Andrew Roberts

Cotargeting BCL-2 and MCL-1 in high-risk B-ALL

Donia M Moujalled, Diane T Hanna, Soroor Hediyeh-zadeh, Giovanna Pomilio, Lauren Brown, Veronique Litalien, Ray Bartolo, Shaun Fleming, Maia Chanrion, Sebastien Banquet, Ana-Leticia Maragno, Laurence Kraus-Berthier, Marie Schoumacher, Charles G Mullighan, Angela Georgiou, Christine A White, Guillaume Lessene, David CS Huang, Andrew W Roberts, Olivier Geneste, et al.

Journal article  |  2020  |  BLOOD ADVANCES

Improving survival outcomes in adult B-cell acute lymphoblastic leukemia (B-ALL) remains a clinical challenge. Relapsed disease ha..

BTK inhibitor therapy is effective in patients with CLL resistant to venetoclax.

Victor S Lin, Thomas E Lew, Sasanka M Handunnetti, Piers Blombery, Tamia Nguyen, David A Westerman, Bryone J Kuss, Constantine S Tam, Andrew W Roberts, John F Seymour, Mary Ann Anderson

Journal article  |  2020  |  Blood

Highly active BTK inhibitors (BTKis) and the BCL2 inhibitor venetoclax have transformed the therapeutic landscape for chronic lymp..

Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML

CD DiNardo, IS Tiong, A Quaglieri, S MacRaild, S Loghavi, FC Brown, R Thijssen, G Pomilio, A Ivey, JM Salmon, C Glytsou, SA Fleming, Q Zhang, H Ma, KP Patel, SM Kornblau, Z Xu, CC Chua, Xufeng Chen, P Blombery, et al.

Journal article  |  2020  |  Blood

The BCL-2 inhibitor venetoclax combined with hypomethylating agents or low-dose cytarabine represents an important new therapy for..

Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on

Piers Blombery, Ella R Thompson, Nguyen Tamia, Richard W Birkinshaw, Jia-Nan Gong, Xiangting Chen, Michelle McBean, Rachel Thijssen, Thomas Conway, Mary Ann Anderson, John F Seymour, David A Westerman, Peter E Czabotar, David CS Huang, Andrew W Roberts

Journal article  |  2020  |  Blood

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

Michael A Dengler, Charis E Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J Herold, Daniel H Gray, Gemma L Kelly, Andrew W Roberts, Jerry M Adams

Journal article  |  2020  |  Oncogene

Apoptosis-regulating BCL-2 family members, which can promote malignant transformation and resistance to therapy, have become prime..

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma

Thijs WH Flinsenberg, Charnelle C Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin YT Thia, Tahereh Noori, Xiaomin Song, Han X Aw Yeang, Daniela G Tantalo, Sasanka Handunnetti, John F Seymour, Andrew W Roberts, David Ritchie, Rachel Koldej, Paul J Neeson, Lai Wang, Joseph A Trapani, Constantine S Tam, Ilia Voskoboinik

Journal article  |  2020  |  Haematologica

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells

Charis E Teh, Jia-Nan Gong, David Segal, Tania Tan, Cassandra J Vandenberg, Pasquale L Fedele, Michael SY Low, George Grigoriadis, Simon J Harrison, Andreas Strasser, Andrew W Roberts, David CS Huang, Garry P Nolan, Daniel HD Gray, Melissa E Ko

Journal article  |  2020  |  Cell Death & Differentiation

Multiple myeloma is an incurable and fatal cancer of immunoglobulin-secreting plasma cells. Most conventional therapies aim to ind..

Undetectable peripheral blood MRD should be the goal of venetoclax in CLL, but attainment plateaus after 24 months

Thomas E Lew, Mary Ann Anderson, Victor S Lin, Sasanka M Handunnetti, Neil A Came, Piers Blombery, David A Westerman, Meaghan Wall, Constantine S Tam, Andrew W Roberts, John F Seymour

Journal article  |  2020  |  Blood Advances

The highly selective BCL2 inhibitor venetoclax achieves deep responses in patients with relapsed or refractory (R/R) chronic lymph..

Changing of the guard ... the old and the new

Nancy Berliner, Andrew Roberts

Journal article  |  2020  |  Blood

Targeting MCL-1 in hematologic malignancies: Rationale and progress

AH Wei, AW Roberts, A Spencer, AS Rosenberg, D Siegel, RB Walter, S Caenepeel, P Hughes, Z McIver, K Mezzi, PK Morrow, A Stein

Journal article  |  2020  |  Blood Reviews

Ptpn6 inhibits caspase-8-and Ripk3/Mlkl-dependent inflammation

Mary Speir, Cameron J Nowell, Alyce A Chen, Joanne A O'Donnell, Isaac S Shamie, Paul R Lakin, Akshay A D'Cruz, Roman O Braun, Jeff J Babon, Rowena S Lewis, Meghan Bliss-Moreau, Inbar Shlomovitz, Shu Wang, Louise H Cengia, Anca I Stoica, Razq Hakem, Michelle A Kelliher, Lorraine A O'Reilly, Heather Patsiouras, Kate E Lawlor, et al.

Journal article  |  2020  |  Nature Immunology

Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin-1 (IL-1) receptor-dependent, caspase-1-ind..

Venetoclax in Lymphoid Malignancies: New Insights, More to Learn

Rachel Thijssen, Andrew W Roberts

Journal article  |  2019  |  Cancer Cell

A Phase 1, First-in-Human Study of AMG 176, a Selective MCL-1 Inhibitor, in Patients With Relapsed or Refractory Multiple Myeloma

Andrew Spencer, Aaron Seth Rosenberg, Andrzej Jakubowiak, Noopur Raje, Manik Chatterjee, Suzanne Trudel, Nizar J Bahlis, David S Siegel, Stefan Wilop, Simon J Harrison, Murthy NagaKrishna, Shyeilla Dhuria, Antreas Hindoyan, Zach McIver, Haby Henary, Phuong Khanh Morrow, Andrew Roberts

Conference Proceedings  |  2019  |  Clinical Lymphoma Myeloma and Leukemia

Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL

Constantine S Tam, Judith Trotman, Stephen Opat, Jan A Burger, Gavin Cull, David Gottlieb, Rosemary Harrup, Patrick B Johnston, Paula Marlton, Javier Munoz, John F Seymour, David Simpson, Alessandra Tedeschi, Rebecca Elstrom, Yiling Yu, Zhiyu Tang, Lynn Han, Jane Huang, William Novotny, Lai Wang, et al.

Journal article  |  2019  |  Blood

Zanubrutinib is a potent and highly selective inhibitor of Bruton tyrosine kinase (BTK). In this first-in-human, open--label, mult..

Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

Piers Blombery, Richard W Birkinshaw, Tamia Nguyen, Jia-nan Gong, Ella R Thompson, Zhen Xu, David A Westerman, Peter E Czabotar, Michael Dickinson, David CS Huang, John F Seymour, Andrew W Roberts

Journal article  |  2019  |  British Journal of Haematology

Polyclonal Heterogeneity: The New Norm for Secondary Clinical Resistance to Targeted Monotherapy in Relapsed Leukemia?

Andrew H Wei, Andrew W Roberts

Journal article  |  2019  |  Cancer Discovery

Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables

Andrew W Roberts, Shuo Ma, Thomas J Kipps, Steven E Coutre, Matthew S Davids, Barbara Eichhorst, Michael Hallek, John C Byrd, Kathryn Humphrey, Lang Zhou, Brenda Chyla, Jacqueline Nielsen, Jalaja Potluri, Su Young Kim, Maria Verdugo, Stephan Stilgenbauer, William G Wierda, John F Seymour

Journal article  |  2019  |  Blood

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

Richard W Birkinshaw, Jia-nan Gong, Cindy S Luo, Daisy Lio, Christine A White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J Majewski, Rachel Thijssen, Andrew W Roberts, David CS Huang, Peter M Colman, Peter E Czabotar

Journal article  |  2019  |  Nature Communications

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

Donia M Moujalled, Giovanna Pomilio, Corina Ghiurau, Adam Ivey, Jessica Salmon, Sewa Rijal, Sarah Macraild, Lan Zhang, Tse-Chieh Teh, Ing-Soo Tiong, Ping Lan, Maia Chanrion, Audrey Claperon, Francesca Rocchetti, Adrien Zichi, Laurence Kraus-Berthier, Youzhen Wang, Ensar Hamovic, Erick Morris, Frederic Colland, et al.

