Katherine Kedzierska

Prime-boost, double-dose influenza vaccine immunity in COPD: a pilot observational study.

Gary P Anderson, Louis B Irving, Andrew Jarnicki, Katherine Kedzierska, Marios Koutsakos, Stephen Kent, Aeron C Hurt, Adam K Wheatley, Thi HO Nguyen, Natale Snape, John W Upham

Journal article  |  2023  |  ERJ Open Res

BACKGROUND: COPD patients are more susceptible to viral respiratory infections and their sequelae, and have intrinsically weaker i..

SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses

Marios Koutsakos, Arnold Reynaldi, Wen Shi Lee, Julie Nguyen, Thakshila Amarasena, George Taiaroa, Paul Kinsella, Kwee Chin Liew, Thomas Tran, Helen E Kent, Hyon-Xhi Tan, Louise C Rowntree, Thi HO Nguyen, Paul G Thomas, Katherine Kedzierska, Jan Petersen, Jamie Rossjohn, Deborah A Williamson, David Khoury, Miles P Davenport, et al.

Journal article  |  2023  |  Immunity

Circulating effector gamma delta T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals

Anouk von Borstel, Thi HO Nguyen, Louise C Rowntree, Thomas M Ashhurst, Lilith F Allen, Lauren J Howson, Natasha E Holmes, Olivia C Smibert, Jason A Trubiano, Claire L Gordon, Allen C Cheng, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Martin S Davey

Journal article  |  2023  |  IMMUNOLOGY AND CELL BIOLOGY

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a smal..

Prospective comprehensive profiling of immune responses to COVID-19 vaccination in patients on zanubrutinib therapy.

Thi HO Nguyen, Chhay Lim, Masa Lasica, Ashley Whitechurch, Surekha Tennakoon, Natalie R Saunders, Lilith F Allen, Louise C Rowntree, Brendon Y Chua, Lukasz Kedzierski, Hyon-Xhi Tan, Adam K Wheatley, Stephen J Kent, Theo Karapanagiotidis, Suellen Nicholson, Deborah A Williamson, Monica A Slavin, Constantine S Tam, Katherine Kedzierska, Benjamin W Teh

Journal article  |  2023  |  EJHaem

Zanubrutinib-treated and treatment-naïve patients with chronic lymphocytic leukaemia (CLL) or Waldenstrom's macroglobulinaemia wer..

Viral immunity: Basic mechanisms and therapeutic applications-a Keystone Symposia report.

Jennifer Cable, Siddharth Balachandran, Lisa P Daley-Bauer, Arjun Rustagi, Ferrin Antony, Justin J Frere, Jamie Strampe, Katherine Kedzierska, Judy L Cannon, Maureen A McGargill, Daniela Weiskopf, Robert C Mettelman, Julia Niessl, Paul G Thomas, Bryan Briney, Sophie A Valkenburg, Jesse D Bloom, Pamela J Bjorkman, Sho Iketani, C Garrett Rappazzo, et al.

Journal article  |  2023  |  Ann N Y Acad Sci

Viruses infect millions of people each year. Both endemic viruses circulating throughout the population as well as novel epidemic ..

T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance

Xin Gao, Kaiming Luo, Diya Wang, Yunbo Wei, Yin Yao, Jun Deng, Yang Yang, Qunxiong Zeng, Xiaoru Dong, Le Xiong, Dongcheng Gong, Lin Lin, Kai Pohl, Shaoling Liu, Yu Liu, Lu Liu, Thi HO Nguyen, Lilith F Allen, Katherine Kedzierska, Yanliang Jin, et al.

Journal article  |  2023  |  ELIFE

A defining feature of successful vaccination is the ability to induce long-lived antigen-specific memory cells. T follicular helpe..

Identification of human progenitors of exhausted CD8 T cells associated with elevated IFN-γ response in early phase of viral infection.

Curtis Cai, Jerome Samir, Mehdi R Pirozyan, Thiruni N Adikari, Money Gupta, Preston Leung, Brendan Hughes, Willem Van der Byl, Simone Rizzetto, Auda Elthala, Elizabeth Keoshkerian, Jean-Louis Palgen, Timothy Peters, Thi HO Nguyen, Raymond Louie, Katherine Kedzierska, Silvana Gaudieri, Rowena A Bull, Andrew R Lloyd, Fabio Luciani

Journal article  |  2022  |  Nat Commun

T cell exhaustion is a hallmark of hepatitis C virus (HCV) infection and limits protective immunity in chronic viral infections an..

Cutting Edge: High-Dose Live Attenuated Influenza Vaccines Elicit Pulmonary Tissue-Resident Memory CD8 T Cells in the Face of Pre-Existing Humoral Immunity.

Ming ZM Zheng, Svenja Fritzlar, Zhongfang Wang, Tiong Kit Tan, Katherine Kedzierska, Alain Townsend, Patrick C Reading, Linda M Wakim

Journal article  |  2022  |  J Immunol

In this study, we investigated how pre-existing Ab immunity to influenza virus established from prior immunizations affects the de..

Cutting Edge: High-Dose Live Attenuated Influenza Vaccines Elicit Pulmonary Tissue-Resident Memory CD8( ) T Cells in the Face of Pre-Existing Humoral Immunity

Ming ZM Zheng, Svenja Fritzlar, Zhongfang Wang, Tiong Kit Tan, Katherine Kedzierska, Alain Townsend, Patrick C Reading, Linda M Wakim

Journal article  |  2022  |  JOURNAL OF IMMUNOLOGY

In this study, we investigated how pre-existing Ab immunity to influenza virus established from prior immunizations affects the de..

Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques

Brendon Y Chua, Toshiki Sekiya, Marios Koutsakos, Naoki Nomura, Louise C Rowntree, Thi HO Nguyen, Hayley A McQuilten, Marumi Ohno, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Yasushi Itoh, Jennifer R Habel, Kevin J Selva, Adam K Wheatley, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, David C Jackson, et al.

Journal article  |  2022  |  PLOS PATHOGENS

Although antibody-inducing split virus vaccines (SV) are currently the most effective way to combat seasonal influenza, their effi..