Andrew Roberts

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.

Donia M Moujalled, Fiona C Brown, Chong Chyn Chua, Michael A Dengler, Giovanna Pomilio, Natasha S Anstee, Veronique Litalien, Ella Thompson, Thomas Morley, Sarah MacRaild, Ing S Tiong, Rhiannon Morris, Karen Dun, Adrian Zordan, Jaynish Shah, Sebastien Banquet, Ensar Halilovic, Erick Morris, Marco J Herold, Guillaume Lessene, et al.

Journal article  |  2023  |  Blood

Randomized trials in acute myeloid leukemia (AML) have demonstrated improved survival by the BCL-2 inhibitor venetoclax combined w..

Venetoclax treatment in cancer patients has limited impact on circulating T and NK cells.

Charis E Teh, Hongke Peng, Mengxiao Luo, Tania Tan, Marie Trussart, Lauren J Howson, Chong Chyn Chua, Christine Muttiah, Fiona C Brown, Matthew E Ritchie, Andrew H Wei, Andrew W Roberts, Vanessa L Bryant, Mary Ann Anderson, Geoffrey J Lindeman, David Ching Siang Huang, Rachel Thijssen, Daniel HD Gray

Journal article  |  2022  |  Blood Adv

Venetoclax is an effective treatment for certain blood cancers, such as chronic lymphocytic leukemia (CLL) and acute myeloid leuke..

Sensitivity of canine hematological cancers to BH3 mimetics

Selvi Jegatheeson, Claire Cannon, Caroline Mansfield, Joanne Devlin, Andrew Roberts

Thesis / Dissertation  |  2022  |  Journal of Veterinary Internal Medicine

BACKGROUND: Inhibition of antiapoptotic B-cell lymphoma 2 (BCL2) proteins by small molecule Bcl-2 homology 3 (BH3) mimetics causes..

Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy

Rachel Thijssen, Luyi Tian, Mary Ann Anderson, Christoffer Flensburg, Andrew Jarratt, Alexandra L Garnham, Jafar S Jabbari, Hongke Peng, Thomas E Lew, Charis E Teh, Quentin Gouil, Angela Georgiou, Tania Tan, Tirta M Djajawi, Constantine S Tam, John F Seymour, Piers Blombery, Daniel HD Gray, Ian J Majewski, Matthew E Ritchie, et al.

Journal article  |  2022  |  BLOOD

Venetoclax (VEN) inhibits the prosurvival protein BCL2 to induce apoptosis and is a standard therapy for chronic lymphocytic leuke..

Shielding the Vulnerable: A Multicentre Australian Rollout of Evusheld to Patients with Chronic Lymphocytic Leukaemia (CLL-SHIELD)

Ashley Whitechurch, Rory Bennett, Shafqat Inam, Benjamin Hartog, Rebecca Blackwood, Shevon Fernando, Felanita Hutani, Hadley Bortz, Mitchel Lincoln, Dennis Carney, Andrew W Roberts, Mary Ann Anderson, Constantine S Tam, John F Seymour

Conference Proceedings  |  2022  |  Blood

Enrichment of BTK Leu528Trp mutations in patients with CLL on zanubrutinib: potential for pirtobrutinib cross-resistance

Piers Blombery, Ella R Thompson, Thomas E Lew, Ing Soo Tiong, Rory Bennett, Chan Y Cheah, Katharine Louise Lewis, Sasanka M Handunnetti, Chloe Pek Sang Tang, Andrew Roberts, John F Seymour, Constantine S Tam

Journal article  |  2022  |  BLOOD ADVANCES

The covalent Bruton's tyrosine kinase inhibitors (BTKis) are highly effective for the treatment of chronic lymphocytic leukemia (C..

Trajectories of glycemic control with clinical pharmacy specialist management of veterans with type 2 diabetes.

Ted R Grabarczyk, Andrew W Roberts, Jonathan D Mahnken, Dennis Grauer

Journal article  |  2022  |  Res Social Adm Pharm

BACKGROUND: Improved control of glycemic control likely lowers the risk of diabetes complications and clinical pharmacy specialist..

Germline MBD4 deficiency causes a multi-tumor predisposition syndrome

Claire Palles, Hannah D West, Edward Chew, Sara Galavotti, Christoffer Flensburg, Judith E Grolleman, Erik AM Jansen, Helen Curley, Laura Chegwidden, Edward H Arbe-Barnes, Nicola Lander, Rebekah Truscott, Judith Pagan, Ashish Bajel, Kitty Sherwood, Lynn Martin, Huw Thomas, Demetra Georgiou, Florentia Fostira, Yael Goldberg, et al.

Journal article  |  2022  |  AMERICAN JOURNAL OF HUMAN GENETICS

We report an autosomal recessive, multi-organ tumor predisposition syndrome, caused by bi-allelic loss-of-function germline varian..

Acute leukaemia in Australia: outcomes have improved, but there is still much to do

Zhi Han Yeoh, Andrew W Roberts

Journal article  |  2022  |  MEDICAL JOURNAL OF AUSTRALIA

Classification of myeloid neoplasms/acute leukemia: Global perspectives and the international consensus classification approach COMMENT

Daniel A Arber, Robert P Hasserjian, Attilio Orazi, Vikram Mathews, Andrew W Roberts, Charles A Schiffer, Anne Stidsholt Roug, Mario Cazzola, Hartmut Doehner, Ayalew Tefferi

Journal article  |  2022  |  AMERICAN JOURNAL OF HEMATOLOGY