Journal article  |  2019  |  Leukemia

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, Mary Ann Anderson, Jia-nan Gong, Rachel Thijssen, Richard W Birkinshaw, Ella R Thompson, Charis E Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E Lew, Ian J Majewski, Daniel HD Gray, David A Westerman, Constantine S Tam, John F Seymour, Peter E Czabotar, David CS Huang, Andrew W Roberts

Journal article  |  2019  |  Cancer Discovery

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

Sheau W Lok, James R Whittle, Francois Vaillant, Charis E Teh, Louisa L Lo, Antonia N Policheni, Alice RT Bergin, Jayesh Desai, Sarah Ftouni, Luke C Gandolfo, Danny Liew, He K Liu, G Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W Roberts, Mark A Rosenthal, Kylie Shackleton, Maria Joao Silva, et al.

Journal article  |  2019  |  Cancer Discovery

Targeting Mcl-1 is a promising strategy to kill mantle cell lymphoma cells

Michael A Dengler, Charis E Teh, Marco J Herold, Andrew W Roberts, Jerry M Adams

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Rishu Agarwal, Yih-Chih Chan, Constantine S Tam, Tane Hunter, Dane Vassiliadis, Charis E Teh, Rachel Thijssen, Paul Yeh, Stephen Q Wong, Sarah Ftouni, Enid YN Lam, Mary Ann Anderson, Christiane Pott, Omer Gilan, Charles C Bell, Kathy Knezevic, Piers Blombery, Kathleen Rayeroux, Adrian Zordan, Jason Li, et al.

Journal article  |  2019  |  Nature Medicine

Revised Dose Ramp-Up to Mitigate the Risk of Tumor Lysis Syndrome When Initiating Venetoclax in Patients With Mantle Cell Lymphoma

Matthew S Davids, Gottfried von Keudell, Craig A Portell, Jonathon B Cohen, David C Fisher, Francine Foss, Andrew W Roberts, John F Seymour, Rod A Humerickhouse, Constantine S Tam

Journal article  |  2018  |  Journal of Clinical Oncology

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

Delphine Merino, Gemma L Kelly, Guillaume Lessene, Andrew H Wei, Andrew W Roberts, Andreas Strasser

Journal article  |  2018  |  Cancer Cell

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Sean Caenepeel, Sean P Brown, Brian Belmontes, Gordon Moody, Kathleen S Keegan, Danny Chui, Douglas A Whittington, Xin Huang, Leszek Poppe, Alan C Cheng, Mario Cardozom, Jonathan Houze, Yunxiao Li, Brian Lucas, Nick A Paras, Xianghong Wang, Joshua P Taygerly, Marc Vimolratana, Manuel Zancanella, Liusheng Zhu, et al.

Journal article  |  2018  |  Cancer Discovery

Minimal Residual Disease Status with Venetoclax Monotherapy Is Associated with Progression-Free Survival in Chronic Lymphocytic Leukemia

William G Wierda, Andrew W Roberts, Paolo Ghia, Jennifer R Brown, Stephan Stilgenbauer, Florence Cymbalista, Nicole Lamanna, John F Seymour, Sebastian Boettcher, Madlaina Breuleux, Brenda Chyla, Lang Zhou, Jacqueline Nielsen, Su Young Kim, Jalaja Potluri, Johnathan C Maher, Peter Hillmen

Conference Proceedings  |  2018  |  Blood

Serial Minimal Residual Disease Evaluation in Patients with Chronic Lymphocytic Leukemia Under Long-Term Venetoclax Treatment

Thomas Lew, Mary Ann Anderson, Constantine S Tam, Sasanka Handunnetti, Dennis Carney, Max Wolf, Surender Juneja, David Alan Westerman, Andrew W Roberts, John F Seymour

Conference Proceedings  |  2018  |  Blood

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, Mary Ann Anderson, Jianan Gong, Rachel Thijssen, Richard W Birkinshaw, Ella Thompson, Charis E Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas Lew, Ian Majewski, Daniel Gray, David Alan Westerman, Constantine S Tam, John F Seymour, Peter E Czabotar, David Huang, Andrew W Roberts

Conference Proceedings  |  2018  |  Blood

Durability of Responses on Continuous Therapy and Following Drug Cessation in Deep Responders with Venetoclax and Rituximab

Danielle M Brander, John F Seymour, Shuo Ma, Mary Ann Anderson, Michael Y Choi, Thomas J Kipps, Kathryn Humphrey, Abdullah Masud, Ruby Nandam, Su Young Kim, Maria E Verdugo, Andrew W Roberts

Conference Proceedings  |  2018  |  Blood

Long-Term Follow-up of Patients with Mantle Cell Lymphoma Treated with Venetoclax Monotherapy

Matthew S Davids, Andrew W Roberts, William G Wierda, Kathryn Humphrey, Debbie J Alter, Abdullah Masud, Eike C Buss, Maria E Verdugo, John F Seymour

Conference Proceedings  |  2018  |  Blood

Identification of Potent BH3-Mimetic Combinations Targeting Pro-Survival Pathways in Human B-Cell Acute Lymphoblastic Leukemia

Donia M Moujalled, Diane T Hanna, Giovanna Pomilio, Veronique Litalien, Shaun Fleming, Marie Chanrion, Ana-Leticia Maragno, Laurence Kraus-Berthier, Seong Lin Khaw, Guillaume Lessene, David Huang, Andrew W Roberts, Olivier Geneste, Paul G Ekert, Ashley P Ng, Andrew H Wei

Conference Proceedings  |  2018  |  Blood

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

Mathijs A Sanders, Edward Chew, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E Miller, Adil S al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara McIennan, Remco M Hoogenboezem, Francois G Kavelaars, Stefan Froehling, Marnie E Blewitt, Eric M Bindels, Warren S Alexander, Bob Lowenberg, Andrew W Roberts, Peter JM Valk, Ian J Majewski

Journal article  |  2018  |  Blood

Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

Matthew S Davids, Michael Hallek, William Wierda, Andrew W Roberts, Stephan Stilgenbauer, Jeffrey A Jones, John F Gerecitano, Su Young Kim, Jalaja Potluri, Todd Busman, Andrea Best, Maria E Verdugo, Elisa Cerri, Monali Desai, Peter Hillmen, John F Seymour

Journal article  |  2018  |  Clinical Cancer Research

MBD4 guards against DNA damage from methylcytosine deamination

Edward Chew, Mathijs A Sanders, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E Miller, Adil S al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara Mclennan, Remco M Hoogenboezem, Francois G Kavelaars, Marnie E Blewitt, Eric M Bindels, Warren S Alexander, Bob Lowenberg, Andrew W Roberts, Ian J Majewski, Peter J Valk

Conference Proceedings  |  2018  |  Molecular and Cellular Biology / Genetics

Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial

Stephan Stilgenbauer, Barbara Eichhorst, Johannes Schetelig, Peter Hillmen, John F Seymour, Steven Coutre, Wojciech Jurczak, Stephen P Mulligan, Anna Schuh, Sarit Assouline, Clemens-Martin Wendtner, Andrew W Roberts, Matthew S Davids, Johannes Bloehdorn, Talha Munir, Sebastian Boettcher, Lang Zhou, Ahmed Hamed Salem, Monali Desai, Brenda Chyla, et al.

Journal article  |  2018  |  Journal of Clinical Oncology

Statins enhance efficacy of venetoclax in blood cancers.

