 7 me..