Eleanor Saunders

Remodeling of Carbon Metabolism during Sulfoglycolysis in Escherichia coli

Janice W-Y Mui, David P De Souza, Eleanor C Saunders, Malcolm J McConville, Spencer J Williams

Journal article  |  2023  |  APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Sulfoquinovose (SQ) is a major metabolite in the global sulfur cycle produced by nearly all photosynthetic organisms. One of the m..

The role of mucosal-associated invariant T cells in visceral leishmaniasis

Marcela de Lima Moreira, Luana Oliveira Borges-Fernandes, Marcelo Antonio Pascoal-Xavier, Agata Lopes Ribeiro, Victoria Hellena Silva Pereira, Troi Pediongco, Marcio Sobreira da Silva Araujo, Andrea Teixeira-Carvalho, Andrea Lucchesi de Carvalho, Maria Vitoria Assumpcao Mourao, Flavia Alves Campos, Marineide Borges, Mariangela Carneiro, Zhenjun Chen, Eleanor Saunders, Malcolm McConville, Moriya Tsuji, James McCluskey, Olindo Assis Martins-Filho, Sidonia Barbara Guiomar Eckle, et al.

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections...

Hit-to-lead optimization of novel phenyl imidazole carboxamides that are active against Leishmania donovani

Nicole McNamara, Eleanor Saunders, Swapna Varghese, Rebecca Zheng, Kaylene Simpson, Devika M Varma, Monica M Johnson, M Shamim Hasan Zahid, Eric M Bachelder, Kristy M Ainslie, Joo Hwan No, Dahae Koh, David Shum, Nirmal Das, Binita Patra, Jayasree Roy, Arindam Talukdar, Dipyman Ganguly, Malcolm McConville, Jonathan Baell

Journal article  |  2022  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Visceral leishmaniasis is a potentially fatal disease caused by the parasitic protists, Leishmania donovani and L. infantum. Curre..

Oxidative desulfurization pathway for complete catabolism of sulfoquinovose by bacteria

Mahima Sharma, James P Lingford, Marija Petricevic, Alexander JD Snow, Yunyang Zhang, Michael A Jarva, Janice W-Y Mui, Nichollas E Scott, Eleanor C Saunders, Ruwan Epa, Bruna M da Silva, Douglas EV Pires, David B Ascher, Malcolm J McConville, Gideon J Davies, Spencer J Williams, Ethan D Goddard-Borger

Journal article  |  2022  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catabolism of sulfoquinovose (SQ; 6-deoxy-6-sulfoglucose), the ubiquitous sulfosugar produced by photosynthetic organisms, is an i..

Metabolic stringent response in intracellular stages of Leishmania

Eleanor C Saunders, Marijke F Sernee, Julie E Ralton, Malcolm J McConville

Journal article  |  2021  |  CURRENT OPINION IN MICROBIOLOGY

Leishmania are unusual in being able to survive long-term in the mature phagolysosome compartment of macrophages and other phagocy..

Identification of Metabolically Quiescent Leishmania mexicana Parasites in Peripheral and Cured Dermal Granulomas Using Stable Isotope Tracing Imaging Mass Spectrometry

Joachim Kloehn, Berin A Boughton, Eleanor C Saunders, Sean O'Callaghan, Katrina J Binger, Malcolm J McConville

Journal article  |  2021  |  MBIO

Leishmania are sandfly-transmitted protists that induce granulomatous lesions in their mammalian host. Although infected host cell..

Immunometabolism ofLeishmaniagranulomas

Eleanor C Saunders, Malcolm J McConville

Journal article  |  2020  |  IMMUNOLOGY AND CELL BIOLOGY

Leishmania are parasitic protists that cause a spectrum of diseases in humans characterized by the formation of granulomatous lesi..

Metabolic characteristics of CD8( ) T cell subsets in young and aged individuals are not predictive of functionality (vol 11, 2857, 2020)

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article  |  2020  |  NATURE COMMUNICATIONS

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Metabolic characteristics of CD8( ) T cell subsets in young and aged individuals are not predictive of functionality

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article  |  2020  |  NATURE COMMUNICATIONS

Virtual memory T (TVM) cells are antigen-naïve CD8+ T cells that exist in a semi-differentiated state and exhibit marked prolifera..

Leishmania Encodes a Bacterium-like 2,4-Dienoyl-Coenzyme A Reductase That Is Required for Fatty Acid beta-Oxidation and Intracellular Parasite Survival

Geo Semini, Daniel Paape, Martin Blume, M Fleur Sernee, Diego Peres-Alonso, Sebastien Calvignac-Spencer, Joerg Doellinger, Stefan Jehle, Eleanor Saunders, Malcolm J McConville, Toni Aebischer

Journal article  |  2020  |  MBIO

Leishmania spp. are protozoan parasites that cause a spectrum of important diseases in humans. These parasites develop as extracel..