J Scott Lee, Andrew Roberts, Dennis Juarez, Thanh-Trang T Vo, Shruti Bhatt, Lee-Or Herzog, Sharmila Mallya, Richard J Bellin, Suresh K Agarwal, Ahmed Hamed Salem, Tu Xu, Jia Jia, Lingxiao Li, John R Hanna, Matthew S Davids, Angela G Fleischman, Susan O'Brien, Lloyd T Lam, Joel D Leverson, Anthony Letai, et al.

Journal article  |  2018  |  Science Translational Medicine

Statins have shown promise as anticancer agents in experimental and epidemiologic research. However, any benefit that they provide..

Mitigation of tumor lysis syndrome (TLS) complications with venetoclax (VEN) in CLL.

Matthew Steven Davids, John Francis Seymour, Andrew Warwick Roberts, Barbara Eichhorst, Thomas J Kipps, Anthony R Mato, Stephan Stilgenbauer, Mehrdad Mobasher, Monali Bhardwaj Desai, Jalaja Potluri, German E Pena, Maria E Verdugo, Jacqueline Nielsen, Aimee Cyr, Leanne Lash Fleming, Michael J Hallek

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Venetoclax (VEN) in Patients with Relapsed/Refractory Non-Hodgkin Lymphoma (NHL).

M Davids, A Roberts, J Seymour, W Wierda, S Puvvada, L Gressick, D Alter, L Zhou, S Kim, M Verdugo, J Gerecitano

Conference Proceedings  |  2018  |  BRITISH JOURNAL OF HAEMATOLOGY

Long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis

A Pardanani, J Gotlib, AW Roberts, M Wadleigh, S Sirhan, J Kawashima, JA Maltzman, L Shao, V Gupta, A Tefferi

Journal article  |  2018  |  Leukemia

Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma

Constantine S Tam, Mary Ann Anderson, Christiane Pott, Rishu Agarwal, Sasanka Handunnetti, Rodney J Hicks, Kate Burbury, Gillian Turner, Juliana Di Iulio, Mathias Bressel, David Westerman, Stephen Lade, Martin Dreyling, Sarah-Jane Dawson, Mark A Dawson, John F Seymour, Andrew W Roberts

Journal article  |  2018  |  New England Journal of Medicine

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

T-C Teh, N-Y Nguyen, DM Moujalled, D Segal, G Pomilio, S Rijal, A Jabbour, K Cummins, K Lackovic, P Blombery, E Thompson, PG Ekert, G Lessene, SP Glaser, DCS Huang, AW Roberts, MA Guthridge, AH Wei

Journal article  |  2018  |  Leukemia

Impact of Number of Prior Therapies and Bulk of Disease on Outcomes with Venetoclax (VEN) Monotherapy for Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL)

William G Wierda, John F Seymour, Andrew W Roberts, Su Young Kim, Leanne Lash-Fleming, Johnathan Maher, Todd Busman, Lang Zhou, Jacqueline Nielsenand Stephan Stilgenbauer

Conference Proceedings  |  2017  |  BLOOD

Promising efficacy and acceptable safety of venetoclax plus bortezomib and dexamethasone in relapsed/refractory MM

Philippe Moreau, Asher Chanan-Khan, Andrew W Roberts, Amit B Agarwal, Thierry Facon, Shaji Kumar, Cyrille Touzeau, Elizabeth A Punnoose, Jaclyn Cordero, Wijith Munasinghe, Jia Jia, Ahmed Hamed Salem, Kevin J Freise, Joel D Leverson, Sari Heitner Enschede, Jeremy A Ross, Paulo C Maciag, Maria Verdugo, Simon J Harrison

Journal article  |  2017  |  Blood

Venetoclax in Patients with Previously Treated Chronic Lymphocytic Leukemia

Andrew W Roberts, Stephan Stilgenbauer, John F Seymour, David CS Huang

Journal article  |  2017  |  Clinical Cancer Research

Bisphosphonate guidelines for treatment and prevention of myeloma bone disease

Oi Lin Lee, Noemi Horvath, Cindy Lee, Doug Joshua, Joy Ho, Jeff Szer, Hang Quach, Andrew Spencer, Simon Harrison, Peter Mollee, Andrew W Roberts, Dipti Talaulikar, Ross Brown, Bradley Augustson, Silvia Ling, Wilfrid Jaksic, John Gibson, Anna Kalff, Anna Johnston, Akash Kalro, et al.

Journal article  |  2017  |  Internal Medicine Journal

Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax

Mary Ann Anderson, Constantine Tam, Thomas E Lew, Surender Juneja, Manu Juneja, David Westerman, Meaghan Wall, Stephen Lade, Alexandra Gorelik, David CS Huang, John F Seymour, Andrew W Roberts

Journal article  |  2017  |  Blood

Safety and efficacy of the BCL2 inhibitor venetoclax in estrogen receptor (ER) and BCL2-positive metastatic breast cancer: The mBEP study.

Geoffrey John Lindeman, Sheau Wen Lok, Alice Ruth Bergin, James Richard Whittle, Kylie Shackleton, Peter Sherman, Sarah-Jane Dawson, Jayesh Desai, Danny Liew, Bruce Mann, Anand Murugasu, Andrew Warwick Roberts, Mark Rosenthal, Jane Visvader

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Idarubicin Dose Escalation During Consolidation Therapy for Adult Acute Myeloid Leukemia

Kenneth F Bradstock, Emma Link, Juliana Di Iulio, Jeff Szer, Paula Marlton, Andrew H Wei, Arno Enno, Anthony Schwarer, Ian D Lewis, James D'Rozario, Luke Coyle, Gavin Cull, Phillip Campbell, Michael F Leahy, Uwe Hahn, Paul Cannell, Campbell Tiley, Ray M Lowenthal, John Moore, Kimberly Cartwright, et al.

Journal article  |  2017  |  Journal of Clinical Oncology

Combination ibrutinib (Ibr) and venetoclax (Ven) for the treatment of mantle cell lymphoma (MCL): Primary endpoint assessment of the phase 2 AIM study.

Constantine Si Lun Tam, Andrew Warwick Roberts, Mary Ann Anderson, Sarah-Jane Dawson, Rodney J Hicks, Kate Burbury, Gillian Turner, Juliana Di Iulio, Mathias Bressel, David A Westerman, Rishu Agarwal, Christiane Pott, Martin H Dreyling, Mark A Dawson, John Francis Seymour

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Phase I First-in-Human Study of Venetoclax in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

Matthew S Davids, Andrew W Roberts, John F Seymour, John M Pagel, Brad S Kahl, William G Wierda, Soham Puvvada, Thomas J Kipps, Mary Ann Anderson, Ahmed Hamed Salem, Martin Dunbar, Ming Zhu, Franklin Peale, Jeremy A Ross, Lori Gressick, Monali Desai, Su Young Kim, Maria Verdugo, Rod A Humerickhouse, Gary B Gordon, et al.

Journal article  |  2017  |  Journal of Clinical Oncology

Venetoclax: a primer

Andrew W Roberts

Journal article  |  2017  |  Blood Advances

Venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukaemia: a phase 1b study

John F Seymour, Shuo Ma, Danielle M Brander, Michael Y Choi, Jacqueline Barrientos, Matthew S Davids, Mary Ann Anderson, Anne W Beaven, Steven T Rosen, Constantine S Tam, Betty Prine, Suresh K Agarwal, Wijith Munasinghe, Ming Zhu, L Leanne Lash, Monali Desai, Elisa Cerri, Maria Verdugo, Su Young Kim, Rod A Humerickhouse, et al.

Journal article  |  2017  |  The Lancet Oncology

Treatment of patients with Waldenstrom macroglobulinaemia: clinical practice guidelines from the Myeloma Foundation of Australia Medical and Scientific Advisory Group

Dipti Talaulikar, Constantine S Tam, Douglas Joshua, Joy Phoebe Ho, Jeff Szer, Hang Quach, Andrew Spencer, Simon Harrison, Peter Mollee, Andrew W Roberts, Noemi Horvath, Cindy Lee, Andrew Zannettino, Ross Brown, Bradley Augustson, Wilfrid Jaksic, John Gibson, Anna Kalff, Anna Johnston, Judith Trotman, et al.

Journal article  |  2017  |  Internal Medicine Journal

Targeting BCL2 With BH3 Mimetics: Basic Science and Clinical Application of Venetoclax in Chronic Lymphocytic Leukemia and Related B Cell Malignancies Genome Editing Techniques and Their Therapeutic Applications

AW Roberts, DCS Huang

Journal article  |  2017  |  Clinical Pharmacology & Therapeutics

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Andras Kotschy, Zoltan Szlavik, James Murray, James Davidson, Ana Leticia Maragno, Gaetane Le Toumelin-Braizat, Maia Chanrion, Gemma L Kelly, Jia-Nan Gong, Donia M Moujalled, Alain Bruno, Marton C Sekei, Attila Paczal, Zoltan B Szabo, Szabolcs Sipos, Gabor Radics, Agnes Proszenyak, Balazs Balint, Levente Ondi, Gabor Blasko, et al.

Journal article  |  2016  |  Nature

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1

Jia-Nan Gong, Tiffany Khong, David Segal, Yuan Yao, Chris D Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume Lessene, Andrew Spencer, Marco J Herold, Andrew W Roberts, David CS Huang

Journal article  |  2016  |  Blood

Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia

Seong Lin Khaw, Santi Suryani, Kathryn Evans, Jennifer Richmond, Alissa Robbins, Raushan T Kurmasheva, Catherine A Billups, Stephen W Erickson, Yuelong Guo, Peter J Houghton, Malcolm A Smith, Hernan Carol, Andrew W Roberts, David CS Huang, Richard B Lock

Journal article  |  2016  |  Blood

Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells

Takashi Ushiki, Nicholas D Huntington, Stefan P Glaser, Hiu Kiu, Angela Georgiou, Jian-Guo Zhang, Donald Metcalf, Nicos A Nicola, Andrew W Roberts, Warren S Alexander

Journal article  |  2016  |  PLOS ONE

Targeting BCL-2-like Proteins to Kill Cancer Cells

Suzanne Cory, Andrew W Roberts, Peter M Colman, Jerry M Adams

Journal article  |  2016  |  Trends in Cancer

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells

Z Xu, PP Sharp, Y Yao, D Segal, CH Ang, SL Khaw, BJ Aubrey, J Gong, GL Kelly, MJ Herold, A Strasser, AW Roberts, WS Alexander, CJ Burns, DCS Huang, SP Glaser

Journal article  |  2016  |  Leukemia

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism

Mary Ann Anderson, Jing Deng, John F Seymour, Constantine Tam, Su Young Kim, Joshua Fein, Lijian Yu, Jennifer R Brown, David Westerman, Eric G Si, Ian J Majewski, David Segal, Sari L Heitner Enschede, David CS Huang, Matthew S Davids, Anthony Letai, Andrew W Roberts

Journal article  |  2016  |  Blood

New Agents to Treat Chronic Lymphocytic Leukemia

Farasat Zaman, Lars Savendahl

Journal article  |  2016  |  The New England journal of medicine

New Agents to Treat Chronic Lymphocytic Leukemia REPLY

Andrew W Roberts, Matthew S Davids, John F Seymour

Journal article  |  2016  |  New England Journal of Medicine

Nephrotic syndrome as a complication of chronic graft-versus-host disease after allogeneic haemopoietic stem cell transplantation

E Wong, M Lasica, SZ He, A Bajel, AW Roberts, KD Mason, DS Ritchie, J Szer

Journal article  |  2016  |  Internal Medicine Journal

Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study

Stephan Stilgenbauer, Barbara Eichhorst, Johannes Schetelig, Steven Coutre, John F Seymour, Talha Munir, Soham D Puvvada, Clemens-Martin Wendtner, Andrew W Roberts, Wojciech Jurczak, Stephen P Mulligan, Sebastian Boettcher, Mehrdad Mobasher, Ming Zhu, Monali Desai, Brenda Chyla, Maria Verdugo, Sari Heitner Enschede, Elisa Cerri, Rod Humerickhouse, et al.

Journal article  |  2016  |  The Lancet Oncology

Progress in BCL2 inhibition for patients with chronic lymphocytic leukemia

Constantine S Tam, John F Seymour, Andrew W Roberts

Journal article  |  2016  |  Seminars in Oncology

Current challenges and novel treatment strategies in double hit lymphomas

Mary Ann Anderson, Alpha Tsui, Meaghan Wall, David CS Huang, Andrew W Roberts

Journal article  |  2016  |  Therapeutic Advances in Hematology

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

Andrew W Roberts, Matthew S Davids, John M Pagel, Brad S Kahl, Soham D Puvvada, John F Gerecitano, Thomas J Kipps, Mary Ann Anderson, Jennifer R Brown, Lori Gressick, Shekman Wong, Martin Dunbar, Ming Zhu, Monali B Desai, Elisa Cerri, Sari Heitner Enschede, Rod A Humerickhouse, William G Wierda, John F Seymour

Journal article  |  2016  |  New England Journal of Medicine

Targeting GM-CSF in inflammatory diseases

Ian P Wicks, Andrew W Roberts

Journal article  |  2016  |  Nature Reviews Rheumatology

Targeting apoptotic pathways to treat lymphoid malignancies.

Andrew W Roberts

Journal article  |  2016  |  [Rinsho ketsueki] The Japanese journal of clinical hematology

Oncogenic transformation through activation of proliferation generates cellular stress which promotes apoptosis, thereby diminishi..

Cellular Mechanisms Underlying Complete Hematological Response of Chronic Myeloid Leukemia to BRAF and MEK1/2 Inhibition in a Patient with Concomitant Metastatic Melanoma

Miles C Andrews, Natalie Turner, Janis Boyd, Andrew W Roberts, Andrew P Grigg, Andreas Behren, Jonathan Cebon

Journal article  |  2015  |  Clinical Cancer Research

Phase 1 study of the safety, pharmacokinetics, and antitumour activity of the BCL2 inhibitor navitoclax in combination with rituximab in patients with relapsed or refractory CD20( ) lymphoid malignancies

Andrew W Roberts, Ranjana H Advani, Brad S Kahl, Daniel Persky, John W Sweetenham, Dennis A Carney, Jianning Yang, Todd B Busman, Sari H Enschede, Roderick A Humerickhouse, John F Seymour

Journal article  |  2015  |  British Journal of Haematology

BCL2 inhibition in double hit lymphoma

Mary Ann Anderson, David CS Huang, Andrew W Roberts

Journal article  |  2015  |  Leukemia & Lymphoma

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1 beta

Man Lyang Kim, Jae Jin Chae, Yong Hwan Park, Dominic De Nardo, Roslynn A Stirzaker, Hyun-Ja Ko, Hazel Tye, Louise Cengia, Ladina DiRago, Donald Metcalf, Andrew W Roberts, Daniel L Kastner, Andrew M Lew, Dena Lyras, Benjamin T Kile, Ben A Croker, Seth L Masters

Journal article  |  2015  |  Journal of Experimental Medicine

A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia

Simon Z He, Samantha Busfield, David S Ritchie, Mark S Hertzberg, Simon Durrant, Ian D Lewis, Paula Marlton, Andrew J McLachlan, Ian Kerridge, Kenneth F Bradstock, Glen Kennedy, Andrew W Boyd, Trina M Yeadon, Angel F Lopez, Hayley S Ramshaw, Harry Iland, Simone Bamford, Megan Barnden, Mark DeWitte, Russell Basser, et al.

Journal article  |  2015  |  Leukemia & Lymphoma

Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis

Rami S Komrokji, John F Seymour, Andrew W Roberts, Martha Wadleigh, L Bik To, Robyn Scherber, Elyce Turba, Andrew Dorr, Joy Zhu, Lixia Wang, Tanya Granston, Mary S Campbell, Ruben A Mesa

Journal article  |  2015  |  Blood

Management of systemic AL amyloidosis: recommendations of the Myeloma Foundation of Australia Medical and Scientific Advisory Group

N Weber, P Mollee, B Augustson, R Brown, L Catley, J Gibson, S Harrison, PJ Ho, N Horvath, W Jaksic, D Joshua, H Quach, AW Roberts, A Spencer, J Szer, D Talaulikar, B To, A Zannettino, HM Prince

Journal article  |  2015  |  Internal Medicine Journal

RARE HAEMATOLOGIC MALIGNANCIES: BAD DISEASES CAN HAVE GREAT OUTCOMES WHEN THE RIGHT TREATMENTS ARE DISCOVERED

Edward Chew, Andrew W Roberts

Journal article  |  2015  |  Cancer Forum

Treatment of patients with multiple myeloma who are not eligible for stem cell transplantation: position statement of the myeloma foundation of Australia Medical and Scientific Advisory Group

H Quach, D Joshua, J Ho, J Szer, A Spencer, S Harrison, P Mollee, AW Roberts, N Horvath, D Talaulikar, B To, A Zannettino, R Brown, L Catley, B Augustson, W Jaksic, J Gibson, HM Prince

Journal article  |  2015  |  Internal Medicine Journal

Fas regulates neutrophil lifespan during viral and bacterial infection

Joanne A O'Donnell, Catherine L Kennedy, Marc Pellegrini, Cameron J Nowell, Jian-Guo Zhang, Lorraine A O'Reilly, Louise Cengia, Stuart Dias, Seth L Masters, Elizabeth L Hartland, Andrew W Roberts, Motti Gerlic, Ben A Croker

Journal article  |  2015  |  Journal of Leukocyte Biology

Donald Metcalf (1929-2014) Obituary

Douglas J Hilton, Nicos A Nicola, Warren S Alexander, Andrew W Roberts, Ashley R Dunn

Journal article  |  2015  |  Cell

Validating the Allogeneic Stem Cell Transplantation Disease Risk Index: Sample Size, Follow-up, and Local Data Are Important

Andrew BM Lim, Andrew W Roberts, Kate Mason, Ashish Bajel, Jeff Szer, David S Ritchie

Journal article  |  2015  |  Transplantation

Treatment of patients with multiple myeloma who are eligible for stem cell transplantation: position statement of the Myeloma Foundation of Australia Medical and Scientific Advisory Group

H Quach, D Joshua, J Ho, J Szer, A Spencer, SJ Harrison, P Mollee, AW Roberts, N Horvath, D Talulikar, B To, A Zannettino, R Brown, L Catley, B Augustson, W Jaksic, J Gibson, HM Prince

Journal article  |  2015  |  Internal Medicine Journal

Thalidomide and prednisolone versus prednisolone alone as consolidation therapy after autologous stem-cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the ALLG MM6 multicentre, open-label, randomised phase 3 study

Anna Kalff, Nola Kennedy, Angela Smiley, H Miles Prince, Andrew W Roberts, Kenneth Bradstock, Richard De Abreu Loureno, Chris Frampton, Andrew Spencer

Journal article  |  2014  |  The Lancet Haematology

Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC

SJ Busfield, M Biondo, M Wong, HS Ramshaw, EM Lee, S Ghosh, H Braley, C Panousis, AW Roberts, SZ He, D Thomas, L Fabri, G Vairo, RB Lock, AF Lopez, AD Nash

Journal article  |  2014  |  Leukemia

Targeting BCL2 for the Treatment of Lymphoid Malignancies

Mary Ann Anderson, David Huang, Andrew Roberts

Journal article  |  2014  |  Seminars in Hematology

Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199

SL Khaw, D Merino, MA Anderson, SP Glaser, P Bouillet, AW Roberts, DCS Huang

Journal article  |  2014  |  Leukemia

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

James A Rickard, Joanne A O'Donnell, Joseph M Evans, Najoua Lalaoui, Ashleigh R Poh, TeWhiti Rogers, James E Vince, Kate E Lawlor, Robert L Ninnis, Holly Anderton, Cathrine Hall, Sukhdeep K Spall, Toby J Phesse, Helen E Abud, Louise H Cengia, Jason Corbin, Sandra Mifsud, Ladina Di Rago, Donald Metcalf, Matthias Ernst, et al.

Journal article  |  2014  |  Cell

GFI1B mutation causes a bleeding disorder with abnormal platelet function

WS Stevenson, M-C Morel-Kopp, Q Chen, HP Liang, CJ Bromhead, S Wright, R Turakulov, AP Ng, AW Roberts, M Bahlo, CM Ward

Journal article  |  2013  |  Journal of Thrombosis and Haemostasis

BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia

Mary Ann Anderson, David CS Huang, Andrew W Roberts

Journal article  |  2013  |  Leukemia and Lymphoma

The genomic landscape of hypodiploid acute lymphoblastic leukemia

Linda Holmfeldt, Lei Wei, Ernesto Diaz-Flores, Michael Walsh, Jinghui Zhang, Li Ding, Debbie Payne-Turner, Michelle Churchman, Anna Andersson, Shann-Ching Chen, Kelly McCastlain, Jared Becksfort, Jing Ma, Gang Wu, Samir N Patel, Susan L Heatley, Letha A Phillips, Guangchun Song, John Easton, Matthew Parker, et al.

Journal article  |  2013  |  Nature Genetics

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263)

Jianlin Qiao, Simone M Schoenwaelder, Kylie D Mason, Tran Huy, Amanda K Davis, Zane S Kaplan, Shaun P Jackson, Benjamin T Kile, Robert K Andrews, Andrew W Roberts, Elizabeth E Gardiner

Journal article  |  2013  |  Blood

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

Kylie D Mason, Ann Lin, Lorraine Robb, Emma C Josefsson, Katya J Henley, Daniel HD Gray, Benjamin T Kile, Andrew W Roberts, Andreas Strasser, David CS Huang, Paul Waring, Lorraine A O'Reilly

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Andrew J Souers, Joel D Leverson, Erwin R Boghaert, Scott L Ackler, Nathaniel D Catron, Jun Chen, Brian D Dayton, Hong Ding, Sari H Enschede, Wayne J Fairbrother, David CS Huang, Sarah G Hymowitz, Sha Jin, Seong Lin Khaw, Peter J Kovar, Lloyd T Lam, Jackie Lee, Heather L Maecker, Kennan C Marsh, Kylie D Mason, et al.

Journal article  |  2013  |  Nature Medicine

The equivalents of human blood and spleen dendritic cell subtypes can be generated in vitro from human CD34( ) stem cells in the presence of fms-like tyrosine kinase 3 ligand and thrombopoietin

AI Proietto, D Mittag, AW Roberts, N Sprigg, L Wu

Journal article  |  2012  |  CELLULAR & MOLECULAR IMMUNOLOGY

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

LM Lindqvist, I Vikstroem, JM Chambers, K McArthur, M Ann Anderson, KJ Henley, L Happo, L Cluse, RW Johnstone, AW Roberts, BT Kile, BA Croker, CJ Burns, MA Rizzacasa, A Strasser, DCS Huang

Journal article  |  2012  |  Cell Death & Disease

Azilsartan Medoxomil Plus Chlorthalidone Reduces Blood Pressure More Effectively Than Olmesartan Plus Hydrochlorothiazide in Stage 2 Systolic Hypertension

William C Cushman, George L Bakris, William B White, Michael A Weber, Domenic Sica, Andrew Roberts, Eric Lloyd, Stuart Kupfer

Journal article  |  2012  |  Hypertension

Azilsartan medoxomil, an effective, long-acting angiotensin II receptor blocker, is a new treatment for hypertension that is also ..

Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival

Marlyse A Debrincat, Emma C Josefsson, Chloe James, Katya J Henley, Sarah Ellis, Marion Lebois, Kelly L Betterman, Rachael M Lane, Kelly L Rogers, Michael J White, Andrew W Roberts, Natasha L Harvey, Donald Metcalf, Benjamin T Kile

Journal article  |  2012  |  Blood

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

Delphine Merino, Seong L Khaw, Stefan P Glaser, Daniel J Anderson, Lisa D Belmont, Chihunt Wong, Peng Yue, Mikara Robati, Belinda Phipson, Walter D Fairlie, Erinna F Lee, Kirsteen J Campbell, Cassandra J Vandenberg, Suzanne Cory, Andrew W Roberts, Mary JC Ludlam, David CS Huang, Philippe Bouillet

Journal article  |  2012  |  Blood

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

Andrew W Roberts, John F Seymour, Jennifer R Brown, William G Wierda, Thomas J Kipps, Seong Lin Khaw, Dennis A Carney, Simon Z He, David CS Huang, Hao Xiong, Yue Cui, Todd A Busman, Evelyn M McKeegan, Andrew P Krivoshik, Sari H Enschede, Rod Humerickhouse

Journal article  |  2012  |  JOURNAL OF CLINICAL ONCOLOGY

Towards a Four-Dimensional View of Neutrophils

Ben A Croker, Andrew W Roberts, Nicos A Nicola

Journal article  |  2012  |  Methods in Molecular Biology

IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3

Ben A Croker, Hiu Kiu, Marc Pellegrini, Jesse Toe, Simon Preston, Donald Metcalf, Joanne A O'Donnell, Louise H Cengia, Kate McArthur, Nicos A Nicola, Warren S Alexander, Andrew W Roberts

Journal article  |  2012  |  Immunology and Cell Biology

Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignancies

Seong Lin Khaw, David CS Huang, Andrew W Roberts

Journal article  |  2011  |  Pathology

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

Emma C Josefsson, Chloe James, Katya J Henley, Marlyse A Debrincat, Kelly L Rogers, Mark R Dowling, Michael J White, Elizabeth A Kruse, Rachael M Lane, Sarah Ellis, Paquita Nurden, Kylie D Mason, Lorraine A O'Reilly, Andrew W Roberts, Donald Metcalf, David CS Huang, Benjamin T Kile

Journal article  |  2011  |  Journal of Experimental Medicine

Bcl-x(L)-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Simone M Schoenwaelder, Kate E Jarman, Elizabeth E Gardiner, My Hua, Jianlin Qiao, Michael J White, Emma C Josefsson, Imala Alwis, Akiko Ono, Abbey Willcox, Robert K Andrews, Kylie D Mason, Hatem H Salem, David CS Huang, Benjamin T Kile, Andrew W Roberts, Shaun P Jackson

Journal article  |  2011  |  Blood

Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1

Ben A Croker, Joanne A O'Donnell, Cameron J Nowell, Donald Metcalf, Grant Dewson, Kirsteen J Campbell, Kelly L Rogers, Yifang Hu, Gordon K Smyth, Jian-Guo Zhang, Michael White, Kurt Lackovic, Louise H Cengia, Lorraine A O'Reilly, Philippe Bouillet, Suzanne Cory, Andreas Strasser, Andrew W Roberts

Journal article  |  2011  |  Proceedings of the National Academy of Sciences of the United States of America

The Comparative Effects of Azilsartan Medoxomil and Olmesartan on Ambulatory and Clinic Blood Pressure

George L Bakris, Domenic Sica, Michael Weber, William B White, Andrew Roberts, Alfonso Perez, Charlie Cao, Stuart Kupfer

Journal article  |  2011  |  The Journal of Clinical Hypertension

The current study assesses the antihypertensive efficacy and safety of the investigational angiotensin receptor blocker (ARB), azi..

Neutrophils Require SHP1 To Regulate IL-1 beta Production and Prevent Inflammatory Skin Disease

Ben A Croker, Rowena S Lewis, Jeff J Babon, Justine D Mintern, Dieter E Jenne, Donald Metcalf, Jian-Guo Zhang, Louise H Cengia, Joanne A O'Donnell, Andrew W Roberts

Journal article  |  2011  |  JOURNAL OF IMMUNOLOGY

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

Marc Kvansakul, Andrew H Wei, Jamie I Fletcher, Simon N Willis, Lin Chen, Andrew W Roberts, David CS Huang, Peter M Colman

Journal article  |  2010  |  PLOS PATHOGENS

Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice

William S Stevenson, Craig D Hyland, Jian-Guo Zhang, Phillip O Morgan, Tracy A Willson, Anthony Gill, Adrienne A Hilton, Elizabeth M Viney, Melanie Bahlo, Seth L Masters, Sarah Hennebry, Samantha J Richardson, Nicos A Nicola, Donald Metcalf, Douglas J Hilton, Andrew W Roberts, Warren S Alexander

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

IL-6 PROMOTES ACUTE AND CHRONIC INFLAMMATORY DISEASE IN THE ABSENCE OF SOCS3

BA Croker, H Kiu, D Metcalf, J O'Donnell, L Cengia, WS Alexander, AW Roberts

Conference Proceedings  |  2010  |  EXPERIMENTAL HEMATOLOGY

Regulation of interleukin-1 beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production

Seth L Masters, Lisa A Mielke, Ann L Cornish, Caroline E Sutton, Joanne O'Donnell, Louise H Cengia, Andrew W Roberts, Ian P Wicks, Kingston HG Mills, Ben A Croker

Journal article  |  2010  |  EMBO Reports

SOCS3 regulates graft-versus-host disease

Geoffrey R Hill, Rachel D Kuns, Neil C Raffelt, Alistair LJ Don, Stuart D Olver, Kate A Markey, Yana A Wilson, Joel Tocker, Warren S Alexander, Andrew D Clouston, Andrew W Roberts, Kelli PA MacDonald

Journal article  |  2010  |  BLOOD

Improved survival for relapsed diffuse large B cell lymphoma is predicted by a negative pre-transplant FDG-PET scan following salvage chemotherapy

Michael Dickinson, Rosemary Hoyt, Andrew W Roberts, Andrew Grigg, John F Seymour, H Miles Prince, Jeff Szer, David Ritchie

Journal article  |  2010  |  British Journal of Haematology

The Bcl-2 Homology Domain 3 Mimetic ABT-737 Targets the Apoptotic Machinery in Acute Lymphoblastic Leukemia Resulting in Synergistic in Vitro and in Vivo Interactions with Established Drugs

Laura M High, Barbara Szymanska, Urszula Wilczynska-Kalak, Nicole Barber, Rosemary O'Brien, Seong Lin Khaw, Ingela B Vikstrom, Andrew W Roberts, Richard B Lock

Journal article  |  2010  |  MOLECULAR PHARMACOLOGY

Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2

Hiu Kiu, Christopher J Greenhalgh, Anne Thaus, Douglas J Hilton, Nicos A Nicola, Warren S Alexander, Andrew W Roberts

Journal article  |  2009  |  GROWTH FACTORS

Thalidomide Maintenance in Multiple Myeloma: Certainties and Controversies Reply

Andrew Spencer, H Miles Prince, Andrew W Roberts

Journal article  |  2009  |  Journal of Clinical Oncology

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia

KD Mason, SL Khaw, KC Rayeroux, E Chew, EF Lee, WD Fairlie, AP Grigg, JF Seymour, J Szer, DCS Huang, AW Roberts

Journal article  |  2009  |  Leukemia

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

Simone M Schoenwaelder, Yuping Yuan, Emma C Josefsson, Michael J White, Yu Yao, Kylie D Mason, Lorraine A O'Reilly, Katya J Henley, Akiko Ono, Sarah Hsiao, Abbey Willcox, Andrew W Roberts, David CS Huang, Hatem H Salem, Benjamin T Kile, Shaun P Jackson

Journal article  |  2009  |  Blood

Vascular endothelial growth factor inhibition is not an effective therapeutic strategy for relapsed or refractory multiple myeloma: a phase 2 study of pazopanib (GW786034)

H Miles Prince, Dirk Hoenemann, Andrew Spencer, David A Rizzieri, Edward A Stadtmauer, Andrew W Roberts, Nizar Bahlis, Guido Tricot, Bill Bell, Douglas J DeMarini, A Benjamin Suttle, Katherine L Baker, Lini N Pandite

Journal article  |  2009  |  BLOOD

Consolidation Therapy With Low-Dose Thalidomide and Prednisolone Prolongs the Survival of Multiple Myeloma Patients Undergoing a Single Autologous Stem-Cell Transplantation Procedure

Andrew Spencer, H Miles Prince, Andrew W Roberts, Ian W Prosser, Kenneth F Bradstock, Luke Coyle, Devinder S Gill, Noemi Horvath, John Reynolds, Nola Kennedy

Journal article  |  2009  |  Journal of Clinical Oncology

Clinical and Immunohistochemical Features Associated with a Response to Bortezomib in Patients with Multiple Myeloma

Mark A Dawson, Stephen S Opat, Yamna Taouk, Mark Donovan, Michele Zammit, Katherine Monaghan, Noemi Horvath, Andrew W Roberts, H Miles Prince, Mark Hertzberg, Catriona A McLean, Andrew Spencer

Journal article  |  2009  |  Clinical Cancer Research

BH3-mimetics - the solution to chemoresistance?

Seong L Khaw, David CS Huang, Andrew W Roberts

Journal article  |  2009  |  Leuk. Lymphoma

A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis

Jo L Eyles, Michael J Hickey, M Ursula Norman, Ben A Croker, Andrew W Roberts, Sarah F Drake, Will G James, Donald Metcalf, Ian K Campbell, Ian P Wicks

Journal article  |  2008  |  Blood

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

Kylie D Mason, Cassandra J Vandenberg, Clare L Scott, Andrew H Wei, Suzanne Cory, David CS Huang, Andrew W Roberts

Journal article  |  2008  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted therapies in haematological malignancies

S He, A Roberts

Journal article  |  2008  |  Cancer Forum

Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation

Ben A Croker, Lisa A Mielke, Sam Wormald, Donald Metcalf, Hiu Kiu, Warren S Alexander, Douglas J Hilton, Andrew W Roberts

Journal article  |  2008  |  Exp. Hematol.

Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3

Hayley A Croom, David J Izon, Mark M Chong, David J Curtis, Andrew W Roberts, Thomas WH Kay, Douglas J Hilton, Warren S Alexander, Robyn Starr

Journal article  |  2008  |  Molecular Immunology

Bortezomib: Putting mantle cell lymphoma on death row

Andrew H Wei, Andrew W Roberts

Journal article  |  2008  |  Leukemia & Lymphoma

Cyclosporin, methotrexate and prednisolone for graft-versus-host disease prophylaxis in allogeneic peripheral blood progenitor cell transplants

R Hoyt, DS Ritchie, AW Roberts, L MacGregor, DJ Curtis, J Szer, AP Grigg

Journal article  |  2008  |  Bone Marrow Transplantation

Renal safety of zoledronic acid with thalidomide in patients with myeloma: a pharmacokinetic and safety sub-study.

Andrew Spencer, Andrew Roberts, Nola Kennedy, Christina Ravera, Serge Cremers, Sanela Bilic, Terry Neeman, Michael Copeman, Horst Schran, Kevin Lynch

Journal article  |  2008  |  BMC Clinical Pharmacology

BACKGROUND: Cases of impaired renal function have been reported in patients who had been treated with both zoledronic acid and tha..

Graft-versus-lymphoma effect in progressive hepatosplenic gamma/delta T-cell lymphoma

Simon He, Andrew Roberts, David Ritchie, Andrew Grigg

Journal article  |  2007  |  Leukemia and Lymphoma

Erratum: Bim and Bad mediate imatinib-induced killing of Bcr/Abl leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic (Proceedings of the National Academy of Sciences of the United States of America (October 3, 2006) 40, 103 (14907-14912) DOI: 10.1073/pnas.0606176103)

J Kuroda, H Puthalakath, MS Cragg, PN Kelly, P Bouillet, DCS Huang, S Kimura, OG Ottmann, BJ Druker, A Villunger, AW Roberts, A Strasser

Journal article  |  2006  |  Proceedings of the National Academy of Sciences

"Bim and Bad mediate imatinib-induced killing of Bcr/Abl( ) leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic" (vol 103, pg 14907, 2006)

Junya Kuroda, Hamsa Puthalakath, Mark S Cragg, Priscilla N Kelly, Philippe Bouillet, David CS Huang, Shinya Kimura, Oliver G Ottmann, Brian J Druker, Andreas Villunger, Andrew W Roberts, Andreas Strasser

Journal article  |  2006  |  Proc. Natl. Acad. Sci. U. S. A.

Allogeneic stem cell transplantation with peripheral blood stem cells mobilized by pegylated G-CSF

Geoffrey R Hill, Edward S Morris, Madonna Fuery, Cheyl Hutchins, Jason Butler, Andrew Grigg, Andrew Roberts, Ken Bradstock, Jeffrey Szer, Glen Kennedy, James Morton, Simon Durrant

Journal article  |  2006  |  Biology of Blood and Marrow Transplantation

Reduced-intensity allogeneic haemopoietic stem cell transplantation induces durable responses in patients with chronic B-lymphoproliferative disorders

M Hertzberg, A Grigg, D Gottlieb, J Szer, A Roberts, R Hoyt, G Huang, KF Bradstock

Journal article  |  2006  |  Bone Marrow Transplantation

Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells

Ariel Forrai, Kristy Boyle, Adam H Hart, Lynne Hartley, Steven Rakar, Tracy A Willson, Ken M Simpson, Andrew W Roberts, Warren S Alexander, Anne K Voss, Lorraine Robb

Journal article  |  2006  |  Stem Cells

Screening and counseling for thalassemia.

David HK Chui, Melody J Cunningham, Hong-Yuan Luo, Lawrence C Wolfe, Ellis J Neufeld, Martin H Steinberg

Journal article  |  2006  |  Blood

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

L Robb, K Boyle, S Rakar, L Hartley, J Lochland, AW Roberts, WS Alexander, D Metcalf

Journal article  |  2005  |  Proceedings of the National Academy of Sciences

A multicenter phase II trial of thalidomide and celecoxib for patients with relapsed and refractory multiple myeloma

HM Prince, L Mileshkin, A Roberts, V Ganju, C Underhill, J Catalano, R Bell, JF Seymour, D Westerman, PJ Simmons, K Lillie, AD Milner, J Di Iulio, JB Zeldis, R Ramsay

Journal article  |  2005  |  Clinical Cancer Research

G-CSF: A key regulator of neutrophil production, but that's not all!

AW Roberts

Journal article  |  2005  |  Growth Factors

SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis

BA Croker, D Metcalf, L Robb, W Wei, S Mifsud, L DiRago, LA Cluse, KD Sutherland, L Hartley, E Williams, JG Zhang, DJ Hilton, NA Nicola, WS Alexander, AW Roberts

Journal article  |  2004  |  Immunity

SOCS3 negatively regulates IL-6 signaling in vivo

BA Croker, DL Krebs, JG Zhang, S Wormald, TA Willson, EG Stanley, L Robb, CJ Greenhalgh, I Forster, BE Clausen, NA Nicola, D Metcalf, DJ Hilton, AW Roberts, WS Alexander

Journal article  |  2003  |  Nat. Immunol.

Morphological effects of imatinib mesylate (STI571) on the bone marrow and blood of patients with Philadelphia chromosome (Ph) positive chronic myeloid leukaemia

C McNamara, A Grigg, J Szer, A Roberts, L Campbell, R Hoyt, K Lynch, S Juneja

Journal article  |  2003  |  Clinical and Laboratory Haematology

Blunt traumatic aortic transection: The endovascular experience

VP Orford, NR Atkinson, K Thomson, PY Milne, WA Campbell, A Roberts, J Goldblatt, J Tatoulis

Journal article  |  2003  |  Annals of Thoracic Surgery

Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites

R Gugasyan, C Quilici, STT I, D Grail, AM Verhagen, A Roberts, T Kitamura, AR Dunn, P Lock

Journal article  |  2002  |  Journal of Cell Biology

Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses

BA Croker, E Handman, JD Hayball, TM Baldwin, V Voigt, LA Cluse, FC Yang, DA Williams, AW Roberts

Journal article  |  2002  |  Immunol. Cell Biol.

The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes

BA Croker, DM Tarlinton, LA Cluse, AJ Tuxen, A Light, FC Yang, DA Williams, AW Roberts

Journal article  |  2002  |  J. Immunol.

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

AW Roberts, L Robb, S Rakar, L Hartley, L Cluse, NA Nicola, D Metcalf, DJ Hilton, WS Alexander

Journal article  |  2001  |  Proceedings of the National Academy of Sciences

Acute left ventricular failure following melphalan and fludarabine conditioning

DS Ritchie, JF Seymour, AW Roberts, J Szer, AP Grigg

Journal article  |  2001  |  Bone Marrow Transplantation

Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization

FC Yang, SJ Atkinson, Y Gu, JB Borneo, AW Roberts, Y Zheng, J Pennington, DA Williams

Journal article  |  2001  |  Proceedings of the National Academy of Sciences

Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation

BY Li, H Yu, WP Zheng, R Voll, SQ Na, AW Roberts, DA Williams, RJ Davis, S Ghosh, RA Flavell

Journal article  |  2000  |  Science

Identification of a genetic locus modulating splenomegaly induced by granulocyte colony-stimulating factor in mice

AW Roberts, M Hasegawa, D Metcalf, SJ Foote

Journal article  |  2000  |  Leukemia

'Mini-allografts' for haematological malignancies: an alternative to conventional myeloablative marrow transplantation

A Grigg, JF Seymour, A Roberts, J Szer

Journal article  |  1999  |  Australian and New Zealand Journal of Medicine

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

AW Roberts, C Kim, L Zhen, JB Lowe, R Kapur, B Petryniak, A Spaetti, JD Pollock, JB Borneo, GB Bradford, SJ Atkinson, MC Dinauer, DA Williams

Journal article  |  1999  |  Immunity

Cytokine production and function in c-mpl-deficient mice: No physiologic role for interleukin-3 in residual megakaryocyte and platelet production

T Gainsford, AW Roberts, S Kimura, D Metcalf, G Dranoff, RC Mulligan, CG Begley, L Robb, WS Alexander

Journal article  |  1998  |  Blood

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin

S Kimura, AW Roberts, D Metcalf, WS Alexander

Conference Proceedings  |  1998  |  Proceedings of the National Academy of Sciences

Mouse loci for malaria-induced mortality and the control of parasitaemia

SJ Foote, RA Burt, TM Baldwin, A Presente, AW Roberts, YL Laural, AM Lew, VM Marshall

Journal article  |  1997  |  Nature Genetics

Optimal regimens for the mobilization and collection of peripheral blood progenitor cells from normal donors

AW Roberts, AP Grigg

Journal article  |  1997  |  Leukemia & Lymphoma

Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor

AW Roberts, S Foote, WS Alexander, C Scott, L Robb, D Metcalf

Journal article  |  1997  |  Blood

G-CSF-mobilized peripheral blood progenitor cells: In vitro growth pattern and hematopoietic growth factor receptor profile

AW Roberts, M Zaiss, AW Boyd, NA Nicola

Journal article  |  1997  |  Experimental Hematology

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-mpl

WS Alexander, AW Roberts, NA Nicola, RL Li, D Metcalf

Journal article  |  1996  |  Blood

The regulation of hematopoiesis in max 41 transgenic mice with sustained excess granulopoiesis

D Metcalf, AW Roberts, TA Willson

Journal article  |  1996  |  Leukemia

Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation.

WS Alexander, AW Roberts, AB Maurer, NA Nicola, AR Dunn, D Metcalf

Journal article  |  1996  |  Stem Cells

The c-mpl gene encodes a receptor for thrombopoietin (TPO), a cytokine that potently stimulates megakaryocytopoiesis. To study the..

OPTIMIZING DOSE AND SCHEDULING OF FILGRASTIM (GRANULOCYTE-COLONY-STIMULATING FACTOR) FOR MOBILIZATION AND COLLECTION OF PERIPHERAL-BLOOD PROGENITOR CELLS IN NORMAL VOLUNTEERS

AP GRIGG, AW ROBERTS, H RAUNOW, S HOUGHTON, JE LAYTON, AW BOYD, KM MCGRATH, D MAHER

Journal article  |  1995  |  Blood

ABNORMAL NEUTROPHIL PHENOTYPE AND NEUTROPHIL FCRIII DEFICIENCY CORRECTED BY BONE-MARROW TRANSPLANTATION

RM MINCHINTON, M DEHAAS, AEGK VONDEMBORNE, M KLEIJER, AW ROBERTS, EA GILLETT

Journal article  |  1995  |  Transfusion

DO STEADY-STATE PERIPHERAL-BLOOD PROGENITOR-CELL (PBPC) COUNTS PREDICT THE YIELD OF PBPC MOBILIZED BY FILGRASTIM ALONE

AW ROBERTS, CG BEGLEY, AP GRIGG, RL BASSER

Journal article  |  1995  |  Blood

BROAD INTERINDIVIDUAL VARIATIONS IN CIRCULATING PROGENITOR-CELL NUMBERS INDUCED BY GRANULOCYTE-COLONY-STIMULATING FACTOR THERAPY

AW ROBERTS, E DELUCA, CG BEGLEY, R BASSER, AP GRIGG, D METCALF

Journal article  |  1995  |  Stem Cells

NONCYCLING STATE OF PERIPHERAL-BLOOD PROGENITOR CELLS MOBILIZED BY GRANULOCYTE-COLONY-STIMULATING FACTOR AND OTHER CYTOKINES

AW ROBERTS, D METCALF

Journal article  |  1995  |  Blood

GRANULOCYTE-COLONY-STIMULATING FACTOR INDUCES SELECTIVE ELEVATIONS OF PROGENITOR CELLS IN THE PERIPHERAL-BLOOD OF MICE

AW ROBERTS, D METCALF

Journal article  |  1994  |  Experimental Hematology

PHASE-II STUDY OF GLYCOSYLATED RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR AFTER HLA-IDENTICAL SIBLING BONE-MARROW TRANSPLANTATION

JD LICKLITER, AW ROBERTS, AP GRIGG

Journal article  |  1994  |  Australian and New Zealand Journal of Medicine

PHASE-II STUDY OF GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) AFTER SIBLING ALLOGENEIC BMT

J LICKLITER, A ROBERTS, A GRIGG

Conference Proceedings  |  1993  |  BLOOD

ALL-TRANS-RETINOIC ACID CHEMOTHERAPY INTERACTIONS IN ACUTE PROMYELOCYTIC LEUKEMIA

AW ROBERTS, WP SHERIDAN, AP GRIGG

Journal article  |  1992  |  Australian and New Zealand Journal of Medicine

IMMUNE THROMBOCYTOPENIA COMPLICATING PULMONARY TUBERCULOSIS - CASE-REPORT AND INVESTIGATION OF MECHANISMS

RJ BOOTS, AW ROBERTS, D MCEVOY

Journal article  |  1992  |  Thorax

Hemolytic uremic syndrome/thrombotic thrombocytopenic purpura: outcome with plasma exchange.

AW Roberts, EA Gillett, SJ Fleming

Journal article  |  1991  |  Journal of Clinical Apheresis

A retrospective analysis was made of 14 consecutive adults with hemolytic uremic syndrome/thrombotic thrombocytopenic purpura (HUS..

A scoring system for the quantitative evaluation of oral mucositis during bone marrow transplantation.

LJ Walsh, G Hill, G Seymour, A Roberts

Journal article  |  1990  |  Special Care in Dentistry

A system for assessing the severity of mucositis in patients undergoing bone marrow transplantation (BMT) is presented. Ten criter..

INVASIVE-CARCINOMA OF THE CERVIX IN YOUNG-WOMEN

AW ROBERTS, DA LANE, D BUNTINE, RG WRIGHT

Journal article  |  1985  |  Medical Journal of Australia